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Review

Recent developments in West Nile virus vaccine and antiviral therapy

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Pages 1113-1125 | Published online: 02 Mar 2005

Bibliography

  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Provisional surveillance summary of the West Nile virus epidemic-United States, January - November 2002. Morb. Mortal. Wkly Rep. (2002) 51:1129–1133.
  • LINDENBACH BD, RICE CM: Flaviviruses. In: Fields Virology (4th edb). Knipe DM, Howley PM (Eds), Lippincott William & Wilkins, Philadelphia, USA (200 1) :991–1042.
  • BURKE DS, MONATH TP: Flaviviruses: In: Fields Virology (4th edn). Knipe DM, Howley PM (Eds), Lippincott William & Wilkins, Philadelphia, USA (2000:1043–1126.
  • LANCIOTTI RS, ROEHRIG JT, DEUBEL V et al: Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science (1999) 286:2333–2337.
  • BERTHET FX, ZELLER HG, DROUET MT et al: Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses. J. Gen. Vim]. (1997) 78:2293–2297.
  • JORDAN I, BRIESE T, LIPKIN WI: Discovery and molecular characterization of West Nile virus NY 1999. Viral Immunol (2000) 13:435–446.
  • LANCIOTTI R, EBEL G, DEUBEL DV et al.: Complete genome sequence and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe and the Middle East. Virology (2002) 298:96–105.
  • SMITHBURN KC, HUGHES TP, BURKE AW et al: A neurotropic virus isolated from the blood of a native of Uganda. Am. I Trop. Med. (1940) 20:471–492.
  • PETERSEN LR, ROEHRIG JT: West Nile virus: a re-emerging global pathogen. Emerg. Infect. Dis. (2001) 7:611–614.
  • TURELL M, SARDELIS M, DOHM D et al.: Potential North American vectors of West Nile virus. Ann. NY Acad. Sci. (2001) 951:317–324.
  • KOMAR N, LANGEVIN S, BUNNING Met al.: Reservoir competence of wild birds for West Nile virus. Proc. Ann. Conf Am. Mow. Control Assoc. (2001) 33.
  • BERNARD KA, KRAMER LD: West Nile virus activity in the United States, 2001. Viral Immunol (2001) 14:319–338.
  • RAPPOLE J, DERRICKSON S, HUBALEK Z: Migratory birds and spread of West Nile virus in the Western Hemisphere. Emerg. Infect. Dis. (2000) 6:319–328.
  • BERNARD KA, MAFFEI JG, JONES SA et al.: West Nile virus infection in birds and mosquitoes, New York State, 2000. Emerg. Infect. Dis. (2001) 7:679–685.
  • NASCI R, WHITED, STIRLING H et al: West Nile virus isolates from mosquitoes in New York and New Jersey, 1999. Emerg. Infect. Dis. (2001) 7:626–630.
  • MAGNARELLI L: Host feeding patterns of Connecticut mosquitoes (Diptera: Culicidae). Am. J. Trop. Med. Hyg. (1977) 23:547–552.
  • JUPP P: The ecology of West Nile virus inSouth Africa and the occurrence of outbreaks in humans. Ann. NY Acad. Sci. (2001) 951:143–152.
  • TAYLOR R, WORK T, HURLBUT H et al.: A study of the ecology of West Nile virus in Egypt. Am. J. Trop. Med. Hyg. (1956) 5:579.
  • HAYES C: The Arboviruses: West Nile fever.In: The Arboviruses: Epidemiology and Ecology Monath TP (Ed.), CRC Press, Inc., Boca Raton, Florida, USA (1989) 49:59–88.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Update: investigations of West Nile virus infections in recipients of organ transplantation and blood transfusion - Michigan, 2002. Morb. Mortal. Wkly Rep. (2002) 51:879.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Possible West Nile virus transmission to an infant through breast-feeding - Michigan, 2002. Morb. Mortal. Wkly Rep. (2002) 51:877–878.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Intrauterine West Nile virus infection - New York, 2002. Morb. Mortal. Wkly Rep. (2002) 51:1135–1136.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Laboratory-acquired West Nile virus infections-United States, 2002. Morb. Mortal. Wkly Rep. (2002) 51:1133–1135.
