Quorum sensing inhibitors: a patent overview

Bibliography

• Tomasz A. Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria. Nature 1965;208:155-9
   PubMed Web of Science ®Google Scholar
• Bassler BL, Losick R. Bacterially speaking. Cell 2006;125:237-46
   PubMed Web of Science ®Google Scholar
• Miller MB, Bassler BL. Quorum sensing in bacteria. Annu Rev Microbiol 2001;55:165-99
   PubMed Web of Science ®Google Scholar
• Nealson KH, Platt T, Hastings JW. Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol 1970;104:313-22
   PubMed Web of Science ®Google Scholar
• Chatterjee A, Cui Y, Chatterjee AK. RsmA and the quorum-sensing signal, N-[3-oxohexanoyl]-L-homoserine lactone, control the levels of rsmB RNA in Erwinia carotovora subsp. carotovora by affecting its stability. J Bacteriol 2002;184:4089-95
   Google Scholar
• Hussain M, Zhang HB, Xu JL, The acyl-homoserine lactone-type quorum-sensing system modulates cell motility and virulence of Erwinia chrysanthemi pv. zeae. J Bacteriol 2008;190:1045-53
   PubMed Web of Science ®Google Scholar
• Pratten J, Foster SJ, Chan PF, Staphylococcus aureus accessory regulators: expression within biofilms and effect on adhesion. Microbes Infect 2001;3:633-7
   PubMedGoogle Scholar
• O'Toole G, Kaplan HB, Kolter R. Biofilm formation as microbial development. Annu Rev Microbiol 2000;54:49-79
   PubMed Web of Science ®Google Scholar
• An D, Danhorn T, Fuqua C, Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures. Proc Natl Acad Sci USA 2006;103:3828-33
   PubMed Web of Science ®Google Scholar
• von Bodman SB, Majerczak DR, Coplin DL. A negative regulator mediates quorum-sensing control of exopolysaccharide production in Pantoea stewartii subsp. stewartii. Microbiol 1998;95:7687-92
   Google Scholar
• Fujii T, Ingham C, Nakayama J, Two homologous agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1. J Bacteriol 2008;190:7655-65
   PubMedGoogle Scholar
• Marketon MM, Glenn SA, Eberhard A, Quorum sensing controls exopolysaccharide production in Sinorhizobium meliloti. J Bacteriol 2003;185:325-31
   PubMed Web of Science ®Google Scholar
• Alekshun MN, Levy SB. Molecular mechanisms of antibacterial multidrug resistance. Cell 2007;128:1037-50
   PubMed Web of Science ®Google Scholar
• Pearson JP, Gray KM, Passador L, Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci USA 1994;91:197-201
   PubMed Web of Science ®Google Scholar
• Gambello MJ, Iglewski BH. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol 1991;173:3000-9
   PubMed Web of Science ®Google Scholar
• Pearson JP, Pesci EC, Iglewski BH. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J Bacteriol 1997;179:5756-67
   PubMed Web of Science ®Google Scholar
• Dunlap PV. Quorum regulation of luminescence in Vibrio fischeri. J Mol Microbiol Biotechnol 1999;1:5-12
   PubMedGoogle Scholar
• Kuo A, Blough NV, Dunlap PV. Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri. J Bacteriol 1994;176:7558-65
   PubMed Web of Science ®Google Scholar
• Lupp C, Ruby EG. Vibrio fischeri LuxS and AinS: comparative study of two signal synthases. J Bacteriol 2004;186:3873-81
   PubMed Web of Science ®Google Scholar
• Lupp C, Urbanowski M, Greenberg EP, The Vibrio fischeri quorum-sensing systems ain and lux sequentially induce luminescence gene expression and are important for persistence in the squid host. Mol Microbiol 2003;50:319-31
   PubMedGoogle Scholar
• Qin Y, Luo ZQ, Smyth AJ, Quorum-sensing signal binding results in dimerization of TraR and its release from membranes into the cytoplasm. EMBO J 2000;19:5212-21
   PubMed Web of Science ®Google Scholar
• Zhu J, Winans SC. The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization. Proc Natl Acad Sci USA 2001;98:1507-12
   PubMed Web of Science ®Google Scholar
• Vannini A, Volpari C, Gargioli C, The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA. EMBO J 2002;21:4393-401
   PubMed Web of Science ®Google Scholar
• Pearson JP, van Delden C, Iglewski BH. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J Bacteriol 1999;181:1203-10
   PubMed Web of Science ®Google Scholar
