Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 72, 2008 - Issue 7
Journal homepage
144
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Taiwanofungus camphoratus Activates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats

Fat-Moon SUKDepartment of Internal Medicine, Taipei Medical University Hospital & Wan-Fang Hospital
,
Shyr-Yi LINDepartment of Primary Care Medicine, Taipei Medical University Hospital;Traditional Herbal Medicine Research Center, Taipei Medical University Hospital
,
Chien-Ho CHENSchool of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University
,
Shish-Jung YENSchool of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University
,
Ching-Hua SUGraduate Institutes of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University;Traditional Herbal Medicine Research Center, Taipei Medical University Hospital
,
Der-Zen LIUGraduate Institutes of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University;Traditional Herbal Medicine Research Center, Taipei Medical University Hospital
,
Wen-Chi HOUGraduate Institute of Pharmacognosy Science, College of Pharmacy, Taipei Medical University;Traditional Herbal Medicine Research Center, Taipei Medical University Hospital
,
Ling-Fang HUNGSchool of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University
,
Pei-Jung LINSchool of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University
&
Yu-Chih LIANGSchool of Medical Laboratory Science & Biotechnology, College of Medicine, Taipei Medical University;Traditional Herbal Medicine Research Center, Taipei Medical University Hospital
 show all
Pages 1704-1713 | Received 13 Dec 2007, Accepted 29 Mar 2008, Published online: 22 May 2014

  • 1) Sorensen, H. N., Treuter, E., and Gustafsson, J. A., Regulation of peroxisome proliferator-activated receptors. Vitam. Horm., 54, 121–166 (1998).
  • 2) Schmidt, A., Endo, N., Rutledge, S. J., Vogel, R., Shinar, D., and Rodan, G. A., Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol., 6, 1634–1641 (1992).
  • 3) Sher, T., Yi, H. F., McBride, O. W., and Gonzalez, F. J., cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry, 32, 5598–5604 (1993).
  • 4) Elbrecht, A., Chen, Y., Cullinan, C. A., Hayes, N., Leibowitz, M. D., Moller, D. E., and Berger, J., Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem. Biophys. Res. Commun., 224, 431–437 (1996).
  • 5) Fajas, L., Auboeuf, D., Raspe, E., Schoonjans, K., Lefebvre, A. M., Saladin, R., Najib, J., Laville, M., Fruchart, J. C., Deeb, S., Vidal-Puig, A., Flier, J., Briggs, M. R., Staels, B., Vidal, H., and Auwerx, J., The organization, promoter analysis, and expression of the human PPARgamma gene. J. Biol. Chem., 272, 18779–18789 (1997).
  • 6) Desvergne, B., and Wahli, W., Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev., 20, 649–688 (1999).
  • 7) Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D. S., Spiegelman, B. M., and Mortensen, R. M., PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell, 4, 611–617 (1999).
  • 8) Willson, T. M., and Wahli, W., Peroxisome proliferator-activated receptor agonists. Curr. Opin. Chem. Biol., 1, 235–241 (1997).
  • 9) Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M., Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA, 91, 7355–7359 (1994).
  • 10) Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A., An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem., 270, 12953–12956 (1995).
  • 11) Dowell, P., Peterson, V. J., Zabriskie, T. M., and Leid, M., Ligand-induced peroxisome proliferator-activated receptor alpha conformational change. J. Biol. Chem., 272, 2013–2020 (1997).
  • 12) Forman, B. M., Chen, J., and Evans, R. M., Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. USA, 94, 4312–4317 (1997).
  • 13) Issemann, I., and Green, S., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645–650 (1990).
  • 14) Corton, J. C., Lapinskas, P. J., and Gonzalez, F. J., Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators. Mutat. Res., 448, 139–151 (2000).
  • 15) Gelman, L., Feige, J. N., and Desvergne, B., Molecular basis of selective PPARgamma modulation for the treatment of type 2 diabetes. Biochim. Biophys. Acta, 1771, 1094–1107 (2007).
