Methadone Maintenance and Male Sexual Dysfunction

References

• Facilities Providing Methadone/LAAM Treatment to Clients with Opiate Addiction , Office of Applied Studies Rockville, MD Substance Abuse and Mental Health Services Administration. 2002. http://www.samhsa.gov/centers/clearinghouse/clearinghouses.html. Accessed 1/8/04
   Google Scholar
• Langendam , M , van Brussel , G , Coutinho , R and van Ameijden , E . 2001 . The impact of harm-reduction-based methadone treatment on mortality among heroin users . Am J Public Health , 91 : 774 – 80 .
   PubMed Web of Science ®Google Scholar
• Fugelstad , A , Rajs , J , Bottiger , M and Gerhardsson de Verdier , M. 1995 . Mortality among HIV-infected intravenous drug addicts in Stockholm in relation to methadone treatment . Addiction , 90 : 711 – 16 .
   PubMed Web of Science ®Google Scholar
• Ward , J , Malrick , R and Halls , W . 1994 . The effectiveness of methadone maintenance treatment: an overview . Drug & Alcohol Review , 13 : 327 – 36 .
   PubMedGoogle Scholar
• Gunne , L and Gronbladh , L . 1981 . The Swedish methadone maintenance program: a controlled study . Drug Alcohol Depend , 7 : 249 – 56 .
   PubMed Web of Science ®Google Scholar
• O'Connor , P , Selwyn , P and Schottenfeld , R . 1994 . Medical care for injection drug users with human immunodeficiency virus infection . N Engl J Med , 331 : 450 – 9 .
   PubMed Web of Science ®Google Scholar
• Ball , J , Lange , W , Myers , C and Friedman , S . 1988 . Reducing the risk of AIDS through methadone maintenance treatment . J Health Soc Behav , 29 : 214 – 26 .
   PubMed Web of Science ®Google Scholar
• Yancovitz , S , Des Jarlais , D , Peyser , N , Drew , E , Friedman , P and Trigg , H . 1991 . A randomized trial of an interim methadone maintenance clinic . Am J Public Health , 81 : 1185 – 91 .
   PubMed Web of Science ®Google Scholar
• Dole , V and Joseph , H . 1978 . Long-term outcome of patients treated with methadone maintenance . Ann N Y Acad Sci , 311 : 181 – 9 .
   PubMedGoogle Scholar
• McGlothlin , W and Anglin , M . 1981 . Long-term follow-up of clients of high- and low-dose methadone programs . Arch Gen Psychiatry , 38 : 1055 – 63 .
   PubMed Web of Science ®Google Scholar
• Bell , J , Hall , W and Byth , K . 1992 . Changes in criminal activity after entering methadone maintenance . Br J Addict , 87 : 251 – 8 .
   PubMedGoogle Scholar
• Hser , Y , Anglin , D and Powers , K . 1993 . A 24-year follow-up of California narcotics addicts . Arch Gen Psychiatry , 50 : 577 – 84 .
   PubMed Web of Science ®Google Scholar
• Strain , E , Stitzer , M , Liebson , I and Bigelow , G . 1993 . Dose-response effects of methadone in the treatment of opioid dependence . Ann Intern Med , 119 : 23 – 7 .
   PubMed Web of Science ®Google Scholar
• Caplehorn , J , Bell , J , Kleinbaum , D and Gebski , V . 1993 . Methadone dose and heroin use during maintenance treatment . Addiction , 88 : 119 – 24 .
   PubMed Web of Science ®Google Scholar
• Simpson , D . 1979 . The relation of time spent in drug abuse treatment to posttreatment outcome . Am J Psychiatry , 136 : 1449 – 53 .
   PubMed Web of Science ®Google Scholar
• Strain , E , Bigelow , G , Liebson , I and Stitzer , M . 1999 . Moderate vs. high-dose methadone in the treatment of opioid dependence: A randomized trial . JAMA , 281 : 1000 – 5 .
   PubMed Web of Science ®Google Scholar
• Hanbury , R , Cohen , M and Stimmel , B . 1977 . Adequacy of sexual performance in men maintained on methadone . Am J Drug Alcohol Abuse , 4 : 13 – 20 .
   PubMed Web of Science ®Google Scholar
• Cicero , T J , Bell , R D , Wiest , W G , Allison , J H , Polakoski , K and Robins , E . 1975 . Function of the male sex organs in heroin and methadone users . N Engl J Med , 292 : 882 – 7 .
   PubMed Web of Science ®Google Scholar
• Kreek , M . 1973 . Medical safety and side effects of methadone in tolerant individuals . JAMA , 223 : 665 – 8 .
   PubMed Web of Science ®Google Scholar
• Ragni , G , De Lauretis , L , Gambaro , V , Di Pietro , R , Bestetti , O , Recalcati , F and Papetti , C . 1985 . Semen evaluation in heroin and methadone addicts . Acta Eur Fertil , 16 : 245 – 9 .
   PubMedGoogle Scholar
• Ragni , G , De Lauretis , L , Bestetti , O , Sghedoni , D and Gambaro , V . 1988 . Gonadal function in male heroin and methadone addicts . Int J Androl , 11 : 93 – 100 .
