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Review

Inhibitors of vascular cell adhesion molecule-1 expression

, &
Pages 149-166 | Published online: 02 Mar 2005

Bibliography

  • VON ANDRIAN UH, MACKAY CR: T-cell function and migration - two sides of the same coin. N Engl. Med. (2000) 343:1020–1034.
  • ••Excellent review covering the principles ofleukocye (expecially T cell) trafficking, including key pioneering work as well as recent cutting-edge papers.
  • ALON R, FEIGELSON S: From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts. Semin. Immunol (2002) 14:93–104.
  • LAUDANNA C, KIM JY, CONSTANTIN G, BUTCHER E: Rapid leukocyte integrin activation by chemokines. Immunol Rev (2002) 186:37–46.
  • PAPAYANNOPOULOU T, PRIESTLEY GV, NAKAMOTO B, ZAFIROPOULOS V, SCOTT LM: Molecular pathways in bone marrow homing: dominant role of a431 over 132-integrins and selectins. Blood (2001) 98:2403–2411.
  • •Compelling evidence that the VLA-4/ VCAM-1 pathway alone, in the absence of 132 integrins or selectins, can effectively capture haematopoietic cells within the bone marrow.
  • SAXENA U, MEDFORD RM: Vascular adhesion molecule-1 (VCAM-1), an inflammatory gene target for new therapeutics. Curl: Opin. Cardiovasc. Palm. Rena] Invest. Drugs (2000) 2:258–262.
  • CARTER RA, WICKS IP: Vascular cell adhesion molecule 1 (CD106): a multifaceted regulator of joint inflammation. Arthritic Rheum. (2001) 44:985–994.
  • HICKEY MJ, GRANGER DN, KUBES P: Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the a4 integrin. Immunol (1999) 163:3441–3448.
  • BAGGIOLINI M: Chemokines in pathology and medicine. Intern. Med. (2001) 250:91–104.
  • OLSON TS, LEY K: Chemokines and chemokine receptors in leukocyte trafficking. Am. j Physiol Regal Integr: Comp. Physiol (2002) 283:R7–R28.
  • •Up-to-date and comprehensive review regarding the role of chemokines and their receptors in leukocyte recruitment.
  • JOHNSTON B, KUBES P: The a4-integrin: an alternative pathway for neutrophil recruitment? Immunol Today (1999) 20:545–550.
  • IBBOTSON GC, DOIG C, KAURJ et al: Functional a4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nat. Med. (2001) 7:465–470.
  • •First description of neutrophil recruitment in human disease mediated by the VLA-4/ VCAM-1 pathway.
  • BOWDEN RA, DING Z-M, DONNACHIE EM et al.: Role of a4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ. Res. (2002) 90:562–569.
  • TAO OKA Y, CHEN J, YEDNOCK T, SHEPPARD D: The integrin a9131 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1. J. Cell Biol. (1999) 145:413–420.
  • VAN DER VIEREN M, CROWE DT, HOEKSTRA D et al.: The leukocyte integrin aD32 binds VCAM- 1: evidence for a binding interface between I domain and VCAM-1. I Immunol (1999) 163:1984–1990.
  • ROTT LS, BRISKIN MJ, BUTCHER EC:Expression of a437 and E-selectin ligand by circulating memory B cells: implications for targeted trafficking to mucosal and systemic sites. Leukoc. Biol. (2000) 68:807–814.
  • ROSE DM, GRABOVSKY V, ALON R, GINSBERG MH: The affinity of integrin c(4131 governs lymphocyte migration. Immunol (2001) 167:2824–2830.
  • NEISH AS, AGGARWAL S, COLLINS T: Transcriptional regulation of VCAM-1. In: Leukocyte recruitment, endothelial cell adhesion molecular, and transcriptional control. Collins T (Ed.), Kluwer Academic Publishers, Boston (2001):175–201.
