IL-17 cytokine/receptor families: emerging targets for the modulation of inflammatory responses

Bibliography

• ROUVIER E, LUCIANI ME MATTEI MG, DENIZOT F, GOLSTEIN P: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpes virus solo-Uri gene. Inununol.(1993) 150:5445–5456.
   Google Scholar
• YAO Z, FANSLOW WC, SELDIN MF et al: Herpesvirus Sahniri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity (1995) 3:811–821.
   PubMed Web of Science ®Google Scholar
• FOSSIEZ F, BANCHEREAU J, MURRAY R et al: Interleukin-17. hat. Rev brununol. (1998) 16:541–551.
   PubMedGoogle Scholar
• YAO Z, SPRIGGS MK, DERRY JM et al: Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine (1997) 9:794–800.
   PubMed Web of Science ®Google Scholar
• AGGARWAL S, GURNEY AL: IL-17: prototype member of an emerging cytokine family. Leukoc. Biol. (2002) 71:1–8.
   PubMed Web of Science ®Google Scholar
• ••Excellent concise review of the IL-17cytokine family.
   Google Scholar
• HYMOWITZ SG, FILVAROFF EH, YIN JP et al.: IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMB0.1. (2001) 20:53321-5341.
   Google Scholar
• ••Detailed structural analysis of IL-17EProvides a template for the topological features of IL-17 cytokine family members.
   Google Scholar
• VITT UA, HSU SY, HSUEH AJ: Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol Endocrinol (2001) 15:681–694.
   PubMedGoogle Scholar
• YAO Z, PAINTER SL, FANSLOW WC et al.: Human IL-17: a novel cytokine derived from T cells. Intinunol (1995) 155:5483–5486.
   Google Scholar
• •Initial biological characterisation of human IL-17.
   Google Scholar
• FOSSIEZ F, DJOSSOU 0, CHOMARAT P et al.: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. .1 Exp. Med. (1996) 183:2593–2603.
   Google Scholar
• •Initial demonstration of the proinflarnmatory character of IL-17.
   Google Scholar
• SHIN HC, BENBERNOU N, ESNAULT S, GUENOUNOU M: Expression of IL-17 in human memory CD45R0i- T lymphocytes and its regulation by protein kinase A pathway. Cytokine (1999) 11:257–266.
   PubMedGoogle Scholar
• •Demonstrates that IL-17 is produced by memory T cells.
   Google Scholar
• KOTAKE S, UDAGAWA N, TAKAHASHI N et al.: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. Clin. Invest. (1999) 103:1345–1352.
   Google Scholar
• SHIN HC, BENBERNOU N, FEKKAR H, ESNAULT S, GUENOUNOU M: Regulation of IL-17, IFN-y and IL-10 in human CD8(*) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine (1998) 10:841–850.
   PubMed Web of Science ®Google Scholar
• MOLET S, HAMID Q, DAVOINE F et al.: IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. Allergy Clin. Inununol. (2001) 108:430–438.
   PubMed Web of Science ®Google Scholar
• FERRETTI S, BONNEAU 0, DUB OIS GR, JONES CE, TRIFILIEFF A: IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. brununol. (2003) 170:2106–2112.
   Google Scholar
• •Demonstrates the role of IL-17 in LPS-induced airway neutrophllia. IL-17 may be produced by neutrophils.
   Google Scholar
• KENNEDY J, ROSSI DL, ZURAWSKI SM et al.: Mouse IL-17: a cytokine preferentially expressed by aB TCR + CD4-CD8-T cells. Interferon Cytokine Res. (1996) 16:611–617.
   PubMed Web of Science ®Google Scholar
• DUMONT FJ: Modulation of Thl and Th2responses for immunotherapy. Expert Opin. Ther. Patents (2002) 12:341–367.
   Web of Science ®Google Scholar
• AARVAK T, CHABAUD M, MIOSSEC P, NATVIG JB: IL-17 is produced by some proinflammatory Thl/Th0 cells but not by Th2 cells. Immunol (1999) 162:1246–1251.
