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Miscellaneous

Aminospiropiperidine quinazoline derivatives as selective inhibitors of nitric oxide synthase

Pages 125-129 | Published online: 25 Feb 2005

Bibliography

  • WU G, MORRIS M: Arginine metabolism: nitric oxide and beyond. J. Biochem. (1998) 336:1–17.
  • ••Very useful publication on the basic biochemistry of nitricoxide.
  • WEBBER RK, METZ S, MOORE WM et al: Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J. Med. Chem. (1998) 41:96–101.
  • ••Excellent publication on heterocyclic amidines as highlyselective inhibitors of inducible NOS.
  • COLLINS JL, SHEARER BG, OPLINGER JA et al.: N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem. (1998) 41:2858–2871.
  • ••Important and very detailed publication on the synthesisand structure-activity relationship of NOS inhibitors
  • BABU BR, GRIFFITH OW: Design of isoform-selective inhibitors of nitric oxide synthase. Curr. Opin. Chem. Biol. (1998) 2:491–500.
  • ••Excellent review article on the design of selective NOSinhibitors.
  • GESSON JP, JACQUESY JC, RAMBAUD D: a-N-acyliminium ion - 2-bromoalkene cyclizations. Tetrahedron (1993) 49(11)2239–2248.
  • LOCHEAD AW, PROCTOR GR: Use of chloroalken-ylamines for the synthesis of 1-azabicyclo-(3.3.0)octane and 1-azabicyclo(4.3.0)nonane deriva-tives. J. Chem. Soc. Perkin Trans. (1984) 11:2477–2489.
  • FORSTERMANN U, SCMIDT HHW, KOHLHAAS KL, MURAD F: Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-6. Eur. J. Pharm. (1992) 225:161–165.
  • MOORE WM, WEBBER RK, FOK KF et al.:2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J. Med. Chem. (1996) 39:669–672.
  • •Early work on heterocyclic amidines as NOS inhibitors.

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