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Original Articles

Brain Morphological Changes and Early Marijuana Use

A Magnetic Resonance and Positron Emission Tomography Study

, , , , &
Pages 1-22 | Published online: 02 Feb 2010

References

  • Pope , H G , Gruber , A J and Yargelun-Todd , D . 1995 . The residual neuropsychological effects of cannabis: the current status of research . Drug and Alcohol Dependence , 38 : 25 – 34 .
  • Block , R I . 1996 . Does heavy marijuana smoking impair human cognition and brain function? . JAMA , 275 : 560 – 561 .
  • University of Michigan . December 11 1995 . Drug use rises again in 1995 among American teens (press release from the Monitoring the future study) , December 11 , Ann Arbor : Michigan .
  • Pope , H G and Yargelun-Todd , D . 1996 . The residual effects of heavy marijuana use in college students . JAMA , 275 ( 7 ) : 521 – 527 .
  • Fletcher , J M , Page , J B , Francis , D J , Copeland , K , Naus , M J , Davis , C M , Morris , R , Krauskopf , D and Satz , P . 1996 . Cognitive correlates of long-term cannabis use in Costa Ri-can men . Arch Gen Psychiatry , 53 : 1051 – 1057 .
  • Campbell , A MG , Evans , M , Thomsom , J and Williams , M . 1971 . Cerebral atrophy in young cannabis smokers . Lancet , 2 : 1219 – 1225 .
  • Co , B T , Goodwin , D , Gado , M , Mikhael , M and Hill , S . 1977 . Absence of cerebral atrophy in chronic cannabis users: evaluation by computerized transaxial tomography . JAMA , 237 ( 12 ) : 1229 – 1230 .
  • Hannerz , J and Hindmarsh , T . 1982 . Neurological and neuroradiological examination of chronic cannabis smokers . Annals of Neurol , 13 ( 2 ) : 207 – 210 .
  • Kuehnle , J , Mendelson , J , Davis , K and New , P . 1977 . Computed tomographic examination of heavy marijuana smokers . JAMA , 237 : 1231 – 1232 .
  • DeCarli , C , Maisog , J , Murphy , D GM , Teichberg , D , Rapoport , S I and Horwits , B . 1992 . Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images . J Comp Assist Tomog , 16 ( 2 ) : 274 – 284 .
  • Mathew , R J , Wilson , W H , Coleman , R E , Turkington , T G and DeGrado , T R . 1997 . Marijuana intoxication and brain activation in marijuana smokers . Life Science , 60 ( 23 ) : 2075 – 2089 .
  • Spitzer , R L , Williams , J BW , Gibbon , M and First , M B . 1984 . User's Guide for the Structured Clinical Interview for the DSM-III-R , American Psychiatric Press, Inc. .
  • Skinner , H A . 1982 . Drug Abuse Screening Test . Addict Behav , 7 : 363
  • Pokorny , A D , Miller , B A and Kaplan , H B . 1972 . The brief MAST: A shortened version of the Michigan Alcoholism Screening Test . Am J Psychiatry , 129 ( 3 ) : 342 – 345 .
  • Beck , A T and Beck , R W . 1972 . Screening depressed patients in family practice . Post-grad Med , 52 : 81 – 85 .
  • Spielberger , C D , Gorsuch , R L and Lushene , R D . 1970 . STAI Manual , Palo Alto, California : Consulting Psychologist Press .
  • Byrum , C E , MacFall , J R , Charles , H C , Chitilla , V R , Boyko , O B , Upchurch , L , Smith , J S , Rajagopalan , P , Passe , T , Kim , D , Xanthakos , S and Krishnan , K RK . 1996 . Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method . Psychiatry Res: Neuroimaging , 67 : 215 – 234 .
  • Talairach , J and Tournoux , P . 1988 . Co-Planar Stereotaxic Atlas of the Human Brain , New York : Thieme Medical Publishers, Inc .
  • Kretschmann , H-J and Weinrich , W . 1992 . Clinical Neuroimaging and Clinical Neuro-anatomy:Magnetic Resonance Imaging and Computed Tomography, () , 2nd ed , New York : Georg Thieme, Verlag Stuttgart .