• Kaplan HB, Greenberg EP. Diffusion of autoinducer is involved in regulation of the Vibrio fischeri luminescence system. J Bacteriol 1985;163:1210-4
   PubMed Web of Science ®Google Scholar
• Thomas GL, Böhner CM, Williams HE, Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages. Mol Biosyst 2006;2:132-7
   PubMedGoogle Scholar
• Evans K, Passador L, Srikumar R, Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J Bacteriol 1998;180:5443-7
   PubMed Web of Science ®Google Scholar
• Stoodley P, Sauer K, Davies DG, Biofilms as complex differentiated communities. Annu Rev Microbiol 2002;56:187-209
   PubMed Web of Science ®Google Scholar
• Romero R, Schaudinn C, Kusanovic JP, Detection of a microbial biofilm in intraamniotic infection. Am J Obstet Gynecol 2008;198:135-7
   PubMed Web of Science ®Google Scholar
• Olson ME, Ceri H, Morck DW, Biofilm bacteria: formation and comparative susceptibility to antibiotics. Can J Vet Res 2002;66:86-92
   PubMed Web of Science ®Google Scholar
• Drenkard E, Ausubel FM. Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 2002;416:740-3
   PubMed Web of Science ®Google Scholar
• Charlton TS, de Nys R, Netting A, A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm. Environ Microbiol 2000;2:530-41
   PubMed Web of Science ®Google Scholar
• Davies DG, Parsek MR, Pearson JP, The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998;280:295-8
   PubMed Web of Science ®Google Scholar
• Yarwood JM, Bartels DJ, Volper EM, Quorum sensing in Staphylococcus aureus biofilms. J Bacteriol 2004;186:1838-50
   PubMed Web of Science ®Google Scholar
• Jacobi CA, Bach A, Eberl L, Detection of N-(3-Oxohexanoyl)-l-homoserine lactone in mice infected with Yersinia enterocolitica serotype O8. Infect Immun 2003;71:6624-6
   PubMedGoogle Scholar
• Wu H, Song Z, Hentzer M, Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiol 2000;146:2481-93
   PubMedGoogle Scholar
• Nakagami G, Sanada H, Sugama J, Detection of Pseudomonas aeruginosa quorum sensing signals in an infected ischemic wound: an experimental study in rats. Wound Repair Regen 2008;16:30-6
   PubMedGoogle Scholar
• Stickler DJ, Morris NS, McLean RJC, Biofilms on indwelling urethral catheters produce quorum-sensing signal molecules in situ and in vitro. Appl Environ Microbiol 1998;64:3486-90
   PubMed Web of Science ®Google Scholar
• Middleton B, Rodgers HC, Camara M, Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS Microbiol Lett 2002;207:1-7
   PubMedGoogle Scholar
• Déziel E, Lépine F, Milot S, Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci USA 2004;101:1339-44
   PubMed Web of Science ®Google Scholar
• Diggle SP, Matthijs S, Wright VJ, The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol 2007;14:87-96
   PubMed Web of Science ®Google Scholar
• Pesci EC, Milbank JBJ, Pearson JP, Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Biochemistry 1999;96:11229-34
   Google Scholar
• Mashburn LM, Whiteley M. Membrane vesicles traffic signals and facilitate group activities in a prokaryote. Nature 2005;437:422-5
   PubMed Web of Science ®Google Scholar
• Diggle SP, Winzer K, Chhabra SR, The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol Microbiol 2003;50:29-43
   PubMed Web of Science ®Google Scholar
• McKnight SL, Iglewski BH, Pesci EC. The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol 2000;182:2702-8
   PubMed Web of Science ®Google Scholar
• Wade DS, Calfee MW, Rocha ER, Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J Bacteriol 2005;187:4372-80
   PubMed Web of Science ®Google Scholar
• Diggle SP, Lumjiaktase P, Dipilato F, Functional genetic analysis reveals a 2-alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria. Chem Biol 2006;13:701-10
   PubMedGoogle Scholar
• Jayaraman A, Wood TK. Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease. Annu Rev Biomed Eng 2008;10:145-67
   PubMed Web of Science ®Google Scholar
• Kleerebezem M, Quadri LEN, Kuipers OP, Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol Microbiol 1997;24:895-904
   PubMed Web of Science ®Google Scholar
• Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003;48:1429-49
