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Improving antidepressant drugs: update on recently patented compounds

Pages 827-845 | Published online: 28 May 2009

Bibliography

  • Available from: http://www.who.int/mental_health/management/depression/definition/en/
  • Mental Health Global Action Programme. Close the gap, dare to care. Geneva: World Health Organization; 2002
  • Elhwuegi AS. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:435-51
  • Frazer A. Antidepressants. J Clin Psychiatr 1997;58:9-25
  • Millan MJ. The role of monoamines in the actions of established and «novel» antidepressant agents: a critical review. Eur J Pharmacol 2004;500:371-84
  • Invernizzi RW, Garattini S. Role of presynaptic α2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. Prog Neuro Psychopharmacol Biol Psychiatry 2004;28:819-27
  • Butler SG, Meegan MJ. Recent development in the design of anti-depressive therapies: targeting the serotonin transporter. Curr Med Chem 2008;15:1737-61
  • Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7:137-51
  • Millan MJ. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 2006;110:135-370
  • Millan MJ. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics 2009;6:53-77
  • Rasmussen K. Creating more effective antidepressants: clues from the clinic. Drug Discov Today 2006;11:623-31
  • Bourin M, Mocaer E, Porsolt R. Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors. J Psychiatry Neurosci 2004;29:126-33
  • Nierenberg AA, Dougherty D, Rosenbaum JF. Dopaminergic agents and stimulants as antidepressant augementation strategies. J Clin Psychiatry 1998;59(Suppl 5):60-3
  • Willner P. The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol 1997;12(Suppl 3):S7-14
  • Schmidt HD, Banasr M, Duman RS. Future antidepressant targets: neurotrophic factors and related signaling cascades. Drug Discov Today Ther Strateg 2008;5:151-6
  • EPO searching engine. Available from: http://ep.espacenet.com/
  • Nencetti S, Lapucci A. 4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders. WO2006106432; 2006
  • Gerdes JM, Bolstad DB. Enantiomers of 2′-fluoralkyl-6-nitroquipazine as Serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics. WO2007127262; 2007
  • Shanghai INST. Pharm. Industry. Aralkyl-alcohol piperazine derivatives adn their uses as antgyepressant. US2005267121; 2005
  • Gruenenthal GMBH. New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma. DE102005030051; 2006
  • Lundbeck & Co As. 2-(1H-indolylsulfanyl)-benzyl amine derivative. P2007277254; 2007
  • Natco Pharma Ltd. 3-Aryloxy 3-Substituted Propanamines. WO2008081477; 2008
  • Perez V, Gilaberte I, Faries D, et al. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet 1997;349:1594-7
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050061470; 2005
  • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. KR20050042192; 2005
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. KR20050042187; 2005
  • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050042176; 2005
  • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. MXPA05002743; 2005
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. MXPA05002740; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-dioxa-3-aza-cyclopenta[a]naphtalene. MXPA03009829; 2005
  • Wyeth Corp. Antidepressant (SSRI) azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1, 3-diazacyclopenta[a]naphtalene. MXPA03009828; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinaxoline. MXPA03009826; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans. MXPA03009825; 2005
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxans. EP1537103; 2005
  • Wyeth Corp. Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole. WO02088146; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene. US2005228010; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene. US2005004209; 2005
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. ZA200502043; 2006
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. ZA200502047; 2006
  • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. ZA200502042; 2006
  • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. ZA200502040; 2006
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2006293301; 2006
  • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. US2006276481; 2006
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. NZ539253; 2006
  • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. US2006160881; 2006
  • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2007004702; 2007
  • Wyeth Corp. Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans. WO2008150848; 2008
  • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. CN101143867; 2008
  • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. CN101239953; 2008
  • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. CN101230066; 2008
  • Cheetham SC, Viggers JA, Slater NA, et al. [3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology 1993;32:737-43
  • Hall MD, El Mestikawy S, Emerit MB, et al. [3H]8-Hydroxy-2-(di-n-propylamino)tetraline binding to pre- and postsynaptic 5-Hydroxytryptamine sites in various regions of the rat brain. J Neurochem 1985;44:1685-96
  • Merck Patent GmbH. Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic. KR20050085038; 2005
  • Merck Patent GmbH. Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs. PL377618; 2006
  • Merck Patent GmbH. Indole derivatives as serotonin reuptake inhibitors. MXPA05013538; 2006
  • UCB SA. 4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments. MXPA05003290; 2005
  • UCB SA. Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases. EP1693061; 2006
  • Ge JA, Barnes NM. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. Br J Pharmacol 1996;117:1475-80
  • Lucas G, Debonnel G. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity. Eur J Neurosci 2002;16:817-22
  • Lucas G, Compan V, Charnay Y, et al. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biol Psychiatry 2005;57:918-925
  • Lucas G, Rymar VV, Du J, et al. Serotonin(4) (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 2007;55:712-25
  • Debonnel G, Lucas G. Stimulators of 5-ht4 receptors and uses thereof. WO2006029520; 2006
  • Heinrich T, Bottcher H. Indole derivatives as serotonin reuptake inhibitors. US2006160824; 2006
  • Pinney KG, Miranda MG. Serotonin reuptake inhibitors. WO2005094896; 2005
  • Pinney KG, Miranda MG. Serotonin reuptake inhibitors. US2008132514; 2008
  • Janssen Pharmaceutica. C–substituted tricyclic isoxazoline derivatives and their use as anti-depressants. US2005256119; 2005
  • Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. WO2006083204; 2006
  • Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. US2008269306; 2008
  • Soares JC, Innis RB. Neurochemical brain imaging investigations of schizophrenia. Biol Psychiatry 1999;46:600-15
  • Lilly Co. Eli. Combination therapy for treatment of psychoses. EP830864; 1997
  • Feenstra R, Ronken E, Koopman T, et al. SLV308. antiparkinsonian, antidepressant, anxiolytic, dopamine D2 partial agonist, 5-HT1A agonist. Drugs Future 2001;26:128-32
  • Solvay Pharmaceuticals BV. New phenylpiperazines useful for treating central nervous system disorders caused by dopaminergic or serotonergic systems. NZ523135; 2005
  • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122189, US2006122190, US2006247256; 2006
  • Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122175, CA2587940; 2006
  • Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptakesites. US2006122177. CA2587928; 2006
  • Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122206, CA2587936; 2006
  • Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122247; 2006
  • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. EP1824479, EP1824480, EP1827426, EP1828161, MX2007006818; 2007
  • Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1824486, MX2007006758; 2007
  • Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1828168, MX2007006757; 2007
  • Solvay Pharmaceuticals BV. 8-{4-[3-(5-fluoro-1H-indol-3-YLl)-propyl]-piperazin-1-YL)-2-methyl-4H-benzo[1,4].oxazin-3-one mesylate with high affinity for the dopamine D2 receptor and the serotonin reuptake site. AU2002250983; 2006
  • Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. SI1827427; 2008
  • Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. MX2007006756; 2007
  • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. HR20090015; 2009
  • Squibb Bristol Myers Co. Antipsychotic heterocycle compounds. EP1598068; 2005
  • Sindrup J. Anesthesia: Biological foundations. In: Yaksh TL, Lynch C, Zapol W, et al. Philadelphia: Lippincott-Raven; 1997
  • Gruenenthal GmbH. C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorder. US2006258741; 2006
  • Maggi CA. The troubled story of tachykinins and neurokinins. Trends Pharmacol Sci 2000;21:173-5
  • Ryckmans T, Balançon L, Berton O, et al. First dual NK1 antagonists serotonin reuptake inhibitors: synthesis and SAR of a new class off potential antidepressants. Bioorg Med Chem Lett 2002;12:261-4
  • Servier Lab. Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists. EP1710240; 2006
  • Sanofi Aventis. Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them. EP1707564; 2006
  • Edmonds-Alt X, Vilain P, Goulaouic P, et al. A potent and selective non-peptide antagonist of the neurokinin a (NH2) receptor. Life Sci 1992;50:PL101-6