  • NASH D, MOSTASHARI F, FINE A et al.:West Nile Outbreak Response Working Group. The outbreak of West Nile virus infection in the New York City area in 1999. N. Engl. J. Med. (2001) 344:1807–1814.
  • WEINBERGER M, PITLIK S, GANDACU D et al: West Nile fever outbreak, Israel, 2000: epidemiologic aspects. Emerg. Infect. Dis. (2001) 7:686–691.
  • MOSTASHARI F, BUNNING M, KITSUTANI P et al.: Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey. Lancet (2001) 358:261–264.
  • MARFIN AA, PETERSEN LR, EIDSON M et al.: Widespread West Nile virus activity, eastern United States, 2000. Emerg. Infect. Dis. (2001) 7:730–735.
  • GOLDBLUM M, STERK V, PADERSKI B: The clinical features of the disease and the isolation of West Nile virus from the blood of nine human cases. Am. Hyg. (1954) 59:89–103.
  • CAMPBELL G, MARFIN A, LANCIOTTI R et al.: West Nile virus. Lancet Infect. Dis. (2002) 2:519–529.
  • SAMPSON BA, AMBROSI C, CHARLOT A et al.: The pathology of human West Nile Virus infection. Human Pathol (2000) 31:527–531.
  • CENTERS FOR DISEASE CONTROL AND PREVENTION: Acute flaccid paralysis syndrome associated with West Nile virus infection-Mississippi and Lousiana, July - August 2002. Morb. Mortal. Wkly Rep. (2002) 51:823–827.
  • CHOWERS M, LANG R, NASSAR F et al: Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg. Infect. Dis. (2000) 7:675–678.
  • TAYLOR R, WORK T, HURLBUT H et al: A study of the ecology of West Nile virus in Egypt. Am. J. Trop. Med. Hyg. (1956) 5:579–620.
  • CHAMBERS TJ, HAHN CS, GALLER R et al.: Flavivirus genome organization, expression, and replication. Ann. Rev Microbial. (1990) 44:649–688.
  • BRINTON MA: The molecular biology of West Nile virus: a new invader of the Western hemisphere. Ann. Rev Microbiol (2002) 56:371–402.
  • •A comprehensive review of the molecular biology of WNV.
  • BRINTON MA, FERNANDEZ AV, DISPOTO JH: The 3'-nucleotides of flavivirus genomic RNA form a conserved secondary structure. Virology (1986) 153:113–121.
  • BRINTON MA, DISPOTO JH: Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA. Virology (1988) 162:290–299.
  • SHI PY, BRINTON MA, VEAL JM et al:Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA. Biochemistry (Marc) (1996) 35:4222–4230.
  • RICE CM, LEN CHES EM, EDDY SR et al: Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution. Science (1985) 229:726–733.
  • WALLNER G, MANDL CW, KUNZ C et al.: The flavivirus 3'-non-coding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus. Virology (1995) 213:169–178.
  • CAHOUR A, PLETNEV A, VAZIELLE-FALCOZ M et al.: Growth-restricted dengue virus mutants containing deletions in the 5' non-coding region of the RNA genome. Virology (1995) 207:68–76.
  • •This paper describes that deletions in the 5'UTR can be used to attenuate DEN virus.
  • MEN R, BRAY M, CLARK D et al.: Dengue Type 4 virus mutants containing deletions in the 3' non-coding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. .1 Virol. (1996) 70:3930–3937.
  • ••This paper demonstrates that deletions inthe 3'UTR attenuate DEN virus.
  • ZENG L, FALGOUT B, MARKOFF L: Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue Type 2 virus genome required for replication. J. Virzi]. (1998) 72:7510–7522.