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Novick RP. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides 2004;25:1389-403
   PubMed Web of Science ®Google Scholar
• Novick RP, Ross HF, Projan SJ, Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J 1993;12:3967-75
   PubMed Web of Science ®Google Scholar
• Abdelnour A, Arvidson S, Bremell T, The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 1993;61:3879-85
   PubMed Web of Science ®Google Scholar
• Gillaspy AF, Hickmon SG, Skinner RA, Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect Immun 1995;63:3373-80
   PubMed Web of Science ®Google Scholar
• Booth MC, Cheung AL, Hatter KL, Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophtha. Infect Immun 1997;65:1550-6
   PubMed Web of Science ®Google Scholar
• Tuomanen EI, Goerke C, Campana S, Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro. Infect Immun 2000;68:1304-11
   PubMedGoogle Scholar
• Yarwood JM, McCormick JK, Paustian ML, Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo. J Bacteriol 2002;184:1095-101
   PubMedGoogle Scholar
• Vuong C, Saenz HL, Götz F, Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 2000;182:1688-93
   PubMed Web of Science ®Google Scholar
• Kong KF, Vuong C, Otto M. Staphylococcus quorum sensing in biofilm formation and infection. Int J Med Microbiol 2006;296:133-9
   PubMed Web of Science ®Google Scholar
• Wright JS, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci USA 2005;102:1691-6
   PubMed Web of Science ®Google Scholar
• Gov Y, Bitler A, Dell'Acqua G, RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis. Peptides 2001;22:1609-20
   PubMed Web of Science ®Google Scholar
• Mayville P, Ji G, Beavis R, Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci USA 1999;96:1218-23
   PubMed Web of Science ®Google Scholar
• McDowell P, Affas Z, Reynolds C, Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus. Mol Microbiol 2001;41:503-12
   PubMed Web of Science ®Google Scholar
• Otto M, Süssmuth R, Jung G, Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett 1998;424:89-94
   PubMed Web of Science ®Google Scholar
• Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997;276:2027-30
   PubMed Web of Science ®Google Scholar
• Schneider KB, Palmer TM, Grossman AD. Characterization of comQ and comX, two genes required for production of ComX pheromone in Bacillus subtilis. J Bacteriol 2002;184:410-9
   PubMed Web of Science ®Google Scholar
• Solomon JM, Lazazzera BA, Grossman AD. Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis. Genes Dev 1996;10:2014-24
   PubMed Web of Science ®Google Scholar
• Grossman AD. Genetic networks controlling the initiation of sporulation and the development of genetic competence in Bacillus subtilis. Annu Rev Genet 1995;29:477-508
   PubMed Web of Science ®Google Scholar
• Bassler BL. How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol 1999;2:582-7
   PubMed Web of Science ®Google Scholar
• Lazazzera BA, Grossman AD. The ins and outs of peptide signaling. Trends Microbiol 1998;6:288-94
   PubMed Web of Science ®Google Scholar
• Ohnishi Y, Kameyama S, Onaka H, The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 1999;34:102-11
   PubMed Web of Science ®Google Scholar
• Takano E, Nihira T, Hara Y, Purification and structural determination of SCB1, a γ-butyrolactone that elicits antibiotic production in Streptomyces coelicolor A3 (2). J Biol Chem 2000;275:11010-6
   PubMedGoogle Scholar
• Tavender TJ, Halliday NM, Hardie KR, LuxS-independent formation of AI-2 from ribulose-5-phosphate. BMC Microbiol 2008;8:98-105
   PubMedGoogle Scholar
• Rader BA, Campagna SR, Semmelhack MF, The quorum-sensing molecule autoinducer 2 regulates motility and flagellar morphogenesis in Helicobacter pylori. J Bacteriol 2007;189:6109-17
   PubMedGoogle Scholar
• Bassler BL, Wright M, Showalter RE, Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol Microbiol 1993;9:773-86
   PubMed Web of Science ®Google Scholar
• Vendeville A, Winzer K, Heurlier K, Making ‘sense’ of metabolism: autoinducer-2, LuxS and pathogenic bacteria. Nat Rev Microbiol 2005;3:383-96
