Plasticity and Reorganization of the Uninjured Brain

REFERENCES

• Turkstra LS, Holland AL, Bays GA. The neuroscience of recovery and rehabilitation: What have we learned from animal research? Arch Phys Med Rehabil. 2003;84(4):604–612.
   PubMed Web of Science ®Google Scholar
• Rockel AJ, Hiorns RW, Powell TP. The basic uniformity in structure of the neocortex. Brain. 1980;103(2):221–244.
   PubMedGoogle Scholar
• Kolb B. Brain Plasticity and Behavior. Mahwah, NJ: Lawrence Erlbaum; 1995.
   Google Scholar
• Coleman PD, Buell Si. Regulation of dendritic extent in developing and aging brain. In: Cotman CW, ed. Synaptic Plasticity. New York: Guilford Press; 1985:311–334.
   Google Scholar
• Benavides-Piccione R, Ballesteros-Yanez I, DeFelipe J, Yuste R. Cortical area and species differences in dendritic spine morphology. I Neurocytol. 2002; 31 (3-5):337–346.
   PubMedGoogle Scholar
• Valverde F. [Structure of the cerebral cortex. Intrinsic organization and comparative analysis of the neocortex]. Rev Neurol. 2002;34(8):758–780.
   PubMed Web of Science ®Google Scholar
• Kovacs AD, Cebers G, Cebere A, Moreira T, Liljequist S. Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity. Exp Neurol. 2001;168(1):47–62.
   PubMed Web of Science ®Google Scholar
• Gazzaniga MS. Neuroscience. Regional differences in cortical organization. Science. 2000;289(5486): 1887–1888.
   PubMed Web of Science ®Google Scholar
• DeFelipe J, Elston GN, Fujita I, et al. Neocortical circuits: evolutionary aspects and specificity versus non-specificity of synaptic connections. Remarks, main conclusions and general comments and discussion. I Neurocytol. 2002; 31(3-5):387–416.
   PubMedGoogle Scholar
• Homer CH. Plasticity of the dendritic spine. Prog Neurobiol. 1993;41(3):281–321.
   PubMed Web of Science ®Google Scholar
• Kolb B, Gibb R. Environmental enrichment and cortical injury: behavioral and anatomical consequences of frontal cortex lesions. Cereb Cortex. 1991;1 (2):189–198.
   PubMed Web of Science ®Google Scholar
• Kleim JA, Lussnig E, Schwarz ER, Comery TA, Greenough WT. Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning. I Neurosci. 1996;16(14):4529–4535.
   Google Scholar
• Ivanco TL, Racine RJ, Kolb B. Morphology of layer III pyramidal neurons is altered following induction of LTP in sensorimotor cortex of the freely moving rat. Synapse. 2000;37(1):16–22.
   PubMed Web of Science ®Google Scholar
• Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature. 1999; 402(6760):421–425.
   PubMed Web of Science ®Google Scholar
• Luscher C, Nicoll RA, Malenka RC, Muller D. Synap-tic plasticity and dynamic modulation of the postsynaptic membrane. Nat Neurosci. 2000;3(6): 545–550.
   PubMed Web of Science ®Google Scholar
• Muller CM. A role for glial cells in activity-dependent central nervous plasticity? Review and hypothesis. Int Rev Neurobiol. 1992;34:215–281.
   PubMed Web of Science ®Google Scholar
• Hebb DO. The Organization of Behavior: A Neuropsy-chological Theory. New York: Wiley; 1949.
   Google Scholar
• Diamond MC, Krech D, Rosenzweig MR. The effects of an enriched environment on the histology of the rat cerebral cortex. I Comp Neurol. 1964;123:111–120.
   Google Scholar
• Greenough WT, Larson JR, Withers GS. Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex. Behav Neural Biol. 1985;44(2):301–314.
   PubMedGoogle Scholar
• Rosenzweig MR, Bennett EL, Krech D. Cerebral ef-fects of environmental complexity and training among adult rats. ] Comp Physiol Psychol. 1964; 57:438–439.
   Google Scholar
• Diamond MC, Lindner B, Raymond A. Extensive cortical depth measurements and neuron size in-creases in the cortex of environmentally enriched rats. ] Comp Neurol. 1967;131:357–364.
   Google Scholar
• Rosenzweig MR, Krech D, Bennet EL, Diamond MC. Effects of environmental complexity and training on brain chemistry and anatomy: a replication and ex-tension. ] Comp Physiol Psychol. 1962;55:429–437.
   PubMed Web of Science ®Google Scholar
• Bennett EL, Diamond MC, Krech D, Rosenzweig MR. Chemical and anatomical plasticity brain. Science. 1964;146:610–619.