  • ••DEN virus containing a 3' stem-looppartially derived from WNV is attenuated. Such chimera virus can be used as a potential vaccine for DEN.
  • SHI PY, TILGNER M, LO MK et al.: Infectious cDNA clone of the epidemic West Nile virus from New York City. ./. Virol (2002) 76:5847–5856.
  • ••The first full-length infectious clone of thehuman epidemic strain of WNV is produced.
  • YOU S, FALGOUT B, MARKOFF L et al.: In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure. J. Biol. Chem. (2001) 276:15581–15591.
  • HAHN CS, HAHN YS, RICE CM et al: Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences. .1 Mo/. Biol. (1987) 198:33–41.
  • YOU S, PADMANABHAN R: A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5t-and 3'-terminal complementary sequence motifs of the viral RNA. J. Biol. Chem. (1999) 274:33714–33722.
  • KHROMYKH AA, MEKA H, GUYATT KJ et al.: Essential role of cyclization sequences in flavivirus RNA replication. J. Virol (2001) 75:6719–6728.
  • MOLENKAMP R, KOOI E, LUCASSEN M et al.: Yellow fever virus replicons as an expression system for hepatitis C virus structural proteins. J. Virol (2003) 77:1644–1648.
  • CORVER J, LENCHES E, SMITH K et al.: Fine mapping of a cis-acting sequence element in yellow fever virus RNA that is required for RNA replication and cyclization.Vico]. (2003) 77:2265–2270.
  • KHROMYKH AA, WESTAWAY EG: Subgenomic replicons of the flavivirus Kunjin: construction and applications. Virol (1997) 71:1497–1505.
  • BAZAN JF, FLETTERICK RJ: Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses. Virology (1989) 171:637–639.
  • GORBALENYA AE, DONCHENKO AP, KOONIN EV et al.: N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Nucleic Acids Res. (1989) 17:3889–3897.
  • ARIAS CF, PREUGSCHAT F, STRAUSS JH: Dengue 2 virus NS2B and N53 form a stable complex that can cleave N53 within the helicase domain. Virology (1993) 193:888–899.
  • PREUGS CHAT F, YAO CW, STRAUSS JH: hi vitro processing of dengue virus Type 2 non-structural proteins NS2A, NS2B, and NS3. Viral. (1990) 64:4364–4374.
  • YUSOF R, CLUM S, WETZEL M et al: Purified NS2B/N53 serine protease of dengue virus Type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro. I Biol. Chem. (2000) 275:9963–9969.
  • WARRENER P, TAMURA JK, COLLETT MS: RNA-stimulated NTPase activity associated with yellow fever virus N53 protein expressed in bacteria. J. Viral. (1993) 67:989–996.
  • WENGLER G, WENGLER G: The carboxy-terminal part of the N53 protein of the West Nile flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase. Virology (1991) 184:707–715.
  • •First report to demonstrate NTPase activity of WNV N53 protein.
  • WENGLER G, WENGLER G: The N53 non-structural protein of flaviviruses contains an RNA triphosphatase activity. Virology (1993) 197:265–273.
  • •First study to show 5'-RTPase activity of WNV N53 protein.
  • BARTELMA G, PADMANABHAN R: Expression, purification, and characterization of the RNA 5'-triphosphatase activity of dengue virus Type 2 non-structural protein 3. Virology (2002) 299:122–132.
  • BOROWSKI P, NIEBUHR A, MUELLER O et al: Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme../. Viral. (2001) 75:3220–3229.
  • •First report to show helicase activity of WNV N53 protein.
  • LI H, CLUM S, YOU S et al: The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus Type 2 N53 converge within a region of 20 amino acids. Viral. (1999) 73:3108–3116.
  • ACKERMANN M, PADMANABHAN R: Be novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase. ./. Biol. Chem. (2001) 276:39926–39937.
  • GUYATT KJ, WESTAWAY EG, KHROMYKH AA: Expression and purification of enzymatically active recombinant RNA-dependent RNA polymerase (N55) of the flavivirus Kunjin. 'Viral. Methods (2001) 92:37–44.