  • YUSUF-MAKAGIANSAR H, ANDERSON ME, YAKOVLEVA TV, MURRAY JS, SIAHAAN TJ: Inhibition of LFA-1/ICAM-1 and VLA-4NCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med. Res. Rev (2002) 22:146–167.
  • KITANI A, NAKASHIMA N, IZUMIHARA T et al.: Soluble VCAM-1 induces chemotaxis of Jurkat and synovial fluid T cells bearing high affinity very late antigen-4. f Immunol (1998) 161:4931–4938.
  • FUKUSHI J, ONO M, MORIKAWA W, IWAMOTO Y, KUVVANO M: The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13. f Immunol (2000) 165:2818–2823.
  • ROSE DM, CARDARELLI PM, COBB RR, GINSBERG MH: Soluble VCAM-1 binding to a4integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells. Blood (2000) 95:602–609.
  • TOKUHIRA M, HOSAKA S, VOLIN MV et al.: Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis. Arthritic Rheum. (2000) 43:1122–1133.
  • BYRNE GJ, GHELLAL A, IDDON J et al.: Serum soluble vascular cell adhesion molecule-1: role as a surrogate marker of angiogenesis. Natl. Cancer Inst. (2000) 92:1329–1336.
  • KOLOPP-SARDA MN, GUILLEMIN F, CHARY-VALCKENAERE I, BENE MC, POUREL J, FAURE GC: Longitudinal study of rheumatoid arthritis patients discloses sustained elevated serum levels of soluble CD106 (V-CAM). Clin. Exp. Rheumatol (2001) 19:165–170.
  • WRIGHT PS, COOPER JR, KROPP KE, BUSCH SJ: Induction of vascular cell adhesion molecule-1 expression by IL-4 in human aortic smooth muscle cells is not associated with increased nuclear NF-icB levels. Cell Physiol (1999) 180:381–389.
  • DE CATERINA R, BOURCIER T, LAUFS U et al.: Induction of endothelial-leukocyte interaction by interferon-y requires coactivation of nuclear factor-KB. Arterioscler: Thromb. Vasc. Biol. (2001) 21:227–232.
  • JESSE TL, LACHANCE R, IADEMARCO ME DEAN DC: Interferon regulatory factor-2 is a transcriptional activator in muscle where it regulates expression of vascular cell adhesion molecule-1. f Cell Biol. (1998) 140:1265–1276.
  • HAWKE TJ, GARRY DJ: Myogenic satellite cells: physiology to molecular biology. Appl. Physiol (2001) 91:534–551.
  • MINAMI T, AIRD WC: Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-icB and GATA motifs. f. Biol. Chem. (2001) 276:47632–47641.
  • UMETANI M, MATAKI C, MINEGISHI N, YAMAMOTO M, HAMAKUBO T, KODAMA T: Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-a. Arterioscler. Thromb. Vase. Biol. (2001) 21:917–922.
  • LEE YW, KOHN H, HENNIG B, NEISH AS, TOBOREK M: IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J. MM. Cardiol (2001) 33:83–94.
  • •Further evidence that IL-4 mediated VCAM-1 expression is NF-x13 independent, following 1995 observations by McCarty etal. WEBS Lett. 372:194-98), and that cytokine activation of NF-x13 depends on specific signal transduction mechanisms rather than ubiquitously induced cellular oxidative stress.
  • LOBB RR, ABRAHAM WM, BURKLY LC et at Pathophysiologic role of a4integrins in the lung. Ann. N Y Acad. Sci. (1996) 796:113–123.
  • JACKSON DY: Alpha 4 integrin antagonists. Carr. Amin. Des. (2002) 8:1229–1253.
  • KUDLACZ E, WHITNEY C, ANDRESEN C et al: Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule a4I31 antagonists. " Pharmacol Exp. Ther: (2002) 301:747–752.
