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Original Articles

Motor Recovery Strategies After Stroke

Pages 12-22 | Published online: 02 Feb 2015

REFERENCES

  • Asanuma C. Mapping movements within a moving motor map. Trends Neurosci. 1991;14:217–218.
  • Jacobs KM, Donoghue JP. Reshaping the cortical motor map by unmasking latent intracortical con-nections. Science. 1991;251:944–947.
  • Nudo RJ, Wise BM, SiFuentes F, Milliken GW. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 1996;272:1791–1794.
  • Fisher CM. Concerning the mechanism of recovery in stroke hemiplegia. Can] Neurol Sci. 1992;19:57–63.
  • Glees P. Functional reorganization following hemi-spherectomy in man and after small experimental lesions in primates. In: Bach-y-Rita P, ed. Recovery of Function: Theoretical Considerations for Brain Injury Rehabilitation. Baltimore, MD: University Park Press; 1980.
  • Sabatini U, Toni D, Pantano P, et al. Motor recovery after early brain damage. Stroke. 1994;25:514–517.
  • Cramer SC, Nelles G, Benson RR, et al. A function-al MRI study of subjects recovered from hemiparet-ic stroke. Stroke. 1997;28:2518–2527.
  • Nudo RJ, Milliken GW, Jenkins WM, Merzenich MM. Use-dependent alterations of movement rep-resentations in primary motor cortex of adult squir-rel monkeys. Neurosci. 1996;16:785–807.
  • Pascual-Leone A, Grafman J, Hallett M. Modulation of cortical motor output maps during development of implicit and explicit knowledge. Science. 1994; 263:1287–1289.
  • Nudo RJ, Milliken GW. Reorganization of move-ment representations in primary motor cortex fol-lowing focal ischemic infarcts in adult squirrel mon-keys. J Neurophysiol. 1996;75:2144–2149.
  • Johansson BB. Functional outcome in rats trans-ferred to an enriched environment 15 days after focal brain ischemia. Stroke. 1996;27:324–326.
  • Ohlsson AL, Johansson BB. The environment influ-ences functional outcome of cerebral infarction in rats. Stroke. 1995;26:644–649.
  • Dickstein R, Hocherman S, Pillar T, Shaham R. Stroke rehabilitation. Three exercise therapy approaches. Phys Ther. 1986;66:1233–1238.
  • Hesse SA, Jahnke MT, Bertelt CM, Schreiner C, Lucke D, Mauritz KH. Gait outcome in ambulatory hemiparetic patients after a 4-week comprehensive rehabilitation program and prognostic factors. Stroke. 1994;25:1999–2004.
  • Butefisch C, Hummelsheim H, Densler P, Mauritz K. Repetitive training of isolated movements improves the outcome of motor rehabilitation of the central-ly paretic hand. J Neurol Sci. 1995;130:59–68.
  • Jongbloed L, Stacey S, Brighton C. Stroke rehabilita-tion: sensorimotor integrative treatment versus func-tional treatment. Am] Occup Ther. 1989;43:391–397.
  • Logigian MK, Samuels MA, Falconer JF. Clinical exercise trial for stroke patients. Arch Phys Med Rehabil. 1983;64:364–367.
  • Lord JP, Hall K. Neuromuscular reeducation versus traditional programs for stroke rehabilitation. Arch Phys Med Rehabil. 1986;67:88–91.
  • Stern PH, McDowell F, Miller JM, Robinson M. Effects of facilitation exercise techniques in stroke rehabili-tation. Arch Phys Med Rehabil. 1970;51:526–531.
  • Trombly CA, Thayer-Nason L, Bliss G, Girard CA, Lyrist LA, Brexa-Hooson A. The effectiveness of therapy in improving finger extension in stroke patients. Am] Occup Ther. 1986;40:612–617.
  • Wagenaar RC, Meijer OG, van Wieringen PC, et al. The functional recovery of stroke: a comparison between neurodevelopmental treatment and the Brunnstrom method. Scand J Rehab Med. 1990; 22:1–8.
  • Duncan P, Studenski S, Richards L, et al. Randomized clinical trial of therapeutic exercise in subacute stroke. Stroke. 2003;34:2173–2180.
  • Fasoli SE, Krebs HI, Stein J, Frontera WR, Hogan N. Effects of robotic therapy on motor impairment and recovery in chronic stroke. Arch Phys Med Rehabil. 2003;84:477–482.