   PubMed Web of Science ®Google Scholar
• Globus A, Rosenzweig MR, Bennett EL, Diamond MC. Effects of differential experience on dendritic spine counts in rat cerebral cortex. ] Comp Physiol Psychol. 1973;82(2): 175–181.
   PubMed Web of Science ®Google Scholar
• Turner AM, Greenough WT. Differential rearing ef-fects on rat visual cortex synapses. I. Synaptic and neuronal density and synapses per neuron. Brain Res. 1985;329(1-2):195–203.
   PubMed Web of Science ®Google Scholar
• Volkmar FR, Greenough WT. Rearing complexity affects branching of dendrites in the visual cortex of the rat. Science. 1972;176(42):1145–1147.
   PubMedGoogle Scholar
• West RW, Greenough WT. Effect of environmental complexity on cortical synapses of rats: preliminary results. Behav Biol. 1972;7(2):279–284.
   PubMedGoogle Scholar
• Rioult-Pedotti MS, Friedman D, Donoghue JP. Learning-induced LTP in neocortex. Science. 2000;290(5491):533–536.
   PubMed Web of Science ®Google Scholar
• Rioult MG, Kohen R, Barrett T. Learning induces widespread changes in gene expression in neocor-tex. Soc Neurosci Abstr. 2000;26:652–658.
   Google Scholar
• Calverley RK, Jones DG. Contributions of dendritic spines and perforated synapses to synaptic plastic-ity. Brain Res Brain Res Rev. 1990;15(3):215–249.
   PubMed Web of Science ®Google Scholar
• Jones TA, Klintsova AY, Kilman VL, Sirevaag AM, Greenough WT. Induction of multiple synapses by experience in the visual cortex of adult rats. Neurobiol Learn Mem. 1997;68(1):13–20.
   PubMed Web of Science ®Google Scholar
• Withers GS, Greenough WT. Reach training selec-tively alters dendritic branching in subpopulations of layer II-III pyramids in rat motor-somatosensory forelimb cortex. Neuropsychologia. 1989;27(1):61–69.
   PubMed Web of Science ®Google Scholar
• Dobrossy MD, Dunnett SB. The influence of envi-ronment and experience on neural grafts. Nat Rev Neurosci. 2001;2(12):871–879.
   PubMed Web of Science ®Google Scholar
• Karni A, Meyer G, Rey-Hipolito C, et al. The acquisi-tion of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proc Natl Acad Sci USA. 1998;95(3):861–868.
   PubMed Web of Science ®Google Scholar
• Kleim JA, Barbay S, Nudo RJ. Functional reorganiza-tion of the rat motor cortex following motor skill learning. ] Neurophysiol. 1998;80(6):3321–3325.
   PubMed Web of Science ®Google Scholar
• Nudo RJ, Wise BM, SiFuentes F, Milliken GW. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 1996;272(5269): 1791–1794.
   PubMed Web of Science ®Google Scholar
• Pascual-Leone A, Nguyet D, Cohen LG, Brasil-Neto JP, Cammarota A, Hallett M. Modulation of muscle responses evoked by transcranial magnetic stimula-tion during the acquisition of new fine motor skills.] Neurophysiol. 1995; 74(3):1037–1045.
   PubMed Web of Science ®Google Scholar
• Plautz EJ, Milliken GW, Nudo RJ. Effects of repetitive motor training on movement representations in adult squirrel monkeys: role of use versus learning. Neurobiol Learn Mem. 2000;74(1):27–55.
   PubMed Web of Science ®Google Scholar
• Castro-Alamancos MA, Borrel J. Functional recovery of forelimb response capacity after forelimb primary motor cortex damage in the rat is due to the reorga-nization of adjacent areas of cortex. Neuroscience. 1995;68(3):793–805.
   PubMed Web of Science ®Google Scholar
• Nudo RJ, Milliken GW, Jenkins WM, Merzenich MM. Use-dependent alterations of movement represen-tations in primary motor cortex of adult squirrel monkeys. ] Neurosci. 1996;16(2):785–807.
   PubMed Web of Science ®Google Scholar
• Nudo RJ, Plautz EJ, Frost SB. Role of adaptive plastic-ity in recovery of function after damage to motor cortex. Muscle Nerve. 2001;24(8):1000–1019.
   PubMed Web of Science ®Google Scholar
• Kolb B. Overview of cortical plasticity and recovery from brain injury. Phys Med Rehabil Clin N Am. 2003;14(1 suppl):S7-25, viii.
