Recent patent trends in the field of progesterone receptor agonists and modulators

Bibliography

• Fieser L & M. Steroids. John Wiley & sons, Inc. New York; 1961
   Google Scholar
• Bell MR, Christiansen RG, Schane HPJr. Chemical control of fertility. Annu Rep Med Chem 1979;14:168-75
   Google Scholar
• Schöllkopf K, Schmees N. Progesterone receptor: overview of modern steroidal progestins and developments in the field of nonsteroidal selective progesterone receptor modulators. 201-222. Methods and principles in medicinal chemistry, nuclear receptors as drug targets. Wiley/VCH; 2008
   Google Scholar
• Stanczyk FZ. All progestins are not created equal. Steroids 2003;68:879-90
   PubMed Web of Science ®Google Scholar
• Sitruk-Ware R. New progestogens: a review of their effects in perimenopausal and postmenopausal women. Drugs Aging 2004;21:865-83
   PubMed Web of Science ®Google Scholar
• Philibert D, Deraedt R, Teutsch G. RU 38486: a potent antiglucocorticoid in vivo. VII International Congress of Pharmacology, Tokyo, Japan; 1981
   Google Scholar
• Benagiano G, Bastianelli C, Farris M. Selective progesterone receptor modulators 2: use in reproductive medicine. Expert Opin Pharmacother 2008;9:2473-84
   PubMed Web of Science ®Google Scholar
• Möller C, Hofmann J, Kirkland TA, Schwede W. Investigational developments for the treatment of progesterone-dependent diseases. Expert Opin Investig Drugs 2008;17:469-79
   PubMed Web of Science ®Google Scholar
• Fedele L, Somigliana E, Frontino G, New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs 2008;17:1187-202
   PubMed Web of Science ®Google Scholar
• Madauss KP, Stewart EL, Williams SP. The evolution of progesterone receptor ligands. Med Res Rev 2007;27:374-400
   PubMed Web of Science ®Google Scholar
• Buijsman RC, Hermkens PHH, van Rijn RD, Non-steroidal steroid receptor modulators. Curr Med Chem 2005;12:1017-75
   PubMed Web of Science ®Google Scholar
• Lin X, Huebner V. Non-steroidal ligands for steroid hormone receptors. Curr Opin Drug Discov 2000;3:383-98
   PubMedGoogle Scholar
• Fuhrmann U, Hess-Stumpp H, Cleve A, Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem 2000;43:5010-6
   PubMed Web of Science ®Google Scholar
• Schoonen WGEJ, de Ries RJH, Joosten JWH, Development of a high-throughput in vitro bioassay to assess potencies of progestagenic compounds using Chinese hamster ovary cells stably transfected with the human progesterone receptor and a luciferase reporter system. Anal Biochem 1998;261:222-4
   PubMedGoogle Scholar
• Kumar N, Koide SS, Tsong YY, Sundaram K. Nesterone®: a progestin with a unique pharmacological profile. Steroids 2000;65:629-36
   PubMed Web of Science ®Google Scholar
• William SP, Sigler PB. Atomic structer of progesterone complexed with its receptor. Nature 1998;393:392-6
   PubMedGoogle Scholar
• Madauss KP, Grygielko ET, Deng S-J, A structural and in vitro characterisation of asoprisnil: a selective progesterone receptor modulator. Mol Endocrinol 2007;21:1066-81
   PubMed Web of Science ®Google Scholar
• Raaijmakers HCA, Versteegh JE, Uitdehaag JCM. The x-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation. J Biol Chem 2009;284:19572-9
   PubMedGoogle Scholar
• Zhang Z, Olland AM, Zhu Y, Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. J Biol Chem 2005;280:28468-75
   PubMed Web of Science ®Google Scholar
• Wyeth. 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators. US0066628; 2007
   Google Scholar
• Wyeth. 4-Aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators. US0066637; 2007
   Google Scholar
• Wyeth. 4-Aryl-indan-1-one and analogs useful as progesterone receptor modulators. US0066675; 2007
   Google Scholar
• Wyeth. 4-Aryl-indan-1-one and analogs useful as progesterone receptor modulators. US0119537; 2008
   Google Scholar
• Wyeth. 6-Amino-1,4-dihydro-benzo[D][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators. US0085470; 2005
   Google Scholar
• Wyeth. 6-Amino-1,4-dihydro-benzo[D][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators. US0225281; 2007
   Google Scholar
• Kern JC, Terefenko EA, Fensome A, SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists. Bioorg Med Chem Lett 2007;17:189-92
   PubMedGoogle Scholar
• Wyeth. Thioamide derivatives as progesterone receptor modulators. US0227971; andUS0167299; 2008
   Google Scholar
• Wyeth. 7-Aryl 1,5-dihydr-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators. WO095366; 2005
   Google Scholar
• Wyeth. 7-Aryl 1,5-dihydr-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators. US0113964; 2008
   Google Scholar
• Zhang P, Kern JC, Terefenko EA, 7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists. Bioorg Med Chem 2008;16:6589-600
   PubMedGoogle Scholar
• Kern JC, Terefenko EA, Fensome A, 1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. Bioorg Med Chem Lett 2008;18:5015-17
   PubMedGoogle Scholar
• Wyeth. Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof. US0030615; 2006
   Google Scholar
• Wyeth. Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof. US0030717; 2006
