Therapeutic opportunities for antagonism of macrophage migration inhibitory factor

Bibliography

• DAVID J: Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc. Natl. Acad. ScL USA (1966) 56:72–77.
   PubMed Web of Science ®Google Scholar
• NATHAN CE REMOLD HG, DAVID JR: Characterization of a lymphocyte factor which alters macrophage functions. J. Exp. Med. (1973) 137(2):275–290.
   PubMedGoogle Scholar
• NACY CA, OSTER CN, JAMES SL, MELTZER MS: Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells. J. Immunol (1975) 114(1Pt2):293–299.
   Google Scholar
• BUCALA R: MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response. FASEB (1996) 10:1607–1613.
   PubMed Web of Science ®Google Scholar
• •This review ably revisits the history of the discovery and rediscovery of MlF.
   Google Scholar
• MITCHELL R, BACHER M, BERNHAGEN J, PUSHKARSKAYA T, SELDIN ME BUCALA R: Cloning and characterization of the gene for mouse macrophage migration inhibitory factor (MIF). Immunol. (1995) 154:3863–3870.
   Google Scholar
• SUN HW, SWOPE M, CINQUINA C etaL: The subunit structure of human macrophage migration inhibitory factor - evidence for a trimer. Protein Eng. (1996) 9:631–635.
   PubMedGoogle Scholar
• BERNHAGEN J, MITCHELL RA, CALANDRA T, VOELTER W, CERAMI A, BUCALA R: Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry Warr) (1994) 33:14144–14155.
   PubMed Web of Science ®Google Scholar
• ROSENGREN E, BUCALA R, AMAN P et al.: The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction. MoL Med. (1996) 2:143–149.
   PubMed Web of Science ®Google Scholar
• BACHER M, MEINHARDT A, LAN HY et al. Migration inhibitory factor expression in experimentally induced endotoxemia PathoL (1997) 150:235–246.
   Google Scholar
• KOZAK CA, ADAMSON MC, BUCKLER CE, SEGOVIA L, PARALKAR V, WISTOW G. Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nne mouse pseudogenes. Genomies (1995) 27:405–411.
   PubMedGoogle Scholar
• PARALKAR V, WISTOW C: Cloning thehuman gene for macrophage migration inhibitory factor (MIF). Genomics (1994) 19:48–51.
   PubMedGoogle Scholar
• HIROKAWA J, SAKAUE S, FURUYA Y et al.: Tumor necrosis factor-a regulates the gene expression of macrophage migration inhibitory factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes. Biochem. (Tokyo) (1998) 123:733–739.
   PubMedGoogle Scholar
• SUN HW, BERNHAGEN J, BUCALA R, LOLIS E: Crystal structure at 2.6-angstrom resolution of human macrophage migration inhibitory factor. Proc. Natl. Acad. Sci. USA (1996) 93:5191–5196.
   PubMed Web of Science ®Google Scholar
• BACHER M, METZ CN, CALANDRA T et al.: An essential regulatory role for macrophage migration inhibitory factor in T cell activation. Proc. Natl. Acad. Sci. USA (1996) 93:7849–7854.
   PubMed Web of Science ®Google Scholar
• ALTBOUM I, PICK E: Antigen and mitogen induced production of macrophage migration inhibitory factor in the mouse. mt. Arc. Allergy Appl. Immunol. (1979) 60(1):29–43.
   PubMedGoogle Scholar
• SORG C: Characterization of murine macrophage migration inhibitory activities (MIF) released by concanavalin A stimulated thymus or spleen cells. Mol. Immunol (1980) 17(5):565–569.
   PubMedGoogle Scholar
• CALANDRA T, SPIEGEL LA, METZ CN, BUCALA R: Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proc. of Nat. Acad. Sci. USA (1998) 95:11383–11388.
   PubMed Web of Science ®Google Scholar
• MIKULOWSKA A, METZ CN, BUCALA R, HOLMDAHL R: Macrophage migration inhibitory factor is involved in the pathogenesis of collagen Type II-induced arthritis in mice. Immund. (1997) 158:5514–5517.
   PubMed Web of Science ®Google Scholar
• XU D, MCSORLEY SJ, TETLEY L et al: Protective effect on Leishmania major infection of migration inhibitory factor, TNF-a, and IFNI, administered orally via attenuated Salmonella Ophimurium. Immunol (1998) 160(3):1285–1289.
   Google Scholar
• BERNHAGEN J, BACHER M, CALANDRA T et al.: An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction. J. Exp. Med. (1996) 183:277–282.
   PubMed Web of Science ®Google Scholar
• WU JY, CUNHA FQ, LIEW FY, WEISERWY: IL-10 inhibits the synthesis of migration inhibitory factor and migration inhibitory factor-mediated macrophage activation. J. Immunol (1993) 151:4325–4332.
   PubMed Web of Science ®Google Scholar
• CALANDRA T, BERNHAGEN J, MITCHELL RA, BUCALA R: The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. Exp. Med. (1994) 179:1895–1902.
   PubMed Web of Science ®Google Scholar
• •This paper initiated the reinvestigation of MIF as a pluripotentig pro-inflammatory cytokine.
   Google Scholar
• BERNHAGEN J, CALANDRA T, MITCHELL RA et al. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature (1993) 365:756–759.
   PubMed Web of Science ®Google Scholar
• CUNHA FQ, WEISER WY, DAVID JR, MOSS DW, MONCADA S, LIEW FY: Recombinant migration inhibitory factor induces nitric oxide synthase in murine macrophages. J. Immunol (1993) 150:1908–1912.