   PubMed Web of Science ®Google Scholar
• Surette MG, Miller MB, Bassler BL. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc Natl Acad Sci USA 1999;96:1639-44
   PubMed Web of Science ®Google Scholar
• Taga ME, Semmelhack JL, Bassler BL. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol 2001;42:777-93
   PubMed Web of Science ®Google Scholar
• Schauder S, Shokat K, Surette MG, The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol 2001;41:463-76
   PubMed Web of Science ®Google Scholar
• Xavier KB, Bassler BL. Interference with AI-2-mediated bacterial cell-cell communication. Nature 2005;437:750-3
   PubMed Web of Science ®Google Scholar
• Blehert DS, Palmer RJ, Xavier JB, Autoinducer 2 production by Streptococcus gordonii DL1 and the biofilm phenotype of a luxS mutant are influenced by nutritional conditions. J Bacteriol 2003;185:4851-60
   PubMed Web of Science ®Google Scholar
• Merritt J, Qi F, Goodman SD, Mutation of luxS affects biofilm formation in Streptococcus mutans. Infect Immun 2003;71:1972-9
   PubMed Web of Science ®Google Scholar
• Gonzálezc Barrios AF, Zuo R, Hashimoto Y, Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol 2006;188:305-16
   PubMedGoogle Scholar
• Rickard AH, Palmer RJJ, Blehert DS, Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth. Mol Microbiol 2006;60:1446-56
   PubMed Web of Science ®Google Scholar
• Wang LH, He Y, Gao Y, A bacterial cell-cell communication signal with cross-kingdom structural analogues. Mol Microbiol 2004;51:903-12
   PubMed Web of Science ®Google Scholar
• He YW, Xu M, Lin K, Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv. campestris: identification of novel cell-cell communication-dependent genes and functions. Mol Microbiol 2006;59:610-22
   PubMedGoogle Scholar
• Fouhy Y, Scanlon K, Schouest K, Diffusible signal factor-dependent cell-cell signaling and virulence in the nosocomial pathogen Stenotrophomonas maltophilia. J Bacteriol 2007;189:4964-8
   PubMed Web of Science ®Google Scholar
• Nickerson KW, Atkin AL, Hornby JM. Quorum sensing in dimorphic fungi: farnesol and beyond. Appl Environ Microbiol 2006;72:3805-13
   PubMed Web of Science ®Google Scholar
• Dahlberg KR, Cotter DA. Autoactivation of spore germination in mutant and wild type strains of Dictyostelium discoideum. Microbios 1978;23:153-66
   PubMedGoogle Scholar
• Hornby JM, Jacobitz-Kizzier SM, Mcneel S, Inoculum size effect in dimorphic fungi: extracellular control of yeast-mycelium dimorphism in Ceratocystis ulmi. Appl Environ Microbiol 2004;70:1356-9
   PubMed Web of Science ®Google Scholar
• Boon C, Deng Y, Wang LH, A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. ISME J 2008;2:27-36
   PubMed Web of Science ®Google Scholar
• Schaefer AL, Greenberg EP, Oliver CM, A new class of homoserine lactone quorum-sensing signals. Nature 2008;454:595-9
   PubMed Web of Science ®Google Scholar
• Sperandio V, Torres AG, Jarvis B, Bacteria-host communication: the language of hormones. Proc Natl Acad Sci USA 2003;100:8951-6
   PubMed Web of Science ®Google Scholar
• Sperandio V, Mellies JL, Nguyen W, Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. Proc Natl Acad Sci USA 1999;96:15196-201
   PubMed Web of Science ®Google Scholar
• Parker CT, Sperandio V. Cell-to-cell signalling during pathogenesis. Cell Microbiol 2009;11:363-9
   Web of Science ®Google Scholar
• Rasko DA, Moreira CG, Li DR, Targeting QseC signaling and virulence for antibiotic development. Science 2008;321:1078-80
   PubMed Web of Science ®Google Scholar
• Bassler BL. Small talk: cell-to-cell communication in bacteria. Cell 2002;109:421-4
   PubMed Web of Science ®Google Scholar
• Ren D, Sims JJ, Wood TK. Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo- 5-(bromomethylene)-3-butyl- 2 (5H)-furanone. Environ Microbiol 2001;3:731-6
   PubMed Web of Science ®Google Scholar
• Defoirdt T, Miyamoto CM, Wood TK, The natural furanone (5Z)- 4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR. Environ Microbiol 2007;9:2486-95
   PubMed Web of Science ®Google Scholar
