Allosteric modulators for the A1 adenosine receptor

Bibliography

• BIRDSALL NJ, COHEN F, LAZARENO S, MATSUI H: Allosteric regulation of G-protein-linked receptors. Biochein. Soc. Trans. (1995) 23:108–111.
   PubMedGoogle Scholar
• BIRDSALL NJ, FARRIES T, GHARAGOZLOO P, KOBAYASHI S, LAZARENO S, SUGIMOTO M: Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies. MM. Pharinacol (1999) 55:778–786.
   PubMedGoogle Scholar
• LINDEN J: Allosteric enhancement of adenosine receptors. In: Purinergic approaches in experimental therapeutics. Jacobson KA, Jarvis MF (Eds) Wiley-Liss, New York, USA (1997):29–37.
   Google Scholar
• BARKER JL, HARRISON NL, MARIANI AP: Benzodiazepine pharmacology of cultured mammalian CNS neurons. Life Sci. (1986) 39:1959–1968.
   PubMedGoogle Scholar
• FREDHOLM BB, IJZERMAN AP, JACOBSON KA, KLOTZ KN, LINDEN J: International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharinacol Revs. (2001) 53:527–552.
   Google Scholar
• DE NINNO MP: Adenosine. In: Annual Reports in Medicinal Chemistry Doherty A (Ed.), Academic Press, San Diego, USA (1998) 33:1111–1120.
   Google Scholar
• STILES GL: Adenosine receptors subtypes: new insights from cloning and functional studies. In: Purineigic approaches in experimental therapeutics. Jacobson KA, Jarvis MF (Eds),Wiley-Liss, New York, USA (1997):29–37.
   Google Scholar
• FREDHOLM BB: Adenosine and neuroprotection. hat. Rev Neurobiol (1997) 40:259–280.
   PubMed Web of Science ®Google Scholar
• UKENA D, OLSSON RA, DALY JW: Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A1 receptors and stimulatory A2 receptors. Can. Physiol Pharinacol (1987) 65:365–376.
   PubMedGoogle Scholar
• SOUDIJIN W, WIJNGAARDEN I, IJZERMAN AP: Allosteric modulation of G-protein-coupled receptors. Expert Opin. Ther. Patents (2001) 11:1889–1904.
   Google Scholar
• BRUNS RE FERGUS JH: Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. MM. Phannacol (1990) 38:939–949.
   Google Scholar
• KOLLIAS-BAKER CA, RUBLE J, JACOBSON M et al: Agonist-independent effect of an allosteric enhancer of the Al-adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. Pharinacol Exp. Ther: (1997) 281:761–768.
   Google Scholar
• MUSSER B, MUDUMBI RV, LIU J, OLSON RD, VESTAL RE: Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD-81723. Phannacol Exp. Ther. (1999) 288:446–454.
   PubMed Web of Science ®Google Scholar
• BRUNS RE FERGUS JH, COUGHENOUR LL et al: Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes. Mol. Phannacol (1990) 38:950–958.
   PubMedGoogle Scholar
• ••This article reports the discovery of thereference compound PD-81723.
   Google Scholar
• KOUROUNAKIS A, VISSER C, DE GROOTE M, IJZERMAN AP: Differential effects of the allosteric enhancer (2-amino-4,5-dimethyl-thienyl)] [3-(trifluoromethyl) phenyl] methanone (PD-81723) on agonist and antagonist binding and function at the human wild-type and a mutant (T277A) adenosine A1 receptor. Biochein. Pharinacol (2001) 61:137–144.
   PubMed Web of Science ®Google Scholar
• JANUSZ CA, BERMAN RF: The adenosine binding enhancer, PD-81723 inhibits epileptiform bursting in the hippocampal brain slice. Brazil Res. (1993) 619:131–136.
