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Miscellaneous

Novel pharmacotherapies and patents for alcohol abuse and alcoholism 1998-2001

Pages 1497-1521 | Published online: 25 Feb 2005

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  • ••Excellent and authoritative review onpharmacotherapy for alcohol withdrawal syndrome.
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  • •This paper contains promising data on the potential efficacy of baclofen in inducing and maintaining abstinence in alcoholics.
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  • •Evidence of the alcohol-like subjective feelings of ketamine in humans.
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  • •First evidence of the maladaptation of the NMDA receptor system in the alcohol withdrawal syndrome.
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  • •First evidence of the alcohol activating on dopamine neurones.
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  • ••Seminal paper demonstrating that alcohol,such as other drugs of abuse, stimulates the mesolimbic dopamine "reward" system.
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  • •This paper reports the activating effect of voluntarily consumed alcohol on the rat mesolimbic dopamine system.
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  • •Elegant, experimental demonstration on the "blockade" and "replacement" mechanisms of drugs capable of reducing alcohol consumption.
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  • •Recent review on pharmacotherapies for alcoholism.
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  • •One of the first demonstration of the reducing effect of naltrexone on alcohol intake.
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  • •First demonstration of the reducing effect of naltrexone on alcohol intake in non-human primates.
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