   Google Scholar
• ALBANESI C, SCARPONI C, CAVANI A et al.: Interleukin-17 is produced by both Thl and Th2 lymphocytes, and modulates interferon-y- and interleukin-4-induced activation of human keratinocytes. Invest. Dermatol (2000) 115:81–87.
   PubMed Web of Science ®Google Scholar
• ••IL-17 production does not fit the Thl/Th2dichotomy.
   Google Scholar
• KAWAGUCHI M, ONUCHIC LF, LI XD et al.: Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. Immunol (2001) 167:4430–4435.
   Google Scholar
• ••Description of ML-1, an IL-17F isoform,and its potential role in asthma.
   Google Scholar
• INFANTE-DUARTE C, HORTON HF, BYRNE MC, KAMRADT T: Microbial lipopeptides induce the production of IL-17 in Th cells. Immunol (2000) 165:6107–6115.
   Web of Science ®Google Scholar
• ••IL-17 is produced by T cells that coexpressTNF-a and GM-CSE
   Google Scholar
• ZIOLKOWSKA M, KOC A, LUSZCZYKIEWICZ G et al.: High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. Immunol (2000) 164:2832–2838.
   Web of Science ®Google Scholar
• ••IL-17 production is enhanced by IL–15.
   Google Scholar
• AGGARWAL S, GHILARDI N, XIE MH, DE SAUVAGE FJ, GURNEY AL: Interleukin 23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin 17.1 Biol. Chem. (2003) 278:11910–1914.
   Google Scholar
• ••Shows that IL-23 promotes IL-17production in CD4+ T cells.
   Google Scholar
• FRUCHT DM: IL-23: A cytokine that acts on memory T cells. Sci. STKE (2002) 114:PE1.
   Google Scholar
• JOVANOVIC DV, DI BATTISTA JA, MARTEL-PELLETIER J et al.: IL-17 stimulates the production and expression of proinflammatory cytokines, IL-I3 and TNF-a, by human macrophages. Immunol (1998) 160:3513–3521.
   Google Scholar
• JONES CE, CHAN K: Interleuldn-17 stimulates the expression of interleukin-8, growth-related oncogene-a, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am. Respir: Cell Ma Biol. (2002) 26:748–753.
   Google Scholar
• WITOWSKI J, PAWLACZYK K, BREBOROWICZ A et al.: IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO a chemokine from mesothelial cells. Immunol (2000) 165:5814–5821.
   Google Scholar
• VAN KOOTEN C, BOONSTRA JG, PAAPE ME et al.: Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J. Am. Soc. Nephrol (1998) 9:1526–1534.
   PubMed Web of Science ®Google Scholar
• HSIEH H, LOONG C, LIN CY: Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. Cytokine (2002) 19:159–174.
   PubMed Web of Science ®Google Scholar
• LEGRAND A, FERMOR B, FINK C et al.: Interleukin-1, tumor necrosis factor a, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritic Rheum. (2001) 44:2078–2083.
   PubMed Web of Science ®Google Scholar
• KATZ Y, NADIV 0, BEER Y: Interleukin-17 enhances tumor necrosis factor a-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts: a possible role as a 'fine-tuning cytokine' in inflammation processes. Arthritic Rheum.(2001) 44:2176–2184.
   PubMed Web of Science ®Google Scholar
• CHABAUD M, PAGE G, MIOSSEC P: Enhancing effect of IL-1, IL-17, and TNF-a on macrophage inflammatory protein-3a production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines.j. Immunol (2001) 167:6015–6020.
   PubMed Web of Science ®Google Scholar
• ANDOH A, SHIMADA M, BAMBA S et al.: Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-a-induced stabilization of interleukin-6 mRNA in human pancreaticmyofibroblasts. Biochem. Biophys. Acta (2002) 1591:69–74.
   PubMedGoogle Scholar
• ALBANESI C, CAVANI A, GIROLOMONI G: IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-y and TNF-a. I Immunol (1999) 162:494–502.
   PubMed Web of Science ®Google Scholar
• ANDOH A, FUJINO S, BAMBA S et al: IL-17 selectively down-regulates TNF-a-induced RANTES gene expression in human colonic subepithelial myofibroblasts. Immunol (2002) 169: 1683-1687.
   Google Scholar
• ••Indicates that IL-17 may exertanti-inflammatory activities.