   PubMed Web of Science ®Google Scholar
• ONODERA S, SUZUKI K, MATSUNO T, KANEDA K, TAKAGI M, NISHIHIRA J: Macrophage migration inhibitory factor induces phagocytosis of foreign particles by macrophages in autocrine and paracrine fashion. Immunology (1997) 92(1):131–137.
   PubMedGoogle Scholar
• FROIDEVAUX C, ROGER T, MARTIN C,GLAUSER MP, CALANDRA T: Macrophage migration inhibitory factor and innate immune responses to bacterial infections. Grit. Care Med. (2001) 29(7Suppl.):S13–S15.
   Google Scholar
• POZZI LA, WEISER WY: Human recombinant migration inhibitory factor activates human macrophages to kill tumor cells. Cell. Immunol (1992) 145(2):372–379.
   PubMedGoogle Scholar
• CALANDRA T, BERNHAGEN J, METZ CN et al.: MIF as a glucocorticoid-induced modulator of cytokine production. Nature (1995) 377:68–71.
   PubMed Web of Science ®Google Scholar
• ••The first description of the bimodalregulation of MIF release by glucocorticoids.
   Google Scholar
• NISHIHIRA J, KOYAMA Y, MIZUE Y: Identification of macrophage migration inhibitory factor (MW) in human vascular endothelial cells and its induction by lipopolysaccharide. Cytokine (1998) 10:199–205.
   PubMed Web of Science ®Google Scholar
• ROSSI AG, HASLETT C, HIRANI N et al: Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J. Clin. Invest. (1998) 101:2869–2874.
   PubMed Web of Science ®Google Scholar
• WAHL SM, IVERSON GM, OPPENHEIM JJ: Induction of guinea pig B cell lymphokine synthesis by mitogenic and nonmitogenic signals to Fc, Ig, and C3 receptors. J. Exp. Med. (1974) 140(6):1631–1645.
   PubMedGoogle Scholar
• WYMANN D, BLUGGEL M, KALBACHER H et al: Human B cells secrete migration inhibition factor (MIF) and present a naturally processed MIF peptide on HLA-DRB1*0405 by a FXXL motif. Immunology (1999) 96:1–9.
   PubMedGoogle Scholar
• TAKAHASHI K, KATO Y, SUGIYAMA T et al: Production of murine collagen-induced arthritis using Klebsiella pneumoniae 03 lipopolysaccharide as a potent immunological adjuvant. Microbiol Immunol (1999) 43(8):795–801.
   PubMedGoogle Scholar
• BUCALA R: Identification of MIF as a new pituitary hormone and macrophage cytokine and its role in endotoxic shock. Immunol Lett. (1994) 43:23–26.
   PubMedGoogle Scholar
• NISHINO T, BERNHAGEN J, SHIIKI H, CALANDRA T, DOHI K, BUCALA R: Localization of macrophage migration inhibitory factor (MIF) to secretory granules within the corticotrophic and thyrotrophic cells of the pituitary gland. Mol Med. (1995) 1:781–788.
   PubMedGoogle Scholar
• BACHER M, MEINHARDT A, LAN HY et al.: MIF expression in the rat brain - implications for neuronal function. Mol Med. (1998) 4:217–230.
   PubMed Web of Science ®Google Scholar
• MATSUNAGA J, SINHA D, PANNELL L et al.: Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines. J. Biol. Chem. (1999) 274:3268–3271.
   PubMed Web of Science ®Google Scholar
• NISHIBORI M, NAKAYA N, TAHARA A, KAWABATA M, MORI S, SAEKI K: Presence of macrophage migration inhibitory factor (MIF) in ependyma, astrocytes and neurons in the bovine brain. Neurosci. Lett. (1996) 213:193–196.
   PubMed Web of Science ®Google Scholar
• MATSUDA A, KOTAKE S, TAGAWA Y, MATSUDA H, NISHIHIRA J: Detection and immunolocalization of macrophage migration inhibitory factor in rat iris and ciliary epithelium Immunol Lett. (1996) 53:1–5.
   Google Scholar
• MATSUDA A, TAGAWA Y, MATSUDA H, NISHIHIRA J: Identification and immunohistochemical localization of macrophage migration inhibitory factor in human cornea. FEBS Lett (1996) 385:225–228.
   PubMedGoogle Scholar
• APTE RS, SINHA D, MAYHEW E, WISTOW GJ, NIEDERKORN JY: Role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege. J. Immunol (1998) 160:5693–5696.
   PubMed Web of Science ®Google Scholar
• NISHIO Y, MINAMI A, KATO H, KANEDA K, NISHIHIRA J: Identification of macrophage migration inhibitory factor (MIF) in rat peripheral nerves: its possible involvement in nerve regeneration. Biochim. Biophys. Acta (1999) 1453(1):74–82.
   PubMed Web of Science ®Google Scholar
• NISHIO Y, NISHIHIRA J, ISHIBASHI T, KATO H, MINAMI A: Role of macrophage migration inhibitory factor (MIF) in peripheral nerve regeneration: anti-MIF antibody induces delay of nerve regeneration and the apoptosis of Schwann cells. Mol Med. (2002) 8(9):509–520.
   PubMedGoogle Scholar
• MARINO MW, DUNN A, GRAIL D et al: Characterization of tumor necrosis factor-deficient mice. Proc. Nat] Acad. Li. USA (1997) 94:8093–8098.