  • MOUSA SA: Anti-integrin as novel drug-discovery targets: potential therapeutic and diagnostic implications. Carr: Opin. Chem. Biol. (2002) 6:534–541.
  • SINGH J, VAN VLIJMEN H, LIAO Y et al.: Identification of potent and novel a4 pi antagonists using in silico screening. J. Med. Chem. (2002) 45:2988–2993.
  • TILLEY JW: VLA-4 antagonists. Expert Opin. Ther. Patents (2002) 12:991–1008.
  • ••Up-to-date patent review of VLA-4antagonists in the pipeline.
  • LIU G: Small molecule antagonists of the LFA-1/ICAM-1 interaction as potential therapeutic agents. Expert Opin. Ther. Patents (2001) 11:1383–1393.
  • DOWNS KM: Early placental ontogeny in the mouse. Placenta (2002) 23:116–131.
  • KONI PA, JOSHI SK, TEMANN U-A, OLSON D, BURKLY L, FLAVELL RA: Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. I Exp. Med. (2001) 193:741–753.
  • •Valuable new animal models due to the generation of VCAM-1 knock-in and transgenic mice, thus overcoming the embryonic lethality seen in conventional VCAM-1 deficiency (Genes Dev. (1995) 1:1-14; Development (1995) 2:489–503).
  • LEUKER CE, LABOW M, MOLLER W, WAGNER N: Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response.j Exp. Med. (2001) 193:755–767.
  • •Similar contribution as for [40], also by generating conditional VCAM-1 mutant mice.
  • ROSS R: Atherosclerosis - an inflammatory disease. N Engl. J. Med. (1999) 340:115–126.
  • ••Elegant and controversial position paper,arguing in part that atherogenesis is an inflammatory response to modified lipoproteins trapped in the arterial wall.
  • KUNSCH C, MEDFORD RM: Oxidative stress as a regulator of gene expression in the vasculature. Circ. Res. (1999) 85:753–766.
  • •Review of evidence that oxidative stress is a major risk factor in atherosderosis.
  • COLLINS T, CYBULSKY MI: NF-icB: pivotal mediator or innocent bystander in atherogenesis?" Clin. Invest. (2001) 107:255–264.
  • •Provocative assessment of NF-x13 role in atherosclerosis.
  • WITZTUM JL, STEINBERG D: The oxidative modification hypothesis of atherosclerosis; does it hold for humans? Trends Cardiovasc. Med. (2001) 11:93–102.
  • •Review supporting the key role of LDL oxidation in atherogenesis.
  • FRUEBIS J, GONZALEZ V, SILVESTRE M, PALINSKI W: Effect of probucol treatment on gene expression of VCAM-1, MCP-1, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis. Arterioscler: Thromb. Vase. Biol. (1997) 17:1289–1302.
  • TRUSKEY GA, HERRMANN RA, KAIT J, BARBER KM: Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. Arterioscler. Thromb. Vase. Biol. (1999) 19:393–401.
  • AIKAWA M, SUGIYAMA S, HILL CC et at Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation (2002) 106:1390–1396.
  • CYBULSKY MI, IIYAMA K, LI H et al: A major role for VCAM-1, but not I CAM-1, in early atherosclerosis. J. Clin. Invest. (2001) 107:1255–1262.
  • ••Study shows for the first time that VCAM-1is critical for the development of atherosclerotic lesions, utilising mice with the LDL receptor-null background and deficient in VCAM-1 domain 4.
  • DANSKY HM, BARLOW CB, LOMINSKA C et al.: Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler: Thromb. Vase. Biol. (2001) 21:1662–1667.
  • TARDIF J-C, COTE G, LESPERANCE Jet al.: Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. N Engl. I Med. (1997) 337:365–372.
  • OKAMOTO E, COUSE T, DE LEON H et al.: Perivascular inflammation after balloon angioplasty of porcine coronary arteries. Circulation (2001) 104:2228–2235.
