Neutron Beam Optimization for Boron Neutron Capture Therapy Using the D-D and D-T High-Energy Neutron Sources

References

• R. F. BARTH, A. H. SOLOWAY, R. G. FAIRCHILD, and R. M. BRUGGER, “Boron Neutron Capture Therapy: Realities and Prospects,” Cancer, 70, 2995 (1992).
   PubMed Web of Science ®Google Scholar
• Y. MISHIMA, M. ICHIHASHI, S. HATTA, C. HONDA, K. YAMAMURA, and T. NAKAGAWA, “New Thermal Neutron Capture Therapy for Malignant Melanoma: Melanogenesis-Seeking 10B Molecule-Melanoma Cell Interaction from In Vitro to First Clinical Trial,” Pigment Cell Res., 2, 226 (1989).
   PubMedGoogle Scholar
• E. BINELLO, S. SHORTKROFF, A. JONES, C. VIVEIROS, A. LY, C. B. SLEDGE, A. DAVISON, R. E. SHEFER, and J. C. YANCH, “Research in Boron Neutron Capture Synovectomy,” Proc. Int. Conf. Neutrons in Research and Industry, Crete, Greece, June 9–15, 1996, SPIE 2867, 68 (1996).
   Google Scholar
• A. D. CHANANA, “Boron Neutron Capture Therapy of Glioblastoma Multiforme at the Brookhaven Medical Research Reactor, A Phase I/II Study,” FDA IND 43317, Protocol 4, Brookhaven National Laboratory (1996).
   Google Scholar
• A. H. W. NIAS, An Introduction to Radiobiology, John Wiley & Sons, New York (1990).
   Google Scholar
• C.-K. C. WANG, T. E. BLUE, and R. GAHBAUER, “A Neutronic Study of an Accelerator-Based Neutron Irradiation Facility for Boron Neutron Capture Therapy”, Nucl. Tehnol., 84, 93 (1989).
   Web of Science ®Google Scholar
• J. C. YANCH, X. L. ZHOU, R. E. SHEFER, and R. E. KLINKOWSTEIN, “Accelerator-Based Epithermal Neutron Beam Design for Neutron Capture Therapy,” Med. Phy., 19, 709 (1992).
   Web of Science ®Google Scholar
• D. A. ALLEN, and T. B. BEYNON, “A Design Study for an Accelerator-Based Epithermal Neutron Beam for BNCT,” Phys. Med. Biol., 40, 807 (1995).
   PubMed Web of Science ®Google Scholar
• J. E. WOOLLARD, T. E. BLUE, N. GUPTA, and R. A. GAHBAUER, “Evaluation of Moderator Assemblies for Use in an Accelerator-Based Neutron Source for Boron Neutron Capture Therapy,” Nucl. Technol., 123, 320 (1998).
   Web of Science ®Google Scholar
• D. L. BLEUEL, S. V. COSTES, R. J. DONAHUE, B. A. LUDEWIGT, and J. VUJIC, “Neutronics Analysis of Three Beam-Filter Assemblies for an Accelerator-Based BNCT Facility,” Proc. Topl. Mtg. Nuclear Applications of Accelerator Technology, Albuquerque, New Mexico, November 16–20, 1997, p. 502, American Nuclear Society (1997).
   Google Scholar
• D. L. BLEUEL, R. J. DONAHUE, and B. A. LUDEWIGT, “On Optimizing the 7Li(p, n) Proton Beam Energy and Moderator Material for BNCT,” presented at the 14th Int. Conf. Application of Accelerators in Research and Industry, Denton, Texas, November 6–9, 1996, LBNL-39057 UC-413, Lawrence Berkeley National Laboratory (1996).
   Google Scholar
• J. F. BRIESMEISTER, “MCNP—A General Monte Carlo N-Particle Transport Code, Version 4B,” LA-12625-M, Los Alamos National Laboratory (1997).
   Google Scholar
• D. NIGG, “Methods for Radiation Dose Analysis and Treatment Planning in BNCT,” Int. J. Radiat. Oncol., Biol. Phys., 28, 1121 (1994).
   Web of Science ®Google Scholar
• J. C. YANCH, X.-L. ZHOU, and G. L. BROWNELL, “A Monte-Carlo Investigation of the Dosimetric Properties of Monoenergetic Neutron Beams for Neutron Capture Therapy,” Radiation Res., 126, 1 (1991).
   Web of Science ®Google Scholar
• W. S. SNYDER, M. R. FORD, and G. G. FORD, “Estimates of Specific Absorbed Fractions for Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom,” MIRD Pamphlet 5 Revised, Society of Nuclear Medicine, New York (1978).
   Google Scholar
• “Photon, Electron, Proton and Neutron Interaction Data for Body Tissues,” ICRU 46, International Commission on Radiation Units and Measurements (1992).
