Harm Reduction Associated with Inhalation and Oral Administration of Cannabis and THC

References

• Abrams , D. I. , Leiser , R. J. , Shade , S. B. , Hilton , J. and Elbeik , T. . Short-term effects of cannabinoids on HIV-1 viral load . Poster presented at the 13th International AIDS Conference in Durban/South Africa, 13th of July 2000 .
   Google Scholar
• Anderson , P. F. , Jackson , D. M. , Chesher , G. B. and Malor , R. 1975 . Tolerance to the effect of delta-9-tetrahydrocannabinol in mice on intestinal motility, temperature and locomotor activity . Psychopharmacologia , 43 ( 1 ) : 31 – 36 .
   PubMed Web of Science ®Google Scholar
• Azorlosa , J. L. , Greenwald , M. K. and Stitzer , M. L. 1995 . Marijuana smoking: effects of varying puff volume and breathhold duration . J Pharmacol Exp Ther , 272 ( 2 ) : 560 – 569 .
   PubMed Web of Science ®Google Scholar
• Bast , G. E. 1997 . Influence of solubility and permeant size on absorption and metabolism of xenobiotics in rabbit skin . Hum Exp Toxicol , 16 : 435 – 440 .
   PubMed Web of Science ®Google Scholar
• Beal , J. E. , Olson , R. , Laubenstein , L. , Morales , J. O. , Bellman , P. , Yangco , B. , Lefkowitz , L. , Plasse , T. F. and Shepard , K. V. 1995 . Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS . J Pain Symptom Manag , 10 ( 2 ) : 89 – 97 .
   PubMed Web of Science ®Google Scholar
• Beal , J. E. , Olson , R. , Lefkowitz , L. , Laubenstein , L. , Bellman , P. , Yangco , B. , Morales , J. O. , Murphy , R. , Powderly , W. , Plasse , T. F. , Mosdell , K. W. and Shepard , K. V. 1997 . Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia . J Pain Symptom Manag , 14 ( 1 ) : 7 – 14 .
   PubMed Web of Science ®Google Scholar
• Benowitz , N. L. and Jones , R. T. 1975 . Cardiovascular effects of prolonged delta-9-tetrahydrocannabinol ingestion . Clin Pharmacol Ther , 18 ( 3 ) : 287 – 297 .
   PubMed Web of Science ®Google Scholar
• Bloom , J. W. , Kaltenborn , W. T. , Paoletti , P. , Camilli , A. and Lebowitz , M. D. 1987 . Respiratory effects of non-tobacco cigarettes . Br Med J , 295 : 1516 – 1518 .
   PubMed Web of Science ®Google Scholar
• Brenneisen , R. 1984 . Psychotrope Drogen. II. Bestimmung der Cannabinoide in Can-nabis sativa L. und in Cannabisprodukten mittels Hochdruckflüssigkeitschroma-tographie (HPLC) . Pharm Acta Helv , 59 ( 9–10 ) : 247 – 259 .
   PubMedGoogle Scholar
• Brenneisen , R. , Egli , A. , ElSohly , M. A. , Henn , V. and Spiess , Y. 1996 . The effect of orally and rectally administered ?9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients . Int J Clin Pharmacol Ther , 34 ( 10 ) : 446 – 452 .
   PubMed Web of Science ®Google Scholar
• Chesher , G. B. , Bird , K. D. , Jackson , D. M. , Perrignon , A. and Starmer , G. A. 1990 . The effects of orally administered delta 9-tetrahydrocannabinol in man on mood and performance measures: a dose-response study . Pharmacol Biochem Behav , 35 ( 4 ) : 861 – 864 .
   PubMed Web of Science ®Google Scholar
• Cleary , J. F. 1997 . Pharmacokinetic and pharmacodynamic issues in the treatment of breakthrough pain . Semin Oncol , 24 ( 5 Suppl 16 ) : 13 – 19 .
   Web of Science ®Google Scholar
• Conant , M. , Roy , D. , Shepard , K. V. and Plasse , T. F. 1991 . Dronabinol enhances appetite and controls weight loss in HIV patients . Proc Annu Meet Am Soc Clin Oncol , 10 : A9
   Google Scholar
• Davis , K. H. , McDaniel , I. A. , Cardwell , L. W. and Moody , P. L. 1984 . “ Some smoking characteristics of marijuana cigarettes ” . In The cannabinoids: Chemical pharmacologic and therapeutic aspects , Edited by: Agurell , S. , Dewey , W. L. and Willette , R. E. 97 – 109 . New York : Academic Press .