   Google Scholar
• Wyeth. Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof. US0114050; 2008
   Google Scholar
• Fensome A, Adams WR, Adams AL, Design, Synthesis and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). J Med Chem 2008;51:1861-73
   PubMed Web of Science ®Google Scholar
• Janssen Pharmaceutica. Pyridine imidazoles and aza-indolones as progesterone receptor modulators. WO049890; 2006
   Google Scholar
• Johnson & Johnson. Pyridine imidazoles and aza-indolones as progesterone receptor modulators. US0119500; 2008
   Google Scholar
• Wyeth. Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof. US0027125; 2007
   Google Scholar
• Wyeth. Cyanopyrrole-sulfonamide progesterone receptor modulators and uses thereof. US0027126; 2007
   Google Scholar
• Wyeth. Use of progesterone receptor modulators. WO016385; 2007
   Google Scholar
• Wyeth. Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof. US0064673; 2008
   Google Scholar
• Wyeth. Oxazolidone derivatives as PR modulators. WO021331; 2008
   Google Scholar
• Wyeth. Oxazinan-2-one derivatives useful as PR modulators. WO021337; 2008
   Google Scholar
• Wyeth. Imidazolidin-2-one derivatives useful as PR modulators. WO021309; 2008
   Google Scholar
• Wyeth. Oxazolidine derivatives as PR modulators. US0045579; 2008
   Google Scholar
• Gao W, Bohl CE, Dalton JT. Chemistry and structural biology of androgen receptor. Chem Rev 2005;105:3352-70
   PubMed Web of Science ®Google Scholar
• Mohler ML, Bohl CE, Jones A, Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem 2009;52:3597-617
   PubMed Web of Science ®Google Scholar
• Dukes M, Furr BJA, Hughes LR, Nonsteroidal progestins and antiprogestins related to flutamid. Steroids 2000;65:725-31
   PubMedGoogle Scholar
• Schering AG. Non-steroidal progesterone receptor modulators. WO136461; 2006
   Google Scholar
• Schering AG. Benzofuranone derivatives as nonsteroidal progesterone receptor modulators. WO136462; 2006
   Google Scholar
• Bayer Schering Pharma AG. Nonsteroidal progesterone receptor modulators. WO007396; 2009
   Google Scholar
• Bayer Schering Pharma AG. Non-steroidal progesterone receptor modulators. US0075989; 2009
   Google Scholar
• Bayer Schering Pharma AG. Nonsteroidal progesterone receptor modulators. WO071252; 2009
   Google Scholar
• Smithkline Beecham. Chemical compounds. WO133216; 2006
   Google Scholar
• Smithkline Beecham. Cyanoarylamines. WO113552; 2006
   Google Scholar
• Hammond M, Patterson JR, Manns S, Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists. Bioorg Med Chem Lett 2009;19:2637-41
   PubMedGoogle Scholar
• Smithkline Beecham. Pyrrolidineanilines. WO065093; 2007
   Google Scholar
• Smithkline Beecham. Pyrrolidinone anilines as progesterone receptor modulators. US0039517; 2008
   Google Scholar
• Smithkline Beecham. Pyrrolidinanilines. WO077089; 2008
   Google Scholar
• Shanghai Institute of Materia Medica. Nonsteroidal progesterone receptor modulator and its preparation, medical composition and medical application. CN101289408; 2008
   Google Scholar
• Pfizer. Pyrazole derivatives as progesterone receptor antagonists. WO111856; 2006
   Google Scholar
• Pfizer. Compounds useful in therapy. US0105909; 2007
   Google Scholar
• Pfizer. Pyrazolyl-4-oxy-benzonitrile derivatives useful in treating endometriosis. WO047224; 2008
   Google Scholar
• Pfizer. Oxyalkylpyrazole compounds useful in therapy. WO135824; 2008
   Google Scholar
• de Giorgio-Miller A, Bungay P, Tutt M, The translational pharmacology of a novel, potent, and selective nonsteroidal progesterone receptor antagonist, 2-[4-(4-Cyano-phenoxy)-3,5-dicyclopropyl-1H-pyrazol-1-yl]-N-methylacetamide (PF-02367982). J Pharmacol Exp Ther 2008;327:78-87
   PubMedGoogle Scholar
• Solvay Pharmaceuticals. Novel C11 modified retrosteroids as progesterone receptor modulator compounds. WO113851; 2008
   Google Scholar
• Johnson and Johnson. Steroids derivatives s selective progesterone receptor modulators. US0221202; 2008
   Google Scholar
• N.V. Organon. Steroids having a mixed androgenic and progestagenic profile. WO134167; 2006
   Google Scholar
• Akzo Nobel N.V. Progesterone receptor modulators. WO092912; 2005
   Google Scholar
• IRM LLC. Compounds and compositions as modulators of steroid hormone nuclear receptors. WO015259; 2006
   Google Scholar
• Janssen Pharmceutica. Trisubstituted thiophenes as progesterone receptor modulators. WO049891; 2006
   Google Scholar
• Janssen Pharmceutica. Indole derivatives useful as progesterone receptor modulators. WO049889; 2006
   Google Scholar
• Organon. Pyridooxazepine progesterone receptor modulators. WO037746; 2008
   Google Scholar
• Organon. New progesterone receptor modulators. US0090804; 2008
   Google Scholar
• Neumann F. The physiological action of progesterone and the pharmacological effects of progestogens – a short review. Postgrad Med J 1978;54(Suppl 2):11-24
   PubMedGoogle Scholar
• Organon. New progesterone receptor modulators. WO135291; 2008
   Google Scholar
• Organon. New progesterone receptor modulators. US0054400; 2009
   Google Scholar