  • Sanofi Aventis. Composition useful to treat e.g. anxiety disorder comprises (S)-(-)-N-(4-(4-acetamido-4-phenyl- 1-piperidyl)-2-(3, 4-dichlorophenyl) butyl)-N-methylbenzamide, (+/-)-N-methyl-3-phenyl- 3-(4-(trifluoromethyl)phenoxy)-propan- 1-amine. FR2904221; 2008
  • Padgett LW. Recent developments in cannabinoid ligands. Life Sci 2005;77:1767-98
  • Muccioli GG, Lambert DM. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors. Curr Med Chem 2005;12:1361-94
  • Lambert DM, Fowler CJ. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 2005;48:5059-87
  • Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 2005;81:331-42
  • Solvay Pharmaceuticals BV. Compounds with a combination of cannabinoid cb1 antagonism and serotonin reuptake inhibition. US2008214559, WO2008084057; 2008
  • Hoyer D, Martin G. 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 1997;36:419-28
  • SmithKline Beecham PLC, Jones BJ, Routledge C. Composition containing 5-HT1A and 5-HTID antagonists. WO9531988; 1995
  • Maura G. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate and inhibition of cyclic GMP production in rat cerebellum in vitro. J Neurochem 1996;66:203-9
  • Pfizer Prod., Inc. 5HT1 antagonists for antidepressant therapy. OA11742; 2005
  • Merck Patent GmbH. New 3-oxo-1-propenyl azo compounds useful as 5-HT receptor antagonists e.g. for treating psychoses, neurological disorders, amyotrophic lateral sclerosis and eating disorders. DE10360151; 2005
  • Merck Patent GmbH. New quinolonyl- or benzopyranonyl-substituted indole derivatives are 5HT(1A)- and/or 5HT(1D)-agonists useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents. DE10353657; 2005
  • Esteve Labor Dr. New tetrahydroisoquinoline substituted sulfonamide compounds useful as 5-HT7 receptor antagonist in the treatment of e.g. central nervous system disorders. ES2257168; 2006
  • Esteve Labor Dr. New dihydro-1H-isoquinoline compounds are 5-hydroxytryptamine-7 inhibitors useful for the treatment of e.g. sleep disorder, shift worker syndrome, depression, migraine, anxiety, psychosis, schizophrenia and pain. ES2257167; 2006
  • Terrón JA. The 5HT7 receptor: a target for novel therapeutic avenues? IDrugs 1998;1:302-10
  • Lovenberg TW, Baron BM, de Lecea L, et al. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of circadian rhythms. Neuron 1993;11:449-58
  • Esteve Labor Dr. New indene derivatives useful for treating e.g. obesity, bulimia, anorexia, cachexia, diabetes, anxiety, panic attacks, depression and bipolar disorders. ES2274725; 2007
  • Yoshioka M, Matsumoto M, Togashi H, et al. Central distribution and function of 5-HT(6) receptor subtype in the rat brain. Ann NY Acad Sci 1998;861:244
  • Bourson A, Boess FG, Bos M, et al. Involvement of 5-HT6 receptors in nigro-striatal function in rodents. Br J Pharmacol 1998;125:1562-6
  • Rogers DC, Robinson TL, Quilter CA, et al. Cognitive enhancement effects of the selective 5-HT6 antagonist SB-271046. Br J Pharmacol Suppl S 1999;127:22P
  • Branchek TA, Blackburn TP. 5-HT6 receptors as emerging targets for drug discovery. Ann Rev Pharmacol Toxicol 2000;40:319-34
  • Routledge C, Bromidge SM, Moss SF, et al. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist. Br J Pharmacol 2000;130:1606-12
  • Roth BL, Craigo SC, Choudhary MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 1994;268:1403-10
  • Glatt CE, Snowman AM, Sibley DR, et al. Clozapine − selective labeling of sites resembling 5ht(6) serotonin receptors may reflect psychoactive profile. Mol Med 1995;1:398-406
  • Monsma FJ, Shen Y, Ward RP, et al. Cloning and expression of a novel serotonin receptor with high-affinity for tricyclic psychotropic-drugs. Mol Pharmacol 1993;43:320-7
  • Shinkai T, Ohmori O, Kojima H, et al. et al. Association study of the 5-HT6 receptor gene in schizophrenia. Am J Med Genet 1999;88:120-2
  • Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of alkyloxindoles as 5-HT7 receptor active agents. HU0500462; 2007
  • Egis Gyogyszergyar Nyilvanosan. Pyperazine derivatives of alkyl-oxindoles. HU0500461; 2007
  • Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of dialkyl-oxindoles. HU0500463; 2007
  • Egis Gyogyszergyar Nyilvanosan. Piperazine derivatives of dialkyl-oxindoles. HU0500464; 2007
  • Fourtillan SNC. New 1-hydroxy- 3-oxo-propen-1-yl-hexahydro-pyrrolo-indole compounds are 5-hydroxy tryptamine-2 receptor antagonists useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's diseases, cancer, skin diseases and anxiety. FR2912747; 2008
  • Fourtillan SNC. New 3H,11H-oxazolo(3′,4′:1,2)pyrido(3,4-b)indole derivatives are 5-hydroxytryptamine- 2 receptor activators useful e.g. to treat insomnia, jet lag, anxiety, depression and Alzheimers. FR2908767; 2008