   PubMed Web of Science ®Google Scholar
• Spring , W D Jr. , Willenbring , M L and Maddux , T L . 1992 . Sexual dysfunction and psychological distress in methadone maintenance . Int J Addict , 27 : 1325 – 34 .
   PubMed Web of Science ®Google Scholar
• Teusch , L , Scherbaum , N , Bohme , H , Bender , S , Eschmann-Mehl , G and Gastpar , M . 1995 . Different patterns of sexual dysfunctions associated with psychiatric disorders and psychopharmacological treatment. Results of an investigation by semistructured interview of schizophrenic and neurotic patients and methadone-substituted opiate addicts . Pharmacopsychiatry , 28 : 84 – 92 .
   PubMed Web of Science ®Google Scholar
• Woody , G , McLellan , A , O'Brien , C , Persky , H , Stevens , G , Arndt , I and Carroff , S . 1988 . Hormone secretion in methadone-dependent and abstinent patients . NIDA Res Monogr , 81 : 216 – 23 .
   PubMedGoogle Scholar
• Sheridan , P J and Buchanan , J M . 1980 . The effects of opiates on androgen binding in the forebrain of the rat . Int J Fertil , 25 : 36 – 43 .
   PubMedGoogle Scholar
• Smith , D , Moser , C , Wesson , D , Apter , M , Buxton , M , Davison , J , Orgel , M and Buffum , J . 1982 . A clinical guide to the diagnosis and treatment of heroin-related sexual dysfunction . J Psychoactive Drugs , 14 : 91 – 9 .
   PubMed Web of Science ®Google Scholar
• Mendelson , J H and Mello , N K . 1975 . Plasma testosterone levels during chronic heroin use and protracted astinence. A study of Hong Kong addicts . Clin Pharmacol Ther , 17 : 529 – 33 .
   PubMed Web of Science ®Google Scholar
• Mendelson , J H , Inturrisi , C E , Renault , P and Senay , E C . 1976 . Effects of acetylmethadol on plasma testosterone . Clin Pharmacol Ther , 19 : 371 – 4 .
   PubMed Web of Science ®Google Scholar
• Mendelson , J H , Ellingboe , J , Judson , B A and Goldstein , A . 1984 . Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal . Clin Pharmacol Ther , 35 : 545 – 7 .
   PubMed Web of Science ®Google Scholar
• Mendelson , J H and Mello , N K . 1978 . Plasma testosterone levels during chronic heroin use and protracted abstinence: study of Hong Kong addicts . NIDA Res Monogr , : 142 – 8 .
   PubMedGoogle Scholar
• Mendelson , J H , Mendelson , J E and Patch , V D . 1975 . Plasma testosterone levels in heroin addiction and during methadone maintenance . J Pharmacol Exp Ther , 192 : 211 – 17 .
   PubMed Web of Science ®Google Scholar
• Mendelson , J H , Meyer , R E , Ellingboe , J , Mirin , S M and McDougle , M . 1975 . Effects of heroin and methadone on plasma cortisol and testosterone . J Pharmacol Exp Ther , 195 : 296 – 302 .
   PubMed Web of Science ®Google Scholar
• Lafisca , S , Bolelli , G , Franceschetti , F , Filicori , M , Flamigni , C and Marigo , M . 1981 . Hor-mone levels inmethadonetreated drug addicts . Drug Alcohol Depend , 8 : 229 – 34 .
   PubMed Web of Science ®Google Scholar
• Cicero , T J , Meyer , E R , Bell , R D and Koch , G A . 1976 . Effects of morphine and methadone on serum testosterone and luteinizing hormone levels and on the secondary sex organs of the male rat . Endocrinology , 98 : 367 – 72 .
   PubMed Web of Science ®Google Scholar
• Cushman , P Jr. and Kreek , M J . 1974 . Methadone-maintained patients. Effect of methadone on plasma testosterone, FSH, LH, and prolactin . NY State J Med , 74 : 1970 – 3 .
   PubMedGoogle Scholar
• Azizi , F , Vagenakis , A G , Longcope , C , Ingbar , S H and Braverman , L E . 1973 . Decreased serum testosterone concentration in male heroin and methadone addicts . Steroids , 22 : 467 – 72 .
   PubMed Web of Science ®Google Scholar
• Koutouvidis , N , Pratikakis , M and Fotiadou , A . 1999 . The use of mirtazapine in a group of 11 patients following poor compliance to selective serotonin reuptake inhibitor treatment due to sexual dysfunction . Int Clin Psychopharmacol , 14 : 253 – 5 .
   PubMed Web of Science ®Google Scholar
• Trotta , M , Ammassari , A , Cozzi-Lepri , A , Zaccarelli , M , Castelli , F , Narciso , P , Melzi , S , De Luca , A , Monforte , A and Antinori , A . 2003 . Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens . AIDS , 17 : 1099 – 102 .
   PubMed Web of Science ®Google Scholar
• Rosen , R C . 1997 . Sexual dysfunction as an obstacle to compliance with antihypertensive therapy . Blood Press Suppl , 1 : 47 – 51 .