  • Kunkel A, Kopp B, Muller G, et al. Constraint-induced movement therapy for motor recovery in chronic stroke patients. Arch Phys Med Rehabil. 1999;80:624–628.
  • Lehmann JF, DeLateur BJ, Fowler RS Jr, et al. Stroke: Does rehabilitation affect outcome? Arch Phys Med Rehabil. 1975;56:375-382.
  • Miltner WH, Bauder H, Sommer M, Dettmers C, Taub E. Effects of constraint-induced movement therapy on patients with chronic motor deficits after stroke: a replication. Stroke. 1999;30:586–592.
  • Tangeman PT, Banaitis DA, Williams AK. Rehabilitation of chronic stroke patients: changes in functional performance. Arch Phys Med Rehabil. 1990;71:876–880.
  • Taub E, Miller NE, Novack TA, et al. Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil. 1993;74:347–354.
  • van der Lee JFI, Wagenaar RC, Lankhorst GJ, Vogelaar TW, Deville WL, Bouter LM. Forced use of the upper extremity in chronic stroke patients: results from a single-blind randomized clinical trial. Stroke. 1999;30:2369–2375.
  • Werner RA, Kessler S. Effectiveness of an intensive outpatient rehabilitation program for postacute stroke patients. Am J Phys Med Rehabil. 1996;75: 114–120.
  • Wolf SL, LeCraw DE, Barton LA, Jann BB. Forced use of hemiplegic upper extremities to reverse the effect of learned nonuse among chronic stroke and head-injured patients. Exp Neurol. 1989;104:125–132.
  • Rodriquez AA, Black PO, Kile KA, et al. Gait training efficacy using a home-based practice model in chronic hemiplegia. Arch Phys Med Rehabil. 1996;77: 801–805.
  • Taub E, Wolf SL. Constraint induced movement techniques to facilitate upper extremity use in stroke patients. Top Stroke Rehabil. 1997;3:38–61.
  • Levy CE, Nichols DS, Schmalbrock PM, Keller P, Chakeres DW. Functional MRI evidence of cortical reorganization in upper-limb stroke hemiplegia treated with constraint-induced movement thera-py. Am] Phys Med Rehabil. 2001;80:4–12.
  • Liepert J, Bauder H, Wolfgang HR, Miltner WH, Taub E, Weiller C. Treatment-induced cortical reor-ganization after stroke in humans. Stroke. 2000;31: 1210–1216.
  • Dromerick AW, Edwards DF, Hahn M. Does the application of constraint-induced movement thera-py during acute rehabilitation reduce arm impair-ment after stroke? Stroke. 2000;31:2984–2988.
  • DeBow SB, Davies ML, Clarke HL, Coulborne F. Constraint-induced movement therapy and reha-bilitation exercises lessen motor deficits and vol-ume of brain injury after striatal hemorrhagic stroke in rats. Stroke. 2003;34:1021–1026.
  • vander Lee JFI. Constraint-induced therapy for stroke: more of the same or something completely different? Curr Opinion Neurol. 2001;14:741-744.
  • Sterr A, Freivogel S. Motor-improvement following intensive training in low-functioning chronic hemi-paresis. Neurology. 2003;61:842–844.
  • Page SJ, Sisto SA, Levine P. Modified constraint-induced therapy in chronic stroke. Am I Phys Med Rehabil. 2002;81:870–875.
  • Page SJ, Sisto S, Johnston MV, Levine P, Hughes M. Modified constraint-induced therapy in subacute stroke: a case report. Arch Phys Med Rehabil. 2002;83:286–290.
  • Winstein CJ, Miller JP, Blanton S, et al. Methods for a multisite randomized trial to investigate the effect of constraint-induced movement therapy in improving upper extremity function among adults recovering from a cerebrovascu lar stroke. Neurorehabil Neural Repair. 2003;17:137–152.
  • Hesse S, Werner C, Uhlenbrock D, von Frankenberg S, Bardeleben A, Brandl-Hesse B. An electro-mechanical gait trainer for restoration of gait in hemiparetic stroke patients: preliminary results. Neurorehab Neural Repair. 2001;15:39–50.
  • Colombo G, Joerg M, Schreier R, Dietz V. Treadmill training of paraplegic patients using a robotic ortho-sis. I Rehabil Res Develop. 2000;37(6):693–700.
