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Miscellaneous

MMP-12 inhibitors

Pages 1637-1640 | Published online: 25 Feb 2005

Bibliography

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  • •Up-to-date review of the area.
  • STOCKLEY RA: Proteases and antiproteases. Novartis Found. Symp. (2001) 234:189–199
  • ••Excellent description of this keyhypothesis.
  • BERNSTEIN PR, EDWARDS PD, WILLIAMS JC: Inhibitors of human leukocyte elastase. Frog. Med. Chem. (1994) 31:59–120
  • ••Excellent review of earlier chemicalapproaches to this target.
  • TREMBLAY GM, JANELLE MF, BOURBONNAIS Y: Anti-inflammatory activity of neutrophil elastase inhibitors. Curr. Opin. Investig. Drugs (2003) 4:556–565.
  • •Recent review of what has been an intensively targeted area.
  • BELVISI MG, BOTTOMLEY KM: The role of matrix metalloproteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs? Inflamm. Res. (2003) 52:95–100.
  • ••Critical background review for this approach to COPD.
  • PETERSON JT: Matrix metalloproteinase inhibitor development and the remodeling of drug discovery. Heart Fail. Rev. (2004) 9(1):63–79.
  • •Timely review of the pitfalls with MMP inhibitors.

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