Melanin-concentrating hormone receptor antagonists as potential antiobesity agents

Bibliography

• RANCE T, BAKER BI: The teleost melanin-concentrating hormone - a pituitary hormone of hypothalamic origin. Gen. Comp. Endocrinol (1979) 37:64–73.
   PubMed Web of Science ®Google Scholar
• KAWAUCHI H, KAWAZOE I, TSUBOKAWA M, KISHIDA M, BAKER BI: Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature (1983) 305:321–323.
   PubMed Web of Science ®Google Scholar
• SKOFITSCH G, JACOBOWITZ DM, ZAMIR N: Immunohistochemical localization of a melanin-concentrating hormone-like peptide in the rat brain. Brain Res. Bull. (1985) 15:635–649.
   PubMed Web of Science ®Google Scholar
• VAUGHAN JM, FISCHER WH, HOEGER C, RIVIER J, VALE W: Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology (1989) 125(3):1660–1665.
   PubMed Web of Science ®Google Scholar
• PRESSE F, NAHON J-L, FISCHER WH, VALE W: Structure of the human melanin-concentrating hormone mRNA. MM. Endocrinol (1990) 4:632–637.
   PubMedGoogle Scholar
• BITTENCOURT JC, PRESSE F, ARIAS C et al.: The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. Comp. Neurol. (1992) 319:218–245.
   PubMed Web of Science ®Google Scholar
• FLIER JS, MARATOS-FLIER E: Obesity and the hypothalamus: novel peptides for new pathways. Cell (1998) 92:437–440.
   PubMed Web of Science ®Google Scholar
• QU D, LUDWIG DS, GAMMELTOFT S et al.: A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature (1996) 380:243–247.
   PubMed Web of Science ®Google Scholar
• PRESSE F, SOROKOVSKY I, MAX J-P, NICOLAIDIS S, NAHON J-L: Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat. Neuroscience (1996) 71(3):735–745.
   PubMed Web of Science ®Google Scholar
• ROSSI M, CHOI SJ, O'SHEA D, MIYOSHI T, GHATEI MA, BLOOM SR: Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology (1997) 138(1):351–355.
   PubMed Web of Science ®Google Scholar
• SHIMADA M, TRITOS NA, LOWELL BB, FLIER JS, MARATOS-FLIER E: Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 396:670–674.
   PubMed Web of Science ®Google Scholar
• ERICKSON JC, CLEGG KE, PALMITER RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature (1996) 381:415–418.
   PubMed Web of Science ®Google Scholar
• LUDWIG DS, TRITOS NA, MASTAMS JW et al: Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance../. Invest. (2001) 107(3):379–386.
   Google Scholar
• CHAMBERS J, AMES RS, BERGSMA D et al.: Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature (1999) 400:261–265.
   PubMed Web of Science ®Google Scholar
• SAITO Y, NOTHACKER H-P, WANG Z, LIN SHS, LESLIE F, CIVELLI O: Molecular characterization of the melanin-concentrating hormone receptor. Nature (1999) 400:265–269.
   PubMed Web of Science ®Google Scholar
• HERVIEU GJ, CLUDERAY JE, HARRISON D et al.: The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur: Neurosci. (2000) 12(01194–1216.
   PubMed Web of Science ®Google Scholar
• SUPLY T, ZUANA OD, AUDINOT V et a/.: SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.' Pharm. Exp. Therap. (2001) 299(1):137–146.
   Google Scholar
• MARSH DJ, WEINGARTH DT, NOVI DE et al.: Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. USA (2002) 99(5):3240–3245.
   PubMed Web of Science ®Google Scholar
• CHEN Y, HU C, HSU C-K et al.: Targeteddisruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 143(7):2469–2477.
   PubMed Web of Science ®Google Scholar
• BOUTIN JA, SUPLY T, AUDINOT V et al.: Melanin-concentrating hormone and its receptors: state of the art. Can. Physiol Pharmacol (2002) 80:388–395.
   PubMed Web of Science ®Google Scholar
• •Recent review of MCH and its receptors.
   Google Scholar
• SAILER AW, SANO H, ZENG Z et al: Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R Proc. Nati Acad. ScL USA (2001) 98(13):7564–7569.
   PubMed Web of Science ®Google Scholar
• AN S, CUTLER G, ZHAO JJ et al.: Identification and characterization of a melanin-concentrating hormone receptor. Proc. NatL Acad. Sci. USA (2001) 98(13):7576–7581.
   PubMed Web of Science ®Google Scholar
• HILL J, DUCKWORTH M, MURDOCK P et al: Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J. Biol. Chem. (2001) 276(23):20125–20129.
   PubMed Web of Science ®Google Scholar
• MORI M, HARADA M, TERAO Y et al: Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem. Biophys. Res Commun. (2001) 283(5):1013–1018.
   PubMed Web of Science ®Google Scholar
• WANG S, BEHAN J, O'NEILL K et al.: Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. J. Biol. Chem. (2001) 276(37):34664–34670.
   Google Scholar
• TAN CP, SANO H, IWAASA H et al.: Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics (2002) 79(6):785–792.
   PubMed Web of Science ®Google Scholar
• BURTON BT, FOSTER WR, HIRSCH J, VANITALLIE T: Health Implications of obesity: NIH consensus development conference. Int. 1 Obes. RelaL Metab. Disord. (1985) 9:155–169.
   PubMed Web of Science ®Google Scholar
• •Review of obesity-related health issues.
   Google Scholar
• NO AUTHORS LISTED: The Surgeon General's call to action to prevent and decrease overweight and obesity. Department of Health and Human Services, Public Health Service, Office of the Surgeon General. Rockville, MD, USA. (2001). Available from: U.S. GPO, Washington.
   Google Scholar
• •This publication is also available on the World Wide Web at: http://www.surgeongeneral.gov/library
   Google Scholar
• TAKEKAWA S, ASAMI A, ISHIHARA Y et al.: T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur: 1 Pharmacol (2002) 438:129–135.
   Google Scholar
• ••First report of an orally active MCH1Rantagonist to suppress food intake following exogenous MCH administration in rats.
   Google Scholar
• BOROWSKY B, DURKIN MM, OGOZALEK K et al: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nature Medicine (2002) 8(8)825–830.
   Google Scholar
• ••First report of an orally active MCH1R antagonist to show antidepressant and anxiolytic activity in rats.
   Google Scholar
• SEGAL-LIEBERMAN G, TSO AWK, TROMBLY D, WANG X, GEE H, MARATOS-FLIER E: Mice lacking melanin-concentrating hormone have impaired fertility secondary to abnormal mating behaviour. 84th Endocrine Socieo, Meeting. San Francisco, USA (2002). OR17–5.
   Google Scholar
• SAITO Y, CHENG M, LESLIE FM, CIVELLI O: Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. j. Comp. Neurol (2001) 435:26–40.
   PubMed Web of Science ®Google Scholar
• BEDNAREK MA, TAN C, HRENIUK DL et al.: Synthesis and biological evaluation M vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. j. Biol. Chem. (2002) 277(16):13821–13826.
   PubMed Web of Science ®Google Scholar
• BEDNAREK MA, HRENIUK DL, TAN C et al.: Synthesis and biological evaluation M vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry (2002) 41:6383–6390.
   PubMed Web of Science ®Google Scholar
• AUDINOT V, BEAU VERGER P, LAHAYE C et al.: Structure-activity relationship studies of melanin-concentrating hormone (MCH)-related peptide ligands at SLC-1, the human MCH receptor. j. Biol. Chem. (2001) 276(17):13554–13562.
   PubMed Web of Science ®Google Scholar