A Double-Blind Randomized Placebo Controlled Parallel Group Study Evaluating the Effects of Ibuprofen and Glucosamine Sulfate on Exercise Induced Muscle Soreness

REFERENCES

• Geis G S, Stead H, Wallemark C B, Nicholson P A. Prevalence of mucosal lesions in the stomach and duodenum due to chronic use of NSAIDs in patients with rheumatoid arthritis or osteoarthritis, and interim report on prevention by misoprostol of diclofenac associated lesions. J Rheumatol 1991, (Suppl 18): 11–14
   Web of Science ®Google Scholar
• Svensson P, Arendt-Nielsen L. Effect of topical NSAID on post-exercise jaw muscle soreness: a placebo controlled experimental study. Journal of Musculoskeletal Pain 1994; 3(4)41–58
   Google Scholar
• Hasson S M, Wible C L, Reich M, Barnes W S, Williams J H. Dexamethasone iontophoresis: effect on delayed muscle soreness and muscle function. Can J Sport Sci: 1992; 17(1)8–13
   PubMedGoogle Scholar
• Svensson P, Houe L, Arendt-Nielsen L. Effect of systemic versus topical nonsteroidal anti-inflammatory drugs on postexercise jaw-muscle soreness: a placebo-controlled study. J Orofac Pain 1997; 11: 353–362
   PubMedGoogle Scholar
• Trappe T A, White F, Lambert C P, Cesar D, Hellerstein M, Evans W J. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. Mar 2002; 282(3)551–556
   Google Scholar
• Stone M B, Merrick M A, Ingersoll C D, Edwards J E. Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. Clin J Sport Med 2002; 12(6)373–378
   PubMed Web of Science ®Google Scholar
• Baldwin A C, Stevenson S W, Dudley G A. Non-steroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals. J Gerontol A Biol Sci Med Sci 2001; 56(8)510–513
   PubMed Web of Science ®Google Scholar
• Tokmakidis S P, Kokkinidis E A, Smilios I, Douda H. The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise. J Strength Cond Res 2003; 17(1)53–59
   PubMed Web of Science ®Google Scholar
• Hasson S M, Daniels J C, Divine J G, Niebuhr B R, Richmond S, Stein P G, Williams J H. Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. Med Sci Sports Exerc 1993; 25(1)9–17
   PubMed Web of Science ®Google Scholar
• Biggee B A, McAlindon T. Glucosamine for osteo-arthritis: part II, biologic and metabolic controversies. Med Health R I 2004a; 87(6)180–181
   PubMedGoogle Scholar
• Biggee B A, McAlindon T. Glucosamine for osteoarthritis: part I, review of the clinical evidence. Med Health R I 2004b; 87(6)176–179
   PubMedGoogle Scholar
• Bourgeois J, MacDougall D, MacDonald J, Tarnopolsky M. Naproxen does not alter indices of muscle damage in resistance-exercise trained men. Med Sci Sports Exerc 1999; 31: 4–9
   PubMed Web of Science ®Google Scholar
• Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Post-exercise muscle soreness after eccentric exercise: Psychophysical effects and implications on mean arterial pressure. Scand J Med Sci Sports 2001; 11: 266–273
   PubMed Web of Science ®Google Scholar
• Bajaj P, Arendt-Nielsen L, Madeleine P, Svensson P. Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force-a double-blind randomized crossover control study. Eur J Pain 2003; 7: 407–418
   PubMed Web of Science ®Google Scholar
• Armstrong R B. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sci Sports Exerc 1984; 16: 529–538
   PubMed Web of Science ®Google Scholar
• Davies C T, White M J. Muscle weakness following eccentric work in man. Pflugers Arch 1981; 392: 168–171
   PubMed Web of Science ®Google Scholar
• Newham D J, Mills K R, Quigley B M, Edwards R H. Pain and fatigue after concentric and eccentric muscle contractions. Clin Sci 1983; 64: 55–62
   PubMed Web of Science ®Google Scholar
• Newham D J, Jones D A, Clarkson P M. Repeated high-force eccentric exercise: effects on muscle pain and damage. J Appl Physiol 1987; 63: 1381–1386
   PubMed Web of Science ®Google Scholar
• Armstrong R B, Warren L, Warren J A. Mechanisms of exercise-induced muscle fibre injury. Sports Med 1991; 12: 184–207
   PubMed Web of Science ®Google Scholar
• Miles M P, Clarkson P M. Exercise-induced muscle pain, soreness, and cramps. J Sports Med Phys Fitness 1994; 34: 203–216
   PubMed Web of Science ®Google Scholar
• Dray A. Inflammatory mediators of pain. Br J Anaesth 1995; 75: 125–131
   PubMed Web of Science ®Google Scholar
• Round J M, Jones D A, Cambridge G. Cellular infiltrates in human skeletal muscle: exercise induced damage as a model for inflammatory muscle disease?. J Neurol Sci 1987; 82(1–3)1–11
   PubMed Web of Science ®Google Scholar
• Smith L L, Wells J M, Houmard J A, Smith S T, Israel R G, Chenier T C, Pennington S N. Increases in plasma prostaglandin E2 after eccentric exercise. A preliminary report. Horm Metab Res 1993; 25(8)451–452
   PubMed Web of Science ®Google Scholar
• Smith L L. Acute inflammation: the underlying mechanism in delayed onset muscle soreness?. Med Sci Sports Exerc 1991; 3(5)542–551
   Google Scholar
• Stauber W T, Clarkson P M, Fritz V K, Evans W J. Extracellular matrix disruption and pain after eccentric muscle action. Appl Physiol 1990; 69(3)868–874
   PubMed Web of Science ®Google Scholar
• Fridén J, Sfakianos P N, Hergens A R. Muscle soreness and intramuscular fluid pressure. Comparison between eccentric and concentric load. J Appl Physiol 1986; 61: 2175–2179
