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Bioscience, Biotechnology, and Biochemistry Volume 73, 2009 - Issue 3
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Original Articles

Multiple Functions of Short Synthetic Enantiomeric Peptides Based on Beetle Defensins

Takashi IWASAKIGraduate School of Life and Environmental Sciences, University of Tsukuba;Innate Immunity Research Unit, National Institute of Agrobiological Sciences
,
Jun ISHIBASHIInnate Immunity Research Unit, National Institute of Agrobiological Sciences
,
Masanori KUBODiagnostic Section, National Institute of Animal Health
,
DeMar TAYLORInstitute of Agriculture and Forestry, University of Tsukuba
&
Minoru YAMAKAWAGraduate School of Life and Environmental Sciences, University of Tsukuba;Innate Immunity Research Unit, National Institute of Agrobiological Sciences
Pages 683-687 | Received 15 Oct 2008, Accepted 02 Dec 2008, Published online: 22 May 2014

  • 1) Bertuch, A. A., and Lundblad, V., The maintenance and masking of chromosome termini. Curr. Opin. Cell Biol., 18, 247–253 (2006).
  • 2) Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W., Specific association of human telomerase activity with immortal cells and cancer. Science, 266, 2011–2015 (1994).
  • 3) Holt, S. E., and Shay, J. W., Role of telomerase in cellular proliferation and cancer. J. Cell Physiol., 180, 10–18 (1999).
  • 4) Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright, W. E., Extension of life-span by introduction of telomerase into normal human cells. Science, 279, 349–352 (1998).
  • 5) Harley, C. B., Futcher, A. B., and Greider, C. W., Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458–460 (1990).
  • 6) Greider, C. W., Telomerase activation: one step on the road to cancer? Trends Genet., 15, 109–112 (1999).
  • 7) Shay, J. W., and Bacchetti, S., A survey of telomerase activity in human cancer. Eur. J. Cancer, 33, 787–791 (1997).
  • 8) Ramirez, R., Carracedo, J., Jimenez, R., Canela, A., Herrera, E., Aljama, P., and Blasco, M. A., Massive telomere loss is an early event of DNA damage-induced apoptosis. J. Biol. Chem., 278, 836–842 (2003).
  • 9) Herbert, B., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., and Corey, D. R., Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA, 96, 14276–14281 (1999).
  • 10) Miyanoshita, A., Hara, S., Sugiyama, M., Asaoka, A., Taniai, K., Yukuhiro, F., and Yamakawa, M., Isolation and characterization of a new member of the insect defensin family from a beetle, Allomyrina dichotoma. Biochem. Biophys. Res. Commun., 220, 526–531 (1996).
  • 11) Ishibashi, J., Saido-Sakanaka, H., Yang, J., Sagisaka, A., and Yamakawa, M., Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros. Eur. J. Biochem., 266, 616–623 (1999).
  • 12) Saido-Sakanaka, H., Ishibashi, J., Sagisaka, A., Momotani, E., and Yamakawa, M., Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide. Biochem. J., 338, 29–33 (1999).
  • 13) Saido-Sakanaka, H., Ishibashi, J., Momotani, E., Amano, F., and Yamakawa, M., In vitro and in vivo activity of antimicrobial peptides synthesized based on the insect defensin. Peptides, 25, 19–27 (2004).
  • 14) Iwasaki, T., Saido-Sakanaka, H., Asaoka, A., Taylor, D., Ishibashi, J., and Yamakawa, M., In vitro activity of diastereomeric antimicrobial peptides alone and in combination with antibiotics against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. J. Insect Biotechnol. Sericol., 76, 25–29 (2007).
  • 15) Saido-Sakanaka, H., Ishibashi, J., Momotani, E., and Yamakawa, M., Protective effects of synthetic antibacterial oligopeptides based on the insect defensins on Methicillin-resistant Staphylococcus aureus in mice. Dev. Comp. Immunol., 29, 469–477 (2005).
  • 16) Yamada, M., Nakamura, K., Saido-Sakanaka, H., Asaoka, A., Yamakawa, M., Sameshima, T., Motobu, M., and Hirota, Y., Effect of modified oligopeptides from the beetle Allomyrina dichotoma on Escherichia coli infection in mice. J. Vet. Med. Sci., 66, 137–142 (2004).
  • 17) Yamada, M., Nakamura, K., Saido-Sakanaka, H., Asaoka, A., Yamakawa, M., Yamamoto, Y., Koyama, Y., Hikosaka, K., Shimizu, A., and Hirota, Y., Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on Methicillin-resistant Staphylococcus aureus (MRSA) infection in mice. J. Vet. Med. Sci., 67, 1005–1011 (2005).
  • 18) Zhang, L., Huang, J., Ren, L., Bai, M., Wu, L., Zhai, B., and Zhou, X., Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase. Bioorg. Med. Chem., 16, 303–312 (2008).
  • 19) Futaki, S., Oligoarginine vectors for intracellular delivery: design and cellular-uptake mechanisms. Biopolymers, 84, 241–249 (2006).
  • 20) Rothbard, J. B., Kreider, E., VanDeusen, C. L., Wright, L., Wylie, B. L., and Wender, P. A., Arginine-rich molecular transporters for drug delivery: role of backbone spacing in cellular uptake. J. Med. Chem., 45, 3612–3618 (2002).
  • 21) Maeji, N. J., Bray, A. M., and Geysen, H. M., Multi-pin peptide synthesis strategy for T cell determinant analysis. J. Immunol. Methods, 134, 23–33 (1990).
  • 22) Trapp, S., and Horobin, R. W., A predictive model for the selective accumulation of chemicals in tumor cells. Eur. Biophys. J., 34, 959–966 (2005).
  • 23) Marks, A. J., Cooper, M. S., Anderson, R. J., Orchard, K. H., Hale, G., North, J. M., Ganeshaguru, K., Steele, A. J., Mehta, A. B., Lowdell, M. W., and Wickremasinghe, R. G., Selective apoptotic killing of malignant hemopoietic cells by antibody-targeted delivery of an amphipathic peptide. Cancer Res., 65, 2373–2377 (2005).
  • 24) Pulczynski, S., Boesen, A. M., and Jensen, O. M., Antibody-induced modulation and intracellular transport of CD10 and CD19 antigens in human B-cell lines: an immunofluorescence and immunoelectron microscopy study. Blood, 81, 1549–1557 (1993).
  • 25) van Der Velden, V. H., te Marvelde, J. G., Hoogeveen, P. G., Bernstein, I. D., Houtsmuller, A. B., Berger, M. S., and van Dongen, J. J., Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells. Blood, 97, 3197–3204 (2001).

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