  • TAN BH, FU J, SUGRUE RJ et al: Recombinant dengue Type 1 virus N55 protein expressed in Escherichia coil exhibits RNA-dependent RNA polymerase activity. Virology (1996) 216:317–325.
  • •The RdRp activity of NS5 gene from dengue virus described in this paper could be used to set up an assay for screening anti-polymerase inhibitors.
  • EGLOFF MP, BENARROCH D, SELISKO B et al.: An RNA cap (nucleoside-2'- O-) -methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J. (2002) 21:2757–2768.
  • ••First crystal structure of the MTase domainof NS5 gene for flaviviruses. The structure can serve as the basis for rational design of Inhibitors. In addition, the paper demonstrated, for the first time, the MTase activity of the NS5 protein.
  • KOONIN EV: Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and X2 protein of reovirus. J. Gen. Virol (1993) 74:733–740.
  • KHROMYKH A, KENNEY M, WESTAWAY E: trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells." Virol (1998) 72:7270–7279.
  • KHROMYKH AA, SEDLAK PL, WESTAWAY EG: trans-Complementation analysis of the flavivirus Kunjin NS5 gene reveals an essential role for translation of its N-terminal half in RNA replication. J. Virol (1999) 73:9247–9255.
  • KAPOOR M, ZHANG L, RAMACHANDRA M et al: Association between NS3 and NS5 proteins of dengue virus Type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5.J.Biol. Chem. (1995) 270:19100–19106.
  • BUCKLEY A, GAIDAMOVICH S, TURCHINSKAYA A et al: Monoclonal antibodies identify the NS5 yellow fever virus non-structural protein in the nuclei of infected cells. J. Gen. Virol (1992) 73:1125–1130.
  • LINDENBACH B, RICE C: trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication. Virol (1997) 71:9608–9617.
  • LINDENBACH BD, RICE CM: Genetic interaction of flavivirus non-structural proteins NS1 and NS4A as a determinant of replicase function." Virol (1999) 73:4611–4621.
  • KUMMERER BM, RICE CM: Mutations in the yellow fever virus non-structural protein NS2A selectively block production of infectious particles. J. Viral. (2002) 76:4773–4784.
  • HEINZ FX, ALLISON SL: Structures and mechanisms in flavivirus fusion. Advance Virus Res. (2000) 55:231–269.
  • MUYLAERT IR, CHAMBERS TJ, GALLER R et al.: Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: effects on virus replication and mouse neurovirulence. Virology (1996) 222:159–168.
  • DIAMOND MS, EDGIL D, ROBERTS TG et al.: Infection of human cells by dengue virus is modulated by different cell types and viral strains. J. Virol. (2000) 74:7814–7823.
  • SHI PY, TILGNER M, LO MK: Construction and characterization of subgenomic replicons of New York strain of West Nile virus. Virology (2002) 296:219–233.
  • WESTAWAY EG, MACKENZIE JM, KENNEY MT et al: Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and N53 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures. 1 Virol (1997) 71:6650–6661.
  • WESTAWAY EG, KHROMYKH AA, KENNEY MT et al: Proteins C and NS4B of the flavivirus Kunjin translocate independently into the nucleus. Virology (1997) 234:31–41.
  • MACKENZIE JM, KHROMYKH AA, JONES MK et al.: Subcellular localization and some biochemical properties of the flavivirus Kunjin non-structural proteins NS2A and NS4A. Virology (1998) 245:203–215.
  • BLACK WELL JL, BRINTON MA: BHK cell proteins that bind to the 3' stem-loop structure of the West Nile virus genome RNA. J. Virol. (1995) 69:5650–5658
  • BLACK WELL JL, BRINTON MA: Translation elongation factor-la interacts with the 3' stem-loop region of West Nile virus genomic RNA." Virol (1997) 71:6433–6444.
