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Original Articles

Poststroke Depression: A Review Emphasizing the Role of Prophylactic Treatment and Synergy with Treatment for Motor Recovery

, &
Pages 139-150 | Published online: 08 Jan 2015

REFERENCES

  • Kaplan A. Neuropsychiatric symptoms in post-stroke patients. Psychiatric Times. 2005;22.
  • Whyte EM, Mulsant BH, Vanderbilt J, Dodge HH, Ganguli M. Depression after stroke: a prospective epidemiological study. I Am Geriatr Soc. 2004;52(5):774–778.
  • Ramasubbu R, Robinson RG, Flint AJ, Kosier T, Price TR. Functional impairment associated with acute poststroke depression: the Stroke Data Bank Study. I Neuropsychiatry Clin Neurosci. 1998;10(1):26–33.
  • Whyte EM, Mulsant BH. Poststroke depression: epidemiology, pathophysiology, and biological treatment. Biol Psychiatry. 2002;52:253–264.
  • Burvill PW, Johnson GA, Jamrozik K, et al. Prevalence of depression after stroke: the Perth Community Stroke Study. Br I Psychiatry. 1995;166:1320–1327.
  • Astrom M, Adolfsson R, Asplund K. Major depression in stroke patients. A 3-year longitudinal study. Stroke. 1993;24(7):976–982.
  • Ayerbe L, Ayis S, Rudd AG, Heuschmann PU, Wolfe CDA. Natural history, predictors, and associations of depression 5 years after stroke: the South London Stroke Register. Stroke. 2011;42(7):1907–1911.
  • Gaetel M,Bogousslavskyl.Post-strokedepression. Exp Rev Neurotherapeutics. 2008;8(1):75–92.
  • de Man-van Ginkel JM, HafsteinsdOttir T, Lindeman E, Burger H, Grobbee D, Schuurmans M. An efficient way to detect poststroke depression by subsequent administration of a 9-item and a 2-item patient health questionnaire. Stroke. 2012;43(3):854–856.
  • Ramasubbu R, Robinson RG, Flint AJ, Kosier T, Price TR. Functional impairment associated with acute poststroke depression: the Stroke Data Bank Study. I Neuropsychiatry Clin Neurosci. 1998;10(1):26–33.
  • Pohjasvaara T, Vataja R, Leppavuori A, Kaste M, Erkinjuntti T. Depression is an independent predictor of poor long-term functional outcome post-stroke. EurJ Neurol. 2001;8(4):315–319.
  • Gillen R, Tennen H, McKee TE, et al. Depressive symptoms and history of depression predict rehabilitation efficiency in stroke patients. Arch Phys Med Rehabil. 2001;82:1645–1649.
  • Singh A, Black SE, Herrmann N, et al. Functional and neuroanatomic correlations in poststroke depression: the Sunnybrook Stroke Study. Stroke. 2000;31:637–644.
  • Vataja R, Pohjasvaara T, Miintyla R, et al. Depression-executive dysfunction syndrome in stroke patients. Am I Geriatr Psychiatry. 2005;13(2):99–107.
  • Kishi Y, Kosier T, Robinson RG. Suicidal plans in patients with acute stroke. I Nerv Ment Dis 1996;184:274–280.
  • House A, Knapp E, Bamford J, et al. Mortality at 12 and 24 months after stroke may be associated with depressive symptoms at 1 month. Stroke. 2001;32(3):696–701.
  • Everson SA, Roberts RE, Goldberg DE, Kaplan GA. Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch Intern Med. 1998;158(10):1133–1138.
  • Robinson RG, Bolduc PL, Price TR. Two-year longitudinal study of poststroke mood disorders: diagnosis and outcome at one and two years. Stroke. 1987;18(5):837–843.
  • Simonsick EM, Wallace RB, Blazer DG, Berkman LF. Depressive symptomatology and hypertension-associated morbidity and mortality in older adults. Psychosom Med. 1995;57(5):427–435.
