Ligands to the melanocortin receptors

Bibliography

• WIKBERG JES: Melanocortin receptors: new opportunities in drug discovery, Expert Opin. Ther. Patents (2001) 11(1):61–76.
   Web of Science ®Google Scholar
• ••Comprehensive review covering most ofrecent achievements in the field.
   Google Scholar
• SHUTTER J, GRAHAM M, KINSEY A et al.: Hypothalamic expression of ART, a novel gene related to agouti, is upregulated in obese and diabetic mutant mice. Genes Dev. (1997) 11:593–602.
   PubMed Web of Science ®Google Scholar
• MILLER M, DUHL D, VRIELING H et al.: Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. (1993) 7:454–467.
   PubMedGoogle Scholar
• EBERLE A: The Melanotropins: chemistry, physiology and mechanisms of action. Karger, Basel, Switzerland (1988).
   Google Scholar
• CHHAJLANI V, WIKBERG JES: Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. (1992) 309:417–420.
   PubMed Web of Science ®Google Scholar
• CHHAJLANI V, MUCENIECE R, WIKBERG JES: Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. (1993) 195(2):866–873.
   PubMedGoogle Scholar
• GANTZ I, MIWA H, KONDA Y et al.: Molecular cloning, expression and gene localization of a fourth melanocortin receptor. J Biol. Chem. (1993) 268:15174–15179.
   PubMed Web of Science ®Google Scholar
• MOUNTJOY K, ROBBINS L, M, CONE R: The cloning of a family of genes that encode the receptors. Science (1992) 257:1248–1251.
   PubMed Web of Science ®Google Scholar
• CONE RD: The melanocortin receptors. Humana Press, NJ, USA (2000).
   Google Scholar
• ••An excellent book covering most of recentachievements in the melanocortin receptor field.
   Google Scholar
• XIA Y, WIKBERG JES: Postnatal expression of melanocortin-3 receptor mRNA in rat diencephalon and mesencephalon. Neuropharmacology (1997) 36(2):217–224.
   PubMedGoogle Scholar
• KISTLER-HEER V, LAUBER M, LICHTENSTEIGER W: Different development patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of MC4 in foetal rat nervous system. J. Neuroendocnnol. (1998) 10:133–146.
   PubMedGoogle Scholar
• STRAND F: New vistas for melanocortins. Finally, an explanation for their pleiotropic functions. Ann. NY Acad. Sci. (1999) 897:1–
   PubMedGoogle Scholar
• LEVINE N, SHEFTEL S, EYTAN T: Induction of skin tanning by the subcutaneous administration of a potent synthetic melanotropin. JAMA. (1991) 266:2730–2736.
   PubMed Web of Science ®Google Scholar
• KRUDE H, BIEBERMANN H, LUCK W et al.: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. genet. (1998) 19:155–157.
   PubMed Web of Science ®Google Scholar
• LUGER T, SCHOLZEN T, GRABBE S: The role of a-melanocyte stimulating hormone in cutaneous biology. J. Invest. Dermatol. Sympos. Proc. (1997) 2:87–93.
   PubMedGoogle Scholar
• STAR R, RAJORA N, HUANG J et al.: Evidence of autocrine modulation of macrophage nitric oxide synthase by a-melanocyte stimulating hormone. Proc. Natl. Acad. Sci. USA (1995) 92:8016–8020.
   PubMed Web of Science ®Google Scholar
• HARTMEYER M, SCHOLZEN T, BECHER E etal.: Human dermal microvascular endothelial cells express the melanocortin receptor type i and produce levels of IL-8 upon stimulation with alpha-melanocyte stimulating hormone. J. Immutiol. (1997) 159:1930–1937.
   Google Scholar
• CATANIA A, RAJORA A, CAPSONI F etal.: The neuropeptide a-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides (1996) 17:675–679.
   Google Scholar
• GRABBE S, BHARDWAJ R, MAHNKE K et al.: a-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice. J. Immutiol. (1996) 156(2):473–478.
   PubMedGoogle Scholar
• HILTZ M, LIPTON J: a-MSH peptides inhibit acute inflammation and contact sensitivity. Peptides. (1990) 11:979–982.
   PubMedGoogle Scholar
• CATANIA A, LIPTON J: a-Melanocyte stimulating hormone in the modulation of host reactions. Endocrine Rev (1993) 14:564–576.
   PubMed Web of Science ®Google Scholar
• MURPHY M, RICHARDS D, LIPTON J: Antipyretic potency of centrally administered a-melanocyte stimulating hormone. Science (1983) 221:192–193.
