Bibliography
- MOORE KW, DE WAAL MALEFYT R, COFFMAN RL, O'GARRA A: Interleukin-10 and the interleukin-10 receptor. Ann. Rev Immunol (2001) 19:683–765.
- ASADULLAH K, STERRYW, VOLK HD: Interleukin -10 therapy - review of a new approach. Pharmacol Rev. (2003) 55:241–269.
- REDPATH S, GHAZAL P, GASCOIGNE NR: Hijacking and exploitation of IL-10 by intracellular pathogens. Trends Microbial. (2001) 9:86–92.
- DUMONT FJ: Therapeutic potential of IL -10 and its viral homologues: an update. Expert Opin. Ther. Patents (2003) 13:1551–1557.
- •Recent review of the biology and therapeutic potential of IL-10 and its viral homologues.
- FICKENSCHER H, HORS, KUPERS H et al: The interleukin-10 family of cytokines. Trends Immunol (2002) 23:89–96.
- •Review of the molecular biology of IL-10-related cytokines and their receptors.
- KOTENKO SV: The family of IL-10- related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev (2002) 13:223–240.
- •Review of the molecular biology of IL-10-related cytokines and their receptors.
- RENAULD JC: Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat. Rev brimanol. (2003) 3:667–676.
- SAUANE M, GOPALKRISHNAN RV, SARKAR D et al.: MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev (2003) 14:35–51.
- •Excellent up-to-date review of IL-24 and its potential for anti-cancer gene therapy.
- GALLAGHER G, DICKENSHEETS H, ESKDALE J et al.: Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Inman. (2000) 1:442–450.
- ••Description of IL-19 and its homology toIL–10.
- LIAO YC, LIANG WG, CHEN FW et aL: IL-19 induces production of IL-6 and TNF-a and results in cell apoptosis through TNF-a. Immunol (2002) 169:4288–4297.
- ••Shows that IL-19 has irnmunostimulatoryactivity in vitro.
- CHANG C, MAGRACHEVA E, KOZLOV S et al.: Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.j Biol. Chem. (2003) 278:3308–3313.
- ••Characterisation of the structure of IL-19.Shows that, unlike IL-10, IL-19 does not form an intercalating dimer but exists as a monomer in solution.
- WOLK K, KUNZ S, ASADULLAH K, SABAT R: Immune cells as sources and targets of the IL-10 family members? Immunol (2002) 168:5397–5402.
- ••Shows that IL-10-related cytokines areproduced by immune cells.
- GHORESCHE K, THOMAS P BREIT S et al.: Interleukin-4 therapy of psoriasis induces TH2 responses and improves human autoimmune disease. Nat. Med. (2003) 9:40–46.
- ROMER J, HASSELAGER E, NORBY PL et al.: Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine A or calcipotriol. J. Invest. Dermatol (2003) 121:1306–1311.
- ••Shows that IL-19 and IL-20 are producedby keratinocytes in psoriasis.
- BLUMBERG H, CONKLIN D, XU WF et al.: Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell (2001) 104:9–19.
- ••Description of IL-20 and of one of itsfunctional receptors, IL-20R1/1L-20R2. Suggests a role for IL-20 in skin biology and inflammation, including psoriasis.
- KINGO K, KOKS S, NIKOPENSIUS T, SILM H, VASAR E: Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis. Genes Litman. (2004) [Epub ahead of print].
- SMEETS TJM, CHANDRASEKHER YA, KRAAN MC, HARINGMAN JJ, TAK PP: Interleukin-20 is expressed in inflamed synovium of patients with psoriatic arthritis and rheumatoid arthritis. ACR Meeting Orlando, USA (2003) Abst 21.
- XU W, CHANDRASEKHER Y, HAUGEN H et al: IL-20 and IL-22 in psoriasis. Ear. Cytokine Netw. (2003) 14:65.
- DUMOUTIER L, LOUAHED J, RENAULD JC: Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIE), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. (2000) 164:1814–1819.