   PubMed Web of Science ®Google Scholar
• MEINHARDT A, BACHER M, MCFARLANE JR et al.: Macrophage migration inhibitory factor production by Leydig cells - evidence for a role in the regulation of testicular function Endocrinology (1996) 137:5090–5095.
   Google Scholar
• SUZUKI H, NISHIHIRA J, KOYAMA Y, KANAGAWA H: The role of macrophage migration inhibitory factor in pregnancy and development of murine embryos. Biochem. Mol Biol. Int. (1996) 38:409–416.
   PubMedGoogle Scholar
• BOZZA M, SATOSKAR AB, LIN G et al: Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. Exp. Med. (1999) 189:341–346.
   PubMed Web of Science ®Google Scholar
• ••The first description of the hypo-inflammatoryphenotype of MN I-mice.
   Google Scholar
• IMAMURA K, NISHIHIRA J, SUZUKI M et al.: Identification and immunohistochemical localization of macrophage migration inhibitory factor in human kidney Biochem. Mo/. Bid Lit. (1996) 40:1233–1242.
   Google Scholar
• SHIMIZU T, OHKAWARA A, NISHIHIRA J, SAKAMOTO W: Identification of macrophage migration inhibitory factor (MIF) in human skin and its immunohistochemical localization. FEBS Lett. (1996) 381:199–202.
   PubMed Web of Science ®Google Scholar
• ONODERA S, SUZUKI K, MATSUNO T, KANEDA K, KURIYAMA T, NISHIHIRA J: Identification of macrophage migration inhibitory factor in murine neonatal calvariae and osteoblasts. Immunology (1996) 89:430–435.
   PubMedGoogle Scholar
• ONODERA S, NISHIHIRA J, IWABUCHI K et al.: Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways. J. Biol. Chem. (2001) 20:20.
   Google Scholar
• KAYSER K, ZEILINGER C, ZENG FY, GABIUS S, GABIUS HJ, WEISER WY: Detection of the lymphokine migration inhibitory factor in normal and disease-affected lung by antibody and by its major binding protein, the interferon antagonist sarcolectin. Pathol Ail& Res. Pract. (1993) 189:992–995.
   PubMedGoogle Scholar
• LENG L, METZ CN, FANG Y et al.: MIF signal transduction initiated by binding to CD 74. j Exp. Med. (2003) 197(11):1467–1476.
   PubMed Web of Science ®Google Scholar
• ••The first description of the MIF receptorfunctionality of CD74.
   Google Scholar
• KUKOL A, TORRES J, ARKIN IT: A structure for the trimeric MHC class II-associated invariant chain transmembrane domain. j. Md. Bid. (2002) 320(5):1109–1117.
   PubMedGoogle Scholar
• FIRESTEIN GS, MANNING AM: Signal transduction and transcription factors in rheumatic disease. Arthritis & Rheumatism (1999) 42:609–621.
   PubMed Web of Science ®Google Scholar
• BARCHOWSKY A, FRLETA D, VINCENTI MP: Integration of the NF-KB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine (2000) 12(10):1469–1479.
   PubMed Web of Science ®Google Scholar
• TAM H, SUGIYAMA E, KURODA A, MINO T, HARADA S, KOBAYASHI M: p38 MAP kinase is activated in rheumatoid synovium: involvement of p38 MAP kinase pathway for IL-1- and TNFoc-stimulated IL-6 and IL-11 production by rheumatoid synoviocytes. Arthritis & Rheumatism (1998) 41:S39.
   Google Scholar
• BENNETT B, AUPPERLE KR, MANNING AM, FIRESTEIN GS: Activation of TO kinase (IKK) in fibroblast-like synoviocytes (FLS). Arthritis & Rheumatism (1998) 41:S351.
   Google Scholar
• HAN Z, BOYLE DL, BENNETT B, AUPPERLE KR, MANNING AM, FIRESTEIN GS: Activation of jun amino-terminal kinase (JNI() in rheumatoid arthritis (RA) synoviocytes. Arthritis & Rheumatism (1998) 41:S136.
   Google Scholar
• MOREL JC, PARK CC, WOODS JM, KOCH AE: A novel role for interleukin-18 in adhesion molecule induction through NFKB and phosphatidylinositol (P1) 3-kinase-dependentsignal transduction pathways. J. Biof Chem. (2001) 276(40)37069–37075.
   Google Scholar
• MITCHELL RA, METZ CN, PENG T, BUCALA R: Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action. J. Biol. Chem. (1999) 274:18100–18106.
   PubMed Web of Science ®Google Scholar
• MORAND EF, SAMPEY AV, LACEY DC: NFKB-independent activation of rheumatoid arthritis synovial cells by MIF. Arthritis & Rheumatism (2000) 43(Suppl):5407.
   Google Scholar
• KLEEMANN R, HAUSSER A, GEIGER G et al.: Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jabl. Nature (2000) 408(6809):211–216.
   PubMed Web of Science ®Google Scholar
• DAUN JM, CANNON JG: Macrophage migration inhibitory factor antagonizes hydrocortisone-induced increases in cytosolic IKBa. Anti. PhysioL (2000) 279:R1043–R1049.
   Google Scholar
• LACEY DC, SAMPEY AV, MITCHELL R et al.: Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor (MIF). Arthritis & Rheumatism (2003) 48:103–109.
   PubMed Web of Science ®Google Scholar
• ROGER T, DAVID J, GLAUSER MP, CALANDRA T: MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature (2001) 414(6866):920–924.
   PubMed Web of Science ®Google Scholar
• SAMPEY AV, HALL P, MITCHELL RA, METZ CN, MORAND EF: Regulation of synoviocyte PLA2 and COX2 by macrophage migration inhibitory factor. Arthritis & Rheumatism (2001) 44:1273–1280.
