405
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Pro-Senescent Effect of Hydrogen Peroxide on Cancer Cells and Its Possible Application to Tumor Suppression

, , , , , & show all
Pages 311-315 | Received 29 Jul 2008, Accepted 30 Sep 2008, Published online: 22 May 2014

  • 1) Chen, Q., and Ames, B. N., Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. USA, 91, 4130–4134 (1994).
  • 2) Gorbunova, V., Seluanov, A., and Pereira-Smith, O. M., Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J. Biol. Chem., 277, 38540–38549 (2002).
  • 3) Duan, J., Duan, J., Zhang, Z., and Tong, T., Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int. J. Biochem. Cell Biol., 37, 1407–1420 (2005).
  • 4) Zdanov, S., Debacq-Chainiaux, F., Remacle, J., and Toussaint, O., Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts. FEBS Lett., 580, 6455–6463 (2006).
  • 5) Toussaint, O., Medrano, E. E., and von Zglinicki, T., Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol., 35, 927–945 (2000).
  • 6) Toussaint, O., Remacle, J., Dierick, J. F., Pascal, T., Frippiat, C., Zdanov, S., Magalhaes, J. P., Royer, V., and Chainiaux, F., From the Hayflick mosaic to the mosaics of ageing: role of stress-induced premature senescence in human ageing. Int. J. Biochem. Cell Biol., 34, 1415–1429 (2002).
  • 7) Frippiat, C., Chen, Q. M., Zdanov, S., Magalhaes, J. P., Remacle, J., and Toussaint, O., Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem., 276, 2531–2537 (2001).
  • 8) Katakura, Y., Nakata, E., Miura, T., and Shirahata, S., Transforming growth factor beta triggers two independent-senescence programs in cancer cells. Biochem. Biophys. Res. Commun., 255, 110–115 (1999).
  • 9) Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H., Schlegelberger, B., Stein, H., Dorken, B., Jenuwein, T., and Schmitt, C. A., Oncogene-induced senescence as an initial barrier in lymphoma development. Nature, 436, 660–665 (2005).
  • 10) Chen, Z., Trotman, L. C., Shaffer, D., Lin, H. K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., Cordon-Cardo, C., and Pandolfi, P. P., Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436, 725–730 (2005).
  • 11) Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguria, A., Zaballos, A., Flores, J. M., Barbacid, M., Beach, D., and Serrano, M., Tumour biology: senescence in premalignant tumours. Nature, 436, 642 (2005).
  • 12) Michaloglou, C., Vredeveld, L. C., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M., Majoor, D. M., Shay, J. W., Mooi, W. J., and Peeper, D. S., BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436, 720–724 (2005).
  • 13) Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., Peacocke, M., and Campisi, J., A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA, 92, 9363–9367 (1995).
  • 14) Dimri, G. P., What has senescence got to do with cancer? Cancer Cell, 7, 505–512 (2005).
  • 15) Beausejour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., and Campisi, J., Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J., 22, 4212–4222 (2003).
  • 16) Iavarone, A., and Massague, J., Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature, 387, 417–422 (1997).
  • 17) Jia, L. Q., Osada, M., Ishioka, C., Gamo, M., Ikawa, S., Suzuki, T., Shimodaira, H., Niitani, T., Kudo, T., Akiyama, M., Kimura, N., Matsuo, M., Mizusawa, H., Tanaka, N., Koyama, H., Namba, M., Kanamaru, R., and Kuroki, T., Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog., 19, 243–253 (1997).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.