   PubMedGoogle Scholar
• MARTIN L, LIPTON J: Acute phase response to endotoxin: rise in plasma aMSH and effects of aMSH injection. Am. J. Physiol. (1990) 259:R768–R772.
   Google Scholar
• DAVIDSON J, MILTON A, ROTONDO D: a-Melanocyte-stimulating-hormone suppresses fever and increases in plasma levels of prostaglandin E2 in the rabbit. J. Physiol. (1992) 451:491–502.
   PubMedGoogle Scholar
• MARTIN L, CATANIA A, HILTZ A, LIPTON J: Neuropeptide aMSH antagonizes IL-6 and TNF-induced fever. Peptides (1991) 12:297–299.
   PubMed Web of Science ®Google Scholar
• HORI T, NAKASHIMA T, TAKE S et al:Immune cytokines and regulation of body temperature, food intake and cellular immunity. Brain Res. Bull. (1991) 27:309–313.
   PubMedGoogle Scholar
• RICHARDS D, LIPTON J: Effects of aMSH [11-13] (lysine-proline-valine) on fever in the rabbit. Peptides (1984) 5:815–817.
   PubMed Web of Science ®Google Scholar
• DAO T, BELL R, FENG J, JAMESON D,LIPTON J: C-reactive protein, leukocytes and fever after central IL-1 and aMSH an aged rabbits. Am. j Physic] (1988) 254:R401–R409.
   Google Scholar
• CERIANI G, DIAZ J, MURPHREE S, CATANIA A, LIPTON J: The neuropeptide a-melanocyte stimulating hormone inhibits experimental arthritis in rats. Neuroimmurromodulation (1994) 1:28–32.
   PubMedGoogle Scholar
• CHIAO H, FOSTERS, THOMAS R, LIPTON J, STAR A: a-melanocyte stimulating hormone reduces endotoxin-induced liver inflammation, j Chi]. Invest. (1996) 97:2038–2044.
   Google Scholar
• RAJORA N, BOCCOLI G, BURNS D et al.: a-MSH modulates local and circulating tumor necrosis factor-a in experimental brain inflammation. j Neurosci. (1997) 17(6):2181–2186.
   PubMedGoogle Scholar
• HUH S, LIPTON J, BATJER H: The protective effects of a-melanocyte stimulating hormone on canine brain stem ischaemia. Neurosurgery (1997) 40:132–139.
   PubMedGoogle Scholar
• VAN D, HAMERS E LANKHORST A, JOOSTEN E, GISPEN W: Beneficial effects of the melanocortin a-melanocyte stimulating hormone on clinical and neurophysiological recovery after experimental spinal cord injury. Neurosurgery (1997) 40:122–130.
   PubMedGoogle Scholar
• GUARINI S, BAZZANI C, BERTOLINI A: Resuscitating effect of melanocortin peptides after prolonged respiratory arrest. Br. J. Pharmacol. (1997) 121:1454–1460.
   PubMedGoogle Scholar
• CHIAO H, KOHDA Y, MCLEROY P et al.: a-Melanocyte-stimulating-hormone projects against renal injury after ischaemia in mice and rats. j Chi]. Invest. (1997) 99(6):1165–1172.
   PubMed Web of Science ®Google Scholar
• XIA Y, WIKBERG JES: Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland. Cell Tissue Res. (1996) 286:63–68.
   PubMedGoogle Scholar
• SLOMINSKI A, ERMAK G, MIHM M: ACTH, CYP11A1, CYP17 and CYP21A2 are expressed in skin. I Chi]. Endomirol. Metab. (1996) 81:2746–2749.
   PubMed Web of Science ®Google Scholar
• WESSELLS H, LEVINE N, HADLEY M, DORR R, HRUBY VJ: Melanocortin receptor agonists, penile erection and sexual motivation: human studies with Melanotan II. Int. I Impotence Res. (2000) suppl 12:S74–S79.
   Google Scholar
• •Clinical study of MTII in humans.
   Google Scholar
• CRAGNOLINI A, SCIMONELLI T, CELIS ME, SCHIOTH HB: The role of melanocortin receptors in sexual behaviour in female rats. Neuropeptides (2000) 34(3-4):211–215.
   PubMedGoogle Scholar
• SCIMONELLI T, MEDINA E WILSON, CELIS M: Interaction of a-melanotropin (alpha-MSH) and noradrenaline in the median eminence in the control of female sexual behaviour. Peptides (2000) 21(2):219–223.