  • OGUCHI S, DIMAYUGA P, ZHU Jet al.:Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. ArteriOSCIer. Thromb. Vase. Biol. (2000) 20:1729–1736.
  • HUO Y, HAFEZI-MOGHADAM A, LEY K: Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ. Res. (2000) 87:153–159.
  • BARNES KC: Evidence for common genetic elements in allergic disease. I Allergy Clin. Immunol (2000) 106:5192–5200.
  • TERREEHORST I, OOSTING AJ, TEMPELS-PAVLICA Z et al.: Prevalence and severity of allergic rhinitis in house dust mite-allergic patients with bronchial asthma or atopic dermatitis. Clin. Exp. Allergy(2002) 32:1160–1165.
  • CONROY DM, WILLIAMS TJ: Eotaxin and the attraction of eosinophils to the asthmatic lung. Respir. Res. (2001) 2:150–156.
  • RIFFO-VASQUEZ Y, SPINA D: Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation. Pharmacol Ther: (2002) 94:185–211.
  • TEMANN U-A, RAY P, FLAVELL RA: Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J. Clin. Invest. (2002) 109:29–39.
  • WALTER DM, MCINTIRE JJ, BERRY G et al.: Critical role for IL-13 in the development of allergen-induced airway hyperreactivity." Immunol (2001) 167:4668–4675.
  • FALCONE FH, HAAS H, GIBBS BF: The human basophil: a new appreciation of its role in immune responses. Blood (2000) 96:4028–4038.
  • PAGE S, AMMIT AJ, BLACK JL, ARMOUR CL: Human mast cell and airway smooth muscle cell interactions: implications for asthma. Am. I Physiol. Lung Cell Ma Physiol. (2001) 281:L1313–L1323.
  • BOONE M, LESPAGNARD L, RENARD N, SONG M, RIHOUX JP: Adhesion molecule profiles in atopic dermatitis vs. allergic contact dermatitis: pharmacological modulation by cetirizine. Eur. Acad. Dermatol Venereol (2000) 14:263–266.
  • BRAUNSTAHL G-J, OVERBEEK SE, KLEINJAN A, PRINS J-B, HOOGSTEDEN HC, FOKKENS WJ: Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. I Allergy Clin. Immunol (2001) 107:469–476.
  • WILSON SJ, WALLIN A, DELLA-CIOPPA G, SANDSTROM T, HOLGATE ST: Effects of budesonide and formoterol on NF-icB, adhesion molecules, and cytokines in asthma. Am. I Respic Grit. Care Med. (2001) 164:1047–1052.
  • FOSTER CA: VCAM-1/a4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. J. Allergy Clin. Immunol (1996) 98:S270–277.
  • NAGAI K, LARKIN S, HARTNELL A et al.: Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of a4 integrins and vascular cell adhesion molecule-1. Immunology (1999) 96:176–183.
  • KAMINUMA O, FUJIMURA H, FUSHIMI K et al.: Dynamics of antigen-specific helper T cells at the initiation of airway eosinophilic inflammation. Euc Immunol (2001) 31:2669–2679.
  • WANG S, FAN Y, HAN X, YANG J, BILENKI L, YANG X: IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. Immunol (2001) 166:2741–2749.
  • •Recent study in IL-12 knockout mice highlighting the importance of VCAM-1 in promoting circulating eosinophil migration into airways.
  • BOLGER GT: Bio-1211 (Biogen). Curr. Opin. Anti-In/lam. Immunomod. Invest. Drugs (2000) 2:108–112.
  • PODOLSKY DK: Inflammatory bowel disease. N Engl. J. Med. (2002) 347:417–429.
  • •Up-to-date review of the etiology, pathophysiology and treatment of IBD, including status of investigational agents.
  • SORIANO A, SALAS A, SALAS A et al.: VCAM-1, but not I CAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab. Invest. (2000) 80:1541–1551.