   Google Scholar
• MAERTZDORFJ, OSTERHAUS AD, VERJANS GM: IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. Inman& (2002) 169:5897–5903.
   Google Scholar
• NAKAE S, KOMIYAMA Y, NAMBU A et al.: Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity (2002) 17:375–387.
   PubMed Web of Science ®Google Scholar
• ••Important study demonstrating theconsequences of IL-17 ablation in mice. IL-17 plays a role in T cell sensitisation to antigen.
   Google Scholar
• ANTONYSAMY MA, FANSLOW WC, FU F et al: Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. Immunol (1999) 162:577–584.
   Google Scholar
• SCHWARZENBERGER P, KOLLS JK: Interleukin-17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis." Cell. Biochem. (2002) S38:88–95.
   Google Scholar
• ••Shows that IL-17 is a link between T cellactivation and haematopoiesis.
   Google Scholar
• SCHWARZENBERGER P, HUANG W, YE P et al: Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. Immunol (2000) 164:4783–4789.
   Google Scholar
• SCHWARZENBERGER P, HUANG W, OLIVER P et al: IL-17 mobilizes peripheral blood stem cells with short- and long-term repopulating ability in mice.," Immunol(2001) 167:2081–2086.
   Google Scholar
• LI H, CHEN J, HUANG A etal.: Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Pim Natl. Acad. Sci.USA (2000) 97:773–778.
   Google Scholar
• ••First description of IL-17B and IL–17C.
   Google Scholar
• SHI Y, ULLRICH SJ, ZHANG Jet al.: A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. Biol. Chem. (2000) 275:19167–19176.
   Google Scholar
• ••First description of IL-17Rhl (IL-17BR).
   Google Scholar
• MOORE EE, PRESNELL S, GARRIGUES U etal.: Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neummusad Disord (2002) 12:141–150.
   Google Scholar
• HURST SD, MUCHAMUEL T, GORMAN DM et al.: New IL-17 family members promote Thl or Th2 responses in the lung: in vivo function of the novel cytokine IL-25.11rnmunol (2002) 169:443–453.
   Google Scholar
• ••Functional characterisation in vivoof several IL-17 family members, including IL-17E (IL–25).
   Google Scholar
• STARNES T, BROXMEYER HE, ROBERTSON MJ, HROMAS R: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. Immunol (2002) 169:642–646.
   Google Scholar
• ••Description and initial functionalcharacterisation of IL-17D. Sequence alignment of IL-17 cytokine family members.
   Google Scholar
• LEE J, HO WH, MARUOKA M et al: IL-17E, a novel proinflammatory ligand for the IL-17 receptor homologBiol. Chem. (2001) 276:1660-1664.
   Google Scholar
• ••Demonstrates that IL-17E is a high affinityligand for IL-17Rhl.
   Google Scholar
• KIM MR, MANOUKIAN R, YEH R et al.: Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood (2002) 100:2330–2340.
   PubMed Web of Science ®Google Scholar
• FORT MM, CHEUNG J, YEN D et al: IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity (2001) 15:985–995.
   PubMed Web of Science ®Google Scholar
• ••First evidence that IL-17E (IL-25) isproduced by Th2 cells and induces the production of Th2 cytokines in vivo.
   Google Scholar
• IKEDA K, NAKAJIMA H, SUZUKI K et al.: Mast cells produce interleukin-25 upon Fc{E}RI-mediated activation. Blood In Press. [Electronically published ahead of print].
   Google Scholar
• ••Shows that activated mast cells produceIL-17E (IL-25) in mice.
   Google Scholar
• PANG, FRENCH D, MAO W et al: Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in Immunol (2001) 167:6559–6567.
   Google Scholar
• STARNES T, ROBERTSON MJ, SLEDGE G et al.: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. Immunol (2001) 167:4137–4140.
   Google Scholar
• NUMASAKI M, FUKUSHI JI, ONO M et al.: Interleukin-17 promotes angiogenesis and tumor growth. Blood In Press. [Electronically published ahead of print].
   Google Scholar
• ••IL-17 has pro-angiogenic activity.
