TRPV1 (vanilloid receptor, capsaicin receptor) agonists and antagonists

Bibliography

• MONTELL C, BIMBAUMER L, FLOCKERZI V: The TRP channels, a remarkably functional family. Cell (2002) 108:595–598.
   PubMed Web of Science ®Google Scholar
• ••A general review on the structure andfunction of TRPV channels.
   Google Scholar
• GUNTHORPE MJ, BENHAM CD, RANDALL A, DAVIS JB: The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci (2002) 23:183–191.
   PubMed Web of Science ®Google Scholar
• ••A general review on the various vanilloidreceptors.
   Google Scholar
• CATERINA MJ, SCHUMACHER MA, TOMINAGA M et al.: The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 398:816–824.
   Google Scholar
• MONTELL C, BIRNBAUMER L, FLOCKERZI V et al.: A unified nomenclature for the superfamily of TRP cation channels. Mo/. Ce//(2002) 9:229–231.
   PubMed Web of Science ®Google Scholar
• PEIER AM, REEVE AJ, ANDERSSON DA et al.: A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 296:2046–2049.
   PubMed Web of Science ®Google Scholar
• SMITH GD, GUNTHORPE MJ, KELSELL RE et al: TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (2002) 418:186–190.
   PubMed Web of Science ®Google Scholar
• XU H, RAMSEY IS, KOTECHA SA et al.: TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 418:181–186.
   PubMed Web of Science ®Google Scholar
• STERNER O, SZALLASI A: Novel natural vanilloid receptor agonists: new therapeutic targets for drug development. Trends Pharmacol Sci.(1999) 20:431–439.
   Google Scholar
• DI MARZO V, BLUMBERG PM, SZALLASI A: Endovanilloid signaling in pain. Cum Opin Neumbiol (2002) 12:372–379.
   PubMedGoogle Scholar
• ••An important review on the interactionsbetween the vanilloid and cannabinoid systems.
   Google Scholar
• SZALLASI A: Vanilloid (capsaicin) receptors in health and disease. Am. Clin. Pathol. (2002) 118:110–121.
   PubMedGoogle Scholar
• SZALLASI A, BLUMBERG PM: Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev (1999) 51:159–211.
   PubMed Web of Science ®Google Scholar
• ••A comprehensive review on TRPV1 with> 200 references.
   Google Scholar
• HUANG SM, BISOGNO T, TREVISANI M et al: An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Nati Acad. Sci. USA (2002) 99:8400–8405.
   PubMed Web of Science ®Google Scholar
• CHU CJ, HUANG SM, DE PETROCELLIS L et al.: N-Oleolydopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J. Biol. Chem. (2003) 278:13633–13639.
   Google Scholar
• PRESCOTT ED, JULIUS D: A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 300:1284–1288.
   PubMed Web of Science ®Google Scholar
• •A mechanistic insight on the role of PIP2 as a tuner of vanilloid activity.
   Google Scholar
• SZALLASI A: Vanilloid receptor ligands. Hopes and realities for the future. Drugs Aging (2001) 18:561–573.
   Google Scholar
• LASTRES-BECKER I, DE MIGUEL R, DE PETROCELLIS L et al.: Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J.Neurochem. (2003) 84:1097–1109.
   Google Scholar
• NUMAZAKI M, TOMINAGA T, KUMIKO T et al.: Structural determinant of TRPV1 desensitization interacts with calmodufin. Proc. Nati Acad. Sci USA (2003) 100:8002–8006.
   PubMed Web of Science ®Google Scholar
• SZALLASI A: After a decade of intravescical vanilloid therapy: still more questions than answers. Lancet Neurobiol. (2002) 1:167–172.
   PubMed Web of Science ®Google Scholar
• ••A critical review discussing the applicationof vanilloids in urology.
   Google Scholar
• KARLSSON JA: The role of capsaicin-sensitive C-fiber afferent nerves in the cough reflex. Palm. Pharmacol. (1996) 9:315–321.