- DUMOUTIER L, VAN ROOST E, COLAU D, RENAULD JC: Human interleukin-10-related T-cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Nat! Acad. SclUSA (2000) 97:10144–10149.
- ••Description of human IL-22 andcharacterisation of its role as an inducer of acute-phase proteins.
- XIE MH, AGGARWAL S, HO WH et al: Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. Biol . Chem. (2000) 275:31335–31339.
- ••Description of human IL-22 anddemonstration that it signals through the IL -22R1/IL-10R2 receptor complex.
- DUMOUTIER L, VAN ROOST E, AMEYE G, MICHAUX L, RENAULD JC: IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Inainuna (2000) 1:488–494.
- NAGEM RA, COLAU D, DUMOUTIER L et al.: Crystal structure of recombinant human interleukin-22. Structure (Carob) (2002) 10:1051–1062.
- ••Structural analysis of IL-22 and evidencethat it exists as a monomer in solution.
- LOGSDON NJ, JONES BC, JOSEPHSON K, COOK J, WALTER MR: Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. .1. Interferon Cytokine Res. (2002) 22:1099–1112.
- JIANG H, UN JJ, SU ZZ, GOLDSTEIN NI, FISHER PB: Subtraction hybridization identifies a novel melanoma differentiation-associated gene, inda-7, modulated during human melanoma differentiation, growth and progression. Oncogene (1995) 11:2477–2486.
- •Discovery of the human IL-24 gene.
- HUANG EY, MADIREDDI MT, GOPALKRISHNAN RV et al.: Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (inda-4 gene with cancer-specific growth suppressing and apoptosis-inducing properties. Oncogene (2001) 20:7051–7063.
- CAUDELL EG, MUMM JB, POINDEXTER N et al.: The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. J. Ioannina (2002) 168:6041–6046.
- ••Demonstration that IL-24 acts as acytokine with irmrtunostimulatory properties.
- WANG M, TAN Z, ZHANG R, KOTENKO SV, LIANG P: Interleuldn 24 (MDA-7/M0B-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. I Biol. Chem. (2002) 277:7241–7347.
- ••Demonstration that IL-24 acts as acytokine that signals through two distinct receptors.
- SCHAEFER G, VENKATARAMAN C, SCHINDLER U: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by TH2 cells. J. Immuna (2001) 166:5859–5863.
- SOO C, SHAW WW, FREYMILLER E et al.: Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7. Cell. Biochem. (1999) 74:1–10.
- ZHANG R, TAN Z, LIANG P: Identification of a novel ligand-receptor pair constitutively activated by ras oncogenes. J. Biol. Chem. (2000) 275:24436–24443.
- JONES BC, LOGSDON NJ, JOSEPHSON K et al.: Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc. Nat] Acad. Sci.USA (2002) 99:9404–9409.
- GARN H, SCHMIDT A, GRAU V et a/.: IL-24 is expressed by rat and human macrophages. Immunobiology (2002) 205:321–334.
- •Shows that IL-24 is produced by macrophages.
- EKMEKCIOGLU S, ELLERHORST J, MHASHILKAR AM etal.: Down-regulated melanoma differentiation associated gene (mda-4 expression in human melanomas. Int. Cancer (2001) 94:54–59.
- ELLERHORST JA, PRIETO VG, EKMEKCIOGLU S et al.: Loss of MDA-7 expression with progression of melanoma. Gin. °flea (2002) 20:1069–1074.
- MADIREDDI MT, DENT P, FISHER PB: Regulation of mda-7gene expression during human melanoma differentiation. Oncogene (2000) 19:1362–1368.
- MADIREDDI MT, DENT P, FISHER PB: AP-1 and C/EBP transcription factors contribute to mda-7gene promoter activity during human melanoma differentiation. Cell . Physic] (2000) 185:36–46.
- KNAPPE A, HORS, WITTMANN S, FICKENSCHER H: Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. Vim/. (2000) 74:3881–3887.
- ••Description of IL-26 and its homologywith IL–10.
- GORIS A, MARROSU MG, VANDENBROECK K: Novel polymorphisms in the IL-10-relatedAK155 gene (chromosome 12q15). Genes Liman. (2001) 2:284–286.