  • Jorge RE, Robinson RG, Arndt S, Starkstein S. Mortality and poststroke depression: a placebo-controlled trial of antidepressants. Am Psychiatry. 2003;160(10):1823–1829.
  • Morris PL, Robinson RG, Samuels J. Depression, introversion and mortality following stroke. Aust N Z J Psychiatry. 1993;27(3):443–449.
  • Robinson RG, Kubos KL, Starr LK, et al. Mood disorders in stroke patients: importance of location of lesion. Brain. 1984;107:81–93.
  • Starkstein SE, Robinson RG, Price TR. Comparison of cortical and subcortical lesions in the production of poststroke mood disorders. Brain. 1987;110:1045–1059.
  • Schwartz A, Speed NM, Brunberg JA, et al. Depression in stroke rehabilitation. Biol Psychiatry. 1993;33:694–699.
  • Agrell B, Dehlin O. Depression in stroke patients with left and right hemisphere lesions: a study in geriatric rehabilitation in-patients. Aging. 1994;6:49–56.
  • Robinson RG, Starkstein SE, Price TR. Post-stroke depression and lesion location. Stroke. 1988;19(1):125–126.
  • Starkstein SE, Cohen BS, Fedoroff P, Parikh RM, Price TR, Robinson RG. Relationship between anxiety disorders and depressive disorders in patients with cerebrovascular injury. Arch Gen Psychiatry. 1990;47(3):246–251.
  • Starkstein SE, Robinson RG, Berthier ML, Parikh RM, Price TR. Differential mood changes following basal ganglia vs thalamic lesions. Arch Neurol. 1988;45(7):725–730.
  • Robinson RG, Kubos KL, Starr LB, Rao K, Price TR. Mood changes in stroke patients: relationship to lesion location. Compr Psychiatry. 1983;24(6):555–566.
  • Carson AJ, MacHale S, Allen K, et al. Depression after stroke and lesion location: a systematic review. Lancet. 2000;356(9224):122–126.
  • Vataja R, Pohjasvaara T, Leppavuori A, et al. Magnetic resonance imaging correlates of depression after ischemic stroke. Arch Gen Psychiatry. 2001;58(10):925.
  • Tang WK, Lu JY, Chen YK, et al. Association of frontal subcortical circuits infarcts in poststroke depression: a magnetic resonance imaging study of 591 Chinese patients with ischemic stroke. I Geriatr Psychiatry Neurol. 2011;24(1):44–49.
  • Terroni L, Amaro E Jr, Losifescu DV, et al. Stroke lesion in cortical neural circuits and post-stroke incidence of major depressive episode: a 4-month prospective study. World I Biol Psychiatry. 2011;12(7):539–548.
  • Drevets WC, Price IL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct. 2008;213(1): 93–118.
  • Sachdev PS, Chen X, Joscelyne A, Wen W, Brodaty H. Amygdala in stroke/transient ischemic attack patients and its relationship to cognitive impairment and psychopathology: the Sydney Stroke Study. Am J Geriatr Psychiatry. 2007; 15(6):487–496.
  • de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry. 2000;57(11):1071–1076.
  • Taylor WD, Macrall JR, Payne ME, etal. Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms. Psychol Med. 2007;37(12):1763–1773.
  • Alexopoulos GS, Meyers BS, Young RC, Kakuma T, Silbersweig D, Charlson M. Clinically defined vascular depression. Am I Psychiatry. 1997;154(4):562–565.
  • Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. "Vascular depression" hypothesis. Arch Gen Psychiatry. 1997;54(10):915–922.
  • Brodaty H, Withall A, Altendorf A, Sachdev PS. Rates of depression at 3 and 15 months poststroke and their relationship with cognitive decline: the Sydney Stroke Study. Am I Geriatr Psychiatry. 2007; 15(6):477–486.