   Google Scholar
• R. S. CASWELL, J. J. COYNE, and M. L. RANDOLPH, “Kerma Factors of Elements and Compounds for Neutron Energies Below 30 MeV,” Int. J. Appl. Radiat. Isot., 33, 1227 (1982).
   Google Scholar
• D. L. BLEUEL, R. J. DONAHUE, B. A. LUDEWIGT, and J. VUJIC, “Development of a Neutron Energy-Biased In-Air Figure-of-Merit for Predicting In-Phantom BNCT Neutron Beam Characteristics,” Proc. 8th Int. Symp. Neutron Capture Therapy for Cancer, La Jolla, California, September 13-18, 1998, Plenum Press, New York (1998).
   Google Scholar
• J. B. MARION and J. L. FOWLER, Fast Neutron Physics, Part I, Monographs and Texts in Physics and Astronomy,J. B. MARION and J. L. FOWLER, Eds., Interscience Publishers, New York (1960).
   Google Scholar
• H. B. LIU, D. D. GREENBERG, J. COPALA, and F. J. WHEELER, “An Improved Neutron Collimator for Brain Tumor Irradiations in Clinical Boron Neutron Capture Therapy,” Med. Phys., 23, 2051 (1996).
   PubMed Web of Science ®Google Scholar
• D. L. BLEUEL, R. J. DONAHUE, B. A. LUDEWIGT, and J. VUJIC, “Designing Accelerator-Based Epithermal Neutron Beams for BNCT,” Med. Phys., 25, 9, 1725 (1998).
   PubMed Web of Science ®Google Scholar
• J. A. CODERRE, R. BERGLAND, J. CAPALA, M. CHADHA, A. J. CHANANA, E. ELOWITZ, D. D. JOEL, H. B. LIU, and D. SLATKIN, “Boron Neutron Capture Therapy for Glioblastoma Multiforme Using p-boronophenylalanine and Epithermal Neutrons—Trial Design and Early Clinical Results,” J. Neuro-Oncol., 33, 93 (1997).
   Web of Science ®Google Scholar
• T. GOORLEY, F. WHEELER, J. CAPALA, W. S. KIGER III, M. PALMER, and R. ZAMENHOF, “A Comparison of Two Treatment Planning Programs: MacNCTPlan and BNCT_RTPE,” Proc. 8th Int. Symp. Neutron Capture Therapy for Cancer, La Jolla, California, September 13–18, 1998, Plenum Press, New York (1998).
   Google Scholar
• R. G. ZAMENHOF, S. D. CLEMENT, O. K. HARLING, J. K. BRENNER, D. E. WAZER, H. MADOC-JONES, and J. C. YANCH, “Monte Carlo Based Dosimetry and Treatment Planning for Neutron Capture Therapy of Brain Tumors,” Neutron Beam Design, Development, and Performance for Neutron Capture Therapy, O. K. HARLING, J. A. BERNARD, and R. G. ZAMENHOF, Eds., Basic Life Sciences, Vol. 54, p. 283, Plenum Press, New York (1990).
   Google Scholar
• Y. KARNI, E. GREENSPAN, J. VUJIC, and B. LUDEWIGT, “Optimal Beam-Shaping Assemblies for BNCT Facilities,” Trans. Am. Nucl. Soc., 73, 29 (1995).
   Google Scholar
• I. AUTERINEN and P. HIISMAKI, “Design of an Epithermal Neutron Beam for the TRIGA Reactor in Otaniemi,” Proc. CLINCT BNCT Workshop, Helsinki, Finland, 1993, TKK-F-A718, p. 14–24(1994).
   Google Scholar
• High Voltage Engineering Corporation, Burlington, Massachusetts.
   Google Scholar
• L. A. SHOPE, “Theoretical Thick Target Yields for the D-D, D-T, and T-D Nuclear Reactions Using the Metal Occluders Ti and Er and Energies up to 300 keV,” SC-TM-66-247, Sandia Laboratory (1966).
   Google Scholar
• J. M. VERBEKE, Y. LEE, K. N. LEUNG, J. VUJIC, M. D. WILLIAMS, L. K. WU, and N. ZAHIR, “Neutron Tube Design Study for Boron Neutron Capture Therapy Application,” Proc. Particle Accelerator Conf., New York, New York, March 29–April 2, 1999, Vol. 4, p. 1926, Institute of Electrical and Electronics Engineers (1999).
   Google Scholar
• J. M. VERBEKE, S. V. COSTES, D. BLEUEL, J. VUJIC, and K. N. LEUNG, “Designing an Epithermal Neutron Beam for Boron Neutron Captive Therapy for the Fusion Reactions 2H(d, n) 3He and 3H(d, n) 4He,” Proc. Int. Conf. Physics of Nuclear Science and Technology, Long Island, New York, October 5–8, 1998, Vol. 2, p. 1600, American Nuclear Society (1998).
   Google Scholar