  • 16) Wang, M., and Tafuri, S., Modulation of PPARgamma activity with pharmaceutical agents: treatment of insulin resistance and atherosclerosis. J. Cell. Biochem., 89, 38–47 (2003).
  • 17) Huang, A., and Raskin, P., Thiazolidinediones and insulin: rationale for use and role of combination therapy in type 2 diabetes mellitus. Treat. Endocrinol., 4, 205–220 (2005).
  • 18) Tsai, Z. T., and Liaw, S. L., “The Use and the Effect of Ganoderma,” Sheng-Yun Publishers, Inc., Taichung, pp. 116–117 (1985).
  • 19) Chen, C. H., Yang, S. W., and Shen, Y. C., New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum. J. Nat. Prod., 58, 1655–1661 (1995).
  • 20) Chiang, H. C., Wu, D. P., Cherng, I. H., and Ueng, C. H., A sesquiterpene lactone, phenyl and biphenyl compounds from Antrodia cinnamomea. Phytochemistry, 39, 613–616 (1995).
  • 21) Cherng, I. H., Wu, D. P., and Chiang, H. C., Triterenoids from Antrodia cinnamomea. Phytochemistry, 41, 263–267 (1996).
  • 22) Shen, C. C., Kuo, Y. C., Huang, R. L., Lin, L. C., Don, M. J., Chang, T. T., and Chou, C. J., New ergostane and lanostane from Antrodia camphorata. J. Chin. Med., 14, 247–258 (2003).
  • 23) Liu, D. Z., Liang, H. J., Chen, C. H., Su, C. H., Lee, T. H., Huang, C. T., Hou, W. C., Lin, S. Y., Zhong, W. B., Lin, P. J., Hung, L. F., and Liang, Y. C., Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. J. Ethnopharmacol., 113, 45–53 (2007).
  • 24) Liang, Y. C., Tsai, S. H., Tsai, D. C., Lin-Shiau, S. Y., and Lin, J. K., Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett., 496, 12–18 (2001).
  • 25) Hammarstedt, A., Andersson, C. X., Rotter Sopasakis, V., and Smith, U., The effect of PPARgamma ligands on the adipose tissue in insulin resistance. Prostaglandins Leukot. Essent., 73, 65–75 (2005).
  • 26) Balakumar, P., Rose, M., and Singh, M., PPAR ligands: are they potential agents for cardiovascular disorders? Pharmacology, 80, 1–10 (2007).
  • 27) Nissen, S. E., and Wolski, K., Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med., 356, 2457–2471 (2007).
  • 28) Han, K. L., Jung, M. H., Sohn, J. H., and Hwang, J. K., Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol. Pharm. Bull., 29, 110–113 (2006).
  • 29) Krawinkel, M. B., and Keding, G. B., Bitter gourd (Momordica Charantia): a dietary approach to hyperglycemia. Nutr. Rev., 64, 331–337 (2006).
  • 30) Harinantenaina, L., Tanaka, M., Takaoka, S., Oda, M., Mogami, O., Uchida, M., and Asakawa, Y., Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem. Pharm. Bull. (Tokyo), 54, 1017–1021 (2006).
  • 31) Chuang, C. Y., Hsu, C., Chao, C. Y., Wein, Y. S., Kuo, Y. H., and Huang, C. J., Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). J. Biomed. Sci., 13, 763–772 (2006).
  • 32) Takahashi, N., Kawada, T., Goto, T., Yamamoto, T., Taimatsu, A., Matsui, N., Kimura, K., Saito, M., Hosokawa, M., Miyashita, K., and Fushiki, T., Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett., 514, 315–322 (2002).
  • 33) Chen, C. C., Shiao, Y. J., Lin, R. D., Shao, Y. Y., Lai, M. N., Lin, C. C., Ng, L. T., and Kuo, Y. H., Neuroprotective diterpenes from the fruiting body of Antrodia camphorata. J. Nat. Prod., 69, 689–691 (2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.