   PubMedGoogle Scholar
• SAMPEY AV, HALL P, BUCALA R, MORAND EF: Macrophage migration inhibitory factor (MIF) activation of rheumatoid synoviocytes. Arthritis & Rheumatism (1999) 42:S283.
   Google Scholar
• VANDEN BERGHE W, PLAISANCE S, BOONE E et al.: p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-KB p65 transactivation mediated by tumor necrosis factor. .1 Biol. Chem. (1998) 273:3285–3290.
   Google Scholar
• BUCALA R: Signal transduction. A most interesting factor. Nature (2000) 408(6809):146–147.
   Google Scholar
• HARBUZ MS, REES RG, LIGHTMAN SL: HPA axis responses to acute stress and adrenalectomy during adjuvant-induced arthritis in the rat. Am. Physiol (1993) 264:R179–R185.
   Google Scholar
• LEECH M, SANTOS LL, METZ C, HOLDSWORTH SR, BUCALA R, MORAND EF: Control of macrophage migration inhibitory factor (MIF) by endogenous glucocorticoids in rat adjuvant arthritis. Arthritis & Rheumatism (2000) 43:827–833.
   PubMed Web of Science ®Google Scholar
• CHROUSOS GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New Eng. I Med. (1995) 332:1351–1362.
   PubMed Web of Science ®Google Scholar
• DONNELLY SC, HASLETT C, REID PT et al.: Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat. Med. (1997) 3:320–323.
   PubMed Web of Science ®Google Scholar
• ••First description of potential MIF involvementin acute severe respiratory disease.
   Google Scholar
• LEECH M, METZ C, HALL P et al: Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum. (1999) 42(8):1601–1608.
   PubMed Web of Science ®Google Scholar
• •First description of MIF expression in rheumatoid arthritis, together with the demonstration of MIF induction of monocyte TNE
   Google Scholar
• FINGERLE-ROWSON G, KOCH P et al.: Regulation of macrophage migration inhibitory factor expression by glucocorticoids in vivo. Am. Pathol (2003) 162(1):47–56.
   PubMedGoogle Scholar
• SANTOS LL, HALL P, METZ CN, BUCALA R, MORAND EF: Role of macrophage migration inhibitory factor (MIF) in murine antigen-induced arthritis: interaction with glucocorticoids. Chit. Exp. Immunol (2001) 123:309–314.
   PubMed Web of Science ®Google Scholar
• BARNES PJ: Anti-inflammatory actions of glucocorticoids - molecular mechanisms. Sci. (1998) 94:557–572.
   Google Scholar
• SWANTEK JL, COBB M H, GEPPERT TD: Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor-a (TNF) translation: glucocorticoids inhibit TNF translation by blocking JNK/ SAPK. Md. Cell. Biol. (1997) 17:6274–6282.
   Web of Science ®Google Scholar
• HUDSON JD, SHOAIBI MA, MAESTRO R, CARNERO A, HANNON GJ, BEACH DH: A proinflammatory cytokine inhibits p53 tumor suppressor activity. I Exp. Med. (1999) 190:1375–1382.
   PubMed Web of Science ®Google Scholar
• •The first link between MIF and p53 activity.
   Google Scholar
• LEECH M, LACEY DC, XUE JR et al.: Macrophage migration inhibitory factor (MIF) regulates p53 in inflammatory arthritis. Arthritis & Rheumatism (2003) (In Press).
   Google Scholar
• •Demonstration that MIF downregulates p53 expression in human arthritis tissue cells and in rodent models of arthritis, accompanied by reductions in apoptosis.
   Google Scholar
• MITCHELL RA, LIAO H, CHESNEY J et al.: Macrophage migration inhibitory factor (MIF) sustains macrophage pro-inflammatory function by inhibiting p53: regulatory role in the innate immune response. Floc Natl. Acad Li. USA (2002) 99:345–350.
   PubMed Web of Science ®Google Scholar
• PETRENKO 0, FINGERLE-ROWSON G, PENG T, MITCHELL RA, METZ CN: Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to ras-mediated transformation. J. Biol. Chem. (2003) 278(13):11078–11085.
   PubMedGoogle Scholar
• NGUYEN MT, LUE H, KLEEMANN R, THIELE M, TOLLE G, FINKELMEIER D et al.: The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis. ./. Immunol. (2003) 170(6)3337–3347.
   Google Scholar
• LIAO H, BUCALA R, MITCHELL RA: Adhesion-dependent signaling by macrophage migration inhibitory factor (MIF). .1 Biol. Chem. (2003) 278(1):76–81.
   Google Scholar
• MORAND EF, BUCALA R, LEECH M: Macrophage migration inhibitory factor: an emerging therapeutic target in rheumatoid arthritis. Arthritis Rheum. (2003) 48(2):291–299.
   PubMedGoogle Scholar
• LEECH M, METZ CN, SANTOS LL et al.: Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Arthritis & Rheumatism (1998) 41:910–917.
   PubMed Web of Science ®Google Scholar
• MORAND EF, LEECH M, WEEDON H, METZ C, BUCALA R, SMITH MD: Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations. Rheumatology (Oxford) (2002) 41 (5):558–562.
   PubMed Web of Science ®Google Scholar
• SAMPEY AV, HALL PH, MITCHELL RA, METZ CN, MORAND EF: Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor. Arthritis Rheum. (2001) 44(6):1273–1280.
