Bibliography
- DARNELL JE, HARVEY, HF, D: Molecular Cell Biology. Scientific American Books, W. H. Freeman and Company, NY, USA (1986) 1192.
- COCHRAN AG: Antagonists of protein-protein interactions. Chem. Biol. (2000) 7:R85–R94.
- HENIG L, CORNISH WC: ha vivo protein-protein interaction assays: Beyond proteins. Angew. Chem. Int. Ed. (2001) 40:871–875.
- VON ANGERER E: New inhibitors of tubulin polymerisation. Expert Opin. Titer. Patents (1999) 9(8):1069–1081.
- JORDAN A, HADFIELD JA, NJ, MCGOWN AT: Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev (1998) 18(4):259–296.
- RAI SS, WOLFF J: Localization of the-binding site on 3-tubulin. J. Biol. Chem. (1996) 271(25):14707–14711.
- HAMEL E: Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol The,: (1992) 55(1):31–51.
- UCKUN FM: SUDBECK EA, MAO C et al. Structure-based design of novel anticancer agents. Carr. Cancer Drug Targets (2001) 1(1):59–71.
- REILLY TM, MOUSA SA, RACANELLI AL: New antiplatelet drugs. Emerging Drugs (1999) 4:197–208
- VAISMAN D, FERGUSON JJ: Therapeutic of GPreceptor antagonistsin acute myocardial infarction. Expert Opin. Investig. Drugs (2001) 10(11):1965–1976.
- PALANKI MSS, MANNING AM: Interleukin-2 inhibitors in autoimmune disease. Expert Opin. Ther. Patents (1999) 9(1):27–39.
- TILLEY JVV, CHEN L, FRY, DC et al: Identification of a Small Molecule Inhibitor the IL-2/IL-2Ra Receptor Interaction Which Binds to IL-2. I Am. Chem. Soc. (1997) 119(32):7589–7590.
- LIU G: Small molecule antagonists of the LFA-1/ICAM-1 interaction as potential therapeutic agents. Expert Opin. Ther. Patents (2001) 11(9):1383–1393.
- KALLENJ, WELZENBACH K, RAMAGE P et al.: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD1 la I-domain. J. Ma Biol. (1999) 292:1–9.
- HUTH JR, OLENJNICZAK ET, MENDOZA R et al: NMR and mutagenesis evidence for an I-domain allosteric site that regulates lymphocyte function-associated antigen-1 ligand binding. Proc. Nati Acad. Sci. USA (2000) 97:5231–5236.
- GADEK TR, MARSTERS Jr. JC, STANLEY M et al.: Identification and characterization of antagonists of the LFA-1/ ICAM-1 protein-protein interaction as novel immunomodulatory agents. 220th ACS National Meeting, Washington DC, USA (2000) MEDI 177.
- GADEK TR, BURDICK DJ, McDOWELLRS et al: Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science (2002) 295:1086–1089.
- DUGGAN ME, HUTCHINSON JH: Ligands to the Integrin Receptor ad33. Expert Opin. The]: Patents(2000) 10(9):1367–1383.
- CONNELL, RD, BEEBE JS: Patent focuson cancer chemotherapeutics. III Angiogenesis agents: October 2000 - March 2001. Expert Opin. The]: Patents (2001) 11(7):1171–1203.
- HARTMAN GD, DUGGAN ME: aj33 integrin antagonists as inhibitors of bone resorption. Expert Opin. Investig. Drugs (2000) 9(6):1281–1291.
- HORTON MA, RODAN GA: Integrins as therapeutic targets in bone disease. In: Adhesion Receptors as Therapeutic Targets. Horton MA (Ed.), CRC Press, Boca Raton, FL, USA (1996):223–245.
- BROOKS PC, CLARK RAF, CHERESH DA: Requirement of vascular integrin aj33 for angiogenesis. Science (1994) 264:569–571.
- CHICO, TJA, CHAMBERLAIN J, GUNN J et al.: Effect of selective or combined inhibition of integrins allbl33 and aj33 on thrombosis and neointima after oversized porcine coronary angioplasty. Circulation (2001) 103:1135–1141.
- CARRON CP, MEYER DM, PEGG JA et al.: A peptidomimetic antagonist of the integrin avI33 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. (1998) 58(9):1930–1935.
- ZIMMERMAN CN: Peptide and peptidomimetic inhibitors of VLA-4. Expert Opin. The]: Patents(1999) 9:129–133.
- LIN K-C, CASTRO AC: Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curt Opin. Chem. Biol. (1998) 2:453–457.
- JACKSON DY: a4 Integrin Antagonists. Curt Pharm. Design. (2002). In press.
- TUBRIDY N, BEHAN PO, CAPILDEO R et al.: The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology (1999) 53: 466–472.
- PLEISS MA, THORSETT ED, T: Discovery of a novel binding epitope for the a4 integrin based on sequence homology between VCAM-1 and third heavy chain complementary-determining region of anti-a4 antibodies. Abstr. Pap. Am. Chem. Soc. (2000) 220th: MEDI–132.
- MULLER G: Peptidomimetic 5H2 domain antagonists for targeting signal transduction. Top. Curt Chem. (2001) 211:17–59.
- SHAKESPEARE WC: 5H2 domain inhibition: a problem solved? Can: Opin. Chem. Biol. (2001) 5(4):409–415.
- No authors listed. New inhibitors of 5H2-mediated processes. Expert Opin. Titer: Patents. (1998) 8(3):333–335.
- SMITHGALL TE: 5H2 and 5H3 domains: potential targets for anti-cancer drug design. Pharmacol Toxicol Methods. (1995) 34(3):125–132.
- MCBRIDE CB, MCPHAIL LT, STEEVES JD: Emerging therapeutic targets in caspase-dependent disease. Emerging The]: Targets (1999) 3:391–411.
- DEGTEREV A, LUGOVSKOY A, CARD ONE M et al.: Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-XL. Nat. Cell Biol. (2001) 3(2):173–182.
- HOLINGER EP, CHITTENDEN T, LUTZ RJ: Bak BH3 peptides antagonize Bc1-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J. Biol. Chem. (1999) 274(19):13298–13304.
- TZUNG S-P, KIM KM, BASANEZ G et al.: Antimycin A mimics a cell-death-inducing Bc1-2 homology domain 3. Nat. Cell Biol. (2001) 3(2):183–192.
- ZUTSHI R, BRICKNER M, J: Inhibiting the assembly of protein-protein interfaces. Curt: Opin. Chem. Biol. (1998) 2:62–66.
- SHULTZ MD, BOWMAN MJ, HAM Y-W et al: Small-molecule inhibitors of HIV-1 protease dimerization derived from cross-linked interfacial peptides. Angew. Chem. mt. Ed. (2000) 39(15):2710–2713.
- FAN X, FLENTKE GR, RICH DH: Inhibition of HIV-1 Protease by a Subunit of Didemnaketal A. J. Am. Chem. Soc. (1998) 120(34):8893–8894.
Websites
- Genentech, Inc. Press Release: Phase III Clinical Trials of Xanelim Humanized Monoclonal Antibody for Moderate-to-Severe Psoriasis Show Preliminary Positive Results. May 24, 2001: http://www.gene.com/gene/news/ press_pipe.html
- Protein Design Labs, Inc. http://www.pdl.com/wt/ sec.php3?page_nameproducts
- ICOS, Inc.: Information on the development status of IC747: http://www.icos.com
- MedImmune, Inc.://www.medimmune.com