   Google Scholar
• KAWAGUCHI M, ONUCHIC LF, HUANG SK: Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-i.j Biol. Chem. (2002) 277:15229–15232.
   PubMedGoogle Scholar
• YE P, RODRIGUEZ FH, KANALY S et al.:Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. (2001) 194:519–527.
   PubMed Web of Science ®Google Scholar
• TIAN E, SAWYER JR, LARGAESPADA DA et al.: Evi27 encodes a novel membrane protein with homology to the IL-17 receptor. Oncogene (2000) 19:2098–2109.
   PubMedGoogle Scholar
• HAUDENSCHILD D, MOSELEYT, ROSE L, REDDI AH: Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. Biol. Chem. (2002) 277:4309–4316.
   Google Scholar
• ••Description of IL-17Rh2 (IL-17RL) and itsmultiple splice variants.
   Google Scholar
• KINUGASA T, SAKAGUCHI T, GU X, REINECKER HC: Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology (2000) 118:1001–1011.
   PubMed Web of Science ®Google Scholar
• LAAN M, LOTVALL J, CHUNG KF, LINDEN A: IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogen-activated protein (MAP) kinases. Br. Pharmacol (2001) 133:200–206.
   PubMed Web of Science ®Google Scholar
• •Involvement of MAP kinases in IL-17 signalling.
   Google Scholar
• KAWAGUCHI M, KOKUBU F, KUGA H et al.: Modulation of bronchial epithelial cells by IL-17. j. Allergy Clin. Immunol (2001) 108:804–809.
   PubMed Web of Science ®Google Scholar
• HATA K, ANDOH A, SHIMADA M et al.: IL-17 stimulates inflammatory responses via NF-icB and MAP kinase pathways in human colonic myofibroblasts. Am. PhysioL Gastrointest. Liver Physic] (2002) 282:G1035–1044.
   PubMed Web of Science ®Google Scholar
• •Roles of MAP kinases and NF-KB in IL-17 signalling.
   Google Scholar
• KEHLEN A, THIELE K, RIEMANN D, LANGNER J: Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Clin. Exp. Immunol (2002) 127:539–546.
   PubMed Web of Science ®Google Scholar
• KYRIAKIS JM, AVRUCH J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 81:807–869.
   PubMed Web of Science ®Google Scholar
• BENDERDOUR M, TARDIF G, PELLETIER JP et al.: Interleuldn 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-113. Rheumatol (2002) 29:1262–1272.
   Google Scholar
• LI Q,VERIVIA IM: NF-icB regulation in theimmune system. Nat. Rev Immunol (2002) 2:725–734.
   PubMed Web of Science ®Google Scholar
• SHALOM-BARAK T, QUACH J, LOTZ M: Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-icB. I. Biol. Chem. (1998) 273:27467–27473.
   Google Scholar
• AWANE M, ANDRES PG, LI DJ, REINECKER HC: NF-ic B-inducing kinase is a common mediator of IL-17-, TNF- a-, and IL-1 I3-induced chemokine promoter activation in intestinal epithelial cells. Immunol (1999) 162:5337–5344.
   Google Scholar
• •IL-17, TNF-a and IL-113 share NEKB-inducing kinase in their signalling mechanisms.
   Google Scholar
• VAN BEZOOIJEN RL, PAPAPOULOS SE, LOWIK CW: Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-KB and receptor activator of nuclear factor icB (RANK)/RANK ligand signaling? Bone (2001) 28:378–386.
   PubMed Web of Science ®Google Scholar
• OJO-AMAIZE EA, KAPAHI P, KAKKANAIAH VN et al.: Hypoestwdde, a novel anti-inflammatory natural diterpene, inhibits the activity of IicB kinase. Cell Immunol (2001) 209:149–157.
   PubMedGoogle Scholar
• BRADLEY JR, POBER JS: Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene (2001) 20:6482–6491.
   PubMedGoogle Scholar
• CHUNG JY, PARK YC, YE H, WU H: Ail TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. I Cell Sci. (2002) 115:679–688.
   PubMed Web of Science ®Google Scholar
• SCHWANDNER R, YAMAGUCHI K, CAO Z: Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. I Exp. Med. (2000) 191:1233–1240.