  • Eichling , J O , Raichle , M E , Grubb , R L JR and Ter-Pogossian , M M . 1974 . Evidence of the limitations of water as a freely diffusible tracer in brain of monkey . Circ Res , 35 : 358 – 364 .
  • Frackowiak , R S , Lenzi , G L , Jones , G and Heather , J D . 1980 . Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: Theory, procedure and normal values . J Comput Assist Tomography , 4 : 727 – 736 .
  • Huang , S C , Carson , R E , Hoffman , E J , Carson , J , MacDonald , N , Barrio , J R and Phelps , M E . 1983 . Quantitative measurement of local cerebral blood flow in humans by positron emission tomography and 15 O-water . J Cereb Blood Flow Metab , 3 : 141 – 153 .
  • Meyer , E . 1989 . Simultaneous correction for tracer arrival delay and dispersion in CBF measurements by the H2 15O autoradiographic method and dynamic PET . J Nuclear Med , 30 : 1069 – 1078 .
  • Chen , C T , Pelizzari , C A , Chen , T Y , Hu , X , Lebin , D N and Cooper , M D . 1989 . Integration of brain images from multiple modalities . J Cereb Blood Flow Metab , 9 ( 1 ) : S402
  • Pelizzari , C A , Chen , G TY , Spelbring , D R , Weichsebaum , R R and Chen , C T . 1989 . Accurate three-dimensional registration of CT, PET and/or MR images of the brain . J Comput Assist Tomog , 13 : 20 – 26 .
  • Turkington , T G , Jasczak , R J , Pelizzari , C A , Harris , C C , McFall , J R , Hoffman , J M and Coleman , R E . 1993 . Accuracy of registration of PET, SPECT and MR images of a brain phantom . J Nuclear Med , 34 ( 9 ) : 1587 – 1594 .
  • Turkington , T G , Hoffman , J M , Jasczak , R J , MacFall , J R , Harris , C G , Kilts , C D , Pelizzari , C A and Coleman , R E . 1995 . Accuracy of surface fit registration for PET and MR images using full and incomplete brain surfaces . J Comput Assist Tomog , 19 ( 1 ) : 117 – 124 .
  • Kirk , R E . 1982 . Experimental Design: Procedures for the Behavioral Sciences. , 2nd Ed. , Belmont, CA : Brooks/Cole .
  • Yoshii , F , Barker , W W Chang , J Y . 1988 . Sensitivity of cerebral glucose metabolism to age, sex, brain volume, brain atrophy, and cerebrovascular risk factors . J Cer-eb Blood Flow Metab , 8 : 654 – 661 .
  • Scallet , A C , Uemura , E , Andrews , A , Ali , S F , McMillan , D E , Paule , M G , Brown , R M and Slikker , W Jr . 1987 . Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC) . Brain Res , 436 : 193 – 198 .
  • Jernigan , T L and Tallal , P . 1990 . Late childhood changes in brain morphology observable with MRI . Devel Med Child Neurology , 32 : 379 – 385 .
  • Herkenham , M . 1992 . Cannabinoid receptor localization in brain: relationship to motor and reward systems . Ann New York Acad Sci , 654 : 19 – 32 .
  • Dekaban , A S and Sadowsky , D . 1978 . Changes in brain weights during the span of human life: relation of brain weights to body heights and weights . Ann Neurol , 4 : 345 – 356 .
  • Dobbing , J and Sands , J . 1973 . Quantitative growth and development of human brain . Arch Dis Childhood , 48 : 757 – 767 .
  • Jernigan , T L , Trauner , D A , Hasselink , J R and Tallal , P A . 1991 . Maturation of human cerebrum observed in vivo during adolescence . Brain , 114 : 2037 – 2049 .
  • Reiss , A L , Abrams , M T , Singer , H S , Ross , J L and Denckla , M B . 1996 . Brain development, sex and IQ in children. A volumetric imaging study . Brain , 119 : 1763 – 1774 .
  • Purves , D . 1988 . Body and Brain: A Tropic Theory of Neural Connections , Cambridge and London, MA : Harvard University Press .