   PubMedGoogle Scholar
• Creti , L , Fichten , C , Amsel , R , Brender , W , Schover , L , Kalogeropoulos , D and Libman , E . 1998 . Global Sexual Functioning: A single summary score for Nowinksi and LoPiccolo's Sexual History Form (SHF) , Thousand Oaks, CA : Sage Publications .
   Google Scholar
• Beck , A , Steer , R and Brown , G . 1996 . Beck Depression Inventory Manual , San Antonio, TX : Psychological Corporation .
   Google Scholar
• Schover , L and Jensen , S . 1988 . Sexuality and chronic illness: A comprehensive approach , 126 – 36 . New York, NY : Guilford Press .
   Google Scholar
• Creti , L , Fichten , C , Libman , E , Kalogeropoulos , D and Brender , W . 1987 . A global score for the “Sexual History Form” and its effectiveness . Paper presented at 21st annual convention ofthe Association for Advancement of Behavior Therapy . 1987 , Boston, MA.
   Google Scholar
• Libman , E , Fichten , C , Creti , L , Weinstein , N , Amsel , R and Brender , W . 1989 . Transurethral prostatectomy: Differential effects of age category and presurgery sexual functioning on postprostatectomy sexual adjustment . J Behav Med , 12 : 469 – 85 .
   PubMed Web of Science ®Google Scholar
• Schover , L R , Friedman , J M , Weiler , S J , Heiman , J R and LoPiccolo , J . Multiaxial problem-oriented system for sexual dysfunctions: An alternative to DSM-III . Arch Gen Psychiatry , 39 614 – 9 .
   Web of Science ®Google Scholar
• Morley , J . 1986 . Impotence . Am J Med , 80 : 897 – 905 .
   PubMed Web of Science ®Google Scholar
• Mulligan , T , Retchin , S , Chinchilli , V and Bettinger , C . 1988 . The role of aging and chronic disease in sexual dysfunction . J Am Geriatr Soc , 36 : 520 – 4 .
   PubMed Web of Science ®Google Scholar
• Blanker , M , Bosch , J and Groeneveld , F . 2001 . Erectile and ejaculatory dysfunction in a community-based sample of men 50–78 years old: Prevalence, concern, and relation to sexual activity . Urology , 57 : 763 – 8 .
   PubMed Web of Science ®Google Scholar
• Feldman , H , Goldstein , I , Hatzichristou , D , Krane , R and McKinlay , J . 1994 . Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study . J Urol , 151 : 54
   PubMed Web of Science ®Google Scholar
• Cushman , P . 1972 . Sexual behavior in heroin addiction and methadone maintenance . NY State J Med , 72 : 1261 – 5 .
   PubMedGoogle Scholar
• Cushman , P and Kreek , M . 1974 . Methadone maintained patients: Effect of methadone on plasma testosterone, FSH, LH, and prolactin . N Y State J Med , 74 : 1970 – 3 .
   PubMedGoogle Scholar
• Nickel , J C , Morales , A , Condra , M , Fenemore , J and Surridge , D H . 1984 . Endocrine dys-function in impotence: Incidence, significance and cost-effective screening . J Urol , 130 : 40
   Google Scholar
• Bodie , J , Lewis , J , Schow , D and Monga , M . 2003 . Laboratory evaluations of erectile dys-function: An evidence based approach . J Urol , 169 : 2262 – 4 .
   PubMed Web of Science ®Google Scholar
• Lue , T F . 2003 . Male sexual dysfunction-how little do we know? . J Urol , 169 : 2265
   PubMed Web of Science ®Google Scholar
• Johnson , A III and Jarow , J . 1992 . Is routine endocrine testing of impotent men necessary? . J Urol , 147 : 1542
   PubMed Web of Science ®Google Scholar
• Morales , A , Johnston , B , Heaton , J P and Lundie , M . 1997 . Testosterone supplementation for hypogonadal impotence: Assessment of biochemical measures and therapeutic outcomes . J Urol , 157 : 849 – 54 .
   PubMed Web of Science ®Google Scholar
• Seftel , A D . 2003 . Erectile dysfunction in the elderly: Epidemiology, etiology and approaches to treatment . J Urol , 169 : 1999 – 2007 .
   PubMed Web of Science ®Google Scholar
• Nehra , A , Steers , W , Althof , S , Andersson , K , Burnett , A , Costabile , R , Goldstein , I , Kloner , R , Lue , T , Morales , A , Rosen , R , Shabsigh , R , Siroky , M and King , L . 2003 . Third International Conference on the Management of Erectile Dysfunction: Linking Pathophysiology and Therapeutic Response . J Urol , 170 : S3 – 5 .
   PubMed Web of Science ®Google Scholar
• Abs , R , Verhelst , J , Maeyaert , J , Van Buyten , J , Opsomer , F , Adriaensen , H , Verlooy , J , Van Havenbergh , T , Smet , M and Van Acker , K . 2000 . Endocrine consequences of long-term intrathecal administration of opioids . J Clin Endocrinol Metab , 85 : 2215 – 22 .
   PubMed Web of Science ®Google Scholar