   PubMed Web of Science ®Google Scholar
• ••TRAF6 associates with IL-17R and isinvolved in IL-17 signaling.
   Google Scholar
• SUBRAMANIAM SV, COOPER RS, ADUNYAH SE: Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem. Biophys. Res. Commun. (1999) 262:14–19.
   PubMed Web of Science ®Google Scholar
• GOLDBACH-MANSKY R, LIPSKY PE: New concepts in the treatment of rheumatoid arthritis. Ann. Rev Med (2003) 54:197–216.
   PubMed Web of Science ®Google Scholar
• GABAY C: Cytokine inhibitors in the treatment of rheumatoid arthritis. Expert Opin. Biol. The]: (2002) 2:135–149.
   PubMed Web of Science ®Google Scholar
• MIOSSEC P: Cytokines in rheumatoid arthritis: is it all TNF-a? Cell. Ma Biol. (2001) 47:675–678.
   Google Scholar
• CHABAUD M, DURAND JM, BUCHS N et al.: Human interleukin-17: a T cell derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. (1999) 42:963–970.
   PubMed Web of Science ®Google Scholar
• •Production of IL-17 in the joints of RA patients.
   Google Scholar
• JOVANOVIC DV, MARTEL- PELLETIER J, DI BATTISTA JA et al.: Stimulation of 9 2-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/ macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum. (2000) 43:1134–1144.
   Google Scholar
• HONORATI MC, MELICONI R, PULSATELLI L et al.: High M vivo expression of interleukin-1 7 receptor in synovial endothelial cells and chondrocytes from arthritis patients. Rheumatology (2001) 40:522–527.
   PubMed Web of Science ®Google Scholar
• HONORATI M, BOVARA M, CATTINI L, PIACENTINI A, FACCHINI A: Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage (2002) 10:799-807. ao. WIPKE BT, ALLEN PM: Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. Immunol (2001) 167:1601–1608.
   Google Scholar
• MATSUI T, AKAHOSHI T, NAMAI R et al.:Selective recruitment of CCR6-expressing cells by increased production of MIP-3 a in rheumatoid arthritis. Clin. Exp. Immunol (2001) 125:155–161.
   PubMed Web of Science ®Google Scholar
• ATTUR MG, PATEL RN, ABRAMSON SB, AMIN AR: Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum. (1997) 40:1050–1053.
   PubMed Web of Science ®Google Scholar
• BERNARDEAU C, DERNIS-LABOUS E, BLANCHARD H, LAMARQUE D, BREBAN M: Nitric oxide in rheumatology. Joint Bone Spine (2001) 68:457–462.
   PubMedGoogle Scholar
• CAI L, SUBOC P, HOGUE DA, FEI DT, FILVAROFF EH: Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown. .1 Rheumatol (2002) 29:1725–1736.
   PubMedGoogle Scholar
• VAN BEZOOIJEN RL, VAN DER WEE-PALS L, PAPAPOULOS SE, LOWIK CW: Interleukin 17 synergises with tumour necrosis factor a to induce cartilage destruction M vitro. Ann. Rheum. Dis. (2002) 61:870–876.
   PubMed Web of Science ®Google Scholar
• CHABAUD M, GARNERO P, DAYERJM et al.: Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine (2000) 12:1092–1099.
   PubMed Web of Science ®Google Scholar
• JOVANOVIC DV, DI BATTISTA JA, MARTEL-PELLETIER J et al: Modulation of TIMP-1 synthesis by anti-inflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/ macrophages. Rheumatol (2001) 28:712–718.
   Web of Science ®Google Scholar
• KOSHY PJ, HENDERSON N, LOGAN C et al.: Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann. Rheum. Dis. (2002) 61:704–713.
   PubMed Web of Science ®Google Scholar
• ••IL-17 induces cartilage breakdown insynergy with TNF-a and IL–10.
   Google Scholar
• ARNER EC: Aggrecanase-mediated cartilage degradation. Curr: Opin. Pharmacol (2002) 2:322–329.
   PubMed Web of Science ®Google Scholar
• CAI L, YIN JP, STAROVASNIK MA et al.: Pathways by which interleukin 17 induces articular cartilage breakdown M vitro and in vivo. Cytokine (2001) 16:10–21.