   PubMedGoogle Scholar
• Penfield W Boldrey E. Somatic motor and sensory representation in the cerebral cortex of man as stud-ied by electrical stimulation. Brain. 1937;60:389-443.
   Google Scholar
• Elbert T, Heim S, Rockstroh B. Neural plasticity and development. In: Nelson CA LM, ed. Handbook of Developmental Cognitive Neuroscience. Cambridge, MA: MIT Press; 2001:191–204.
   Google Scholar
• Humphrey DR. Representation of movements and muscles within the primate precentral motor cortex: historical and current perspectives. Fed Proc. 1986;45(12):2687–2699.
   PubMedGoogle Scholar
• Cohen LG, Gerloff C, Lkoma K, Hallett M. Plasticity of motor cortex elicited by training of synchronous movements of hand and shoulder. Soc Neurosci Abstr. 1995;21:517.
   Google Scholar
• Cohen LG, Gerloff C, Raiz L, Uenishi N, Hallett M. Directional modulation of motor cortex plasticity induced by synchronicity of motor outputs in hu-mans. Soc Neurosci Abstr. 1996;22:1452.
   Google Scholar
• Crisostomo EA, Duncan PW, Propst M, Dawson DV, Davis IN. Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Ann Neurol. 1988;23(1):94–97.
   PubMed Web of Science ®Google Scholar
• Grafton ST, Mazziotta JC, Presty S, Friston KJ, Frackowiak RS, Phelps ME. Functional anatomy of human procedural learning determined with re-gional cerebral blood flow and PET. ] Neurosci. 1992;12(7):2542–2548.
   PubMed Web of Science ®Google Scholar
• Neumann-Haefelin T, Witte OW. Periinfarct and re-mote excitability changes after transient middle ce-rebral artery occlusion. I Cereb Blood Row Metab. 2000;20(1):45–52.
   PubMed Web of Science ®Google Scholar
• Hallett M. Plasticity of the human motor cortex and recovery from stroke. Brain Res Brain Res Rev. 2001;36(2-3):169–174.
   PubMed Web of Science ®Google Scholar
• Liepert J, Tegenthoff M, Malin JP. Changes of corti-cal motor area size during immobilization. Electroencephalogr Clin Neurophysiol. 1995;97(6): 382–386.
   PubMedGoogle Scholar
• Ottenbacher KJ, JanneII S. The results of clinical trials in stroke rehabilitation research. Arch Neurol. 1993;50(1):37–44.
   PubMed Web of Science ®Google Scholar
• Krech D, Rosenzweig MR, Bennett EL. Effects of environmental complexity and training on brain chemistry. I Comp Physiol Psychol. 1960;53:509–519.
   Google Scholar
• Rosenzweig MR, Bennett EL. Psychobiology of plas-ticity: effects of training and experience on brain and behavior. Behav Brain Res. 1996;78(1):57–65.
   PubMed Web of Science ®Google Scholar
• Greenough WT, Volkmar FR. Pattern of dendritic branching in occipital cortex of rats reared in com-plex environments. Exp Neurol. 1973;40(2):491–504.
   PubMed Web of Science ®Google Scholar
• Mollgaard K, Diamond MC, Bennet EL, Rosenzweig MR, Lindner B. Quantitative synaptic changes with differential experience in rat brain. Int I Neurosci. 1971;2(3):113–127.
   PubMedGoogle Scholar
• Greenough WT, Hwang HM, Gorman C. Evidence for active synapse formation or altered postsynaptic metabolism in visual cortex of rats reared in com-plex environments. Proc Natl Acad Sci USA. 1985;82(13):4549–4552.
   PubMed Web of Science ®Google Scholar
• Diamond MC, Ingham CA, Johnson RE, Bennett EL, Rosenzweig MR. Effects of environment on mor-phology of rat cerebral cortex and hippocampus. I Neurobiol. 1976;7(1):75–85.
   Google Scholar
• Greenough WT, McDonald JW, Parnisari RM, Camel JE. Environmental conditions modulate degenera-tion and new dendrite growth in cerebellum of senescent rats. Brain Res. 1986;380(1):136–143.
   PubMed Web of Science ®Google Scholar
• Fuchs IL, Montemayor M, Greenough WT. Effect of environmental complexity on size of the superior colliculus. Behav Neural Biol. 1990;54(2):198–203.
   PubMedGoogle Scholar
• Kolb B, Forgie M, Gibb R, Gorny G, Rowntree S. Age, experience and the changing brain. Neurosci Biobehav Rev. 1998;22(2):143–159.
