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Expert Opinion on Therapeutic Patents Volume 13, 2003 - Issue 6
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Miscellaneous

Homogenous non-isotopic assays for histone deacetylase activity

Manfred Jung Westfälische Wilhelms-Universität Münster, Department of Pharmaceutical and Medicinal Chemistry, Hittorfstrasse 58 – 62, 48149 Münster, Germany. jungm@uni-münster.de
Page 935 | Published online: 02 Mar 2005

Bibliography

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  • WEGENER D, WIRSCHING F, RIESTER D, SCHWIENHORST A: A fluorogenic histone deacetylase assay well suited for high-throughput activity screening. Chem. Biol. (2003) 10:61–68.
  • HOFFMANN K, BROSCH G, LOIDL P,JUNG M: A non-isotopic assay for histone deacetylase activity. Nucleic Acids Res. (1999) 27:2057–2058.
  • HELTWEG B, JUNG M: A micro plate reader based non-isotopic histone deacetylase activity assay. Anal. Biochem. (2002) 302:175–183.
  • HELTWEG B, JUNG M: A homogeneous non-isotopic histone deacetylase activity assay. Biomol. Screen. (2003) 8:89–95.
  • GRAY SG, EKSTROM TJ: The human histone deacetylase family. Exp. Cell Res. (2001) 262:75–83.
  • HELTWEG B, DEQUIEDT F, VERDIN E,JUNG M: A non isotopic substrate for assaying both human zinc and NAID±-dependent histone deacetylases. Anal. Biochem. (2003) [in press].

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