   PubMedGoogle Scholar
• ONODERA S, KANEDA K, MIZUE Y, KOYAMA Y, FUJINAGA M, NISHIHIRA J: Macrophage migration inhibitory factor upregulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J. Biol. Chem. (2000) 275:444–450.
   PubMed Web of Science ®Google Scholar
• LAN HY, MU W, YANG NS, MEINHARDTA, NIKOLICPATERSON DJ, NG YY et al: Be novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis Am..! Pathol (1996) 149:1119–1127.
   PubMedGoogle Scholar
• LAN HY, BACHER M, YANG N, MU W, NIKOLIC-PATERSON DJ, METZ C et al.: The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat. J. Exp. Med. (1997) 185:1455–1465.
   PubMed Web of Science ®Google Scholar
• ••The role of MIF in the regulation of immune-mediated renal injury is confirmed in this study.
   Google Scholar
• YANG NS, NIKOLIC-PATERSON DJ, NG YY, MU W, METZ C, BACHER M et al.: Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF) - potential role of MIF in regulating glucocorticoid production. Mol. Med. (1998) 4:413–424.
   PubMedGoogle Scholar
• TANIGUCHI Y, YORIOKA N, YAMASHITA K, MASAKI T, YAMAKIDO M: Macrophage migration inhibitory factor in IgA nephropathy. Kidney Int. (1998) 54(6):2245–2246.
   PubMedGoogle Scholar
• MIYAZAKI K, ISBEL NM, LAN HY et al.: Upregulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Clin. Exp. Immunol. (1997) 108(2):318–323.
   PubMedGoogle Scholar
• LAN HY, YANG N, BROWN FG et al: Macrophage migration inhibitory factor expression in human renal allograft rejection. Transplantation (1998) 66(11):1465–1471.
   PubMedGoogle Scholar
• LAN HY, YANG N, NIKOLIC-PATERSON DJ et al: Expression of macrophage migration inhibitory factor in human glomerulonephritis. Kidney Int. (2000) 57:499–509.
   PubMed Web of Science ®Google Scholar
• BROWN FG, NIKOLIC-PATERSON DJ, HILL PA, ISBEL NM, DOWLING J, METZ CM et al.: Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritis. I Am. Soc. Nephrol (2002) 13\(Supp1.1):S7–S13.
   Google Scholar
• DE JONG YP, ABADIA-MOLINA AC et al.: Development of chronic colitis is dependent on the cytokine MIF. Nat. Immun. (2001) 2(11):1061–1066.
   Google Scholar
• ••The role of MN' in models of colitis isdemonstrated using MIF mice.
   Google Scholar
• OHKAWARA T, NISHIHIRA J, TAKEDA H et al: Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Gastroenterology(2002) 123(1):256–270.
   PubMedGoogle Scholar
• MURAKAMI H, AKBAR SM, MATSUI H, ONJI M: Macrophage migration inhibitory factor in the sera and at the colonic mucosa in patients with ulcerative colitis: clinical implications and pathogenic significance. Eur. Clin. Invest. (2001) 31(4):337–343.
   PubMedGoogle Scholar
• MAKITA H, NISHIMURA M, MIYAMOTO K et al.: Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. Am. I Resp. Crit. Care Med. (1998) 158:573–579.
   PubMed Web of Science ®Google Scholar
• LAI KN, LEUNG JC, METZ CN, LAI FM, BUCALA R, LAN HY: Role for macrophage migration inhibitory factor in acute respiratory distress syndrome. I Pathol. (2003) 199(4):496–508.
   Google Scholar
• KORSGREN M, KALLSTROM L, ULLER L et al.: Role of macrophage migration inhibitory factor (MIF) in allergic and endotoxin-induced airway inflammation in mice. Medial-. In /lam. (2000) 9:15–23.
   Google Scholar
• BEISHUIZEN A, THIJS LG, HAANEN C, VERMES I: Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness. Endocrinol Metab. (2001) 86(6):2811–2816.
   Google Scholar
• YAMAGUCHI E, NISHIHIRA J, SHIMIZU T et al: Macrophage migration inhibitory factor (MIF) in bronchial asthma. Clin. Exp. Allergy (2000) 30:1244–1249.
   PubMedGoogle Scholar
• LANE SJ, ADCOCK IM, RICHARDS D, HAWRYLOWICZ C, BARNES PJ, LEE TH: Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. Clin. Invest. (1998) 102(12):2156–2164.
   Google Scholar
• ADCOCK IM, LANE SJ, BROWN CR, LEE TH, BARNES PJ: Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J. Exp. Med. (1995) 182(6):1951–1958.
   PubMedGoogle Scholar
• SABROE I, PEASE JE, WILLIAMS TJ: Asthma and MIF: innately Thl and Th2. Clin. Exp. Allergy (2000) 30(9):1194–1196.
   PubMedGoogle Scholar
• NIINO M, OGATA A, KIKUCHI S, TASHIRO K, NISHIHIRA J: Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behcet's disease. Neurol Sci. (2000) 179:127–131.
   Google Scholar
• DENKINGER CM, DENKINGER M, KORT JJ, METZ C, FORSTHUBER TG: In vivo blockade of macrophage migration inhibitory factor ameliorates acute experimental autoimmune encephalomyelitis by impairing the homing of encephalitogenic T cells to the central nervous system. Immunol (2003) 170(3):1274–1282.
   Google Scholar
• ••Description of the pathogenic role of MIFIn a model of multiple sclerosis.