- GORIS A, HEGGARTY S, MARROSU MG et al.: Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118 kb interval around interferon-gamma (IFN-y) that is involved in male versus female differential susceptibility. Genes Immun. (2002) 3:470–476.
- KOTENKO SV, PESTKA S: Jak-Stat signaltransduction pathway through the eyes of cytokine Class II receptor complexes. Oncogene (2000) 19:2557–2565.
- JOSEPHSON K, LOGSDON NJ, WALTER MR: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity (2001) 15:35–46.
- PARRISH-NOVAK J, XU W, BRENDER T et al.: Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J. Biol. Chem. (2002) 277:47517–47523.
- ••Shows that IL-19, -20 and -24 share theType 1 and 2 IL-20R complexes.
- DUMOUTIER L, LEEMANS C, LEJEUNE D, KOTENKO SV, RENAULD JC: STAT activation by IL-19, IL-20 and mda-7through IL-20 receptor complexes of two types. Immuna (2001) 167:3545–3549.
- ••Shows that IL-19, IL-20 and IL-24 sharethe Type 1 and Type 2 IL-20R complexes.
- SHEIKH F, BAURIN VV, LEWIS -ANTES A et al.: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Immuna (2003) 172:2006–2010.
- ••Shows that IL-26 signals through the IL -20R1/IL-10R2 receptor complex.
- PLETNEV S, MAGRACHEVA E, KOZLOV S et al.: Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. Biochemistry (2003) 42:12617–12624.
- ••Shows that IL-19 and -20 bind with highaffinity to IL-20R2 alone. This creates a new site to which IL-20R1 binds, resulting in formation of a signaling receptor complex that consists of one ligand molecule and one molecule of each receptor chain.
- KOTENKO SV, IZOTOVA LS, MIROCHNITCHENKO OV et al.: Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-101213) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J. Biol. Chem. (2001) 276:2725–2732.
- •Characterisation of the IL-22 receptor complex.
- AGGARWAL S, XIE MH, MARUOKA M, FOSTER J, GURNEY AL: Acinar cells of the pancreas are a target of interleukin-22. .1 Interferon Cytokine Res. (2001) 21:1047–1053.
- TACHIIRI A, IMAMURA R, WANG Y et al.: Genomic structure and inducible expression of the IL-22 receptor a chain in mice. Genes Inman. (2003) 4:153–159.
- LI J, TOMKINSON N, TAN XY et al: Temporal associations between IL-22 and the extracellular domains of IL-22R and IL-10R2. Eur. Cytokine Netw. (2003) 14:91.
- LECART S, MOREL F, NORAZ N et al.: IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells. bit. Immunol. (2002) 14:1351–1356.
- RAMESH R, MHASHILKAR AM, TANAKA F et al.: Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. Cancer Res. (2003) 63:5105–5113.
- ••Demonstrates that IL-24 inhibitsendothelial cell differentiation and migration by acting via the IL-22 receptor.
- DUMOUTIER L, LEJEUNE D, COLAU D, RENAULD JC: Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J. Immunol. (2001) 166:7090–7095.
- •Description of IL-22BP and characterisation of its role as an IL-22 antagonist.
- KOTENKO SV, IZOTOVA LS, MIROCHNITCHENKO OV et al.: Identification, cloning and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Immunol. (2001) 166:7096–7103.
- •Description of IL-22BP and characterisation of its role as an IL-22 antagonist.
- XU W, PRESNELL SR, PARRISH -NOVAK J et al.: A soluble Class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl. Acad. &L USA (2001) 98:9511–9516.
- •Description of IL-22BP and characterisation of its role as an IL-22 antagonist.
- GRUENBERG BH, SCHOENEMEYER A, WEISS B et al.: A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta. Genes Immunol. (2001) 2:329–334.
- DOKKA S, SHI X, LEONARD S et al.: Interleukin-10-mediated inhibition of free radical generation in macrophages. Am. .1. Physiol. Lung Cell. Mol. Physiol. (2001) 280:L1196–L1202.