   PubMed Web of Science ®Google Scholar
• PALMQVIST P, PERSSON E, CONAWAY HH, LERNER UH: IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-icB ligand, osteoprotegerin, and receptor activator of NF-xB in mouse calvariae. .1 Immunol (2002) 169:3353–3362.
   Google Scholar
• NAKASHIMA T, KOBAYASHI Y, YAMASAKI S et al.: Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-xB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem. Biophys. Res. Commun. (2000) 272:768–775.
   Google Scholar
• ROMAS E, GILLESPIE MT, MARTIN TJ: Involvement of receptor activator of NFicB ligand and tumor necrosis factor-a in bone destruction in rheumatoid arthritis. Bone (2002) 30:340–346.
   PubMed Web of Science ®Google Scholar
• CHABAUD M, LUBBERTS E, JOOSTEN L, VAN DEN BERG W, MIOSSEC P: IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res (2001) 3:168–177.
   PubMedGoogle Scholar
• ••Evidence that IL-17 contributes to boneerosion in RA.
   Google Scholar
• DUDLER J, RENGGLI-ZULLIGER N, BUSSO N, LOTZ M, SO A: Effect of interleukin 17 on proteoglycan degradation in murine knee joints. Ann. Rheum. Dis. (2000) 59:529–532.
   PubMed Web of Science ®Google Scholar
• HOLMDAHL R, BOCKERMANN R, BACKLUND J, YAMADA H: The molecular pathogenesis of collagen-induced arthritis in mice-a model for rheumatoid arthritis. Ageing Res. Rev (2002) 1:135–147.
   PubMed Web of Science ®Google Scholar
• LUBBERTS E, JOOSTEN LA, OPPERS B et al.: IL- 1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. Immunol (2001) 167:1001–1013.
   Google Scholar
• ••Treatment with IL-17R:Fc fusion proteinattenuates joint destruction in mouse model of RA.
   Google Scholar
• LUBBERTS E, JOOSTEN LA, VAN DE LOO FA et al: Overexpression of IL-17 in the knee joint of collagen Type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm. Res. (2002) 51:102–104.
   PubMed Web of Science ®Google Scholar
• LUBBERTS E, VAN DEN BERSSELAAR L, OPPERS-WAL GREENB et al.: IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-xB ligand/osteoprotegerin balance. J Immunol (2 00 3) (in press). loo. BUSH KA, FARMER KM, WALKER JS, KIRKHAM BW: Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. (2002) 46:802–805.
   Google Scholar
• ••Treatment with IL-17R:Fc fusion proteinattenuates joint destruction in rat model of RA.
   Google Scholar
• CHABAUD M, MIOSSEC P: The combination of tumor necrosis factor a blockade with interleukin-1 and interleukin-1 7 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo model. Arthritis Rheum. (2001) 44:1293–1303.
   PubMedGoogle Scholar
• ••IL-17R:Fc fusion protein potentiates thebeneficial effect of TNF-a and IL-1 blockade in an ex vivo model of joint inflammation.
   Google Scholar
• LAAN M, CUT ZH, HOSHINO H et al: Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. .1. Immunol (1999) 162:2347–2352.
   PubMed Web of Science ®Google Scholar
• JONES CE, CHAN K: Interleuldn-17 stimulates the expression of interleukin-8 growth-related oncogene-a, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am. J. Respir. Cell. MM. Biol. (2002) 26:748–753.
   PubMed Web of Science ®Google Scholar
• YE P, GARVEY PB, ZHANG Petal.: Interleukin-17 and lung host defense against Klebsiella pneumoniaeinfection. Am. I Respir: Cell. Ma Biol. (2001) 25:335–340.
   Google Scholar
• HOSHINO H, LAAN M, SJOSTRAND M et al.: Increased elastase and myeloperwddase activity associated with neutrophil recruitment by IL-17 in airways M vivo. I Allergy Clin. Immunol (2000) 105:143–149.
   PubMed Web of Science ®Google Scholar
• LAAN M, PALMBERG L, LARSSON K, LINDEN A: Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur. Respir. (2002) 19:534–537.