  • Aisen FL, Krebs HI, Hogan N, McDowell F, Volpe BT. The effect of robot-assisted therapy and rehabilita-tive training on motor recovery following stroke. Arch Neurol. 1997;54:443–446.
  • Volpe BT, Krebs HI, Hogan N, Edelstein L, Diels C, Aisen M. A novel approach to stroke rehabilitation: robot-aided sensorimotor stimulation. Neurology 2000;54(10):1938–1944.
  • Ferraro M, Palazzolo JJ, Krol J, Krebs HI, Hogan N, Volpe BT. Robot-aided sensorimotor arm training improves outcome in patients with chronic stroke. Neurology. 2003;61:1604–1607.
  • Lum PS, Burgar CG, Shor PC, Majmundar M, Vander Loos M. Robot-assisted movement training com-pared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke. Arch Phys Med Rehabil. 2002;83:952–959.
  • Volpe BT, Krebs HI, Hogan N, Edelsteinn L, Diels CM, Aisen ML. Robot training enhanced motor outcome in patients with stroke maintained over 3 years. Neurology. 1999;53(8):1874–1876.
  • Fasoli SE, Krebs HI, Stein J, Frontera WR, Hughes R, Hogan N. Robotic therapy for chronic motor impairments after stroke: follow-up results. Arch Phys Med Rehabil. In press.
  • Rohrer B, Fasoli S, Krebs HI, et al. Movement smoothness changes during stroke recovery. I Neurosci. 2002;22(18):8297–8304.
  • Jack D, Bojan R, Merians AS, et al. Virtual reality enhanced stroke rehabilitation. IEEE Trans Neural Systems Rehab Eng. 2001;9:308–318.
  • Holden MK, Dettwiler A, Dyar T, Niermann G, Bizzi E. Retraining movement in patients with acquired brain injury using a virtual environment. Stud Health Technol Inform. 2001;81:192–198.
  • Merians AS, Jack D, Boian R, et al. Virtual reality-augmented rehabilitation for patients following stroke. Phys Ther. 2002;82:898–915.
  • Kozak JJ, Hancock PA, Arthur EJ, Chrysler ST. Transfer of training from virtual reality. Ergonomics. 1993;36:777–784.
  • Lovely RG, Gregor RJ, Roy RR, et al. Effects of train-ing on the recovery of full weight-bearing stepping in the adult spinal cat. Exp Neurol. 1986;92: 421–435.
  • Dobkin B, Fowler E, Gregor R. A strategy to train locomotion in patients with chronic hemiplegic stroke. Ann Neurol. 1991;30:278.
  • Hesse S, Bertelt C, Schaffrin A, Malezic M, Mauritz KH. Restoration of gait in nonambulatory hemi-paretic patients by treadmill training with partial bodyweight support. Arch Phys Med Rehabil. 1994;75:1087–1093.
  • Hesse S, Bertelt C, Jahnke MT, et al. Treadmill train-ing with partial body weight support compared with physiotherapy in nonambulatory hemiparetic patients. Stroke. 1995;26:976–981.
  • Visintin M, Barbeau H, Korner-Bitensky N, Mayo NE. A new approach to retrain gait in stroke patients through body weight support and tread-mill stimulation. Stroke. 1998;29:1122–1128.
  • Kosak MC, Reding MJ. Comparison of partial body weight-supported treadmill gait training versus aggressive bracing assisted walking post stroke. Neurorehabil Neural Repair. 2000;14:13–19.
  • Nilsson L, Carlsso J, Danielsson A, et al. Walking training of patients with hemiparesis at an early stage after stroke: a comparison of walking training on a treadmill with body weight support and walk-ing training on the ground. Clin Rehabil. 2001;15: 515–527.
  • Pohl M, Mehrholz J, Ritschel C, Ruckriem S. Speed-dependent treadmill training in ambulatory hemi-paretic stroke patients: a randomized controlled tri-al. Stroke. 2002;33:553–558.
  • Sullivan KJ, Knowlton BJ, Dobkin BH. Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recovery. Arch Phys Med Rehabil. 2002;83:683–691.
  • Hesse S, Uhlenbrock D, Sarkodie-Gyan T. Gait pat-tern of several disabled hemiparetic subjects on a new controlled gait trainer as compared to assisted treadmill walking with partial body weight sup-port. Clin Rehabil. 1999;12:401–410.
