483
Views
19
CrossRef citations to date
0
Altmetric
Original Articles

Improvement of L-Lactate Production by CYB2 Gene Disruption in a Recombinant Saccharomyces cerevisiae Strain under Low pH Condition

, , , , &
Pages 3063-3066 | Received 16 Jul 2008, Accepted 06 Aug 2008, Published online: 22 May 2014

  • 1) Gill, R. T., Wildt, S., Yang, Y. T., Ziesman, S., and Stephanopoulos, G., Genome-wide screening for trait conferring genes using DNA microarray. Proc. Natl. Acad. Sci. USA, 99, 7033–7038 (2002).
  • 2) Imaizumi, A., Takikawa, R., Koseki, C., Usuda, Y., Yasueda, H., Kojima, H., Matsui, K., and Sugimoto, S., Improved production of L-lysine by disruption of stationary phase-specific rmf gene in Escherichia coli. J. Biotechnol., 117, 111–118 (2005).
  • 3) Hirasawa, T., Yoshikawa, K., Nakakura, Y., Nagahisa, K., Furusawa, C., Katakura, Y., Shimizu, H., and Shioya, S., Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis. J. Biotechnol., 131, 34–44 (2007).
  • 4) Porro, D., Brambilla, L., Ranzi, B. M., Martegani, E., and Alberghina, L., Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid. Biotechnol. Prog., 11, 294–298 (1995).
  • 5) Adachi, E., Torigoe, M., Sugiyama, M., Nikawa, J., and Shimizu, K., Modification of metabolic pathways of Saccharomyces cerevisiae by the expression of lactate dehydrogenase and deletion of pyruvate decarboxylase genes for the lactic acid fermentation at low pH value. J. Ferment. Bioeng., 86, 284–289 (1998).
  • 6) Ishida, N., Saitoh, S., Onishi, T., Tokuhiro, K., Nagamori, E., Kitamoto, K., and Takahashi, H., The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production. Biosci. Biotechnol. Biochem., 70, 1148–1153 (2006).
  • 7) Ishida, N., Saitoh, S., Tokuhiro, K., Nagamori, E., Matsuyama, T., Kitamoto, K., and Takahashi, H., Efficient production of L-lactic acid by metabolically engineered Saccharomyces cerevisiae with a genome-integrated L-lactate dehydrogenase gene. Appl. Environ. Microbiol., 71, 1964–1970 (2005).
  • 8) Sawai, K., Sawai, H., Sonoki, K., and Mimitsuka, T., Japan Kokai Tokkyo Koho, 2008–29329 (Feb. 14, 2008).
  • 9) Sawai, K., Sawai, H., Sonoki, K., and Hatahira, S., Japan Kokai Tokkyo Koho, 2006–280368 (Oct. 19, 2006).
  • 10) Yang, I. V., Chen, E., Hasseman, J. P., Liang, W., Frank, B. C., Wang, S., Sharov, V., Saeed, A. I., White, J., Li, J., Lee, N. H., Yeatman, T. J., and Quackenbush, J., Within the fold: assessing differential expression measures and reproducibility in microarray assays. Genome Biol., 3, research0062.1–0062.12 (2002).
  • 11) Guiard, B., Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b 2). EMBO J., 4, 3265–3272 (1985).
  • 12) Lodi, T., and Ferrero, I., Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Mol. Gen. Genet., 238, 315–324 (1993).
  • 13) Casal, M., Paiva, S., Andrade, R. P., Gancedo, C., and Leão, C., The lactate-proton symport of Saccharomyces cerevisiae is encoded by JEN1. J. Bacteriol., 181, 2620–2623 (1999).
  • 14) Güldener, U., Heck, S., Fielder, T., Beinhauer, J., and Hegemann, J. H., A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res., 24, 2519–2524 (1996).
  • 15) Gietz, R. D., and Woods, R. A., Transformation of yeast by the lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol., 350, 87–96 (2002).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.