• Manefield M, Rasmussen TB, Henzter M, Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiol 2002;148:1119-27
   PubMed Web of Science ®Google Scholar
• Ren D, Bedzyk LA, Ye RW, Differential gene expression shows natural brominated furanones interfere with the autoinducer-2 bacterial signaling system of Escherichia coli. Biotechnol Bioeng 2004;88:630-42
   PubMed Web of Science ®Google Scholar
• Janssens JCA, Steenackers H, Robijns S, Brominated furanones inhibit biofilm formation by Salmonella enterica serovar typhimurium. Appl Environ Microbiol 2008;74:6639-48
   PubMed Web of Science ®Google Scholar
• Rice SA, McDougald D, Kumar N, The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections. Curr Opin Investig Drugs 2005;6:178-84
   PubMedGoogle Scholar
• Han Y, Hou S, Simon KA, Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli. Bioorg Med Chem Lett 2008;18:1006-10
   PubMed Web of Science ®Google Scholar
• Hentzer M, Wu H, Andersen JB, Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J 2003;22:3803-15
   PubMed Web of Science ®Google Scholar
• Unisearch Ltd. Synthesis of cyclic compounds. AU2001267155B2; 2001
   Google Scholar
• Unisearch Ltd. Inhibition of fungi. WO01/68091A1; 2001
   Google Scholar
• Syracuse University. System and method for controlling Candida albicans and wood decay fungi with brominated furanones. 61/114265; 2008
   Google Scholar
• Ren D, Sins JJ, Wood TK. Inhibition of biofilm formation and swarming of Bacillus subtilis by (5Z)-4-bromo- 5-(bromomethylene)-3-buty- 2 (5H)-furanone. Lett Appl Microbiol 2002;34:293-9
   PubMed Web of Science ®Google Scholar
• Jones MB, Jani R, Ren D, Inhibition of Bacillus anthracis growth and virulence-gene expression by inhibitors of quorum-sensing. J Infect Dis 2005;191:1881-8
   PubMed Web of Science ®Google Scholar
• New York University B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production. US7365184; 2004
   Google Scholar
• Hume EBH, Baveja J, Muir B, The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones. Biomaterials 2004;25:5023-30
   PubMed Web of Science ®Google Scholar
• Unisearch Ltd. Methods for microbial regulation. US6555356; 1998
   Google Scholar
• Unisearch Ltd 1. Methods for microbial regulation. WO96/29392A1; 1996
   Google Scholar
• Unisearch Ltd. Regulation of bacterial virulence. WO2002/047681A1; 2001
   Google Scholar
• Unisearch Ltd. Inhibition of Gram positive bacteria. WO99/53915A1; 1999
   Google Scholar
• Unisearch Ltd. Microbial inhibitory compositions. WO2001/068090A1; 2001
   Google Scholar
• Unisearch Ltd. Inhibition of two-component signal transduction systems. WO2001/043739A1; 2000
   Google Scholar
• Aquaculture CRC. Antifouling of shellfish and aquaculture apparatus. WO1999/005227A1; 1998
   Google Scholar
• Unisearch Ltd. Antifouling compositions. WO1996/001294A1; 1995
   Google Scholar
• Syracuse University. Biocatalytic materials built by water-in-water emulsion. 12/233337; 2008
   Google Scholar
• Unisearch Ltd. Production of furanones. WO1999/054323A1; 1999
   Google Scholar
• Montana State University, University of Iowa Research Foundation and University of Rochester. Homoserine lactones biofilm regulating compounds and their methods of use. AU753329B2; 1998
   Google Scholar
• Wisconsin Alumni Research Foundation. Modulation of bacterial quorum sensing with synthetic ligands. US20080312319A1; 2008
   Google Scholar
• Wisconsin Alumni Research Foundation. Compounds and methods for modulating communication and virulence in quorum sensing bacteria. US20060178430; 2006
   Google Scholar
• Geske GD, O'Neill JC, Miller DM, Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. J Am Chem Soc 2007;129:13613-25
   PubMed Web of Science ®Google Scholar
• The Research Foundation of State University Of New York. Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof. US20080027115; 2007
   Google Scholar
• Suga H, Smith KM. Molecular mechanisms of bacterial quorum sensing as a new drug target. Curr Opin Chem Biol 2003;7:586-91
   PubMed Web of Science ®Google Scholar