   Google Scholar
• STEINHOFF M, MEINHARDT A, STEINHOFF A, GEMSA D, BUCALA R, BACHER M: Evidence for a role of matiuphage migration inhibitory factor in psoriatic skin disease. Br. J. Dermatol (1999) 141:1061–1066.
   PubMedGoogle Scholar
• SHIMIZU T, NISHIHIRA J, MIZUE Y et al.: High macrophage migration inhibitory factor (MIF) serum levels associated with extended psoriasis. Invest. Dermatol (2001) 116(6):989–990.
   PubMed Web of Science ®Google Scholar
• ROVENSKY J, SVEJCAR J, PEKAREK J, ZITNAN D, HAJZOK O, CEBECAUER L: Correlation between the results of the migration inhibitory factor production test with DNA and the severity of the disease in the systemic lupus erythematosus patients. Z Immunitatsforsch.Exp.Klin.Immunol (1975) 150:24–30.
   PubMedGoogle Scholar
• MIZUE Y, NISHIHIRA J, MIYAZAKI T et al.: Quantitation of macrophage migration inhibitory factor (MIF) using the one-step sandwich enzyme immunosorbent assay: elevated serum MIF concentrations in patients with autoimmune diseases and identification of MIF in erythrocytes. Int. J. Mol. Med. (2000) 5:397–403.
   PubMed Web of Science ®Google Scholar
• SELVI E, TRIPODI SA, CATENACCIO M et al.: Expression of macrophage migration inhibitory factor in diffuse systemic sclerosis. Ann. Rheum. Dis. (2003) 62 (5):460–464.
   PubMedGoogle Scholar
• LIVNI E, LAPIDOTH M, HALEVY S: In vitro release of interferon 7 and macrophage migration inhibitory factor in drug-induced urticaria and angioedema. Acta Dermato-Ven (1999) 79:18–22.
   PubMedGoogle Scholar
• KITAICHI N, KOTAKE S, SASAMOTO Y et al.: Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis. Invest. Ophthalmol Vis. ScL (1999) 40:247–250.
   PubMedGoogle Scholar
• CHAISAVANEEYAKORN S, MOORE JM, OTHORO C et al.: Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood. J. Infect. Dis. (2002) 186(9):1371–1375.
   Google Scholar
• YU CM, LAI KW, CHEN YX, HUANG XR, LAN HY: Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury. Histochem. Cytochem. (2003) 51(5):625–631.
   PubMedGoogle Scholar
• TAKAHASHI M, NISHIHIRA J, KATSUKI T, KOBAYASHI E, IKEDA U, SHIMADA K: Elevation of plasma levels of macrophage migration inhibitory factor in patients with acute myocardial infarction. Am. J. Cardiol (2002) 89(2):248–249.
   PubMedGoogle Scholar
• BURGER-KENTISCHER A, GOEBEL H, SEILER R et al.: Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis. Circulation (2002) 105(13):1561–1566.
   PubMed Web of Science ®Google Scholar
• LIN SG, YU XY, CHEN YX et al: De novo expression of macrophage migration inhibitory factor in atherogenesis in rabbits. Circ. Res. (2000) 87(12):1202–1208.
   PubMedGoogle Scholar
• CHESNEY J, METZ C, BACHER M, PENG T, MEINHARDT A, BUCALA R: An essential role for macrophage migration inhibitory factor (MIF) in angiogenesis and the growth of a murine lymphoma. Mol. Med. (1999) 5:181–191.
   PubMed Web of Science ®Google Scholar
• TAKAHASHI N, NISHIHIRA J, SATO Y et al.: Involvement of macrophage migration inhibitory factor (MIF) in the mechanism of tumor cell growth. Mol. Med. (1998) 4:707–714.
   PubMedGoogle Scholar
• CAMPA MJ, WANG MZ, HOWARD B, FITZGERALD MC, PATZ EF Jr: Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin A as potential molecular targets in non-small cell lung cancer. Cancer Res. (2003) 63(7):1652–1656.
   PubMedGoogle Scholar
• WHITE ES, FLAHERTY KR, CARSKADON S et al: Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis. Clin. Cancer Res. (2003) 9(2):853–860.
   PubMed Web of Science ®Google Scholar
• MEYERSIEGLER K, HUDSON PB: Enhanced expression of macrophage migration inhibitory factor in prostatic adenocarcinoma metastases. Urology (1996) 48:448–452.
   PubMedGoogle Scholar
• TAMPANARU-SARMESIU A, STEFANEANU L et al.: Immunocytochemical localization of macrophage migration inhibitory factor in human hypophysis and pituitary adenomas. Arch. PathoL Lab. Med. (1997) 121:404–410.
   PubMedGoogle Scholar
• PYLE ME, KORBONITS M, GUEORGUIEV M et al: Macrophage migration inhibitory factor expression is increased in pituitary adenoma cell nuclei. J.Endocrinol. (2003) 176(1):103–110.
   PubMedGoogle Scholar
• DONN RP, SHELLEY E, OLLIER WE, THOMSON W: A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. (2001) 44(8):1782–1785.
   PubMedGoogle Scholar
• DONN R, ALOURFI Z, DE BENEDETTI F et al.: Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. Arthritis Rheum. (2002) 46(9):2402–2409.
   Google Scholar
• AMOLI MM, DONN RP, THOMSON W etal.: Maumphage migration inhibitory factor gene polymorphism is associated with sarcoidosis in biopsy proven erythema nodosum. Rheurnatol (2002) 29(8):1671–1673.
   Google Scholar
• BAUGH JA, CHITNIS S, DONNELLY SC et al.: A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun. (2002) 3(3):170–176.