   PubMed Web of Science ®Google Scholar
• •IL-17 is released in the lung during airway inflammation in human.
   Google Scholar
• LARSSON R, ROCKSEN D, LILLIEHOOK B, JONSSON A, BUCHT A: Dose-dependent activation of lymphocytes in endotoxin-induced airway inflammation. Infect. Inman. (2000) 68:6962–6969.
   PubMedGoogle Scholar
• WONG CK, HO CY, KO FW et al: Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-y, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol (2001) 125:177–183.
   PubMed Web of Science ®Google Scholar
• HELLINGS PW, KASRAN A, LIU Z et al: Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am. J. Respir: Cell Ma Biol. (2003) 28:42–50.
   Google Scholar
• ••Demonstrates that IL-17 is responsible forairway neutrophilia but may dampen IL-5 production in a mouse model of allergic asthma.
   Google Scholar
• ORDONEZ CL, SHAUGHNESSY TE, MATTHAY MA, FAHY JV: Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: clinical and biologic significance. Am. Respir. Crit. Care Med. (2000) 161:1185–1190.
   PubMed Web of Science ®Google Scholar
• LITTLE SA, MACLEOD KJ, CHALMERS GW et al.: Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. Am.j Med. (2002) 112:446–452.
   PubMed Web of Science ®Google Scholar
• STOCKLEY RA: Neutrophils and the pathogenesis of COPD. Chest (2002) 121:1515-155S.
   Google Scholar
• CHMIEL JF, BERGER M, KONSTAN MW: The role of inflammation in the pathophysiology of CF lung disease. Clin. Rev Allergy Immunol (2002) 23:5–27.
   PubMed Web of Science ®Google Scholar
• LINDEN A: Role of interleukin-17 and the neutrophil in asthma. Int. Arch. Allergy Appl. Immunol (2001) 126:179–184.
   Google Scholar
• LAAN M, LINDEN A: IL-17 as a potential target for modulating airway neutrophilia. Carr. Pharm. Des. (2002) 8:1855–1861.
   PubMed Web of Science ®Google Scholar
• ••Excellent review of the role of IL-17 inairway inflammation.
   Google Scholar
• UMETSU DT, MCINTIRE JJ, AKBARI 0, MACAUBAS C, DEKRUYFF RH: Asthma: an epidemic of dysregulated immunity. Nat. Immunol (2002) 3:715–720.
   PubMed Web of Science ®Google Scholar
• LUZZA F, PARRELLO T, MONTELEONE G et al: Up-regulation of IL-17 is associated with bioactive IL-8 expression in Hel/wbacterpyloii-infected human gastric mucosa." Immunol (2000) 165:5332–5337.
   PubMed Web of Science ®Google Scholar
• CHUNG DR, CHITNIS T, PANZO RJ et al.: CD4+ T cells regulate surgical and postinfectious adhesion formation. " Exp. Med. (2002) 195:1471–1478.
   Google Scholar
• ••Very interesting study implicating IL-17 as apossible mediator of abdominal adhesion formation.
   Google Scholar
• CHUNG DR, KASPER DL, PANZO RJ et al.: CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17 dependent mechanism. Immunol (2003) 170: 1958-1963.
   Google Scholar
• TEUNISSEN MB, KOOMEN CW, DE WAAL MALEFYT R, WIERENGA EA, BOS JD: Interleukin-17 and interferon-y synergize in the enhancement of proinflammatory cytokine production by human keratinocytes." Invest. Dermatol (1998) 111:645–649.
   PubMed Web of Science ®Google Scholar
• HOMEY B, DIEU-NOSJEAN MC, WIESENBORN A et al: Up-regulation of macrophage inflammatory protein-3 a/CCL20 and CC chemokine receptor 6 in psoriasis. Immunol (2000) 164:6621–6632.
   Google Scholar
• GIROLOMONI G, SEBASTIANI S, ALBANESI C, CAVANI A: T-cell subpopulations in the development of atopic and contact allergy. Carr: Opin. Immunol (2001) 13:733–737.
   PubMed Web of Science ®Google Scholar
• KURASAWA K, HIROSE K, SANO H et al: Increased interleukin-17 production in patients with systemic sclerosis. Arthritic Rheum. (2000) 43:2455–2463.