  • BURNS RC, RIVERA-NIEVES J, MOSKALUK CA, MATSUMOTO S, COMINELLI F, LEY K: Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/ Yit adoptive transfer model of Crohn's disease in mice. Gastroenterology (2001) 121:1428–1436.
  • RIJCKEN E, KRIEGLSTEIN CE ANTHONI C et al: ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Gut (2002) 51:529–535.
  • GORDON FH, HAMILTON MI, DONOGHUE S et al: A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin. Ailment. Pbarmacol Tber. (2002) 16:699–705.
  • •UK group reports first results of anti-a4 integrin antibody natalizumab in ulcerative colitis, also citing their clinical studies in Crohn's disease.
  • HEMMER B, ARCHELOS JJ, HARTUNG HP: New concepts in the immunopathogenesis of multiple sclerosis. Nat. Rev. Neurosci. (2002) 3:291–301.
  • ••Recent insightful review on the pathogenesis of MS and the outlook for new therapeutic strategies.
  • FLOGEL A, BERKOWICZ T, RITTER T et al: Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity (2001) 14:547–560.
  • VAJKOCZY P, LASCHINGER M, ENGELHARDT B: acintegrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. I Clin. Invest. (2001) 108:557–565.
  • •Elegant intravital fluorescence videomicroscopy study providing the first direct in vivo evidence that VCAM-1 may function as a CNS-specific addressin.
  • PIRAINO PS, YEDNOCK TA, FREEDMAN SB et al: Prolonged reversal of chronic experimental allergic encephalomyelitis using a small molecule inhibitor of a4 integrin. Neurnimmunol (2001) 131:147–159.
  • TUBRIDY N, BEHAN PO, CAPILDEO R et al.: The effect of anti-a4 integrin antibody on brain lesion activity in MS. Neurology (1999) 53:466–472.
  • •Report of first clinical studies using anti-a4 integrin antibody in MS patients.
  • SMITH JB, HAYNES MK: Rheumatoid arthritis - a molecular understanding. Ann. Intern. Med. (2002) 136:908–922.
  • LI P, SANZ I, O'KEEFE RJ, SCHWARZ EM: NF-icB regulates VCAM-1 expression on fibroblast-like synoviocytes. Immunol (2000) 164:5990–5997.
  • ISSEKUTZ TB, MIYASAKA M, ISSEKUTZ AC: Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. (1996) 183:2175–2184.
  • CARTER RA, CAMPBELL IK, O'DONNELL K, WICKS IP: Vascular cell adhesion molecule-1 (VCAM-1) blockade in collagen-induced arthritis reduces joint involvement and alters B cell trafficking. Clin. Exp. Immunol (2002) 128:44–51.
  • KRAAN MC, REECE RJ, BARG EC et al.: Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Arthritis Rheum. (2000) 43:1820–1830.
  • SMITH MD, SLAVOTINEK J, AU V et al: Successful treatment of rheumatoid arthritis is associated with a reduction in synovial membrane cytokines and cell adhesion molecule expression. Rbeumatology (2001) 40:965–977.
  • CASCALHO M, PLATT JL: The immunological barrier to xenotransplantation. Immunity (2001) 14:437–446.
  • STE GALL MD, DEAN PG, NINOVA D et al.: a4 integrin in islet allograft rejection. Transplantation (2001) 71:1549–1555.
  • ISOBE M, HORI J, SUZUKI J: Immunosuppression by blocking a4-integrinsNCAM-1 adhesion. Curc Top. Microbiol Immunol (1998) 231:85–98.
  • ALLEN AR, MCHALE J, SMITH J et al.: Endothelial expression of VCAM-1 in experimental crescentic nephritis and effect of antibodies to very late antigen-4 or VCAM-1 on glomerular injury. I Immunol (1999) 162:5519–5527.
  • JOHNSTON B, CHEE A, ISSEKUTZ TB et al.: a4 integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. Immunol (2000) 164:3337–3344.