   PubMed Web of Science ®Google Scholar
• Barlas P, Walsh D M, Baxter G D, Allen J M. Delayed onset muscle soreness: effect of an ischaemic block upon mechanical allodynia in humans. Pain 2000; 87(2)221–225
   PubMed Web of Science ®Google Scholar
• Headley S A, Newham D J. The effect of prednisolone on exercise-induced muscle soreness and damage. Clinical Science 1985; 70: 85
   Web of Science ®Google Scholar
• Kuipers H, Keizer H A, Verstappen F T, Costill D L. Influence of a prostaglandin-inhibiting drug on muscle soreness after eccentric work. Int J Sports Med 1985; 6: 336–339
   PubMed Web of Science ®Google Scholar
• Francis K T, Hoobler T. Effects of aspirin on delayed muscle soreness. J Sports Med Phys Fitness 1987; 27: 333–337
   PubMed Web of Science ®Google Scholar
• Donnelly A E, Maughan R J, Whiting P H. Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage. Br J Sports Med 1990; 24(3)191–195
   PubMedGoogle Scholar
• Weber M D, Servedio F J, Woodall W R. The effects of three modalities on delayed onset muscle soreness. J Orthop Sports Phys Ther 1994; 20: 236–242
   PubMed Web of Science ®Google Scholar
• Rodenburg J B, Steenbeek D, Schiereck P, Bar P R. Warm-up, stretching and massage diminish harmful effects of eccentric exercise. Int J Sports Med 1994; 15: 414–419
   PubMed Web of Science ®Google Scholar
• Nussbaum E L, Gabison S. Rebox effect on exercise-induced acute inflammation in human muscle. Arch Phys Med Rehabil 1998; 79: 1258–1263
   PubMed Web of Science ®Google Scholar
• Vickers A J, Fisher P, Smith C, Wyllie S E, Rees R. Homeopathic Arnica 30× is ineffective for muscle soreness after long-distance running: a randomized, double-blind, placebo-controlled trial. Clin J Pain 1998; 14: 227–231
   PubMed Web of Science ®Google Scholar
• Jones D A. Nature of exercise-induces muscle pain. Advances in Pain Research and Therapy 1987; 10: 207–218
   Google Scholar
• Lecomte J M, Lacroix V J, Montgomery D L. A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength. Clin J Sport Med 1998; 8: 82–87
   PubMed Web of Science ®Google Scholar
• Newham D J, Jones D A, Edwards R H. Large delayed plasma creatine kinase changes after stepping exercise. Muscle Nerve 1983; 6: 380–385
   PubMed Web of Science ®Google Scholar
• Jones D A. Skeletal muscle stiffness and pain following eccentric exercise of the elbow flexors. Pain 1987; 30: 233–242
   PubMed Web of Science ®Google Scholar
• Newham D J. The consequences of eccentric contractions and their relationship to delayed onset muscle pain. Eur J Appl Physiol 1988; 57: 353–359
   PubMed Web of Science ®Google Scholar
• Jones D A, Newham D J, Torgan C. Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain. J Physiol (Lond.) 1989; 412: 415–427
   Google Scholar
• Politino V, Smith S L, Waggoner WMC. A clinical study of topical 10% trolamine salicylate for relief of delayed onset exercies-induced artharalgia/myalgia. Curr Ther Res 1985; 38: 321–327
   Web of Science ®Google Scholar
• Svensson P, Arendt-Nielsen L. Effect of topical NSAID on post-exercise jaw muscle soreness: A placebo-controlled experimental study. J Musculoske Pain 1994; 3: 41–58
   Google Scholar
• Dudley G A, Czerkawski J, Meinrod A, Gillis G, Baldwin A, Scarpone M. Efficacy of naproxen sodium for exercise-induced dysfunction muscle injury and soreness. Clin J Sport Med 1997; 7: 3–10
   PubMed Web of Science ®Google Scholar
• Donnelly A E, McCormick K, Maughan R J, Whiting P H, Clarkson P M. Effects of a non-steroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage. Br J Sports Med 1988; 22: 35–38
   PubMedGoogle Scholar
• Lecomte J M, Lacroix V J, Montgomery D L. A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength. Clin J Sport Med 1998; 8: 82–87
   PubMed Web of Science ®Google Scholar
• Mishra D K, Friden J, Schmitz M C, Lieber R L. Anti-inflammatory medication after muscle injury. A treatment resulting in short-term improvement but subsequent loss of muscle function. J Bone Joint Surg Am 1995; 77: 1510–1519
   PubMed Web of Science ®Google Scholar
• Setnikar I. Antireactive properties of “chondro-protective” drugs. Int J Tissue React 1992; 14(5)253–261
   PubMedGoogle Scholar
• Das A, Hammad T A. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteo-arthritis. Osteoarthritis Cartilage 2000; 8: 343–350
   PubMed Web of Science ®Google Scholar
• Muller-Fassbender H, Bach G L, Haase W, Rovati L C, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2(1)61–69
   PubMedGoogle Scholar
• McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med 1 2004; 117(9)643–649
   PubMed Web of Science ®Google Scholar
• Hughes R, Carr A A. Randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology 2002; 41: 279–284
   PubMed Web of Science ®Google Scholar
• Rindone J P, Hiller D, Collacott E, Nordhaugen N, Arriola G. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 2000; 172(2)91–94
   PubMedGoogle Scholar
• Bruyere O, Pavelka K, Rovati L C, Deroisy R, Olejarova M, Gatterova J, Giacovelli G, Reginster J Y. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004; 11(2)138–143
   PubMed Web of Science ®Google Scholar