• University of Tokyo, Otsuka Chemical Co Ltd. Amide compound or salt thereof, and biofilm inhibitor, biofilm remover and disinfectant containing the same. US2009/0068120A1; 2007
   Google Scholar
• Persson T, Hansen TH, Rasmussen TB, Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic. Org Biomol Chem 2005;3:253-62
   PubMed Web of Science ®Google Scholar
• Rasmussen TB, Bjarnsholt T, Skindersoe ME, Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol 2005;187:1799-814
   PubMed Web of Science ®Google Scholar
• University of Iowa Research Foundation and Vertex Pharmaceuticals (San Diego) LLC. Quorum sensing signaling in bacteria. US6855513 B1; 2000
   Google Scholar
• The University of Iowa Research Foundation, University of Rochester and East Carolina University. Autoinducer molecules and uses therefor. US7442798B2; 2004
   Google Scholar
• Kiran MD, Adikesavan NV, Cirioni O, Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol 2008;73:1578-86
   PubMed Web of Science ®Google Scholar
• Tufts University and Case Western Reserve University. Identification and use of non-peptide analogs of RNAIII-inhibiting peptide for the treatment of staphylococcal infections. US20070293435; 2007
   Google Scholar
• Kiran MD, Giacometti A, Cirioni O, Suppression of biofilm related, device-associated infections by staphylococcal quorum sensing inhibitors. Int J Artif Organs 2008;31:761-70
   PubMed Web of Science ®Google Scholar
• Quorex Pharmaceuticals Inc. Anti-bacterial agents based upon oxoanion binding. US7074776B2; 2002
   Google Scholar
• Tedder ME, Nie Z, Margosiak S, Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors. Bioorg Med Chem Lett 2004;14:3165-8
   PubMed Web of Science ®Google Scholar
• Princeton University, Quorex Pharmaceuticals, Inc and University Technologies International, Inc. Compounds and methods for regulating bacterial growth and pathogenesis. US6559176B1; 2001
   Google Scholar
• Semmelhack MF, Campagna SR, Hwa C, Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett 2004;6:2635-7
   PubMedGoogle Scholar
• Ni N, Li M, Wang J, Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev 2009;29:65-124
   PubMed Web of Science ®Google Scholar
• Peng H, Cheng Y, Ni N, Synthesis and evaluation of new antagonists of bacterial quorum sensing in Vibrio harveyi. ChemMedChem 2009; doi: 10.1002/cmdc.200900180
   Google Scholar
• Li M, Ni N, Chou HT, Structure-based discovery and experimental verification of novel AI-2 quorum sensing inhibitors against Vibrio harveyi. ChemMedChem 2008;3:1242-9
   PubMedGoogle Scholar
• Lowery CA, Park J, Kaufmann GF, An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. J Am Chem Soc 2008;130(13):9200-1
   PubMedGoogle Scholar
• Ganin H, Tang X, Meijler MMM. Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs. Bioorg Med Chem Lett 2009;19:3941-4
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Mayville P, Muir TW, Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc Natl Acad Sci USA 2000;97:13330-5
   PubMed Web of Science ®Google Scholar
• Lyon GJ, Wright JS, Muir TW, Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry 2002;41:10095-104
   PubMed Web of Science ®Google Scholar
• The Rockefeller University. Staphylococcus peptides for bacterial interference. US7419954; 2005
   Google Scholar
• Muir TW, Mayville P, Novick RP, Novel Staphylococcus peptides for bacterial interference. US20070185016; 2005
   Google Scholar
• New York University. Blocking expression of virulence factors in S. aureus. US6447786; 1997
   Google Scholar
• Balaban N, Stoodley P, Fux CA, Prevention of Staphylococcal biofilm-associated infections by the quorum sensing inhibitor RIP. Clin Orthop Relat Res 2005;437:48-54
   PubMedGoogle Scholar
• Vieira-Da-Motta O, Damasceno Ribeiro P, Dias da Silva W, RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production. Peptides-New York 2001;22:1621-8
   PubMed Web of Science ®Google Scholar
• Cirioni O, Giacometti A, Ghiselli R, RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections. J Infect Dis 2006;193:180-6
   PubMed Web of Science ®Google Scholar