  • Sheline YI, Pieper CF, Barch DM, et al. Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial. Arch Gen Psychiatry. 2010;67(3):277.
  • Debette S, Beiser A, DeCarli C, et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality. The Framingham Offspring Study. Stroke. 2010;41(4):600–606.
  • Maillard P, Carmichael O, Fletcher E, Reed B, Mungas D, DeCarli C. Coevolution of white matter hyperintensities and cognition in the elderly. Neurology. 2012;79(5): 442–448.
  • Firbank MJ, Teodorczuk A, van der Flier WM, et al. Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study. Br Psychiatry. 2012;201(1):40–45.
  • Steffens DC, Taylor WD, Krishnan KRR. Progression of subcortical ischemic disease from vascular depression to vascular dementia. Am Psychiatry. 2003;160(10):1751–1756.
  • Ohira T, Iso H, Satoh S, et al. Prospective study of depressive symptoms and risk of stroke among Japanese. Stroke. 2001;32(4):903–908.
  • Hickie I, Scott E. Late-onset depressive disorders: a preventable variant of cerebrovascular disease? Psychol Med. 1998;28(5):1007–1013.
  • Aben I, Verhey F, Strik J, Lousberg R, Lodder J, Honig A. A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction. I Neurol Neurosurg Psychiatry. 2003;74(5):581–585.
  • Lyness JM. The cerebrovascular model of depression in late life. CNS Spectr. 2002;7(10):712–715.
  • Lyness JM, Caine ED, King DA, Conwell Y, Cox C, Duberstein PR. Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression. Am I Geriatr Psychiatry. 1999;7(3):252–258.
  • Steffens DC, Krishnan KR, Crump C, Burke GL. Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke. 2002;33(6):1636–1644.
  • Holley C, Murrell SA, Mast BT. Psychosocial and vascular risk factors for depression in the elderly. Am J Geriatr Psychiatry. 2006;14(1):84–90.
  • Small GW, Mazziotta JC, Collins MT, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA. 1995;273:942–947.
  • Krishnan KRR, Tupler IA. Ritchie JC, et al. Apolipoprotein E-e4 frequency in geriatric depression. Biol Psychiatry. 1996;40:69–71.
  • Steffens DC, Norton MC, Hart AD, et al. Apolipoprotein E geno- type and major depression in a community of older adults. Psychol Med. 2003;331:541–547.
  • Panza F, Frisardi V, Seripa D, et al. Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's disease. Ageing Res Rev. 2012;11(1):87–103.
  • Kang Y. Effect of uncertainty on depression in patients with newly diagnosed atrial fibrillation. Prog Cardiovasc Nurs. 2006;21(2):83–88.
  • Thrall G, Lip GY, Carroll D, Lane D. Depression, anxiety and quality of life in patients with atrial fibrillation. Chest.2007;132(4):1259–1264.
  • Heresco-Levy U, Javitt DC. The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur Neuropsychopharmacol. 1998;8(2):141–152.
  • Glodzik-Sobanska L, Slowik A, McHugh P, et al. Single voxel proton magnetic resonance spectroscopy in post-stroke depression. Psychiatry Res. 2006;148(2-3):111–120.
  • Wang X, Li YH, Li MH, et al. Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression. Eur Arch Psychiatry Clin Neurosci. 2012;262(1):33–38.
  • Auer DP, Pütz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 2000;47(4):305–313.
  • Hashimoto K. Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Res Rev. 2009;61(2):105–123.
  • Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006;63(3):273–279.
  • Verdelho A, Henon H, Lebert F, Pasquier F, Leys D. Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study. Neurology. 2004;62(6): 905–911.
  • Salaycik KJ, Kelly-Hayes M, Beiser A, et al. Depressive symptoms and risk of stroke: the Framingham study. Stroke. 2007;38(1):16–21.
  • O'Donnell MJ, Xavier D, Liu L, et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376(9735):112–123.
  • Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012;43(1):32–37.
  • Musselman DL, Evans DL, Nemeroff CB. The relationship of depression to cardiovascular disease. Arch Gen Psychiatry. 1998;55:580–592.
  • Stewart JC, Rand KL, Muldoon MF, Kamarck TW. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immunity. 2009;23(7):936.
  • Bruce EC, Musselman DL. Depression, alterations in platelet function, and ischemic heart disease. Psychosom Med. 2005;67\(suppl 1):S34–S36.
  • Broadley AJM, Korszun A, Jones CIFI, et al. Arterial endothelial function is impaired in treated depression. Heart. 2002;88:521–523.
  • Godfrey PSA, Toone BK, Carney MW, et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet. 1990;336: 1392–1395.
  • Enns MW, Cox BJ. Personality dimensions and depression: review and commentary. Can I Psychiatry. 1997;42(3):274–284.
  • Aben I, Denollet J, Lousberg R, Verhey F, Wojciechowski F, Honig A. Personality and vulnerability to depression in stroke patients:a 1-year prospective follow-up study. Stroke. 2002;33(10):2391–2395.
  • Verdelho A, Henon H, Lebert F, Pasquier F, Leys D. Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study. Neurology. 2004;62(6): 905–911.
  • Herrmann N, Black SE, Lawrence J, Szekely C, Szalai JP. The Sunnybrook Stroke Study: a prospective study of depressive symptoms and functional outcome. Stroke. 1998;29(3): 618–624.
  • Nys GMS, Van Zandvoort MJE, Van Der Worp HB, et al. Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke. Neurol Sci. 2006;247(2):149–156.
  • Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe, K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006;63(3):273.
  • Andersen G, Vestergaard K, Ingemann-Nielsen M., Lauritzen L.. Risk factors for post-stroke depression. Acta Psychiatrica Scand. 2007;92(3):193–198.
  • Paolucci S, Antonncci G, Pratesi L, et al. Poststroke depression and its role in rehabilitation of inpatients. Arch Phys Med Rehabil. 1999;802: 985–990.
  • Carota A, Berney A, Aybek S, et al. A prospective study of predictors of poststroke depression. Neurology. 2005;64(3):428–433.
  • Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008;358(1):55–68.
  • Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry. 1997;54(7):597–606.
  • Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59(12):1116–1127.
  • Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nature Med. 2001;7(5):541–547.
  • Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003;301(5634):805–809.
  • Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci. 2003;4(12):1002–1012.
  • Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry. 2000;5(3):262–269.
  • Radley JJ, Jacobs BL. 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Res. 2002:9550(2): 264–267.
  • Banasr M, Hery M, Printemps R, Daszuta A. Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology. 2004;29(3):450–460.
  • Encinas JM, Vaahtdkari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci USA. 2006;103(21):8233–8238.
  • Cramer SC. Repairing the human brain after stroke, II: restorative therapies. Ann Neurol. 2008;63(5):549–560.
  • Cramer SC. Repairing the human brain after stroke: I. mechanisms of spontaneous recovery. Ann Neurol. 2008;63(3):272–287.
  • Spalletta G, Bossu P, Ciaramella A, Bria P, Caltagirone C, Robinson R. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Molecular Psychiatry. 2006;11 (11):984–991.
  • Kawada H, Takizawa S, Takanashi T, et al. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation. 2006;11 3(5): 701–710.
  • Su JA, Chou SY, Tsai CS, Hung TH. Cytokinechanges in the pathophysiology of poststroke depression. Gen Hosp Psychiatry.2012;39(1):35–39.
  • Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell. 2008;132(4):645–660.
  • Jin K, Wang X, Xie L, et al. Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci USA. 2006;103(35):13198–13202.
  • Marti-Fabregas J, Romaguera-Ros M, Górnez-Pined° U, et al. Proliferation in the human ipsilateral subventricular zone after ischemic stroke. Neurology. 2010;74(5):357–365.