  • Werner C, Von Frankenberg S, Treig T, Konrad M, Hesse S. Treadmill training with partial body weight support and an electromechanical gait trainer for restoration of gait in subacute stroke patients: a randomized crossover trial. Stroke. 2002;33: 2895–2901.
  • Basmajian JV, Kukulka CG, Narayan MG, Takebe K. Biofeedback treatment of foot-drop after stroke compared with standard rehabilitation technique: effects on voluntary control and strength. Arch Phys Med Rehabil. 1975;56:231–236.
  • Mroczek N, Halpern D, McHugh R. Electro-myographic feedback and physical therapy for neuromuscular retraining in hemiplegia. Arch Phys Med Rehabil. 1978;59:258–267.
  • Shiavi RG, Champion SA, Freeman FR, Bugel HJ. Efficacy of myofeedback therapy in regaining con-trol of lower extremity musculature following stroke. Am I Phys Med. 1979;58:185–194.
  • Hurd WW, Pegram V, Nepomuceno C. Comparison of actual and simulated EMG biofeedback in the treatment of hemiplegic patients. Am I Phys Med. 1980;59:73–82.
  • Prevo AJ, Visser SL, Vogelaar TW. Effect of EMG feedback on paretic muscles and abnormal cocon-traction in the hemiplegic arm, compared with conventional physical therapy. Scand J Rehabil Med. 1982;14:121–131.
  • Basmajian JV, Gowland C, Brandstater ME, Swanson L, Trotter J. EMG feedback treatment of upper limb in hemiplegic stroke patients: a pilot study. Arch Phys Med Rehabil. 1982;63:613–616.
  • Burnside IG, Tobias S, Bursill D. Electromyographic feedback in the remobilization of stroke patients: a controlled trial. Arch Phys Med Rehabil. 1982;63: 217–222.
  • Wolf SL, Binder-Macleod SA. Electromyographic biofeedback applications to the hemiplegic patient: changes in upper extremity neuromuscular and functional status. Phys Ther. 1983;63:1393–1403.
  • Wolf SL, Binder-Macleod SA. Electromyographic biofeedback applications to the hemiplegic patient: changes in lower extremity neuromuscular and functional status. Phys Ther. 1983;63:1404–1413.
  • Inglis J, Donald MW, Monga TN, Sproule M, Young MJ. Electromyographic biofeedback and physical therapy of the hemiplegic upper limb. Arch Phys Med Rehabil. 1984;65:755–759.
  • John J. Failure of electrical myofeedback to aug-ment the effects of physiotherapy in stroke. Int Rehabil Res. 1986;9:35–45.
  • Mulder T, Hulstijn W, Van der Meer J. EMG feed-back and the restoration of motor control. A con-trolled group study of 12 hemiparetic patients. Am I Phys Med. 1986;65:173–188.
  • Basmajian JV, Gowland CA, Finlayson MA, et al. Stroke treatment: comparison of integrated behav-ioral-physical therapy vs traditional physical thera-py programs. Arch Phys Med Rehabil. 1987;68: 267–272.
  • Cozean CD, Pease WS, Hubbell SI. Biofeedback and functional electric stimulation in stroke rehabilita-tion. Arch Phys Med Rehabil. 1988;69:401–405.
  • Crow IL, Lincoln NB, Nouni FM, DeWeerdt W. The effectiveness of EMG biofeedback in the treatment of arm function after stroke. Int Disabil Studies. 1989;11:155–160.
  • Mandel AR, Nymark NJ, Balmer SJ, Grinnell DM, O'Riain MD. Electromyographic versus rhythmic positional biofeedback in computerized gait retraining with stroke patients. Arch Phys Med Rehabil. 1990;71:649–654.
  • Colborne GR, Olney SJ, Griffin MR Feedback of ankle joint angle and soleus electromyography in the rehabilitation of hemiplegic gait. Arch Phys Med Rehabil. 1993;74:1100–1106.
  • Intiso D, Santilli V, Grasso MG, Rossi R, Caruso I. Rehabilitation of walking with electromyographic biofeedback in footdrop after stroke. Stroke. 1994;25:1189–1192.
  • Bradley L, Hart BB, Mandan S, Flowers K, Riches M, Sanderson P. Electromyographic biofeedback for gait training after stroke. Clin Rehabil. 1998; 12:11–22.
  • Schleenbaker RE, Mainous AG. Electromyographic biofeedback for neuromuscular reeducation in the hemiplegic stroke patient: a meta-analysis. Arch Phys Med Rehabil. 1993;74:1301–1304.