   PubMed Web of Science ®Google Scholar
• DIOS A, MITCHELL RA, ALJABARI B et al.: Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. J. Med. Chem. (2002) 45(12):2410–2416.
   PubMed Web of Science ®Google Scholar
• CALANDRA T, ECHTENACHER B, ROY DL et al.: Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. (2000) 6:164–170.
   PubMed Web of Science ®Google Scholar
• ARCURI F, RICCI C, IETTA F et al: Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy. Biol. Reprod. (2001) 64(4):1200–1205.
   PubMedGoogle Scholar
• IETTA F, TODROS T, TICCONI C et al: Macrophage migration inhibitory factor in human pregnancy and labor. Am. J. Reprod. Immunol (2002) 48(6):404–409.
   PubMedGoogle Scholar
• SUZUKI M, SUGIMOTO H, NAKAGAWA A, TANAKA I, NISHIHIRA J, SAKAI M: Crystal structure of the macrophage migration inhibitory factor from rat liver. Nat. Struct. Biol. (1996) 3:259–266.
   PubMedGoogle Scholar
• ZHANG M, AMAN P, GRUBB A et al: Cloning and sequencing of a cDNA encoding rat D-dopachrome tautomerase. FEBS Lett. (1995) 373(3):203–206.
   PubMed Web of Science ®Google Scholar
• BENDRAT K, AL-ABED Y, CALLAWAY DJ et al: Biochemical and mutational investigations of the enzymatic activity of macrophage migration inhibitory factor. Biochemistry (Morr) (1997) 36(49):15356–15362.
   PubMedGoogle Scholar
• SWOPE M, SUN HW, BLAKE PR, LOLIS E: Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor. EMBO J. (1998) 17:3534–3541.
   PubMed Web of Science ®Google Scholar
• STAMPS SL, TAYLOR AB, WANG SC, HACKERT ML, WHITMAN CP: Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the PIG, PIA, Y95F, and N97A mutants. Biochemistry Warr) (2000) 39:9671–9678.
   PubMedGoogle Scholar
• STAMPS SL, FITZGERALD MC, WHITMAN CP: Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. Biochemistry (Most) (1998) 37:10195–10202.
   PubMed Web of Science ®Google Scholar
• NISHIHIRA J, FUJINAGA M, KURIYAMA T et al.: Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. Biochem. Biophys. Res. Commun. (1998) 243:538–544.
   PubMedGoogle Scholar
• HERMANOWSKI-VOSATKA A, MUNDT SS et al.: Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration. Biochemistry War) (1999) 38:12841–12849.
   PubMed Web of Science ®Google Scholar
• SOARES T, GOODSELL D, FERREIRA R, OLSON A, BRIGGS J: Ionization state and molecular docking studies for the macrophage migration inhibitory factor: the role of lysine 32 in the catalytic mechanism. .1 MoL Recognit. (2000) 13:146–156.
   PubMedGoogle Scholar
• SUGIMOTO H, TANIGUCHI M, NAKAGAWA A, TANAKA I, SUZUKI M, NISHIHIRA J: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. Biochemistry (Marr) (1999) 38:3268–3279.
   PubMed Web of Science ®Google Scholar
• TAYLOR AB, JOHNSON WH, JR., CZERWINSKI RM, LI HS, HACKERT ML, WHITMAN CP: Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition. Biochemistry (Most) (1999) 38(23):7444–7452.
   Google Scholar
• SENTER PD, AL-ABED Y, METZ CN, BENIGNI F, MITCHELL RA, CHESNEY J et al.: Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc. Natl. Acad. Sri. USA (2002) 2:2.
   Google Scholar
• LUBETSKY JB, DIOS A, HAN J et al.: The tautomerase activity of MIF is a potential target for discovery of novel anti-inflammatory agents. .1 Biol. Chem. (2002) 277(28):24976–24982.
   Google Scholar
• ORITA M, YAMAMOTO S, KATAYAMA N et al.: Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J. Med. Chem. (2001) 44(4):540–547.
   PubMedGoogle Scholar
• ORITA M, YAMAMOTO S, KATAYAMA N, FUJITA S: Macrophage migration inhibitory factor and the discovery of tautomerase inhibitors. Curl: Pharm. Dec. (2002) 8(14):1297–1317.
   PubMed Web of Science ®Google Scholar
• ••A review of the potential for small moleculeMIF antagonist discovery.
   Google Scholar
• MAINI R, ST CLAIR EW, BREED VELD F et al: Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised Phase III trial. ATTRACT Study Group. Lancet (1999) 354(9194):1932–1939.
   PubMed Web of Science ®Google Scholar
• SCHOPF RE, AUST H, KNOP J: Treatment of psoriasis with the chimeric monoclonal antibody against tumor necrosis factor a, infliximab. J. Am. Acad. Dermatol (2002) 46(6):886–891.
   PubMedGoogle Scholar
• TARGAN SR, HANAUER SB, VAN DEVENTER SJ et al: A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl. J. Med. (1997) 337(15):1029–1035.
   Google Scholar
• BRESNIHAN B, ALVARO-GRACIA JM, COBBY M et al.: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. (1998) 41(12):2196–2204.
   PubMed Web of Science ®Google Scholar
• MORELAND LW SCHIFF MH, BAUMGARTNER SW et al: Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann. Intern. Med. (1999) 130(6):478–486.
   PubMedGoogle Scholar
• IWAKI T, SUGIMURA M, NISHIHIRA J, MATSUURA T, KOBAYASHI T, KANAYAMA N: Recombinant adenovirus vector bearing antisense macrophage migration inhibitory factor cDNA prevents acute lipopolysaccharide-induced liver failure in mice. Lab. Invest. (2003) 83(4):561–570.