   Google Scholar
• ElSohly , M. A. , Ross , S. A. , Mehmedic , Z. , Arafat , R. , Yi , B. and Banahan , B. F. 3rd . 2000 . Potency trends of delta 9-THC and other cannabinoids in confiscated marijuana from 1980–1997 . J Forensic Sci , 45 ( 1 ) : 24 – 30 .
   PubMed Web of Science ®Google Scholar
• Elsohly , M. A. , Little , T. L. Jr. , Hikal , A. , Harland , E. , Stanford , D. F. and Walker , L. 1991 . Rectal bioavailability of delta-9-tetrahydrocannabinol from various esters . Pharmacol Biochem Behav , 40 ( 3 ) : 497 – 502 .
   PubMed Web of Science ®Google Scholar
• Fairbairn , J. W. , Liebmann , J. A. and Rowan , M. G. 1976 . The stability of cannabis and its preparations on storage . J Pharm Pharmacol , 28 ( 1 ) : 1 – 7 .
   PubMed Web of Science ®Google Scholar
• Feldman , A. , Sullivan , J. T. , Passero , M. A. and Lewis , D. C. 1993 . Pneumothorax in polysubstance abusing marijuana and tobacco smokers: 3 cases . J Subst Abuse , 5 ( 2 ) : 183 – 186 .
   PubMedGoogle Scholar
• Fligiel , S. E.G. , Roth , M. D. , Kleerup , E. C. , Barsky , S. H. , Simmons , M. S. and Tashkin , D. P. 1997 . Tracheobronchial histopathology in habitual smokers of cocaine, marijuana and/or tobacco . Chest , 112 ( 2 ) : 319 – 326 .
   PubMed Web of Science ®Google Scholar
• Frytak , S. , Moertel , C. G. and Rubin , J. 1984 . Metabolic studies of delta-9-tetrahy-drocannabinol in cancer patients . Cancer Treat Rep , 68 ( 12 ) : 1427 – 1431 .
   PubMedGoogle Scholar
• Frytak , S. , Moertel , C. G. , O'Fallon , J. R. , Rubin , J. , Creagan , E. T. , O'Connell , M. J. , Schutt , A. J. and Schwartau , N. W. 1979 . Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo . Ann Intern Med , 91 ( 6 ) : 825 – 830 .
   PubMed Web of Science ®Google Scholar
• Gieringer , D. 1996 . Marijuana research: Waterpipe study . Bull Multidisc Assoc Psychedel Stud , 6 ( 3 ) : 59 – 66 .
   Google Scholar
• Gieringer , D. 2000 . Marijuana water pipe and vaporizer study , San Francisco : California NORML . http://www.maps.org/news-letters/v06n3/06359mj1.html
   Google Scholar
• Gieringer , D. January 7 2001 . California NORML Press Release January 7 ,
   Google Scholar
• Gormeley , M. January 21 2000 . January 21 , Associated Press .
   Google Scholar
• Gorter , R. , Seefried , M. and Volberding , P. 1992 . Dronabinol effects on weight in patients with HIV infection . AIDS , 6 ( 1 ) : 127
   PubMed Web of Science ®Google Scholar
• Guy , G. W. and Flint , M. E. A phase one study of sublingual cannabis based medicinal extracts. 2000 Symposium on the Cannabinoids . pp. 115 Burlington, Vermont : International Cannabinoid Research Society .
   Google Scholar
• Hadgraft , J. 1996 . Recent developments in topical and transdermal delivery . Eur J Drug Metab Pharmacokinet , 21 : 165 – 173 .
   PubMed Web of Science ®Google Scholar
• Hall , W. and Solowij , N. 1998 . Adverse effects of cannabis . Lancet , 352 ( 9140 ) : 1611 – 1616 .
   PubMed Web of Science ®Google Scholar
• Hall , W. , Room , R. and Bondy , S. 1999 . “ Comparing the health and psychological risks of alcohol, cannabis nicotine and opiate use ” . In The health effects of cannabis , Edited by: Kalant , H. , Corrigan , W. , Hall , W. and Smart , R. 477 – 508 . Toronto : Addiction Research Foundation .
   Google Scholar
• Holdcroft , A. , Smith , M. , Jacklin , A. , Hodgson , H. , Smith , B. , Newton , M. and Evans , F. 1997 . Pain relief with oral cannabinoids in familial Mediterranean fever . Anaesthesia , 52 ( 5 ) : 483 – 486 .
   PubMed Web of Science ®Google Scholar
• Huber , G. L. and Mahajan , V. K. . The comparative response of the lung to marihuana or tobacco smoke inhalation . Marijuana: An international research report. Proceedings of Melbourne Symposium on Cannabis 2–4 September . Edited by: Chesher , Greg , Consroe , Paul and Musty , Richard . pp. 19 – 24 . Canberra : Australian Government Publishing Service . National Campaign Against Drug Abuse Monograph Series No. 7
   Google Scholar
• Jones , R. T. , Benowitz , N. L. and Herning , R. I. 1981 . Clinical relevance of cannabis tolerance and dependence . J Clin Pharmacol , 21 ( 8–9 Suppl ) : 143S – 152S .