  • Moreland J, Thomson MA. Efficacy of electromyo-graphic biofeedback compared with conventional physical therapy for upper extremity function in patients following stroke: a research overview and meta-analysis. Phys Ther. 1994;74:534–543.
  • Glanz M, Klawansky S, Stason W, Berkey C, Phan H, Shah N. Biofeedback therapy in poststroke rehabil-itation: a meta-analysis of the randomized con-trolled trials. Arch Phys Med Rehabil. 1995;76: 508–515.
  • Greenberg S, Fowler RS Jr. Kinesthetic biofeedback: a treatment modality for elbow range of motion in hemiplegia. Am] Occup Ther. 1980;34:738–743.
  • Morris ME, Matyas TA, Bach TM, Goldie PA. Electrogoniometric feedback: its effect on genu recurvatum in stroke. Arch Phys Med Rehabil. 1992; 73:1147–1154.
  • Bourbonnais D, Bilodeau S, Lepage Y, Beaudoin N, Gravel D, Forget R. Effect of force-feedback treat-ments in patients with chronic motor deficits after a stroke. Am] Phys Med Rehabil. 2002;18:890–897.
  • Maulucci RA, Eckhouse RH. Retraining reaching in chronic stroke with real-time auditory feedback. Neurorehabilitation. 2001;16:171–182.
  • Merletti R, Zelaschi F, Latella D, Galli M, Angeli S, Sessa MB. A control study of muscle force recovery in hemiparetic patients during treatment with functional electrical stimulation. Scand J Rehabil Med. 1978;10:147–154.
  • Bowman BR, Baker LL, Waters RL. Positional feed-back and electrical stimulation: an automated treatment for the hemiplegic wrist. Arch Phys Med Rehabil. 1979;60:492–502.
  • Winchester P, Montgomery J, Bowman B, Hislop H. Effects of feedback stimulation training and cyclical electrical stimulation on knee extension in hemi-paretic patients. Phys Ther. 1983;63:1096–1103.
  • Kraft GH, Fitts SS, Hammond MC. Techniques to improve function of the arm and hand in chronic hemiplegia. Arch Phys Med Rehabil. 1992;73: 220–227.
  • Levin MF, Hui-Chan CWY. Relief of hemiparetic spasticity by TENS is associated with improvement in reflex and voluntary motor functions. Electroencephelogr Clin Neurophysiol. 1992;85: 131–142.
  • Faghri PD, Rodgers MM, Glaser RM, Bors JG, Ho C, Akuthota P. The effects of functional electrical stim-ulation on shoulder subluxation, arm function recovery, and shoulder pain in hemiplegic stroke patients. Arch Phys Med Rehabil. 1994;75:73–79.
  • Bogataj U, Gros N, Kljajic M, Acimovic R, Malezic M. The rehabilitation of gait in patients with hemi-plegia: a comparison between conventional thera-py and multichannel functional electrical stimula-tion therapy. Phys Ther. 1995;75:490–502.
  • Hummelsheim H, Maier-Loth ML, Eickhof C. The functional value of electrical muscle stimulation for the rehabilitation of the hand in stroke patients. Scand I Rehabil Med. 1997;29:3–10.
  • Chae J, Bethoux F, Bohine T, Dobos L, Davis T, Friedl A. Neuromuscular stimulation for upper extremity motor and functional recovery in acute hemiplegia. Stroke. 1998;29:975–979.
  • Glanz M, Klawansky S, Stason W, Berkey C, Chalmers TC. Functional electrostimulation in post-stroke rehabilitation: a meta-analysis of the ran-domized controlled trials. Arch Phys Med Rehabil. 1996;77:549–553.
  • de Kroon JR, van der Lee JFI, Ljzerman MJ, Lankhorst GJ. Therapeutic electrical stimulation to improve motor control and functional abilities of the upper extremity after stroke: a systematic review. Clin Rehabil. 2002;16:350–360.
  • Fields RW. Electromyographically triggered electri-cal muscle stimulation for chronic hemiplegia. Arch Phys Med Rehabil. 1987;68:407–414.
  • Francisco G, Chae J, Chawla H, et al. Electromyogram-triggered neuromuscular stimula-tion for improving the arm function of acute stroke survivors: a randomized pilot study. Arch Phys Med Rehabil. 1998;79:570–575.