  • Callado LF, Meana JJ, Grijalba B, et al. Selective increase of alpha2a-adrenoceptor agonist binding sites in brains of depressed suicide victims. J Neurochem 1998;70:1114-23
  • Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, et al. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: Selective supersensitivity of alpha2A-adrenoceptors. Mol Psychiatry 2002;7:755-67
  • Mateo Y, Fernandez-Pastor B, Meana JJ. Acute and chronic effects of desipramine and clorgyline on alpha2-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. Br J Pharmacol 2001;133:1362-70
  • Fernandez-Pastor B, Meana JJ. In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2-adrenoceptors. Eur J Pharmacol 2002;442:225-9
  • Devoto P, Flore G, Pani L, Gessa GL. Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol Psychiatry 2001;6:657-64
  • Mateo Y, Pineda J, Meana JJ. Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine. J Neurochem 1998;71:790-8
  • Hennings JM, Owashi T, Binder EB, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients – findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res 2009;43:215-229
  • Rozas I, Rodriguez F, et al. Guanidine based Compounds. EP2008068199; 2008
  • Rozas I, Rodriguez F, et al. α2-Adrenoceptor Ligands. UK08234205; 2008
  • Van Der Burg WJ. Psychofarmaceutical Preparation. WO2006006858; 2006
  • Gmeiner P, Huebner H. New N-substituted 1-benzyl-1H-(1,2,3)- triazole-4-carboxamides, are dopamine and alpha-1 adrenergic receptor ligands useful for treating diseases of the urinary tract, vascular system or CNS. DE102004039065; 2006
  • Millan MJ, Bervoets K, Rivet JM, et al. Multiple alpha-2-adrenergic receptor subtypes .2. Evidence for a role of rat r(alpha-2a), adrenergic-receptors in the control of nociception, motor behavior and hippocampal synthesis of nor adrenaline. J Pharmacol Exp Ther 1994;270:958-72
  • Millan MJ, Gobert A, Rivet JM, et al. Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha(2)-adrenergic and serotonin(2C) receptors: a comparison with citalopram. Eur J Neurosci 2000;12:1079-95
  • Gobert A, Di Cara B, Cistarelli L, et al. Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha(2A)-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. J Pharmacol Exp Ther 2003;305:338-46
  • Kennett GA, Wood MD, Bright F, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 1997;36:609-20
  • Servier Lab. Benzoindoline derivatives with adrenergic activity. EP1516871; 2005
  • Kinney GG, Sur C. Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia. Curr Neuropharmacol 2005;3:35-43
  • Tech Egon. Combating stress states or nervous system or metabolic disorders, using glycine as neurotransmission modulator showing antistress, stress protective, nootropic and toxin binding actions. DE102005027905; 2005
  • Sanofi Aventis. New N-heterocyclylmethyl benzamide derivatives useful as glycine transporter inhibitors for e.g. treating dementia-associated behavioral problems, psychoses, anxiety, depression and alcohol abuse. FR2861076; 2005
  • Sanofi Aventis. Use of tricyclic compounds as glycine transport inhibitors. CN1882587; 2006
  • Swanson CJ, Bures M, Johnson MP, et al. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nature Rev Drug Discov 2005;4:131-44
  • Nazakato A, Chaki S. 6-Fluorobicyclo[3.1.0]hexane derivatives. US2005119345; 2005
  • Servier Lab. Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators. EP1557412; 2005
  • Servier Lab. Benzothiazine and benzothiadiazine derivatives, process for their preparation and phamaceutical compositions containing them. EP1669072; 2006
  • Servier Lab. Benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them. EP1655030; 2006
  • Servier Lab. Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them. EP1655299; 2006
  • Sanacora G, Rothman DL, Mason G, Krystal JH. Clinical studies implementing glutamate neurotransmission in mood disorders. Ann NY Acad Sci 2003;1003:292-308
  • Paul IA, Skolnick P. Glutamate and depression: clinical and preclinical studies. Ann NY Acad Sci 2003;1003:250-72
  • Gozin M, Weiner HL. Novel neuroprotective compounds and uses thereof. WO2006077597; 2006
  • Hermann HL. Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder. DE102007009888; 2008
  • Hatt H, Kragler A. Use of 1,3-dioxane derivatives to enhance the activity of gamma-aminobutyric acid (GABA) on GABA-A receptors. DE102007010077; 2008
  • Sanol Arznei Schwarz GmbH. Ferrocenecarboxamide derivatives for use as dopamine D3 ligands for the treatment of CNS disorders. EP1733727; 2006
  • Bioproject Soc Civ Ile. New arylpiperazine derivatives, useful to prevent and/or treat neuropsychiatric disorders e.g. disorders of drug dependence, sexual disorders and motor disturbance, are dopamine D3 receptor ligands. FR2878524; 2006