  • SHI PY, LI W, BRINTON MA: Cell proteins bind specifically to West Nile virus minus-strand 3' stem-loop RNA. J. Virol (1996) 70:6278–6287.
  • LI W, LI Y, KEDERSHA N et al: Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. J. Viral. (2002) 76:11989–12000.
  • REY FA, HEINZ FX, MANDL C et al: The envelope glycoprotein from tick-borne encephalitis virus at 2A resolution. Nature (1995) 375:291–298.
  • ••First crystal structure of the ectodomain ofthe E protein for flaviviruses.
  • MONATH T: Prospects for development of a vaccine against the West Nile virus. Ann. NY Acad. Li. (2001) 951:1–12.
  • DAVIS B, CHANG G, CROPP B et al: West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a non-infectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.' Virol (2001) 75:4040–4047.
  • KONISHI E, FUJII A, MASON PW: Generation and characterization of a mammalian cell line continuously expressing Japanese encephalitis virus subviral particles. Virol (2001) 75:2204–2212.
  • SCHALICH J, ALLISON S, STIASNY K et al.: Recombinant subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope glycoprotein functions. Virol (1996) 70:4549–4557.
  • WANG T, ANDERSON JF, MAGNARELLI LA et al.: Immunization of mice against West Nile virus with recombinant envelope protein. J. Immunol (2001) 167:5273–5277.
  • YANG JS, KIM JJ, HWANG D et al.: Induction of potent Thl -typeimmune responses from a novel DNA vaccine for West Nile virus New York isolate (WNV-NY1999). Infec. Dis. (2001) 184:809–816.
  • MONATH TP, ARROYO J, MILLER C et al.: West Nile virus vaccine. Curr. Drug Targets - Infect. Disorders (2001) 1:37–50.
  • ••YF 17D vaccine strain as a backbone to make chimera virus for WNV vaccine.
  • GUIRAKHOO F, ZHANG ZX, CHAMBERS TJ et al.: Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis. Virology (1999) 257:363–372.
  • MONATH TP, SOIKE K, LEVENBOOK I et al.: Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (5A14-14-2) virus and the capsid and non-structural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-human primates. Vaccine (1999) 17: 1869-1882.
  • MONATH TP, LEVENBOOK I, SOIKE K et al.: Chimeric yellow fever virus 17D-Japanese encephalitis virus vaccine: dose-response effectiveness and extended safety testing in rhesus monkeys. J. Virol (2000) 74:1742–1751.
  • GUIRAKHOO F, PUGACHEV K, ARROYO J et al.: Viremia and immunogenicity in non-human primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates. Virology (2002) 298:146–159.
  • GUIRAKHOO F, ARROYO J, PUGACHEV KV et al.: Construction, safety, and immunogenicity in non-human primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J. Viral. (2001) 75:7290–7304.
  • GUIRAKHOO F, WELTZIN R, CHAMBERS TJ et al.: Recombinant chimeric yellow fever-dengue Type 2 virus is immunogenic and protective in non-human primates. Virol. (2000) 74:5477–5485.
  • TESH RB, ARROYO J, TRAVASSOS DA ROSA AP et al.: Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model. Emerg. Infect. Dis. (2002) 8:1392–1397.
  • PLETNEV AG, PUTNAK R, SPEICHER J et al.: West Nile virus/ dengue Type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy. Proc. Nati Acad. Sci USA (2002) 99:3036–3041.
  • •DEN virus as a backbone to make DEN/WNV chimera for VVNV vaccine development.
  • MANDL CW, HOLZMANN H, MEIXNER T et al.: Spontaneous and engineered deletions in the 3' non-coding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus.Virol. (1998) 72:2132–2140.
  • •Attenuation of TBE virus through deletions In the 3'UTR for vaccine development.
  • MANDL CW, ABERLE JH, ABERLE SW et al.: hi vitro-synthesized infectious RNA as an attenuated live vaccine in a flavivirus model. Nat. Med. (1998) 4:1438–1440.