  • Carmichael ST. Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol. 2006;59(5):735–742.
  • Lipsey JR, Robinson RG, Pearlson GD, Rao K, Price TR. Nortriptyline treatment of post-stroke depression: a double-blind study. Lancet. 1984;1 (8372):297–300.
  • Robinson RG, Schultz SK, Castillo C, et al. Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. Am Psychiatry. 2000;157(3):351–359.
  • Narushima K, Kosier JT, Robinson RG. Preventing poststroke depression: a 12-week double-blind randomized treatment trial and 21-month follow-up. Nerv Ment Dis. 2002;190(5):296–303.
  • Andersen G, Vestergaard K, Lauritzen LU. [Effective treatment of depression following apoplexy with citalopram. J Ugeskr Laeger. 1995;157(14):2000–2003.
  • Wiart L, Petit H, Joseph PA, Mazaux JM, Barat M. Fluoxetine in early poststroke depression: a double-blind placebo-controlled study. Stroke. 2000;31 (8):1829–1832.
  • Narushima K, Robinson RG. The effect of early versus late antidepressant treatment on physical impairment associated with poststroke depression: Is there a time-related therapeutic window? New Ment Dis. 2003;191:645–652.
  • Murray V, von Arbin M, Barfai A, et al. Double-blind comparison of sertraline and placebo in stroke patients with minor depression or less severe major depression. J Clin Psychiatry. 2005;66:708–716.
  • Hackett ML, Anderson CS, House AO. Management of depression after stroke: a systematic review of pharmacological therapies. Stroke. 2005;36(5):1092–1097.
  • Chen Y, Guo JJ. Meta-analysis of antidepressant treatmentfor patients with poststroke depression. Stroke. 2006;37(6):1365–1366.
  • Williams LS, Kroenke K, Bakas T, et al. Care management of poststroke depression. Stroke. 2007;38(3):998–1003.
  • Chen Y, Guo JJ, Li H, Wulsin L, Patel NC. Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study. Ann Pharmacother. 2008;42(2):177–184.
  • Robinson RG, Jorge RE, Moser DJ, et al. Escitalopram and problem-solving therapy for prevention of poststroke depression. JAMA. 2008;299(20):2391–2400.
  • Jorge RE, et al. Escitalopram and enhancement of cognitive recovery following stroke. Arch Gen Psychiatry. 2010;67:187–196.
  • Knopman DS, Rocca WA, Cha RH., Ed land SD, Kokmen E. Survival study of vascular dementia in Rochester, Minnesota. Arch Neurol. 2003;60(1):85–90.
  • Hachinski V. The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approach. Stroke. 2007;38(4):1396.
  • Tsai CS, Wu CL, Chou SY, Tsang HY, Hung TH, Su JA. Prevention of poststroke depression with milnacipran in patients with acute ischemic stroke: a double-blind randomized placebo-controlled trial. Int Clin Psychopharmacol. 2011;26(5):263–267.
  • Salter KL, Foley NC, Zhu L, Jutai JW, Teasell RW. Prevention of poststroke depression: Does prophylactic pharmacotherapy work? [published online ahead of print May 1, 2012]. J Stroke Cerebrovasc Dis.
  • Mead GE, Hsieh CF, Lee R, et al. Selective serotonin reuptake inhibitors (SSR1s) for stroke recovery [published online ahead of print November 14, 2012]. Cochrane Database Syst Rev.
  • Chollet F, Tardy J, Albucher J, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol. 2011;10(2):123–130.
  • Rasmussen A, Lunde M, Loldrup-Poulsen D, et al. A double-blind, placebo controlled study of sertraline in the prevention of depression in stroke patients. Psychosomatics. 2003;44: 216–221.
  • Robinson RG. Neuropsychiatric consequences of stroke. Annu Rev Med. 1997;48:217–229.