  • Bioproject Soc Civ Ile. Arylpiperazuine derivatives as selective ligand for the dopamine D3 receptor. EP1659112; 2006
  • Caldarone BJ, Harrist A, Cleary MA, et al. High affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biol Psychiatry 2004;56:657-64
  • Binder Eva Dkfm. New enantiomerically pure hexahydro-pyrrolo-cyclopenta-pyridine derivatives, useful as central nicotine receptor subtype agonists for e.g. treating Alzheimer's or Parkinson's disease, anxiety and depression. AT414305; 2006
  • Gruenenthal GmbH. New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration. DE102005044814; 2006
  • Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005015957; 2006
  • Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005014628; 2006
  • Esteve Labor. Dr. New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors. ES2251317; 2006
  • Sanofi Aventis Deutschland. Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them. EP1857445; 2007
  • Barden N, Shink E, Labbe M, et al. Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:908-16
  • Lucini V, Spadoni G. Novel melatonin ligands having antidepressant activity as well as sleep inducing properties. CA2636601; 2007
  • Gobbi G, Mor M. Novel elatonin ligands having antidepressant activity as well as sleep inducing properties. EP1973868; 2008
  • Servier Lab. New 3-acylaminoethyl- 3-phenylthio-benzothiophene derivatives, are melatonin receptor ligands useful e.g. for treating sleeping disorders, anxiety, depression, jet lag or appetite disorders. FR2857011; 2005
  • Servier Lab. New indole derivatives are melatonin receptor binders useful to treat e.g. sleep disturbance, stress, anxiety, depression, cardiovascular diseases, digestive system disorders, schizophrenia, panic attack, obesity and insomnia. FR2907452; 2008
  • Servier Lab. New naphthalene derivatives, method of preparing same and pharmaceutical compositions containing them. EP1873140; 2008
  • Servier Lab. Use of agomelatin in the manufacture of a medicament for the treatment of bipolar disorders. EP1714647; 2006
  • Servier Lab. Use of agomelatine to obtain a medication aimed at treating generalised anxiety disorder. EP1842535; 2007
  • Servier Lab. Use of agomelatine to obtain a drug to treat Smith Magenis syndrome, major depression, seasonal depression, sleep disorder, cardiovascular disease, digestive system disorder, insomnia, shiftlag, appetite disorders and obesity. FR2908995; 2008
  • Chaki S, Okuyama S. Involvement of melanocortin-4 receptor in anxiety and depression. Peptides 2005;26:1952-64
  • Poitout L, Brault V. New 1,2,6-trisubstituted benzimidazole derivatives and imidazo-pyridine analogs, are melanocortin receptor ligands useful for treating e.g. obesity, cachexia, anxiety, depression or neuropathic pain. FR2862971; 2005
  • Chaki S, Oshida Y, Ogawa S, et al. MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity. Pharmacol Biochem Behav 2005;82:621-6
  • Takeda Pharmaceutical. Antidepressant. PL371366; 2005
  • Takeda Pharmaceutical. Antidepressant. US2006241168; 2006
  • Bombardelli E, Morazzoni P. Use of hyperforin derivatives as an antidepressant agent. EP1607099; 2005
  • Boehringer Ingelheim Pharma. New 2-amino-imidazo(4,5-d)pyridazin-4-one derivatives are dipeptidyl-peptidase IV inhibitors useful in the treatment of e.g. diabetes mellitus, autoimmune disease, rheumatoid arthritis, and multiple sclerosis. DE102004025552; 2005
  • Lodola A, Mor M, Rivara S, et al. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modeling. Chem Commun 2008;214-6
  • Sanofi Synthelabo. New 1-alkyl-(homo)piperazine-4-carboxylate ester derivatives, are fatty acid amidohydrolase inhibitors useful e.g. for treating pain, cancer or neurodegenerative, cardiovascular, inflammatory or allergic disease. FR2866888; 2005
  • Sanofi Synthelabo. Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof. EP1972616; 2008
  • Halene TB, Siegel SJ. PDE inhibitors in psychiatry – future options for dementia, depression and schizophrenia? Drug Discov Today 2007;12:870-8
  • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005023207; 2006
  • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005019718; 2006
  • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005035575; 2007
  • Boehringer Ingelheim Pharma. New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia. DE102004057645; 2006;
  • Servier Lab. New triazabenzo(a)naphtho(2,1,8-cde)azulene derivatives useful as tyrosine hydroxylase inducers, e.g. for treating depression or anxiety. FR2911141; 2008
  • Medtrack. Available from: http://www.medtrack.com/research/default.asp, Life Science Analytics, Inc

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