  • LARBI KY, ALLEN AR, TAM FVVK et al: VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. Blood(2000) 96:3601–3609.
  • OPALINSKA JB, GEWIRTZ AM: Nucleic-acid therapeutics: basic principles and recent applications. Nat. Rev Drug Discov. (2002) 1:503–514.
  • BENNETT CF, CONDON TP, GRIMM S, CHAN H, CHIANG M-Y: Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. Immunol (1994) 152:3530–3540.
  • MUELLER JP, GIANNONI MA, HARTMAN SL et al.: Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells. Ma Immunol (1997) 34:441–452.
  • ROSES AD: Genome-based pharmacogenetics and the pharmaceutical industry. Nat. Rev Drug Discov. (2002) 1:541–549.
  • DROGE W: Free radicals in the physiological control of cell function. Physiol Rev (2002) 82:47–95.
  • •Broad overview, in textbook style, summarising the main principles of redox regulation.
  • HENRICKS PAJ, NIJKAMP FP: Reactive oxygen species as mediators in asthma. Palm. Pharmacol The]: (2001) 14:409–421.
  • FRUEBIS J, SILVESTRE M, SHELTON D,NAPOLI C, PALINSKI W: Inhibition of VCAM-1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits. .1 Lipid Res. (1999) 40:1958–1966.
  • SOMERS PK, MEDFORD RM, SAXENA U: Dithiocarbamates: effects on lipid hydroperwddes and vascular inflammatory gene expression. Free Radic. Biol. Med. (2000) 28:1532–1537.
  • BOWIE AG, MOYNAGH PN, O'NEILL LAJ: Lipid peroxidation is involved in the activation of NF-icB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Biol. Chem. (1997) 272:25941–25950.
  • LI N, KARIN M: Is NF-icB the sensor of oxidative stress? FASEB J. (1999) 13:1137–1143.
  • TUMMALA PE, CHEN X-L, MEDFORD RM: NF-icB independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production. I Mol Cell Cardiol (2000) 32:1499–1508.
  • KHAN By, PARTHASARATHY SS, ALEXANDER RW, MEDFORD RM: Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J. Clin. Invest. (1995) 95:1262–1270.
  • •Fundamental paper showing the potential for oxLDL and its components to act as an oxidative signal that augments redox-sensitive endothelial VCAM-1 expression. More recently, AtheroGenics identified a unique antioxidant response element (j Biol. Chem. (2003) 278:703–711).
  • MENG CQ, SOMERS PK, RACHITA CL et al.: Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis. Bioorg. Med. Chem. Lett. (2002) 12:2545–2548.
  • •Paper describing medicinal chemistry studies resulting in lead AGI-1067.
  • NAKAMURA R, EGASHIRA K, MACHIDA Y et al.: Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: Roles of oxidative stress and inflammation. Circulation (2002) 106:362–367.
  • ELINDER LS, HADELL K, JOHANSSON J et al.: Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arteriosclei: Thromb. Vasc. Biol. (1995) 15:1057–1063.
  • MENG C, SOMERS P, RACHITA C, HOONG L, HILL R, SUNDELL C: Novel phenolic antioxidants as multifunctional inhibitors of VCAM-1 expression for coronary artery disease. 223rd ACS National Meeting Orlando, USA (2002). MEDI–122.
  • HATCH GM: AGI-1067 AthetoGenics. Carr: Opin. Livestig. Drugs (2002) 3:433–436.
  • CAMPBELL WB: New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. Trends Pharmacol ScL (2000) 21:125–127.
  • HOMMEL U, WEBER H-P, OBERER L, NAEGELI HU, OBERHAUSER B, FOSTER CA: The 3D-structure of a natural inhibitor of cell adhesion molecule expression. FEBS Lett. (1996) 379:69–73.
  • BOGER DL, KEIM H, OBERHAUSER B, SCHREINER EP, FOSTER CA: Total synthesis of HUN-7293. I Am. Chem. Soc. (1999) 121:6197–6205.