  • DURBIN A, KARRON R, SUN W et al: Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region. Am. I Trop. Med. Hyg. (2001) 65:405–413.
  • •Attenuation of DEN virus through deletions in the 3'UTR for vaccine development.
  • KOFLER R, HEINZ F, MANDL C: Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence. J. Viral. (2002) 76:3534–3543.
  • ••First report to describe attenuation of TBEvirus through deletions in the capsid coding region.
  • KOFLER R, LEITNER A, ORIORDAIN G et al.: Spontaneous mutations restore the viability of tick-borne encephalitis virus mutants with large deletions in protein C. Ora (2003) 77:443–451.
  • HALEVY M, AKOV Y, BEN-NATHAN D et al.: Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice. Archiv. Viral. (1994) 137:355–370.
  • LUSTIG S, OLSHEVSKY U, BEN-NATHAN D et al.: A live attenuated West Nile virus strain as a potential veterinary vaccine. Viral Immunol (2000) 13:401–410.
  • WARDA M, MARKS R, LINHARDT R: Patents related to dengue virus infection. Expert Opin. Ther. Patents (2002) 12:1127–1143.
  • BOROWSKI P, LANG M, HAAG A et al: Characterization of imidazo14,5-dlpyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme. Antimicrob. Agents Chemother. (2002) 46:1231–1239.
  • ••This paper reported a nucleoside analogue,1-(2'- O-methyl D ribo furanosy6imidazo [4,5- dlpyridazine-4, 7 (5H, 61–4 -dione, as a helicase inhibitor with an EC50 of -30 j.tM in both enzyme and viral infection assays.
  • MORREY J, SMEE D, SIDWELL R et al.: Identification of active antiviral compounds against a New York isolate of West Nile virus. Antiviral Res. (2002) 55:107–116.
  • ••A panel of 34 compounds was tested foranti-WNV activity in a viral infection assay. The compounds 6-azauridine, 6-azauridine triacetate, cyclopententylcytosine, mycophenolic acid, and pyrazofurin showed good antiviral activities.
  • JORDAN I, BRIESE T, FISCHER N et al.: Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J. Infect. Dis. (2000) 182:1214–1217.
  • ••Ribavirin was shown to have anti-WNVactivity in a viral infection assay.
  • CROTTY S, CAMERON CE, ANDINO R: RNA virus error catastrophe: direct molecular test by using ribavirin. Proc. Natl. Acad. Li. USA (2001) 98:6895–6900.
  • GRACI J, CAMERON C: Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology (2002) 298:175–180.
  • LEUNG D, SCHRODER K, WHITE H et al.: Activity of recombinant dengue 2 virus N53 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. J. Biol. Chem. (2001) 276:45762–45771.
  • ••Peptic compounds mimicking the conservedcleavage sites (basic residues at the P2 and P1 positions and a residue with a small side chain at the P1' position) with a-keto amide backbones were found to inhibit DEN NS3 protease activity at micromolar concentrations.
  • WU S-F, LEE C-J, LIAO C-L et al.: Antiviral effects of an iminosugar derivative on flavivirus infections. J. Virol (2002) 76:3596–3604.
  • ••ER a-glucosidase inhibitors, which blockthe trimming stem of N-linked glycosylation, were shown to eliminate the production of several ER-budding viruses. One such inhibitor, N-nonyl-deozynojirimycin, was found to inhibit both JE and DEN viruses at micromolar levels.
  • ROEHRIG JT, STAUDINGER LA, HUNT AR et al.: Antibody prophylaxis and therapy for flavivirus encephalitis infections. Ann. NY Acad. Li. (2001) 951:286–297.
  • MATHEWS JH, ROEHRIG JT: Elucidation of the topography and determination of the protective epitopes on the E glycoprotein of Saint Louis encephalitis virus by passive transfer with monoclonal antibodies. Immunol (1984) 132:1533–1537.
  • KIMURA-KURODA J, YASUI K: Protection of mice against Japanese encephalitis virus by passive administration with monoclonal antibodies. I Immunol (1988) 141:3606–3610.
