Bibliography
- MONCADA S, HIGGS EA: Molecular mechanisms andtherapeutic strategies related to nitric oxide. FASEBJ. (1995) 9:1319–1330.
- KERWIN JF, JR., HELLER M: The arginine-nitric oxidepathway: a target for new drugs. Med. Res. Rev. (1994) 14 (1):23–74.
- GRIFFITH OW, STUEHR DJ: Nitric oxide synthases:properties and catalytic mechanism. Ann. Rev. Physic)]. (1995) 57:707–736.
- MARLETTA MA: Nitric oxide synthase structure and mechanism. J. Biol. Chem. (1993) 268:12231–12234.
- KNOWLES RG, MONCADA S: Nitric oxide synthases in mammals. Biochem. J (1994) 298:249–258.
- KERWIN JF, JR., LANCASTER JR, JR., FEKDMAN PL: Nitricoxide: a new paradigm for second messengers. J. Med. Chem. (1995) 38(22):4343–4362.
- MARLETTA MA, HURSHMAN AR, RUSCHE KM: Catalysis nitric oxide synthase. Curr. Opin. Chem. Biol. (1998) 2:656–663.
- •Excellent review of literature regarding the mechanism of NOS.
- ANDREW PJ, MAYER B: Enzymatic function of nitric oxide synthases. Cardiovasc. Res. (1999) 43:521–531.
- MACDONALD JE: Nitric oxide synthase inhibitors. Ann. Rep. Med. Chem. (1996) 31:221–230.
- •Very useful compilation of NOS inhibitors.
- BOUCHER JL, MOALI C, TENU JP: Nitric oxide biosyn-thesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol. Life ScL (1999) 55:1015–1028.
- MOORE WM, WEBBER RK, FOK KF, JEROME GM, TJOENG FS, CURRIE MG: Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element. Bioorg. Med. Chem. (1996) 4:1559–1564.
- REES DD, PALMER RMJ, MONCADA S: Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA (1989) 86:3375–3378.
- FURFINE ES, HARMON MF, PAITH JE, GARVEY EP: Selective inhibition of constitutive nitric oxide synthase by NG-nitroarginine. Biochemistry (1993) 32:8512–8517.
- MARLETTA MA: Approaches toward selective inhibi-tion of nitric oxide synthase. J. Med. Chem. (1994) 37:1899–1907.
- MONCADA S: Nitric Oxide: discovery and impact on clinical medicine. J. Royal Soc. Med. (1999) 92:164–169.
- CHARLES IG, SCORER CA, MORO MA et al.: Expression of human nitric oxide synthase isozymes. Methods Enzymol. (1996) 268 (nitric oxide part A):449–460.
- DAWSON J KNOWLES RG: Details of the oxyhaemo-globin assay: a microtiter-plate assay of human NOS isoforms. Methods Mol. Biology (1998) 100:237–242.
- REES DD, PALMER RM, HODSON HF, MONCADA S: A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxa-tion. Br. J. Pharmol (1989) 96:418–424.
- REES DD, CELLEK S, PALMER RM, MONCADA S: Dexamethasone prevent the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem. Biophys. Res. Commun. (1990) 173:541–547.
- FURFINE ES, HARMON MF, PAITH JE et al.: Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-t-thiocitru-Hine. J. Biol. Chem. (1994) 269:26677–26683.
- LIZASOAIN IKNOWLES RG, MONCADA S.: Inhibition by lamotrigine of the generation of nitric oxide in rat forebrain slices. J. Neurochem. (1995) 64:636–642.
- YOUNG RJ, BEAMS RM, CARTER K et al.: Inhibition of inducible nitric oxide synthase by acetamidine deriva-tives of hetero-substituted lysine and homolysine. Bioorg. Med. Chem. Lett. (2000) 10:597–600.
- •Publication encompassing compounds of type covered by this application but lacking chain substitution.