- LEBWOHL M: Psoriasis. Lancet (2003) 361:1197–1204.
- RICH BE: IL-20: a new target for the treatment of inflammatory skin disease. Expert Opin. Ther. Targets (2003) 7:165–174.
- •Review of the role of IL-20 in skin inflammation.
- WANG YC, LI HL, CHEN P et al: IL-20:promoter analysis and characterization of biological function. Ear: Cytokine Netw. (2003) 14:64.
- KONDO M, WAGERS AJ, MANZ MG et al.: Biology of hematopoietic stem cells and progenitors: implications for clinical application. Ann. Rev Immunol. (2003) 21:759–806.
- LIU L, DING C, ZENG W et al: Selective enhancement of multipotential hematopoietic progenitors M vitro and in vivo by IL-20. Blood (2003) 102:3206–3209.
- ••Demonstrates that IL-20 selectivelyenhances the proliferation of multipotential haematopoietic progenitors.
- LEJEUNE D, DUMOUTIER L, CONSTANTINESCU S et al: Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J. Biol Chem. (2002) 277:33676–33682.
- ••Analysis of the signaling pathwaysrecruited by IL-22 in hepatoma cells. Demonstrates that IL-22, but not IL-10, induces STAT3 serine phosphorylation and MAPK activation.
- RESMINI C, SHIELDS KM, LAMBERT AJ et al.: An anti-murine IL-22 monoclonal antibody decreases disease severity in a murine model of collagen induced arthritis. Ear: Cytokine Netw. (2003) 14:129.
- GABAY C, KUSHNER I: Acute-phase proteins and other systemic responses to inflammation. N Engl. I Med. (1999) 340:448–454.
- DESIDERIO S, Y00 JY: A genome-wideanalysis of the acute-phase response and its regulation by Stat3-3. Ann. NY Acad. Sci. (2003) 987:280–284.
- BAEZA N, SANCHEZ D, CHRISTA L et al.: Pancreatitis-associated protein (HIP/PAP) gene expression is upregulated in NOD mice pancreas and localized in exocrine tissue during diabetes. Digestion (2001) 64:233–239.
- VASSEUR S, FOLCH-PUY E, HLOUSCHEK V et al.: P8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein PAP I.,/ Biol. Chem. (2003) [Epub ahead of print].
- HOLMDAHL R, BOCKERMANN R, BACKLUND J, YAMADA H: The molecular pathogenesis of collagen-induced arthritis in mice-a model for rheumatoid arthritis. Ageing Res. Rev (2002) 1:135–147.
- JIANG H, SU ZZ, LIND et aL: The melanoma differentiation associated gene mda-7suppresses cancer cell growth. Proc. Natl. Acad Sci.USA (1996) 93:9160–9165.
- •First demonstration of the anti-tumour activity of Ad.mda-7
- SU ZZ, MADIREDDI MT, LIN JJ et al: The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc. Nati Acad. Sci.USA (1998) 95:14400–14405.
- LEBEDEVA IV, SU ZZ, CHANG Y et al.: The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene (2002) 21:708–718.
- MHASHILKAR AM, SCHROCK RD, HINDI M et al.: Melanoma differentiation associated gene-7 (mda-4: a novel anti-tumor gene for cancer gene therapy. Mol. Med. (2001) 7:271–282.
- FISHER PB, GOPALKRISHNAN RV, CHADA S et al.: Mda-7/I1-24, a novel cancer-selective apoptosis-inducing cytokine gene: from the laboratory into the clinic. Cancer Biol. Ther. (2003) 2:S23–S37.
- •Review of the potential of Ad.mda-7for cancer gene therapy.
- SU ZZ, LEBEDEVA IV, SARKAR D et al: Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene (2003) 22:1164–1180.
- SARKAR D, SU ZZ, LEBEDEVA IV et al.: Mda-7 (11,-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc. Nati Acad. SciUSA (2002) 99:10054–10059.