   Google Scholar
• AMOAH-APRAKU B, XU J, LU JY JY, PELLEG A, BRUNS RF, BELARDINELLI L: Selective potentiation by an Al-adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. j. Pharinacol Exp. Ther: (1993) 266:611–617.
   PubMedGoogle Scholar
• MUDUMBI RV, MONTAMAT SC, BRUNS RE VESTAL RE: Cardiac functional responses to adenosine by PD-81723, an allosteric enhancer of the adenosine A1 receptor. Am. Physiol (1993) 264:H1017–1022.
   PubMed Web of Science ®Google Scholar
• BHATTACHARYA S, LINDEN J: The allosteric enhancer, PD-81723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochim. Biophys. Acta (1995) 1265:15–21.
   PubMed Web of Science ®Google Scholar
• BHATTACHARYA S, LINDEN J: Effects of long-term treatment with the allosteric enhancer, PD-81723, on Chinese hamster ovary cells expressing recombinant human A1 adenosine receptors. Ma Pharmacol (1996) 50:104–111.
   PubMedGoogle Scholar
• BRUNS RF: Conformational induction versus conformational selection: evidence from allosteric enhancers. Trends Pharmacol Sci. (1996) 17:189.
   PubMedGoogle Scholar
• GALE NW, YANCOPOULUS GD: Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. (1999) 13:1055–1066.
   PubMed Web of Science ®Google Scholar
• RIBATTI D, VACCA A, RONCALI L, DAMMACCO F. The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis. Carr: Pharm. Biotechnol (2000) 1:73–82.
   PubMedGoogle Scholar
• JAKOBSSON AE. Angiogenesis induced by mast cell secretion in rat peritoneal connective tissue is a process of three phases. Microvasc. Res. (1994) 2:252–269.
   Google Scholar
• BARALDI PG, ZAID AN, LAMPRONTI I et al.: Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of Al-adenosine receptor. Bioorg. Med. Chem. Lett. (2000) 10:1953–1957.
   PubMed Web of Science ®Google Scholar
• VAN DER KLEIN PAM, KOUROUNAKIS AP, IJZERMAN AP: Allosteric modulation of the adenosine A1 receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding, .1 Med. Chem. (1999) 42:3629–3635.
   Google Scholar
• ••This article expands the panel ofcompounds available for more detailed structure-activity analysis.
   Google Scholar
• KOUROUNAKIS AP, VISSER C, DE GROOTE M, IJZERMAN AP: Allosteric modulation of the rat adenosine A1 receptor: differential effects on agonist and antagonist binding. Drug Develop. Res. (2000) 51:207–215.
   Google Scholar
• TRANBERG CE, ZICKGRAF A, GIUNTA BN et al.: 2-Amino-3-aroy1-4,5-alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors. Med. Chem.(2002) 45:382–389.
   Google Scholar
• •This article describes several attractive series of compounds needed to establish structure-activity roles.
   Google Scholar
• LOTJENS H, ZICKGRAF A, FINGLER H, LINDEN J, OLSSON RA, SCAMMELS PJ: 2-Amino-3-benzoylthiophene allosteric enhancers of Al-adenosine agonist binding: new 3,4-, and 5-modifications. I Med. Chem. (2003) 46:1870–1877.
   PubMedGoogle Scholar
• TOPLISS JG: Utilization of operational schemes for analogue synthesis in drug design. I Med. Chem. (1972) 15:1006–1011.
   PubMed Web of Science ®Google Scholar
• BARALDI PG, ROMAGNOLI R, PAVANI MG et al: Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of Al-adenosine receptor. Med. Chem. (2003) 46:794–809.
   Google Scholar
• CHORDIA MD, MURPHREE LJ, MACDONALD TL, LINDEN J, OLSSON RA: 2-Aminothiazole derivatives: a new class of agonist allosteric enhancers of Al-adenosine receptors. Bioorg. Med. Chem. Lett. (2002) 12:1563–1566.
   PubMed Web of Science ®Google Scholar