  • FOSTER CA, DREYFUSS M, MANDAK B et al.: Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. " Dermatol (1994) 21:847–854.
  • FOSTER CA, BESEMERJ, MEINGASSNER JG et al.: Novel inhibitor of endothelial cell-associated VCAM-1. Skin Pharmacol (1996) 9:149.
  • LIANG X, ANDO A, TAKAHASHI K et al: An inhibitor of VCAM-1 decreases retinal neovascularization and capillary nonperfusion in a model of ischemic retinopathy. Invest. Ophthalmol Vis. Sci. (2001) 42:S89.
  • CHEN Y, BILBAN M, FOSTER CA, BOGER DL: Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides. I Am. Chem. Soc. (2002) 124:5431–5440.
  • •Paper reporting the first SAR information for HUN-7293 analogues.
  • SCHREINER EP, KERN M, STECK A: A convenient protocol for selective cleavage of 2-hydroxy acid amides. Application to semisynthesis of the cyclic heptapeptide aza HUN-7293.j Org. Chem. (2002) 67:8299–8304.
  • BOGER DL, CHEN Y, FOSTER CA: Synthesis and evaluation of aza HUN-7293. Bioorg. Med. Chem. Lett. (2000) 10:1741–1744.
  • SCHREINER EP, GODIN G, BROUTIN P-E, FOSTER CA: Design and synthesis of cyclophanes related to the VCAM-1 expression inhibitor HUN-7293. 222nd ACS National Meeting. Chicago, USA (2001) MEDI–131.
  • WANG S, WINISKI AP, SCHEEL G et al.: Discovery of two new natural products in a high-throughput assay: potent inhibition of VCAM-1 expression by distinctly different mechanisms. Mol Biol. Cell (2000) 11:467a.
  • WOLLE J, HILL RR, FERGUSON E et al.: Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-icB. Arteriosclec Thromb. Vase. Biol. (1996) 16:1501–1508.
  • DIMMOCK JR, ELIAS DW, BEAZELY MA, KANDEPU NM: Bioactivities of chalcones. Can: Med. Chem. (1999) 6:1125–1149.
  • •Comprehensive overview of biologically active chalcones.
  • ZHU G-D, SCHAEFER V, BOYD SA, OKASINSKI GF: Synthesis and mode of action of 1251- and 3H-labeled thieno[2,3-dpyridine antagonists of cell adhesion molecule expression.' Org. Chem. (2002) 67:943–948.
  • WALKER G, LANGHEINRICH AC, DENNHAUSER E et al: 3-Deazaadenosine prevents adhesion molecule expression and atherosclerotic lesion formation in the aortas of C57BL/6J mice. Arterioscler. Thromb. Vase. Biol. (1999) 19:2673–2679.
  • AHMAD M, ZHANG Y, ZHANG Y, PAPHARALAMBUS C, ALEXANDER RW: Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-a stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler. Thromb. Vase. Biol. (2002) 22:759–764.
  • LIM LHK, BO CHNER BS, WAGNER EM: Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation. Am. I Physic] Lung Cell. Mel Physic] (2002) 282:L959–L967.

Websites

  • •First paper using intravital microscopy to study inflammation in the airway circulation.
  • http://www.biogen.com Biogen corporate website.
  • http://www.isp.com ISIS Pharmaceuticals corporate website.
  • http://www.antisense.com.au/d1/89.pdf Antisense Therapeutics Limited, Dec 2001 market analysis website.
  • http://www.mc.vanderbilt.edu/cancer Vanderbilt-Ingram Cancer Center website.
  • http://www.atherogenics.com AtheroGenic press release.
  • http://www.aventis.com Aventis corporate website.
  • http://www.gsk.com GlaxoSmithKline corporate website.
  • http://wwwxenogen.com Xenogen corporate website.

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