  • BRANDRISS MW, SCHLESINGER JJ, WALSH EE et al.: Lethal 17D yellow fever encephalitis in mice. I. Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses. J. Gen. Viral. (1986) 67:229–234.
  • SCHLESINGER JJ, BRANDRISS MW, WALSH EE: Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the non-structural glycoprotein gp48 and by active immunization with gp48. I Immunol (1985) 135:2805–2809.
  • SHIMONI Z, NIVEN MJ, PITLICK S: Treatment of West Nile virus encephalitis with intravenous immunoglobulin. Enterg. Infect. Dis. (2001) 7:759.
  • MURTHY HM, JUDGE K, DELUCAS L et al.: Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design. J. Mai Biol. (2000) 301:759–767.
  • ••This paper reported the crystal structure ofNS3 protease domain complexed with a Bowman-Birk inhibitor. Compared with the unliganded NS3, the inhibitor-liganded protease showed a similar overall structure but with significant differences in regions that interact with the inhibitor.
  • MURTHY HM, CLUM S, PADMANABHAN R: Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. J. Biol. Chem. (1999) 274:5573–5580.
  • ••This paper reported the first crystalstructure of NS3 protease domain that could be used for rational design of anti-flavivirus inhibitors.
  • LAM PY, JADHAV PK, EYERMANN CJ et al.: Rational design of potent, bioavailable, non-peptide cyclic ureas as HIV protease inhibitors. Science (1994) 263:380–384.
  • SHI PY: Strategies for the identification ofinhibitors of West Nile virus and otherflaviviruses. Curr. Opin. Investig. Drugs (2002) 3:1567–1573.
  • •Summarises strategies for the identification of inhibitors of WNV and other flaviviruses.
  • YAMSHCHIKOV VF, WENGLER G, PERELYGIN AA et al.: An infectious clone of the West Nile flavivirus. Virology (2001) 281:294–304.
  • KHROMYKH AA, VARNAVSKI AN, WESTAWAY EG: Encapsidation of the flavivirus Kunjin replicon RNA by using a complementation system providing Kunjin virus structural proteins in trans. J. Virzi]. (1998) 72:5967–5977.
  • MARTIN D, BIGGERSTAFF B, ALLEN B et al.: Use of immunoglobulin M cross-reactions in differential diagnosis of human flaviviral encephalitis infections in the United States. Ora Drag. Lab. bronunol (2002) 9:544–549.
  • TARDEI G, RUTA S, CHITU V et al: Evaluation of Immunoglobulin M (IgM) and IgG enzyme immunoassays in serologic diagnosis of West Nile virus infection. ./. Clin. Microbiol (2000) 38:2232–2239.
  • EBEL G, DUPUIS A, NICHOLAS D et al.: Detection by enzyme-linked immunosorbent assay of antibodies to West Nile virus in birds. Enterg. Infect. Dis. (2002) 8:979–982.
  • HEINZ FX, ROEHRIG JT: Flaviviruses. In: konunochernistry of viruses II Van Regenmortel MHV, Neurath AR (Eds), Amsterdam-New York-Oxford, Elsevier (1990):289–305.
  • KUNO G, VORNDAM AV, GUBLER DJ et al.: Study of anti-dengue NS1 antibody by western blot. J. Med. Viral. (1990) 32:102–108.
  • SHU PY, CHEN LK, CHANG SF et al: Potential application of non-structural protein NS1 serotype-specific immunoglobulin G enzyme-linked immunosorbent assay in the seroepidemiologic study of dengue virus infection: correlation of results with those of the plaque reduction neutralization test. Clin. Microbiol (2002) 40:1840–1844.
  • YOUNG PR, HILDITCH PA, BLETCHLY C: An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients. J. Chit. Microbiol (2000) 38:1053–1057.
  • ROTHMAN AL, KURANE I, LAI CJ et al: Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes. J. Virol (1993) 67:801–806.

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