• Balaban N. Methods and compositions for the treatment and prevention of Staphylococcus and other bacterial infections. AU2004258797B2; 2004
   Google Scholar
• Balaban N, Goldkorn T, Nhan RT, Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science 1998;280:438-40
   PubMed Web of Science ®Google Scholar
• Centegen Inc. Methods and compositions for the treatment and prevention of staphylococcal infections. US7534857; 2006
   Google Scholar
• Centegen Inc. Methods and compositions for the treatment and prevention of Staphylococcus aureus infections. US7067135; 2001
   Google Scholar
• Centegen Inc. Methods and compositions for the treatment and prevention of Staphylococcus and other bacterial infections. US7323179; 2003
   Google Scholar
• Simonetti O, Cirioni O, Ghiselli R, RNAIII-inhibiting peptide enhances healing of wounds infected with methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2008;52:2205-11
   PubMed Web of Science ®Google Scholar
• Cirioni O, Ghiselli R, Minardi D, RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection. Antimicrob Agents Chemother 2007;51:4518-20
   PubMed Web of Science ®Google Scholar
• Anguita-Alonso P, Giacometti A, Cirioni O, RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation. Antimicrob Agents Chemother 2007;51:2594-6
   PubMed Web of Science ®Google Scholar
• Balaban N, Goldkorn T, Gov Y, Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP). J Biol Chem 2001;276:2658-67
   PubMed Web of Science ®Google Scholar
• Korem M, Gov Y, Kiran MD, Transcriptional profiling of target of RNAIII-activating protein, a master regulator of staphylococcal virulence. Infect Imm 2005;73:6220-8
   PubMed Web of Science ®Google Scholar
• Dell'Acqua G, Giacometti A, Cirioni O, Suppression of drug-resistant staphylococcal infections by the quorum-sensing inhibitor RNAIII-inhibiting peptide. J Infect Dis 2004;190:318-20
   PubMed Web of Science ®Google Scholar
• Giacometti A, Cirioni O, Ghiselli R, RNAIII-inhibiting peptide improves efficacy of clinically used antibiotics in a murine model of Staphylococcal sepsis. Peptides 2005;26:169-75
   PubMedGoogle Scholar
• Balaban N, Cirioni O, Giacometti A, Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP. Antimicrob Agents Chemother 2007;51:2226-9
   PubMed Web of Science ®Google Scholar
• Shaw LN, Jonsson IM, Singh VK, Inactivation of traP has no effect on the agr quorum-sensing system or virulence of Staphylococcus aureus. Infect Immun 2007;75:4519-27
   PubMedGoogle Scholar
• Novick RP, Ross HF, Figueiredo AMS, Activation and inhibition of the staphylococcal AGR System. Science 2000;287:391a
   Google Scholar
• University of Rochester. Method for detecting a gram-negative bacterial autoinducer molecule. US6958219; 2004
   Google Scholar
• University of Rochester. Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule. US7384639; 2005
   Google Scholar
• Park J, Jagasia R, Kaufmann GF, Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol 2007;14:1119-27
   PubMed Web of Science ®Google Scholar
• Kaufmann GF, Sartorio R, Lee SH, Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. J Am Chem Soc 2006;128:2802-3
   PubMed Web of Science ®Google Scholar
• Kaufmann GF, Park J, Mee JM, The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone. Mol Immunol 2008;45:2710-4
   PubMed Web of Science ®Google Scholar
• Miyairi S, Tateda K, Fuse ET, Immunization with 3-oxododecanoyl- L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection. J Med Microbiol 2006;55:1381-7
   PubMed Web of Science ®Google Scholar
• Leadbetter JR, Greenberg EP. Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J Bacteriol 2000;182:6921-6
   PubMed Web of Science ®Google Scholar
• Thomas PW, Stone EM, Costello AL, The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein. Biochemistry 2005;44:7559-69
   PubMed Web of Science ®Google Scholar
• Zhang LH. Quorum quenching and proactive host defense. Trends Plant Sci 2003;8:238-44
   PubMed Web of Science ®Google Scholar
• Dong YH, Wang LH, Xu JL, Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 2001;411:813-7
   PubMed Web of Science ®Google Scholar