   PubMed Web of Science ®Google Scholar
• MATUSEVICIUS D, KIVISAKK P, HE B et al.: Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Malt. Scler: (1999) 5:101–104.
   Google Scholar
• LOCK C, HERMANS G, PEDOTTI R et al.: Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. (2002) 8:500–508.
   PubMed Web of Science ®Google Scholar
• ANDOH A, HATA K, ARAKI Y, FUJIYAMA Y, BAMBA T: Interleukin (IL) -4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. Int. .1. MM. Med. (2002) 10:631–614.
   Google Scholar
• FUJINO S, ANDOH A, BAMBA S et al: Increased expression of interleukin 17 in inflammatory bowel disease. Gut (2003) 52:65–70.
   PubMed Web of Science ®Google Scholar
• •Suggests a role for IL-17 in inflammatory bowel disease.
   Google Scholar
• PELIDOU SH, ZOU LP, DERETZI G et al.: Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role. Exp. Nemo]. (2000) 163:165–172.
   PubMed Web of Science ®Google Scholar
• HSIEH HG, LOONG CC, LUI WY, CHEN A, LIN CY: IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection. Transplant Int. (2001) 14:287–298.
   PubMed Web of Science ®Google Scholar
• LOONG CC, HSIEH HG, LUI WY, CHEN A, LIN CY: Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. Pathol (2002) 197:322–332.
   Google Scholar
• TANG JL, SUBBOTIN VM, ANTONYSAMY MA et al.: Interleuldn-17 antagonism inhibits acute, but not chronic, vascular rejection. Transplantation (2001) 72:348–350.
   PubMed Web of Science ®Google Scholar
• ••Blocking IL-17 with IL-17R:Fc fusionprotein attenuates acute but not chronic rejection of aorta allograft in mice.
   Google Scholar
• DUMONT FJ: Immunosuppressive strategies for prevention of transplant rejection. Expert Opin. Ther. Patents (2001) 11:377–404.
   Web of Science ®Google Scholar
• WOLTMAN AW, DE FIJTER JW, VAN DER KOOIJ SW et al: Potential role for MIP-3a produced by renal epithelial cells in the attraction of DC during renal allograft rejection. Am. Transplant Congress (26–27 April 2002) Abst 904.
   Google Scholar
• TARTOUR E, FOSSIEZ F, JOYEUX let al.: Interleukin 17, a T cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. (1999) 59:3698–3704.
   Google Scholar
• •IL-17 promotes tumourigenesis in T cell-deficient mice.
   Google Scholar
• KATO T, FURUMOTO H, OGURA T et al.: Expression of IL-17 mRNA in ovarian cancer. Biochem. Biophys. Res. Commun. (2001) 282:735–738.
   PubMed Web of Science ®Google Scholar
• HIRAHARA N, NIO Y, SASAKI Set al.: Reduced invasiveness and metastasis of Chinese hamster ovary cells transfected with human interleukin-17 gene. Anti-Cancer Res. (2000) 20:3137–3142.
   Google Scholar
• HIRAHARA N, NIO Y, SASAKI S et al.: Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Oncology(2001) 61:79–89.
   PubMed Web of Science ®Google Scholar
• BENCHETRIT F, CIREE A, VIVES V et al.: Interleukin-17 inhibits tumor cell growth by means of a T cell-dependent mechanism. Blood (2002) 99:2114–2121.
   PubMed Web of Science ®Google Scholar
• ••IL-17 promotes the generation of tumourantigen-specific cytolytic T lymphocytes in mice.
   Google Scholar
• CAVAILLON JM: Pro- versus anti-inflammatory cytokines: myth or reality. Cell MM. Biol. (2001) 47:695–702.
   PubMed Web of Science ®Google Scholar
• CUZZOCREA S, MAZZON E, DUGO L et al.: Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. Cytokine (2002) 18:274–285.
   PubMed Web of Science ®Google Scholar
• MOCELLIN S, PANELLI MC, WANG E, NAGORSEN D, MARINCOLA FM: The dual role of IL-10. Trends Immunol (2003) 24:36–43.
   PubMed Web of Science ®Google Scholar