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Bioscience, Biotechnology, and Biochemistry Volume 72, 2008 - Issue 4
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Original Articles

Identification of Saccharomyces cerevisiae Tub1 α-Tubulin as a Potential Target for NKH-7, a Cytotoxic 1-Naphthol Derivative Compound

Ruthada CHANKLANDepartment of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
,
Masaki MIZUNUMADepartment of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
,
Ngampong KONGKATHIPNatural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University
,
Komkrit HASITAPANNatural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University
,
Boonsong KONGKATHIPNatural Products and Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Kasetsart University
&
Tokichi MIYAKAWADepartment of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University
Pages 1023-1031 | Received 29 Nov 2007, Accepted 10 Jan 2008, Published online: 22 May 2014

  • 1) Solomon, F., Analyses of the cytoskeleton in Saccharomyces cerevisiae. Annu. Rev. Cell Biol., 7, 633–662 (1991).
  • 2) Botstein, D., Amberg, D., Mulholland, J., Huffaker, T., Adams, A., Drubin, D., and Stearns, T., The yeast cytoskeleton, 1. In “The Molecular and Cellular Biology of the Yeast Saccharomyces cerevisiae,” eds. Pringle, J. R., Broach, J. R., and Jones, E. W., Cold Spring Harbor Laboratory Press, New York, pp. 1–90 (1997).
  • 3) Shitamukai, A., Mizunuma, M., Hirata, D., Takahashi, H., and Miyakawa, T., A positive screening for drugs that specifically inhibit the Ca2+-signaling activity on the basis of the growth promoting effect on a yeast mutant with a peculiar phenotype. Biosci. Biotechnol. Biochem., 64, 1942–1946 (2000).
  • 4) Miyakawa, T., and Mizunuma, M., Physiological roles of calcineurin in Saccharomyces cerevisiae with special emphasis on its roles in G2/M cell-cycle regulation. Biosci. Biotechnol. Biochem., 71, 633–645 (2007).
  • 5) Chanklan, R., Aihara, E., Koga, S., Takahashi, H., Mizunuma, M., and Miyakawa, T., Inhibition of Ca2+-signal-dependent growth regulation by radicicol in budding yeast. Biosci. Biotechnol. Biochem., 72, 132–138 (2008).
  • 6) Koizumi, F., Fukumitsu, N., Zhao, J., Chanklan, R., Miyakawa, T., Kawahara, S., Iwamoto, S., Suzuki, M., Kakita, S., Rahayu, E. S., Hosokawa, S., Tatsuta, K., and Ichimura, M., YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008. J. Antibiotics, 60, 455–458 (2007).
  • 7) Miyamoto, Y., Machida, K., Mizunuma, M., Emoto, Y., Sato, N., Miyahara, K., Hirata, D., Usui, T., Takahashi, H., Osada, H., and Miyakawa, T., Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as target of G1-specific inhibitor of reveromycin A. J. Biol. Chem., 277, 28810–28814 (2002).
  • 8) Kongkathip, N., Hasitapan, K., Pradidphol, N., Kirtikara, K., Jongkon, N., and Kongkathip, B., Synthesis of novel 2-(2′-cyclopentyo)- and 2-(2′-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity. Curr. Med. Chem., 13, 3663–3674 (2006).
  • 9) Mizunuma, M., Hirata, D., Miyaoka, R., and Miyakawa, T., GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast. EMBO J., 20, 1074–1085 (2001).
  • 10) Kobayashi, Y., Mizunuma, M., Osada, H., and Miyakawa, T., Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells. Biosci. Biotechnol. Biochem., 70, 2451–2459 (2006).
  • 11) Straight, A. F., Marshall, W. F., Sedat, J. W., and Murray, A. W., Mitosis in living budding yeast: anaphase A but no metaphase plate. Science, 277, 574–578 (1997).
  • 12) Mizunuma, M., Hirata, D., Miyahara, K., Tsuchiya, E., and Miyakawa, T., Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Nature, 392, 303–306 (1998).
  • 13) Jacobs, C. W., Adams, A. E. M., Szaniszle, P. J., and Pringle, J. R., Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol., 107, 1409–1426 (1988).
  • 14) Schatz, P. J., Solomon, F., and Botstein, D., Genetically essential and nonessential alpha-tubulin gene specify functionally interchangeable proteins. Mol. Cell. Biol., 6, 3722–3733 (1986).
  • 15) Usui, T., Watanabe, H., Nakayama, H., Tada, Y., Kanoh, N., Kondoh, M., Asao, T., Takio, K., Watanabe, H., Nishikawa, K., Kitahara, T., and Osada, H., The anticancer natural product pironetin selectively targets Lys352 of α-tubulin. Chem. Biol., 11, 799–806 (2004).
  • 16) Nogales, E., Wolf, S. G., and Downing, K. H., Structure of αβ tubulin dimer by electron crystallography. Nature, 391, 199–202 (1998).
  • 17) Anders, K. R., and Botstein, D., Dominant-lethal α-tubulin mutants defective in microtubule depolymerization in yeast. Mol. Biol. Cell, 12, 3973–3986 (2001).
  • 18) Anthony, R. G., Waldin, T. R., Ray, J. A., Bright, S. W. J., and Hussey, P. J., Herbicide resistance caused by spontaneous mutation of the cytoskeletal protein tubulin. Nature, 393, 260–263 (1998).

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