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Miscellaneous

Novel pyrimidine-based CXCR2 chemokine receptor antagonists

Pages 1507-1510 | Published online: 25 Feb 2005

Bibliography

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  • •Good review of the therapeutic potential of chemokine antagonism.
  • ONUFFER JJ, HORUK R: Chemokines, chemokine receptors and small-molecule antagonists: recent developments. Trends Pharmacol ScL (2002) 23:459–467.
  • ••Very useful recent review of the literaturein this field.
  • NORMAN P: Developing anti-inflammatory drugs for the treatment of COPD. Inflation. Res. in press.
  • •Up-to-date overview of approaches to the treatment of inflammation in COPD.
  • JIE JL: Small molecule interleukin-8 modulators. Expert Opin. Ther. Patents (2001) 11:1905–1910.
  • ••Recent review of CXCRI and 2antagonists, and the patent literature.
  • TRAVES SL, SMITH SJ, BARNES PJ, DONNELLY LE: Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. Leukoc. Biol. in press.
  • •Suggestive that the CXCR2 receptor is the more pertinent target.
  • WHITE JR, LEE JM, YOUNG PR et al.: Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.j Biol. Chem. (1998) 273:10095–10098.
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  • BAXTER A, BENNION C, BENT J et al.: Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists. Bioorg. Med. Chem. Lett. (2003) 13:2625–2628.

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