   Google Scholar
• REILLY CA, EHLHARDT WJ, JACKSON DA et al.: Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem. Res. Toxicol (2003) 16:336–349.
   PubMed Web of Science ®Google Scholar
• WATANABE H, VRIENS J, PRENEN J et al.: Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 424:438–441.
   PubMedGoogle Scholar
• WATANABE H, DAVIS JB, DARREN S et al.: Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J. Biol. Chem. (2002) 277:13569–13577.
   PubMed Web of Science ®Google Scholar
• •Identification of the first ligand for a vanilloid receptor different from TRPV1.
   Google Scholar
• MCINTYRE P, MCLATCHIE LM, CHAMBERS A et al.: Pharmacological differences between the human and the rat vanilloid receptor 1 (VR1). Br: J. Pharmacol (2001) 132:1084–1094.
   Google Scholar
• JORDT SE, JULIUS D: Molecular basis for species-specific sensitivity to 'hot' chili pepper. Cell (2002) 108:421–430.
   PubMed Web of Science ®Google Scholar
• SAVIDGE J, DAVIS C, SHAH K et al: Cloning and functional characterization of the guinea-pig vanilloid receptor 1. Neuropharmacology (2002) 43:450–456.
   PubMed Web of Science ®Google Scholar
• KOBAYASHI Y, NAKANO Y, KIZAKI M et al.: Capsaicin-like anti-obese activities of evodiamine from fruits Evodia rutaecarpa, a vanilloid receptor antagonist. Planta Med. (2001) 67:628–633.
   PubMed Web of Science ®Google Scholar
• BISOGNO T, HANUS L, DE PETROCELLIS L et al.: Molecular targets for cannabidiol and its synthetic analogues: effects on vanilloid VR1 receptors and on cellular uptake and enzymatic hydrolysis of anandamide. Br. J. Pharmacol (2001) 134:845–852.
   Google Scholar
• YANG BH, PIAO ZG, KIM YB et al.: Activation of vanilloid receptor 1 (VR1) by eugenol. J. Dent. Res (2003) 82:781–785.
   PubMed Web of Science ®Google Scholar
• TOT A, KEDEI N, SZABO T et al: Thapsigargicin binds to and inhibits the cloned vanilloid receptor-1. Biochem. Biophysi. Res. Commun. (2002) 293:777–782.
   PubMedGoogle Scholar
• IIDA T, MORIYAMA T, KOBATA K et al.: TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology (2003) 44:958–967.
   PubMed Web of Science ®Google Scholar
• MACHO A, LUCENA C, SANCHO R et al.: Non-pungent capsacinoids from sweet pepper. Synthesis and evaluation of the chemopreventive and anticancer potential. Eur.j Nuti: (2003) 42:2–9.
   Google Scholar
• TSUTUMI S, TOMIOKA A, SUDO Met at.: Propofol activates vanilloid receptor channels expressed in human embryonic kidney-293 cells. Nernsci. Lett. (2001) 312:45–49.
   Google Scholar
• APPENDINO G, MINASSI A, SCHIANO MORELLO A et al.: N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor. Med. Chem. (2002) 45:3739–3745.
   Google Scholar
• URBAN L, CAMPBELL EA, PANESAR M et al: In vivo pharmacology of SDZ-249665, a novel, non-pungent capsaicin analogue. Pain (2000) 89:65–74.
   PubMed Web of Science ®Google Scholar
• ZYGMUNT PM, CHUANG H, MOVAHED P et al.: The anandamide transport inhibitor AM-404 activates vanilloid receptors. Euc Pharmacol. (2000) 396:39–42.
   PubMed Web of Science ®Google Scholar
• GUHRING H, HAMZA M, SERGEJEVA M et al: A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur. Pharmacol. (2002) 454:153–163.
   PubMedGoogle Scholar
• MCVEY DC, SCHMID PC, SCHMID HHO et al: Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). Pharmacol. Exp. Ther (2003) 304:713–722.