  • Ramasubbu R. Cerebrovascular effects of selective serotonin reuptake inhibitors: a systematic review. J Clin Psychiatry. 2004;65(12): 1642–1653.
  • Serebruany VL, Glassman AH, Malinin Al, et al. Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. Eur J Heart Fail. 2003;5(4):517–521.
  • Sauer WH, Berlin JA, Kimmel SE. Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction. Circulation. 2003;108(1):32–36.
  • De Abajo FJ, Lick H, Derby L, Lick S, Schmitz S. Intracranial haemorrhage and use of selective serotonin reuptake inhibitors. Br Clin Pharmacol. 2001;50(1):43–47.
  • Smoller JW, Allison M, Cochrane BB, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the women's health initiative study. Arch Intern Med. 2009;169(22):2128.
  • O'Connor C, Fiuzat M. Antidepressant use, depression, and poor cardiovascular outcomes: The chicken or the egg?: Comment on "antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the women's health initiative study." Arch Intern Med. 2009;169 (22):2140.
  • Bak S, Tsiropoulos I, Kjrsgaard JO, et al. Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study. Stroke. 2002;33(6):1465–1473.
  • Kharofa J, Sekar P, Haverbusch M, et al. Selective serotonin reuptake inhibitors and risk of hemorrhagic stroke. Stroke. 2007;38(11): 3049–3051.
  • Douglas I, Smeeth L, Irvine D. The use of antidepressants and the risk of haemorrhagic stroke: a nested case control study. Br I Clin Pharmacol. 2011;71 (1):116–120.
  • Abajo Ii, Rodriguez LAG, Montero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. Br Med J. 1999;319(7217):1106–1109.
  • Dalton SO, Sorensen HT, Johansen C. SSRIs and upper gastrointestinal bleeding: What is known and how should it influence prescribing? CNS Drugs. 2006;20(2):143–151.
  • Jacob S, Spinler SA. Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother. 2006;40(9): 1618–1622.
  • Johnson ML, Roberts MD, Ross AR, Witten CM. Methylphenidate in stroke patients with depression. Am Phys Med Rehabil. 1992;71(4): 239–241.
  • Grade C, Redford B, Chrostowski J, Toussaint L, Blackwell B. Methylphenidate in early poststroke recovery: a double-blind, placebo-controlled study. Arch Phys Med Rehabil. 1995;79(9): 1047–1050.
  • Martinsson L, Hardemark H, Eksborg S. Amphetamines for improving recoveryafter stroke. Cochrane Database Syst Rev. 2007;(1): CD002090.
  • Taragano FE, Allegri R, Vicario A, Bagnatti P, Lyketsos CG. A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of "vascular depression". Int J Geriatr Psychiatry. 2001;16(3):254–260.
  • Horn J, Limburg M. Calcium antagonists for ischemic stroke. Stroke. 2001;32(2): 570–576.
  • Brewer L, Horgan F, Hickey A, Williams D. Stroke rehabilitation: recent advances and future therapies. QM. 2013;106(1):11–25.
  • Niedermaier N, Bohrer E, Schulte K, Schlattmann P, Heuser I. Prevention and treatment of poststroke depression with mirtazapine in patients with acute stroke. J Clin Psychiatry. 2004;65(12):1619.
  • Engelter ST, Frank M, Lyrer PA, Conzelmann M. Safetyof pharmacological augmentation of stroke rehabilitation. Eur Neurol. 2010;64(6):325–330.
  • Murray GB, Shea V, Conn DK. Electroconvulsive therapy for post-stroke depression. J Clin Psychiatry. 1986;47:258–260.
  • van der Wurff FB, Stek ML, Hoogendijk WIG, Beekman ATF. The efficacy and safety of ECT in depressed older adults: a literature review. Int J Geriatr Psychiatry. 2003;18(10):894–904.
  • Adams HP, Robinson RG. Improving recovery after stroke: a role for antidepressant medications? Stroke. 2012;43(10):2829–2832.

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