  • Hoffman , M A and Swabb , D F . 1991 . Sexual dimorphism of the human brain: myth and reality . Exp Clin Endocrinology , 98 : 161 – 170 .
  • Witelson , S F . 1991 . Neural sexual mosaicism: sexual differentiation of the human temporoparietal region for functional asymmetry . Psychoneuroendocrinology , 16 : 131 – 133 .
  • Clark , A S and Goldman-Rakic , P S . 1989 . Gonadal hormones influence the emergence of cortical function in nonhuman primates . Behavioral Neuroscience , 103 ( 6 ) : 1287 – 1295 .
  • Wenger , T , Croix , D , Tramu , G and Leonardelli , J . 1992 . “ Effects of delta-9-tetrahydrocan-nabinol on pregnancy, puberty and the neuroendocrine system ” . In Marijuana/Cannabinoids: Neurobiology and Neurophysiology , Edited by: Murphy , L and Bartke , A . Boca Raton : CRC Press, Inc. .
  • Cone , E J , Johnson , R E , Moore , J D and Roache , J D . 1986 . Acute effects of smoking marijuana on hormones, subjective effects and performance in male human subjects . Pharmacol, Biochem & Behavior , 24 : 1749 – 1754 .
  • Mendelson , J H , Mello , N K , Ellingboe , J , Skupny , A ST , Lex , B W and Griffin , M . 1986 . Marihuana smoking suppresses luteinizing hormone in women . J Pharmacology & Exp Therapeutics , 237 ( 3 ) : 862 – 866 .
  • Schlaepfer , T E , Harris , G J , Tien , A Y , Peng , L , Lee , S and Pearlson , G D . 1995 . Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study . Psych Res Neuroimaging , 61 : 129 – 135 .
  • Murphy , D GM , DeCarli , C , McIntosh , A R , Daly , E , Mentis , M , Pietrini , P , Szczepanik , J , Schapiro , M B , Grady , C L , Horwitz , B and Rapoport , S I . 1996 . Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effects of aging . Arch Gen Psychiatry , 53 : 585 – 594 .
  • Fernández-Ruiz , J J , Rodriguez de Fonseca , F , Navarro , M and Ramos , J A . 1992 . “ Maternal cannabinoid exposure and brain development: changes in the ontogeny of dopamine neurons ” . In Marijuana/Cannabinoids: Neurobiology and Neurophysiology , Edited by: Murphy , L and Bartke , A . Boca Raton : CRC Press, Inc. .
  • Walters , D E and Carr , L A . 1988 . Perinatal exposure to cannabinoids alters neurochemi-cal development of the brain . Pharmacol Biochem Behav , 29 : 213
  • Klausner , H A and Dingle , J V . 1971 . The metabolism and excretion of delta-9-tetrahydro-cannabinol in the rat . Life Sci , 10 : 49
  • Stiglick , A and Kalant , H . 1985 . Residual effects of chronic cannabis treatment on behavior in mature rats . Psychopharmacology , 85 : 436
  • Landfield , P W , Cadwallader , L B and Vincent , S . 1988 . Quantitative changes in hippo-campal structure following long-term exposure to delta-9-tetrahydrocannabinol: Possible mediation by glucocorticoid systems . Brain Res , 443 : 47 – 62 .
  • Slikker , W , Paule , M G , Ali , S F , Scallett , A C and Bailey , J R . 1992 . “ Behavioral, neurochem-ical and neurohistological effects of chronic marijuana smoke exposure in the nonhu-man primate. Chap 7 ” . In Marijuana/Cannabinoids: Neurobiology and Neurophysiology , Edited by: Murphy , L and Bartke , A . Boca Raton : CRC Press, Inc. .
  • Compton , D R and Martin , B R . 1995 . Marijuana Neurotoxicology in Handbook of Neuro-toxicology , Edited by: Chang , L W and Dyer , R S . New York : Marcel Dekker, Inc. . Ch. 29
  • Nye , J S , Voglmaier , S , Martinson , R E and Snyder , S H . 1988 . Myelin basic protein is an endogenous inhibitor of the high-affinity cannabinoid binding site in brain . J Neuro-chem , 50 : 1170 – 1178 .