• Agency for Science, Technology and Research. Control of bacterial infection by quenching quorum-sensing of plant pathogenic bacteria. US7205452B2; 2001
   Google Scholar
• Agency for Science, Technology and Research. Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals. AU2000/276976B2; 2000
   Google Scholar
• Zhang L, Xu JL, Lin YH. Ralstonia ahl-acylase gene. US7098014; 2002
   Google Scholar
• Agency for Science, Technology and Research. Nucleic acid molecules encoding bacterial autoinducer inactivation protein as targets for engineering disease resistance. US7309814B1; 1999
   Google Scholar
• Sio CF, Otten LG, Cool RH, Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun 2006;74:1673-82
   PubMed Web of Science ®Google Scholar
• Huang JJ, Han JI, Zhang LH, Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1. Appl Environ Microbiol 2003;69:5941-9
   PubMed Web of Science ®Google Scholar
• Huang JJ, Petersen A, Whiteley M, Identification of QuiP, the product of gene PA1032, as the second acyl-homoserine lactone acylase of Pseudomonas aeruginosa PAO1. Appl Environ Microbiol 2006;72:1190-7
   PubMed Web of Science ®Google Scholar
• Ozer EA, Pezzulo A, Shih DM, Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett 2005;253:29-37
   PubMed Web of Science ®Google Scholar
• Chun CK, Ozer EA, Welsh MJ, Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proc Natl Acad Sci USA 2004;101:3587-90
   PubMed Web of Science ®Google Scholar
• Hastings JW. Bacterial quorum-sensing signals are inactivated by mammalian cells. Proc Natl Acad Sci USA 2004;101:3993-4
   PubMedGoogle Scholar
• Smith RS, Harris SG, Phipps R, The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol 2002;184:1132-9
   PubMed Web of Science ®Google Scholar
• Williams P. Quorum sensing, communication and cross-kingdom signalling in the bacterial world. Microbiol 2007;153:3923-8
   PubMed Web of Science ®Google Scholar
• Kaufmann SHE, Otto M, Echner H, Pheromone cross-inhibition between Staphylococcus aureus and Staphylococcus epidermidis. Infect Immun 2001;69:1957-60
   PubMedGoogle Scholar
• Novick RP, Muir TW. Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Curr Opin Microbiol 1999;2:40-5
   PubMed Web of Science ®Google Scholar
• Otto M, Süßmuth R, Vuong C, Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives. FEBS Lett 1999;450:257-62
   PubMed Web of Science ®Google Scholar
• Chen X, Schauder S, Potier N, Structural identification of a bacterial quorum-sensing signal containing boron. Nature 2002;415:545-9
   PubMed Web of Science ®Google Scholar
• Waters CM, Bassler BL. Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 2005;21:319-46
   PubMed Web of Science ®Google Scholar
• Reading NC, Sperandio V. Quorum sensing: the many languages of bacteria. FEMS Microbiol Lett 2006;254:1-11
   PubMed Web of Science ®Google Scholar
• Hornby JM, Jensen EC, Lisec AD, Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 2001;67:2982-92
   PubMed Web of Science ®Google Scholar
• Oh KB, Miyazawa H, Naito T, Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans. Proc Natl Acad Sci USA 2001;98:4664-8
   PubMed Web of Science ®Google Scholar
• Chen H, Fujita M, Feng Q, Tyrosol is a quorum-sensing molecule in Candida albicans. Proc Natl Acad Sci USA 2004;101:5048-52
   PubMed Web of Science ®Google Scholar
• Hogan DA. Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryot Cell 2006;5:613-9
   PubMed Web of Science ®Google Scholar
• Schachtschabel D, Schimek C, Wöstemeyer J, Biological activity of trisporoids and trisporoid analogues in Mucor mucedo (-). Phytochemistry 2005;66:1358-65
   PubMedGoogle Scholar
• Spellig T, Bölker M, Lottspeich F, Pheromones trigger filamentous growth in Ustilago maydis. EMBO J 1994;13:1620-7
   PubMed Web of Science ®Google Scholar
• Martinelli D, Grossmann G, Séquin U, Effects of natural and chemically synthesized furanones on quorum sensing in Chromobacterium violaceum. BMC Microbiol 2004;4:1471-2180
   Google Scholar
• Geske GD, Mattmann ME, Blackwell HE. Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorg Med Chem Lett 2008;18:5978-81
   PubMedGoogle Scholar