   PubMedGoogle Scholar
• VERGONI AV, BERTOLINI A, MUTULIS E WIKBERG JE, SCHIOTH HB: Differential influence of a selective melanocortin MC4 receptor antagonist (H5014) on melanocortin-induced behavioural effects in rats. Eur. (1998) 362 (2-3) :95–101.
   Google Scholar
• CONE RD: The melanocortin 4 receptor. In: The melanocortin receptors. Humana Press, New York, USA (2000):405–447.
   Google Scholar
• HUSZAR D, LYNCH C, FAIRCHILD-HUNTRESS V et al: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 88:131–141.
   PubMed Web of Science ®Google Scholar
• KASK A, MUTULIS E MUCENIECE R et al.: Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (H5024): evaluation in vitro and in vivo. Endocrinology (1998) 139(12):5006–5014.
   Google Scholar
• KASK A, RAGO L, MUTULIS F et al: Selective antagonist for the melanocortin 4 receptor (H5014) increases food intake in free-feeding rats. Biochem. Biophys. Res. Commun. (1998) 245(1):90–93.
   PubMedGoogle Scholar
• SKULADOTTIR GV, JONSSON L, SKARPHEDINSSON JO et al: Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist. Br Pharmacol (1999) 126(1):27–34.
   PubMedGoogle Scholar
• THIELE T, VAN DIJK G, YAGALOFF K et al: Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am. I Physic] (1998) 274:R248–R254.
   PubMedGoogle Scholar
• FAN W, BOSTON B, KESTERSON R, HRUBY V, CONE R: Role of melanocortic neurons in feeding and the agouti obesity. Nature (1997) 385:165–168.
   PubMed Web of Science ®Google Scholar
• MCMINN J, WILKINSON C, HAVEL P, WOODS S, SCHWARTZ M: Effect of intracerebroventricular a-MSH on food intake, adoposity, c-Fos induction and neuropeptide expression. Am. j Physic] (2000) 279:R695–R703.
   Google Scholar
• VERGONI AV, BERTOLINI A, WIKBERG JES, SCHIOTH HB: Selective melanocortin 4 receptor blockage reduces immobilization stress induced anorexia in rats. Europ.j Pharmacol (1999) 369:11–15.
   PubMedGoogle Scholar
• KASK A, RAGO L, WIKBERG JES, SCHIOTH HB: Evidence for involvement of the melanocortin MC4 receptor in the effects of leptin on food intake and body weight. Eur. j Pharmacol (1998) 360(1):15–19.
   PubMedGoogle Scholar
• SEELEY R, YAGALOFF K, FISHERS et al.: Role of melanocortin receptors in leptin effects. Nature (1997) 390:349.
   PubMed Web of Science ®Google Scholar
• SEELEY R, SCHWARTZ M: regulation of food intake. Acta. Paediam Suppl. (1999) 428:58–61.
   Google Scholar
• BENOIT S, SCHWARTZ M, LACHEY J etal.: A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. j Neurosci. (2000) 20:3442–3448.
   Google Scholar
• SKOTTNER A, RAP OSINHO P, KASK A etal.: New low molecular weight compounds decrease food intake via the melanocortin receptors. American Endocrine Socieo, 82nd Annual Meeting. Toronto, Canada(2000). Poster.
   Google Scholar
• CHEUNG C, CLIFTON D, STEINER R: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology (1997) 138(10):4489–4492.
   PubMed Web of Science ®Google Scholar
• GURA T: Obesity sheds its secrets. Science (1997) 275(5300:751–753.
   PubMedGoogle Scholar
• VRINTEN D, GISPEN W, GROEN G, ADAN R: Antagonism of the melanocortin system reduces cold and mechanical allodynia in mononeuropathic rats. Neurosci. (2000) 20(21):8131–8137.
   Google Scholar
• MORGAN C, BURKE S, LU X et al: Anxiolytic role of the melanocorti-5 receptor. Society for Neuroscience's 30th Annual Meeting. New Orleans, LA, USA (2000) Poster
   Google Scholar
• BUTLER A, KESTERSON R, KHONG K eta].: A unique metabolic syndrome causes obesity in the melanocortin 3 receptor deficient mouse. Endocrinol. (2000) 141(9):3518–3521.
   Google Scholar
• CHEN A, MARSH D, TRUMBAUER M et al.: Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nature Genetics (2000) 26:97–102.
   PubMed Web of Science ®Google Scholar