  • Keith RA, Wilson DB, Gutierrez P. Acute and suba-cute rehabilitation for stroke: a comparison. Arch Phys Med Rehabil. 1995;76:495–500.
  • Kramer AM, Steiner JF, Schlenker RE, et al. Outcomes and costs after hip fracture and stroke: a comparison of rehabilitation settings. JAMA. 1997;277:396–404.
  • Indredavik B, Slordahl SA, Bakke F, Rokseth R, Haheim LL. Stroke unit treatment: long-term effects. Stroke. 1997;28:1861–1866.
  • Kalra L, Eade J. Role of stroke rehabilitation units in managing severe disability after stroke. Stroke. 1995;26:2031–2034.
  • Kaste M, Palomaki H, Sarna S. Where and how should elderly stroke patients be treated? A ran-domized trial. Stroke. 1995;26:249–253.
  • Stevens RS, Ambler NR, Warren MD. A randomised controlled trial of a stroke rehabilitation ward. Age Ageing. 1984;13:65–75.
  • Strand T, Asplund K, Eriksson S, Hagg E, Lithner F, Wester PO. A non-intensive stroke unit reduced functional disability and the need for long-term hospitalisation. Stroke. 1985;16:29–34.
  • Stroke Unit Trialists Collaboration. Collaborative systematic review of the randomized trials of organized inpatient (stroke unit) care after stroke. BMJ. 1997;314:1151–1159.
  • Kwakkel G, Wagenaar RC, Koelman TW, Lankhorst GJ, Koetsier JC. Effects of intensity of rehabilitation after stroke. A research synthesis. Stroke. 1997;28:1550–1556.
  • Seitz RH, Allred KE, Backus ME, Hoffman JA. Functional changes during acute rehabilitation in patients with stroke. Phys Ther. 1987;67:1685–1690.
  • Sivenius J, Pyorala K, Heinonen OP, Salonen JT, Riekkinen P. The significance of intensity of rehabil-itation of stroke: a controlled trial. Stroke. 1985; 16:928–931.
  • Langhorne P, Wagenaar R, Partridge C. Physiotherapy after stroke: more is better? Physiother Res Int. 1996;1: 75–88
  • Nugent JA, Schurr KA, Adams RD. A dose-response relationship between amount of weightbearing exercise and walking outcome following cere-brovascular accident. Arch Phys Med Rehabil. 1994;75:399–402.
  • Smith DS, Goldenberg E, Ashburn A, et al. Remedial therapy after stroke: a randomized con-trolled trial. BMJ. 1981;282:517–520.
  • Richards CL, Malouin F, Wood-Dauphinee S, Williams JI, Bouchard JP, Brunet D. Task-specific physical therapy for optimization of gait recovery in acute stroke patients. Arch Phys Med Rehabil. 1993;74:612–620.
  • Sunderland A, Fletcher D, Bradley L, Tinson D, Hewer RL, Wade TD. Enhanced physical therapy for arm function after stroke: a one year follow up study. J Neurol Neurosurg Psych. 1994;57:856–858.
  • Kwakkel G, Kollen BJ, Wagenaar RC. Long term effects of intensity of upper and lower limb training after stroke: a randomised trial. I Neurol Neurosurg Psych. 2002;72: 473–479.
  • Kwakkel G, Wagenaar RC, Twisk JW, Lankhorst GJ, Koetsier JC. Intensity of leg and arm training after primary middle-cerebral-artery stroke: a ran-domised trial. Lancet. 1999;354(9174):191–196.
  • Johansson K, Lindgren I, Widner H, Wiklund I, Johansson BB. Can sensory stimulation improve the functional outcome in stroke patients? Neurology. 1993;43:2189–2192.
  • Magnusson M, Johansson K, Johansson BB. Sensory stimulation promotes normalization of postural control after stroke. Stroke. 1994;25:1176–1180.
  • Naeser MA, Alexander MP, Stiassny-Eder D, Galler V, Hobbs J, Bachman D. Real versus sham acupunc-ture in the treatment of paralysis in acute stroke patients: a CT scan lesion site study. I Neuro Rehabil. 1992;6: 163–173.
  • Sze FK, Wong E, Yi X, Woo J. Does acupuncture have additional value to standard poststroke motor rehabilitation? Stroke. 2002;33:186–194.
  • Sze FK, Wong E, Or KK, Lau J, Woo J. Does acupuncture improve motor recovery after stroke? A meta-analysis of randomized controlled trials. Stroke. 2002;33:2604–2619.