   PubMed Web of Science ®Google Scholar
• PARK NS, SEONG CM, JUNG YS et al: DA-5018 (Capsavanil, KR-25018). Drugs Fut. (2000) 25:1131–1137.
   Google Scholar
• SZOLCSANYI J, JANCSO-GABOR A: Sensory effects of capsaicin congeners. Artzneim. Forsch. (1975) 25:1877–1881.
   PubMed Web of Science ®Google Scholar
• •An old paper still relevant today.
   Google Scholar
• SZALLASI A, BLUMBERG PM: Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analogue of capsaicin, the irritant constituent in red pepper. Neuroscience (1989) 30:515–520.
   PubMed Web of Science ®Google Scholar
• LEE J, PARK SU, KIM JY et al.: 3-Acyloxy- 2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists. Bioorg. Med. Chem. Lett. (1999) 9:2909–2914.
   PubMedGoogle Scholar
• •Discovery of the first simplified RTX analogues with potency compared to the natural product.
   Google Scholar
• LEE J, LEE J, KANG MS et al: Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics. Bioorg. Med. Chem. (2002) 10:1171–1179.
   PubMedGoogle Scholar
• LEE J, LEE J, KIM J et al.: N- (3-Acyloxy-2-benzylpropy1)-Y- (4- hydroxy-3-methoxybenzy0thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg. Med. Chem. (2001) 9:19–22.
   PubMedGoogle Scholar
• WALPOLE CSI, BEVAN S, BOVERMANN G et al: The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. Med. Chem. (1994) 37:1942–1954.
   Google Scholar
• WAHL P, FOGED C, TULLIN S et al: Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol. Pharmacol (2001) 59:9–15.
   PubMed Web of Science ®Google Scholar
• •Discovery of the first high-affmity TRPV1 antagonist.
   Google Scholar
• MCDONNEL ME, ZHANG SP, DUBIN AE et al: Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg. Med. Chem. Lett. (2002) 12:1189–1192.
   PubMedGoogle Scholar
• APPENDINO G, HARRISON S, DE PETROCELLIS L et al.: Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Br. J. Pharmacol (2003) 139:1417–1424.
   Google Scholar
• SEABROOK GR, SUTTON KG, JAROLIMEK W et al.: Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4 - hydroxy- 5 -io do- 3 - m ethoxyp he nylac etate ester) iodo- resiniferatoxin. Pharmacol. Exper: Therap. (2002) 303:1052–1060.
   Google Scholar
• LEE J, LEE J, KANG M et al.: N-(Methylsulfonylamino)benzyl thiourea analogues: novel potent and high affinity antagonists of vanilloid receptors. Med. Chem. (2003) 46:3116–3126.
   Google Scholar
• RAMI HK, DAVIDS JB, GUNTHORPE MJ et al: Identification of SB-366791, a potent and selective antagonist of vanilloid receptor-1. Drugs Fut. (2002) 27(SuppLA):411.
   Google Scholar
• YOON JVV, CHOI HY, LEE HJ et al: Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13:1549–1552.
   PubMedGoogle Scholar
• LEE SH, PREMKUMAR LS: Inhibition of capsaicin-induced single channel currents by cocaine. Soc. Neurosci. Abstr. (1999) 25:2255.
   Google Scholar
• HAHN JH: Ginsenosides inhibit capsaicin channels in rat dorsal root ganglion neurons. Neurosci. Lett. (2000) 287:45–48.
   PubMed Web of Science ®Google Scholar
• DAX S, DUBIN A, JETTER M et al.: Vanilloid receptor antagonists: structure-activity relationships via parallel and targeted synthesis. Drugs Fut. (2002) 27(SuppLA):93.
   Google Scholar
• WALKER KM, URBAN L, MEDHURST SJ et al: The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. Pharmacol Exp. Ther. (2003) 304:56–62.
   PubMed Web of Science ®Google Scholar