221
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

The Rpd3/HDAC Complex Is Present at the URS1 cis-Element with Hyperacetylated Histone H3

, , , &
Pages 378-384 | Received 03 Sep 2008, Accepted 21 Oct 2008, Published online: 22 May 2014

  • 1) Pokholok, D. K., Harbison, C. T., Levine, S., Cole, M., Hannett, N. M., Lee, T. I., Bell, G. W., Walker, K., Rolfe, P. A., Herbolsheimer, E., Zeitlinger, J., Lewitter, F., Gifford, D. K., and Young, R. A., Genome-wide map of nucleosome acetylation and methylation in yeast. Cell, 122, 517–527 (2005).
  • 2) Robert, F., Pokholok, D. K., Hannett, N. M., Rinaldi, N. J., Chandy, M., Rolfe, A., Workman, J. L., Gifford, D. K., and Young, R. A., Global position and recruitment of HATs and HDACs in the yeast genome. Mol. Cell, 16, 199–209 (2004).
  • 3) Xie, J., Pierce, M., Gailus-Durner, V., Wagner, M., Winter, E., and Vershon, A. K., Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J., 18, 6448–6454 (1999).
  • 4) Kadosh, D., and Struhl, K., Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev., 12, 797–805 (1998).
  • 5) Kadosh, D., and Struhl, K., Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell, 89, 365–371 (1997).
  • 6) Anderson, S. F., Steber, C. M., Esposito, R. E., and Coleman, J. E., UME6, a negative regulator of meiosis in Saccharomyces cerevisiae, contains a C-terminal Zn2Cys6 binuclear cluster that binds the URS1 DNA sequence in a zinc-dependent manner. Protein Sci., 4, 1832–1843 (1995).
  • 7) Strich, R., Surosky, R. T., Steber, C., Dubois, E., Messenguy, F., and Esposito, R. E., UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev., 8, 796–810 (1994).
  • 8) Steber, C. M., and Esposito, R. E., UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression. Proc. Natl. Acad. Sci. USA, 92, 12490–12494 (1995).
  • 9) Bowdish, K. S., Yuan, H. E., and Mitchell, A. P., Positive control of yeast meiotic genes by the negative regulator UME6. Mol. Cell. Biol., 15, 2955–2961 (1995).
  • 10) Rubin-Bejerano, I., Mandel, S., Robzyk, K., and Kassir, Y., Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional repressor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. Mol. Cell. Biol., 16, 2518–2526 (1996).
  • 11) Burgess, S. M., Ajimura, M., and Kleckner, N., GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast. Proc. Natl. Acad. Sci. USA, 96, 6835–6840 (1999).
  • 12) Yukawa, M., Katoh, S., Miyakawa, T., and Tsuchiya, E., Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae, is required for the maximal expression of early meiotic genes. Genes Cells, 4, 99–110 (1999).
  • 13) Washburn, B. K., and Esposito, R. E., Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast. Mol. Cell. Biol., 21, 2057–2069 (2001).
  • 14) Honigberg, S. M., and Purnapatre, K., Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast. J. Cell Sci., 116, 2137–2147 (2003).
  • 15) Inai, T., Yukawa, M., and Tsuchiya, E., Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. Mol. Cell. Biol., 27, 1254–1263 (2007).
  • 16) Carrozza, M. J., Florens, L., Swanson, S. K., Shia, W. J., Anderson, S., Yates, J., Washburn, M. P., and Workman, J. L., Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim. Biophys. Acta, 1731, 77–87 (2005).
  • 17) Carrozza, M. J., Li, B., Florens, L., Suganuma, T., Swanson, S. K., Lee, K. K., Shia, W. J., Anderson, S., Yates, J., Washburn, M. P., and Workman, J. L., Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell, 123, 581–592 (2005).
  • 18) Williams, R. M., Primig, M., Washburn, B. K., Winzeler, E. A., Bellis, M., Sarrauste de Menthiere, C., Davis, R. W., and Esposito, R. E., The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc. Natl. Acad. Sci. USA, 99, 13431–13436 (2002).
  • 19) Kurdistani, S. K., Robyr, D., Tavazoie, S., and Grunstein, M., Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat. Genet., 31, 248–254 (2002).
  • 20) Rothstein, R., Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol., 194, 281–301 (1991).
  • 21) Yukawa, M., Koyama, H., Miyahara, K., and Tsuchiya, E., Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process. FEMS Yeast Res., 2, 87–91 (2002).
  • 22) Koyama, H., Itoh, M., Miyahara, K., and Tsuchiya, E., Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae. FEBS Lett., 531, 215–221 (2002).
  • 23) Fazzio, T. G., Kooperberg, C., Goldmark, J. P., Neal, C., Basom, R., Delrow, J., and Tsukiyama, T., Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol. Cell. Biol., 21, 6450–6460 (2001).
  • 24) Bowdish, K. S., and Mitchell, A. P., Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol. Cell. Biol., 13, 2172–2181 (1993).
  • 25) Rundlett, S. E., Carmen, A. A., Suka, N., Turner, B. M., and Grunstein, M., Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature, 392, 831–835 (1998).
  • 26) Lo, W. S., Duggan, L., Emre, N. C., Belotserkovskya, R., Lane, W. S., Shiekhattar, R., and Berger, S. L., Snf1: a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science, 293, 1142–1146 (2001).
  • 27) Lee, T. I., and Young, R. A., Transcription of eukaryotic protein-coding genes. Annu. Rev. Genet., 34, 77–137 (2000).
  • 28) Jacobson, S. J., Laurenson, P. M., and Pillus, L., Functional analyses of chromatin modifications in yeast. Methods Enzymol., 377, 3–55 (2004).
  • 29) Soushko, M., and Mitchell, A. P., An RNA-binding protein homologue that promotes sporulation-specific gene expression in Saccharomyces cerevisiae. Yeast, 16, 631–639 (2000).
  • 30) Watson, A. D., Edmondson, D. G., Bone, J. R., Mukai, Y., Yu, Y., Du, W., Stillman, D. J., and Roth, S. Y., Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev., 14, 2737–2744 (2000).
  • 31) Papamichos-Chronakis, M., Petrakis, T., Ktistaki, E., Topalidou, I., and Tzamarias, D., Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1. Mol. Cell, 9, 1297–1305 (2002).
  • 32) De Nadal, E., Zapater, M., Alepuz, P. M., Sumoy, L., Mas, G., and Posas, F., The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature, 427, 370–374 (2004).
  • 33) Sharma, V. M., Tomar, R. S., Dempsey, A. E., and Reese, J. C., Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol. Cell. Biol., 27, 3199–3210 (2007).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.