  • Feeney DM, Gonzales A, Law W. Amphetamine, haloperidol and experience interact to affect rate of recovery after motor cortex injury. Science. 1982;217:855–857.
  • Hovda DA, Feeney DM. Amphetamine and experi-ence promote recovery of locomotor function after unilateral frontal cortex injury in the cat. Brain Res. 1984;298:358–361.
  • Crisostomo EA, Duncan PW, Propst M, Dawson DV, Davis IN. Evidence that amphetamine with physical therapy promotes recovery of motor function in stroke patients. Ann Neurol. 1988;23:94–97.
  • Grade C, Redford B, Chrostowski J, Toussaint L, Blackwell B. Methylphenidate in early poststroke recovery: a double-blind, placebo-controlled study. Arch Phys Med Rehabil. 1998;79:1047–1050.
  • Walker-Batson D, Smith P, Curtis S, Unwin H, Greenlee R. Amphetamine paired with physical therapy accelerates motor recovery after stroke. Further evidence. Stroke. 1995;26:2254–2259.
  • Martinsson L, Wahlgren NG. Safety of dexamphet-amine in acute ischemic stroke: a randomized, double-blind, controlled dose-escalation study. Stroke. 2003;34:475–481.
  • Sonde L, Nordstrom M, Nilsson CG, Lokk J, Viitanen M. A double-blind placebo-controlled study of the effects of amphetamine and physiotherapy after stroke. Cerebrovasc Dis. 2001;12(3):253–257.
  • Scheidtmann K, Fries W, Muller F, Koenig E. Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: a prospec-tive, randomised, double-blind study. Lancet. 2001;358(9284):787–790.
  • Dam M, Tonin P, De Boni A, et al. Effects of fluoxe-tine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabil-itation therapy. Stroke. 1996;27:1211–1214.
  • Guiraud-Chaumeil B, Pariente J, Albucher JF, Loubinoux I, Chollet F. Post-ischemia neurologic recovery. Bulletin de I Academie Nationale de Medecine. 2002;186(6):1015–1023.
  • Kozlowski DA, James CD, Schallert T. Use-depend-ent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. I Neurosci. 1996;16: 4776–4786.
  • Schallert T, Kozlowski DA, Humm JS, Cocke RR. Use-dependent structural events in recovery of function. Adv Neurol. 1997;73:229–238.
  • Goldstein LB, and the Sygen in Acute Stroke Study Investigators. Common drugs may influence motor recovery after stroke. Neurology. 1995;45:865–871.
  • Jones TA, Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. Neurosci. 1994;14:2140–2152.
  • Bethel A, Kirsch JR, Koehler RC, Finklestein SP, Traystman RJ. Intravenous basic fibroblast growth factor decreased brain injury resulting from focal ischemia in cats. Stroke. 1997;28:609–615.
  • Kawamata T, Dietrich WD, Schallert T, et al. Intracisternal basic fibroblast growth factor (bFGF) enhances functional recovery and upregulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Nat! Acad Sci USA. 1997;94:8179–8184.
  • Liu Y, Kim D, Nimes BT, et al. Transplants of fibrob-lasts genetically modified to express BDNF pro-mote regeneration of adult rat rubrospinal axons and recovery of forelimb function. I Neurosci. 1999;19(11):4370–4387.
  • Clark WH, Schim JD, Kasner SE, et al. Trafermin in acute ischemic stroke: results of a phase II/111 ran-domized efficacy study [abstract]. Neurology. 2000;54:A88.
  • Bogousslavsky J, Victor SJ, Salinas EO, et al. Fiblast (Trafermin) in acute ischemic stroke: results of the European-Australian phase II/111 safety and efficacy tri-al [abstract]. Cerebrovasc Dis. 2000:10\(suppl. 2):1–16.
  • Kawamata T, Speliotes EK, Finklestein SR The role of polypeptide growth factors in recovery from stroke. Adv Neurol. 1997;73:377–382.
  • Gage FH. Mammalian neural stem cells. Science. 2000;287:1433–1438.
  • Veizovic T, Beech JS, Stroemer RP, Watson WP, Hodges H. Resolution of stroke deficits following contralateral grafts of conditionally immortal neu-roepithelial stem cells. Stroke. 2001;32:1012–1019.
  • Horner PJ, Gage FH. Regeneration in the adult and aging brain. Arch Neurol. 2002;59:1717–1720.

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