   PubMed Web of Science ®Google Scholar
• Joy , J. E. , Watson , S. J. Jr. and Benson , J. A. Jr. 1999 . Marijuana and medicine: Assessing the science base , Washington, DC : National Academy Press . Institute of Medicine
   Google Scholar
• Lee , M. L. , Novotny , M. and Bartle , K. D. 1976 . Gas chromatography/mass spectromet-ric and nuclear magnetic resonance spectrometric studies of carcinogenic poly-nuclear aromatic hydrocarbons in tobacco and marijuana smoke condensates . Anal Chem , 48 ( 2 ) : 405 – 416 .
   PubMed Web of Science ®Google Scholar
• Liguori , A. , Gatto , C. P. and Robinson , J. H. 1998 . Effects of marijuana on equilibrium, psychomotor performance, and simulated driving . Behav Pharmacol , 9 ( 7 ) : 590 – 609 .
   Web of Science ®Google Scholar
• Lucas , V. S. Jr. and Laszlo , J. 1980 . ?9-tetrahydrocannabinol for refractory vomiting induced by cancer chemotherapy . J Amer Med Assoc , 243 ( 12 ) : 1241 – 1243 .
   Web of Science ®Google Scholar
• Mattes , R. D. , Shaw , L. M. and Engelman , K. 1994 . Effects of cannabinoids (marijuana) on taste intensity and hedonic ratings and salivary flow of adults . Chem Senses , 19 ( 2 ) : 125 – 140 .
   PubMed Web of Science ®Google Scholar
• McPartland , J. M. 2001 . “ Contaminants and adulterants in herbal Cannabis ” . In Cannabis and cannabinoids. Pharmacology toxicology and therapeutic potential , Edited by: Grotenhermen , F. and Russo , E. Binghamton, NY : The Haworth Press, Inc. . in press
   Google Scholar
• Meinck , H. M. , Schönle , P. W. and Conrad , B. 1989 . Effect of cannabinoids on spasticity and ataxia in multiple sclerosis . J Neurol , 236 ( 2 ) : 120 – 122 .
   PubMed Web of Science ®Google Scholar
• Miller , W. E. , Spiekerman , R. E. and Hepper , N. G. 1972 . Pneumomediastinum resulting from performing Valsalva maneuvers during marihuana smoking . Chest , 62 ( 2 ) : 233 – 234 .
   PubMed Web of Science ®Google Scholar
• Mutschler , E. 1996 . Arzneimittelwirkungen. Lehrbuch der Pharmakologie und Toxi-kologie , 7th edition , 192 Stuttgart : Wissenschaftliche Verlagsgesellschaft .
   Google Scholar
• Ohlsson , A. , Lindgren , J. E. , Wahlen , A. , Agurell , S. , Hollister , L. E. and Gillespie , H. K. 1980 . Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking . Clin Pharmacol Ther , 28 ( 3 ) : 409 – 416 .
   PubMed Web of Science ®Google Scholar
• O'Shaughnessy , W. B. 1838–1840 . “ On the preparations of the Indian hemp or gunjah (Cannabis indica) Their effects on the animal system in health and their utility in the treatment of tetanus and other convulsive diseases ” . In Transactions of the Medical and Physical Society of Bengal 1838 – 1840 . Reprint in: Mikuriya, Tod H. ed. Marijuana: Medical Papers 1839–1972. Oakland: Medi-Comp Press, 1973
   Google Scholar
• Perez-Reyes , M. , Lipton , M. A. , Timmons , M. C. , Wall , M. E. , Brine , D. R. and Davis , K. H. 1973 . Pharmacology of orally administered ?9-tetrahydrocannabinol . Clin Pharmacol Ther , 14 ( 1 ) : 48 – 55 .
   PubMed Web of Science ®Google Scholar
• Perez-Reyes , M. , Owens , S. M. and Di Guiseppi , S. 1981 . The clinical pharmacology and dynamics of marihuana cigarette smoking . J Clin Pharmacol , 21 ( 8–9 Suppl ) : 201S – 207S .
   PubMed Web of Science ®Google Scholar
• Perlin , E. , Smith , C. G. , Nichols , A. I. , Almirez , R. , Flora , K. P. , Cradock , J. C. and Peck , C. C. 1985 . Disposition and bioavailability of various formulations of tetrahydro-cannabinol in the rhesus monkey . J Pharm Sci , 74 ( 2 ) : 171 – 174 .