- CAO XX, MOHUIDDIN I, CHADA S et al.: Adenoviral transfer of mda-71eads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL. Mol Med. (2002) 8:869–876.
- LEBEDEVA IV, SARKAR D, SU ZZ et al.: Bc1-2 and Bc1-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation-associated gene-7, mda-711L-24. Oncogene (2003) 22:8758–8773.
- SAEKI T, MHASHILKAR A, CHADA S et al.: Tumor-suppressive effects by adenovirus-mediated mda-7gene transfer in non-small cell lung cancer cell M vitro. Gene Ther: (2000) 7:2051–2057.
- PATAER A, CHADA S, HUNT KK, ROTH JA, SWISHER SG: Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release. Thome. Cardiovasc. Surg. (2003) 125:1328–1335.
- GIL J, ESTEBAN M: The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-a receptors. Oncogene (2000) 19:3665–3674.
- MHASHILKAR AM, STEWART AL, SIEGER K et al.: MDA-7 negatively regulates the P-catenin and PI3K signaling pathways in breast and lung tumor cells. Ther . (2003) 8:207–219.
- CHANG F, LEE JT, NAVOLANIC PM et al.: Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia (2003) 17:590–603.
- LI H, PAMUKCU R, THOMPSON WJ: I3-Catenin signaling: therapeutic strategies in oncology. Cancer Biol. The]: (2002) 1:621–625.
- SAEKI T, MHASHILKAR A, SWANSON X et al.: Inhibition of human lung cancer growth following adenovirus-mediated mda-7gene expression in vivo. Oncogene (2002) 21:4558–4566.
- REED JC: Apoptosis-targeted therapies for cancer. Cancer Cell (2003) 3:17–22.
- YACOUB A, MITCHELL C, BRANNON J et al.: MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Mol Cancer Ther: (2003) 2:623–632.
- YACOUB A, MITCHELL C, LISTER A et al: Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo. Clin. Cancer Res. (2003) 9:3272–3281.
- CHEN J, CHADA S, MHASHILKAR A, MIANO JM: Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration. Mol Ther: (2003) 8:220–229.
- SAUANE M, GOPALKRISHNAN RV, LEBEDEVA I et al.: Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. I Cell. Physiol (2003) 196:334–345.
- •Shows that Ad.mda-7induces apoptosis in cancer cells via mechanisms that do not involve JAK/STAT signaling.
- KAWABE S, NISHIKAWA T, MUNSHI A et al.: Adenovirus-mediated mda-7gene expression radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms. Mol Ther. (2002) 6:637–644.
- YACOUB A, MITCHELL C, LEBEDEVA IV et al.: Mda-7 (IL-24) inhibits growth and enhances radiosensitivity of glioma cells M vitro via JNK signaling. Cancer Biol. Ther. (2003) 2:347–353.
- SU Z, LEBEDEVA IV, GOPALKRISHNAN RV et al: A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Proc. Nat] Acad. Sci.USA (2001) 98:10332–10337.
- EKMEKCIOGLU S, ELLERHORST JA, MUMM JB et al.: Negative association of melanoma differentiation-associated gene (mda- and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. Ma Cancer Ther. (2003) 2:9–17.
- LIRK P, HOFFMANN G, RIEDER J: Inducible nitric oxide synthase-time for reappraisal. Cur]: Drug Targets Inflamm. Allergy (2002) 1:89–108.
- GOPALKRISHNAN R: INGN-241. Introgen. Carr. Opin. Investig. Drugs (2002) 3:1773–1777.
- CHADA S, NEMUNAITIS J, TONG Aet al.: Phase I dose-escalation study of Ad- mda7 (INGN-241) in patients with advanced carcinoma. Cancer Gene Ther: (2001) 8:S3.
- KANITAKIS J, BUTNARU AC, CLAUDY A: Novel biological immunotherapies for psoriasis. Expert Opin. Investig. Drugs (2003) 12:1111–1121.
Websites
- http://www.introgen.com/ Introgen Therapeutics homepage.
- http://www.zymogenetics.com/ Zymogenetics homepage.