   PubMed Web of Science ®Google Scholar
• Schallert T, Leasure IL, Kolb B. Experience-associ-ated structural events, subependymal cellular prolif-erative activity, and functional recovery after injury to the central nervous system. I Cereb Blood Row Metab. 2000;20(11):1513–1528.
   PubMed Web of Science ®Google Scholar
• Diamond ME, Huang W, Ebner FF. Laminar com-parison of somatosensory cortical plasticity. Science. 1994; 265(5180):1885–1888.
   PubMed Web of Science ®Google Scholar
• Jones TA, Kleim JA, Greenough WT. Synaptogenesis and dendritic growth in the cortex opposite unilat-eral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination. Brain Res. 1996; 733(1):142–148.
   PubMed Web of Science ®Google Scholar
• Kleim JA, Vij K, Ballard DH, Greenough WT. Learn-ing-dependent synaptic modifications in the cer-ebellar cortex of the adult rat persist for at least four weeks. I Neurosci. 1997;17(2):717–721.
   Google Scholar
• Klintsova AY, Greenough WT. Synaptic plasticity in cortical systems. Curr Opin Neurobiol. 1999;9(2): 203–208.
   PubMed Web of Science ®Google Scholar
• Sirevaag AM, Greenough WT. Plasticity of GFAP-immunoreactive astrocyte size and number in visual cortex of rats reared in complex environments. Brain Res. 1991;540(1-2):273–278.
   PubMed Web of Science ®Google Scholar
• Jones TA, Greenough WT. Ultrastructural evidence for increased contact between astrocytes and syn-apses in rats reared in a complex environment. Neurobiol Learn Mem. 1996;65(1):48–56.
   PubMed Web of Science ®Google Scholar
• Donoghue JP, Sanes IN. Organization of adult mo-tor cortex representation patterns following neona-tal forelimb nerve injury in rats. I Neurosci. 1988;8(9):3221–3232.
   Google Scholar
• Sanes IN, Suner S, Donoghue JP. Dynamic organiza-tion of primary motor cortex output to target muscles in adult rats. I. Long-term patterns of reor-ganization following motor or mixed peripheral nerve lesions. Exp Brain Res. 1990;79(3):479–491.
   PubMed Web of Science ®Google Scholar
• Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E. Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. Neurophysiol. 1990;63(1): 82–104.
   PubMed Web of Science ®Google Scholar
• Recanzone GH, Merzenich MM, Jenkins WM, Grajski KA, Dinse HR. Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. Neurophysiol. 1992;67(5): 1031–1056.
   PubMed Web of Science ®Google Scholar
• Ramachandran VS, Stewart M, Rogers-Ramachandran DC. Perceptual correlates of massive cortical reorganization. Neuroreport. 1992;3(7): 583–586.
   PubMed Web of Science ®Google Scholar
• Aglioti S, Cortese F, Franchini C. Rapid sensory remapping in the adult human brain as inferred from phantom breast perception. Neuroreport. 1994;5(4):473–476.
   PubMed Web of Science ®Google Scholar
• Elbert T, Flor H, Birbaumer N, et al. Extensive reor-ganization of the somatosensory cortex in adult humans after nervous system injury. Neuroreport. 1994;5(18):2593–2597.
   PubMed Web of Science ®Google Scholar
• Halligan PW, Marshall JC, Wade DT. Sensory disor-ganization and perceptual plasticity after limb am-putation: a follow-up study. Neuroreport. 1994;5(11):1341–1345.
   PubMed Web of Science ®Google Scholar
• Yang TT, Gallen CC, Ramachandran VS, Cobb S, Schwartz BJ, Bloom FE. Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. Neuroreport. 1994;5(6):701–704.
   PubMed Web of Science ®Google Scholar
• Mogilner A, Grossman JA, Ribary U, et al. Soma-tosensory cortical plasticity in adult humans re-vealed by magnetoencephalography. Proc Natl Acad Sci USA. 1993;90(8):3593–3597.
   PubMed Web of Science ®Google Scholar
• Pascual-Leone A, Torres F. Plasticity of the sen-sorimotor cortex representation of the reading fin-germn Braille readers. Brain. 1993;116\(pt 1):39–52.
   PubMedGoogle Scholar
• Elbert T, Pantev C, Wienbruch C, Rockstroh B, Taub E. Increased cortical representation of the fingers of the left hand in string players. Science. 1995;270(5234):305–307.
   PubMed Web of Science ®Google Scholar
• Merzenich MM, Jenkins WM. Reorganization of cor-tical representations of the hand following alter-ations of skin inputs induced by nerve injury, skin island transfers, and experience. I Hand Ther. 1993;6(2):89–104.
   PubMedGoogle Scholar