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Editorial

Emerging approaches to the treatment of asthma: highlights from the patents of 2001 and 2002

Pages 949-956 | Published online: 02 Mar 2005

Bibliography

  • NORMAN P: New approaches to asthma therapy; trends from the patent literature 1993-1997. Expert Opin. Ther. Patents (1997) 7:677–686.
  • ••Previous analyses of patenting in these fields.
  • TERAN LM: CCL chemokines and asthma. NIH global strategy for asthma management and prevention April 2002. bronunol Today (2000) 21(5):235–242.
  • •Useful review on chemokines and asthma.
  • BERTRAND CP, PONATH PD: CCR3 blockade as a new therapy for asthma. Expert Opin. Investig. Drugs. (2000) 9(1):43–52.
  • •Good review of the potential of CCR3 antagonists.
  • BLANPAIN C, LIBERT F, VASSART G, PARMENTIER M: CCR5 and HIV infection. Receptors Channels (2002) 8(1):19–31.
  • MCKENNIFF M, ROD GER IW, NORMAN P, GARDINER PJ: Characterisation of receptors mediating the contractile effects of prostanoids in guinea-pig and human airways. Eur. Phartnacol (1988) 153(2-3):149–159.
  • JACKSON DY: a4 integrin antagonists. Carr: Phartn. Des. (2002) 8(14):1229–1253.
  • SPENCE S, VETTER C, HAGMANN WK et al.: Effects of VLA-4 antagonists in rat whole embryo culture. Teratology (2002) 65 (1) : 26–37.
  • BARNES PJ: Cytokine-directed therapies for asthma. I Allergy Clin. bronunol (2001) 108(2 Suppl.):S72–S76.
  • •Useful review on cytokines and asthma.
  • NO AUTHORS LISTED: Small molecule IL-4 antagonists. Expert Opin. Ther. Patents (2002) 12(7):1103–1105.
  • KARIN M, DELHASE M: The I icB kinase (IKK) and NF-icB: key elements of proinflammatory signalling. &min. Irronunol (2000) 12(1):85–98.
  • STENTON GR, KIM MK, NOHARA O et al.: Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation. Irronunol (2000) 164(7):3790–3797.
  • MALAVIYA R, CHEN CL, NAVARA C et al.: Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyflamino-6,7-dimethoxyquinazoline (WHI-P97). Phartnacol Exp. Ther. (2000) 295 (3):912–926.
  • SOUSA AR, LANE SJ, SOH C, LEE TH: In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation. I Allergy Clio. Itinnunol. (1999) 104(3 Pt 1):565–574.
  • EVANS DJ, CULLINAN P, GEDDES DM: Cyclosporin as an oral corticosteroid sparing agent in stable asthma. Cochrane Database Syst. Rev (2001) 2:CD002993.
  • SMITH SJ, BROOKES-FAZAKERLEY S, DONNELLY LE et al.: Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells. Am.j Physiol Lung Cell Ma Physiol (2003) 284(2)1279–L892.
  • NO AUTHORS LISTED: PDE7 inhibitors. Expert Opin. Ther. Patents (2002) 12 (4):601–603.
  • SCHMIDLIN F, AMADESI S, DABBAGH K et al: Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway.' Immunol. (2002) 169(9):5315–5321.
  • RIESE RI, CHAPMAN HA: Cathepsins and compartmentalization in antigen presentation. Curt: Opin. Immunol. (2000) 12(1):107–113.
  • DONNELLY LE, BARNES RI: Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells. Am. J. Respir. Cell Mol. Biol. (2002) 26(1):144–151.
  • HANSELL TT, BARNES PJ: Novel drugs for treating asthma. Curr. Allergy Asthma Rep. (2001) 1(2):164–173.
  • O'REILLY M, ALPERT R, JENKINSON S et al.: Identification of a histamine H4 receptor on human eosinophils-role in eosinophil chemotaxis. I Recept. Signal Tansduct. Res. (2002) 22(1–4):431–448.

Website

  • http://www.gene.com/gene/news/press-releases/detailjsp?detail5707
  • http://www.altana.com/root/ index.php?langen&page_id261

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