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Miscellaneous

Amide derivatives as cytokine inhibitors

Pages 1451-1454 | Published online: 25 Feb 2005

Bibliography

  • SALITURO FG, GERMANN UA, WILSON KP et al: Inhibi- of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases. Curr. Med. Chem. (1999) 6:807–823.
  • ••Excellent comprehensive review of the current p38 area byauthor from Vertex.
  • GALLAGHER TF, SEIBEL GL, KASSIS S et al.: Regulation of stress-induced cytokine production by pyridinylimi-dazoles; inhibition of CSBP kinase. Bioorg. Med. Chem. (1997) 5:49–64.
  • BADGER AM, BRADBEER JN, VOTTA B et al: Pharma-cological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol Exp. Ther. (1996) 279:1453–1461.
  • LEE JC, KASSIS S, KUMAR S et al.: p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol Ther. (1999) 82:389–397.
  • •Interesting survey of the SmithKline Beecham efforts on p38 with additional valuable references.
  • HANSON GJ: Inhibitors of p38 kinase. Exp. Opin. Ther. Patents (1997) 7:729–733.
  • BOEHM JC, ADAMS JL: New inhibitors of p38 kinase. Exp. Opin. Ther. Patents (2000) 10:729–733.
  • ••Excellent review of the current patent literature on p38continuing on from where [5] left off.
  • TONG L, PAV S, WHITE DM et al.: A highly specific of human p38 MAP kinase binds in the ATP pocket. Nature Struct. Biol. (1997) 4:311–316.
  • •Crystal structure showing the binding site of an inhibitor to p38a kinase.

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