  • Gur , R C , Gur , R E Obrist , W D . 1982 . Sex and handedness differences in cerebral blood flow during rest and cognitive activity . Science , 217 : 659 – 661 .
  • Mathew , R J , Wilson , W H and Tant , S . 1986 . Determinants of resting regional cerebral blood flow in normal subjects . Biol Psychiatry , 21 : 907 – 914 .
  • Esposito , G , Van Horn , J D , Weinberger , D R and Berman , K F . 1996 . Sex differences in cerebral blood flow as a function of cognitive state with PET . J Nucl Med , 37 : 559 – 564 .
  • Mazziotta , J C . 1985 . PET scanning principles and applications . Discussions in Neu-rosci , 2 ( 1 ) : 9 – 47 .
  • Raichle , M E , Grubb , R L Gado , M H . 1976 . Correlations between regional cerebral blood flow and oxidative metabolism . Arch Neurol , 33 : 523 – 526 .
  • Roland , P E . 1993 . Brain Activation. (Chapter 18) , New York : Wiley Liss, Inc. .
  • Chugani , H T , Phelps , M E and Mazziota , J C . 1987 . Positron emission tomography study of human brain functional development . Ann Neurol , 22 : 487 – 497 .
  • Chiron , C , Raynaud , C , Maziere , B , Zilbovicius , M , Laflamme , L , Masure , M-C , Dulac , O , Bourguignon , M and Syrota , A . 1992 . Changes in regional cerebral blood flow during brain maturation in children and adolescents . J Nucl Med , 33 ( 5 ) : 696 – 703 .
  • Ogawa , A , Sakurai , Y , Kayama , T and Yoshimoto , T . 1989 . Regional cerebral blood flow with age: changes in rCBF in childhood . Neurol Res , 11 : 173 – 176 .
  • Kety , S S . 1956 . Human cerebral blood flow and oxygen consumption as related to aging . J Chronic Dis , 3 : 478 – 486 .
  • Goldman , H , Skelley , E B , Sandman , C A , Kastin , A J and Murphy , S . 1976 . Hormones and regional brain blood flow . Pharmaco Biochem Behav , 5 ( suppl 1 ) : 165 – 169 .
  • Ohkura , T , Teshima , Y , Isse , K , Matsuda , H , Inoue , T , Sakai , Y , Iwasaki , N and Yaoi , Y . 1995 . Estrogen increases cerebral and cerebellar blood flows in postmenopausal women . J North Amer Menopause Soc , 2 ( 1 ) : 13 – 18 .
  • Devous , M D , Stokley , E M , Chehabi , H H and Bonte , F J . 1986 . Normal distribution of regional blood flow measured by dynamic single-photon emission tomography . J Cer-eb Blood Flow Metab , 6 : 95 – 104 .
  • Swihart , A A , Mathew , R J and Lorgen , J W . 1989 . Menstruation and cerebral blood flow . Biological Psychiatry , 25 : 654 – 657 .
  • Kokka , N and Garcia , J F . 1974 . Effects of delta-9 tetrahydrocannabinol on growth hormone and ACTH secretion in rats . Life Science , 15 : 329
  • Rettori , V , Wenger , T , Snyder , G , Dalterio , S and McCann , S M . 1988 . Hypothalamic action of delta-9-tetrahydrocannabinol to inhibit the release of prolactin and growth hormone in rat . Neuroendocrinology , 47 : 498
  • Ingersoll , G M . 1988 . Adolescents. , 2nd ed. , Englewood Cliffs, New Jersey : Prentice Hall .
  • Comerci , G D . 1987 . Normal pubescent growth and sexual maturation . Seminars Adolescent Medicine , 3 ( 1 ) : 217 – 226 .
  • Gupta , D and Elbracht , C . 1983 . Effects of tetrahydrocannabinols on pubertal body weight spurt and sex hormones in developing male rats . Res Exper Med , 182 : 95 – 104 .
  • Field , E and Tyrey , L . 1990 . Delayed sexual maturation during prepubertal cannabinoid treatment: importance of the timing of treatment . J Pharmaco Exper Therap , 254 ( 1 ) : 171 – 175 .

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