   PubMed Web of Science ®Google Scholar
• Sherrill , D. L. , Krzyzanowski , M. , Bloom , J. W. and Lebowitz , M. D. 1991 . Respiratory effects of non-tobacco cigarettes: A longitudinal study in general population . Int J Epidemiol , 20 ( 1 ) : 132 – 137 .
   PubMed Web of Science ®Google Scholar
• Solowij , N. , Michie , P. T. and Fox , A. M. 1991 . Effects of long-term cannabis use on selective attention: An event-related potential study . Pharmacol Biochem Behav , 40 ( 3 ) : 683 – 688 .
   PubMed Web of Science ®Google Scholar
• Sparacino , C. M. , Hyldburg , P. A. and Hughes , T. J. 1990 . Chemical and biological analysis of marijuana smoke condensate . NIDA Res Monogr , 99 : 121 – 140 .
   PubMedGoogle Scholar
• Stevens , R. A. and Ghazi , S. M. 2000 . Routes of opioid analgesic therapy in the management of cancer pain . Cancer Control , 7 ( 2 ) : 132 – 141 .
   PubMedGoogle Scholar
• Tashkin , D. P. 2001 . “ Respiratory risks from marijuana smoking ” . In Cannabis and cannabinoids. Pharmacology toxicology and therapeutic potential , Edited by: Grotenhermen , F. and Russo , E. Binghamton, NY : The Haworth Press, Inc. . in press
   Google Scholar
• Tashkin , D. P. , Gliederer , F. , Rose , J. , Chang , P. , Hui , K. K. , Yu , J. L. and Wu , T. C. 1991 . Tar, CO and delta 9-THC delivery from the 1st and 2nd halves of a marijuana cigarette . Pharmacol Biochem Behav , 40 ( 3 ) : 657 – 661 .
   PubMed Web of Science ®Google Scholar
• Tashkin , D. P. , Coulson , A. H. , Clark , V. A. , Simmons , M. , Bourque , L. B. , Duann , S. , Spivey , G. H. and Gong , H. 1987 . Respiratory symptoms and lung function in habitual, heavy smokers of marijuana alone, smokers of marijuana and tobacco, smokers of tobacco alone, and nonsmokers . Am Rev Resp Disease , 135 : 209 – 216 .
   PubMed Web of Science ®Google Scholar
• Touitou , E. , Fabin , B. , Dany , S. and Almog , S. 1988 . Transdermal delivery of tetrahy-drocannabinol . Int J Pharm , 43 : 9 – 15 .
   Web of Science ®Google Scholar
• Touitou , E. and Fabin , B. 1988 . Altered skin permeation of a highly lipophilic molecule: Tetrahydrocannabinol . Int J Pharm , 43 : 17 – 22 .
   Web of Science ®Google Scholar
• Turner , C. E. , Elsohly , M. A. and Boeren , E. G. 1980 . Constituents of Cannabis sativa L. XVII. A review of the natural constituents . J Nat Prod , 43 ( 2 ) : 169 – 234 .
   PubMed Web of Science ®Google Scholar
• Ungerleider , J. T. , Andrysiak , T. , Tashkin , D. P. and Gale , R. P. 1982 . Contamination of marihuana cigarettes with pathogenic bacteria-possible source of infection in cancer patients . Cancer Treat Rep , 66 ( 3 ) : 589 – 591 .
   PubMedGoogle Scholar
• Vaughan , C. W. and Christie , M. J. 2001 . “ Mechanisms of cannabinoid analgesia ” . In Cannabis and cannabinoids. Pharmacology toxicology and therapeutic potential , Edited by: Grotenhermen , F. and Russo , E. Binghamton, NY : The Haworth Press, Inc. . in press
   Google Scholar
• Wall , M. E. , Sadler , B. M. , Brine , D. , Taylor , H. and Perez-Reyes , M. 1983 . Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women . Clin Pharmacol Ther , 34 ( 3 ) : 352 – 363 .
   PubMed Web of Science ®Google Scholar
• Wu , T. C. , Tashkin , D. P. , Djahed , B. and Rose , J. E. 1988 . Pulmonary hazards of smoking marijuana as compared with tobacco . N Engl J Med , 318 ( 6 ) : 347 – 351 .
   PubMed Web of Science ®Google Scholar
• Zhang , Z.-F. , Morgenstern , H. , Spitz , M. R. , Tashkin , D. P. , Yu , G.-P. , Marshall , J. R. , Hsu , T. C. and Schantz , S. P. 1999 . Marijuana use and increased risk of squamous cell carcinoma of the head and neck . Cancer Epidemiol Biomarkers Prev , 8 : 1071 – 1079 .
   PubMed Web of Science ®Google Scholar