   PubMedGoogle Scholar
• SASAKI Y, KASUYA K, NISHIHIRA J et aL: Suppression of tumor growth through introduction of an antisense plasmid of macrophage migration inhibitory factor. Int. J. MoL Med. (2002) 10(5):579–583.
   PubMedGoogle Scholar
• SHIMIZU T, ABE R, NAKAMURA H, OHKAWARA A, SUZUKI M, NISHIHIRA J: High expression of macrophage migration inhibitory factor in human melanoma cells and its role in tumor cell growth and angiogenesis. Biochem. Biophys. Res. Commun. (1999) 264:751–758.
   PubMed Web of Science ®Google Scholar
• LEECH M, METZ CN, SMITH M et al: Macrophage migration inhibitory factor (MIF) in rheumatoid arthritis: evidence for pro-inflammatory function and regulation by glucocorticoids. Arthritis & Rheumatism (1999) 42:1601–1608.
   PubMed Web of Science ®Google Scholar
• YANG Y, DEGRANPREE KHARFI A, AKOUM A: identification of mauuphagemigration inhibitory factor as a potent endothelial cell growth-promoting agent released by ectopic human endometrial cells. J. Clin. Endouinol. Metab. (2000) 85(12):4721–4727.
   PubMedGoogle Scholar
• TANINO Y, MAKITA H, MIYAMOTO K et al.: Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice. Am. J. Physiol Lung Cell Mol. Physiol (2002) 283(1)1156–L162.
   Google Scholar
• SAKAI Y, MASAMUNE A, SATOH A, NISHIHIRA J, YAMAGIWA T, SHIMOSEGAWA T: Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Gastroenterology (2003) 124(3):725–736.
   PubMedGoogle Scholar
• KITAICHI N, KOTAKE S, MIZUE Y, MATSUDA H, ONOE K, NISHIHIRA J: Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis. Br. J. Ophthalmol. (2000) 84:1423–1425.
   PubMedGoogle Scholar
• KITAICHI N, MATSUDA A, KOTAKE S et al.: Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. Curr. Eye Res. (2000) 20:109–114.
   PubMedGoogle Scholar
• BROWN FG, NIKOLIC-PATERSON DJ, METZ C, BUCALA R, ATKINS RC, LAN HY: Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat. Clin. Exp. Immunol (1999) 118:329–336.
   PubMedGoogle Scholar
• SHIMIZU T, ABE R, OHKAWARA A, MIZUE Y, NISHIHIRA J: Macrophage migration inhibitory factor is an essential immunoregulatory cytokine in atopic dermatitis. Biochem. Biophys. Res. Commun. (1997) 240:173–178.
   PubMedGoogle Scholar
• LO JW, LEUNG AY, HUANG XR et al: Macrophage migratory inhibitory factor (MIF) expression in acute graft-versus-host disease (GVHD) in allogeneic hemopoietic stem cell transplant recipients. Bone Marrow Transplant (2002) 30(6):375–380.
   PubMedGoogle Scholar
• KAMIMURA A, KAMACHI M, NISHIHIRA J et al.: Intracellular distribution of macrophage migration inhibitory factor predicts the prognosis of patients with adenocarcinoma of the lung. Cancer (2000) 89:334–341.
   PubMed Web of Science ®Google Scholar
• HUANG XR, CHUN HUI CW, CHEN YX et al.: Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflammation in rats. Gastroenterology (2001) 121(3):619–630.
   PubMedGoogle Scholar
• VEDDER H, KRIEG J, GERLACH B, GEMSA D, BACHER M: Expression and glucocorticoid regulation of macrophage migration inhibitory factor (MIF) in hippocampal and neocortical rat brain cells in culture. Brain Res. (2000) 869:25–30.
   PubMedGoogle Scholar
• WEN Y, LI GW, BEKHOR I: Lens epithelial cell mRNA.3. Elevated expression of macrophage migration inhibitory factor mRNA in galactose cataracts. Curr. Eye Res. (1996) 15:125–130.
   Google Scholar
• OGAWA H, NISHIHIRA J, SATO Y et al: An antibody for macrophage migration inhibitory factor suppresses tumour growth and inhibits tumour-associated angiogenesis. Cytokine (2000) 12:309–314.
   PubMed Web of Science ®Google Scholar
• SHIMIZU T, ABE R, OHKAWARA A, NISHIHIRA J: Ultraviolet B radiation upregulates the production of macrophage migration inhibitory factor (MIF) in human epidermal keratinocytes. Invest. Dermatol. (1999) 112:210–215.
   PubMedGoogle Scholar
• MARTINEY JA, SHERRY B, METZ CN et al.: Macrophage migration inhibitory factor release by macrophages after ingestion of plasmodium chabaudi-infected erythrocytes: possible role in the pathogenesis of malarial anemia. Infect. Immun. (2000) 68:2259–2267.
   PubMed Web of Science ®Google Scholar
• YABUNAKA N, NISHIHIRA J, MIZUE Y et al.: Elevated serum content of macrophage migration inhibitory factor in patients with Type 2 diabetes. Diabetes Care (2000) 23(2):256–258.
   PubMedGoogle Scholar
• MITAMURA Y, TAKEUCHI S, MATSUDA A, TAGAWA Y, MIZUE Y, NISHIHIRA J: Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative diabetic retinopathy. BE J. Ophthalmol. (2000) 84(6):636–639.
   Google Scholar