Therapeutic potential of CDK5 inhibitors to promote corneal epithelial wound healing

Bibliography

• DHAVAN R, TSAI LH: A decade of CDK5. Nat. Rev. MoL Cell. Biol. (2001) 2:749–759.
   PubMed Web of Science ®Google Scholar
• •Excellent review of the neuronal functions of CDK5.
   Google Scholar
• LAZARD JB, VANDROMME M, POUL MA, FERNANDEZ A, LAMB M: CDK5 is a positive regulator necessary for myogenesis of C2 cells. Mol. Biol. Cell (1995) 6(Suppl. Nov.):242a.
   Google Scholar
• GAO CY, ZAKERI Z, ZHU Y, HE HY, ZELENKA PS: Expression of CDK-5, p35, and CDK5-associated kinase activity in the developing rat lens. Develop. Genetics (1997) 20:267–275.
   PubMedGoogle Scholar
• CHEN F, STUDZINSKI GP: Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood (2001) 97:3763–3767.
   PubMed Web of Science ®Google Scholar
• TARRICONE C, DHAVAN R, PENG J et al.: Structure and regulation of the CDK5-p25(nck5a) complex. MoL Cell Neurosci. (2001) 8:657–669.
   Google Scholar
• ••X-ray crystal structure of the CDK5/p25complex.
   Google Scholar
• ZUKERBERG LR, PATRICK GN, NIKOLIC M et al.: Cables links CDK5 and c-Abl and facilitates CDK5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron (2000) 26:633–646.
   PubMed Web of Science ®Google Scholar
• SASAKI Y, CHENG C, UCHIDA Yet aL: Fyn and CDK5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron (2002) 35:907–920.
   PubMed Web of Science ®Google Scholar
• MORGAN DO: Principles of CDK regulation. Nature (1995) 374:131–134.
   PubMed Web of Science ®Google Scholar
• OHSHIMA T, GILMORE EC, LONGENECKER G et al.: Migration defects of CDK5(-/-) neurons in the developing cerebellum is cell autonomous. J. Neurosci. (1999) 19:6017–6026.
   PubMedGoogle Scholar
• TAN TC, VALOVA VA, MALLADI CS et al.: CDK5 is essential for synaptic vesicle endocytosis. Nat. Cell Biol. (2003) 5(8):701–10.
   PubMed Web of Science ®Google Scholar
• MOY LY, TSAI LH: Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J. Biol. Chem. (2004) 279:54487–5493.
   Google Scholar
• KANSY JW, DAUBNER SC, NISHI A et al.: Identification of tyrosine hydroxylase as a physiological substrate for CDK5. J. Neurochem. (2004) 91:374–84.
   PubMed Web of Science ®Google Scholar
• LI BS, ZHANG L, TAKAHASHI S et al.: Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J. (2002) 21:324–333.
   PubMed Web of Science ®Google Scholar
• LI BS, MAW, JAFFE H et al.: Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J. Biol. Chem. (2003) 278(37):35702–35709.
   Google Scholar
• CHERGUI K, SVENNINGSSON P, GREENGARD P: Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc. NatL Acad. Sci. USA (2004) 101:2191–2196.
   PubMed Web of Science ®Google Scholar
• TAKAHASHI S, OHSHIMA T, CHO A et al.: Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc. NatL Acad. Sci. USA (2005) 102:1737–1742.
   Google Scholar
• PATRICK GN, ZUKERBERG L, NIKOLIC M et al.: Conversion of p35 to p25 deregulates CDK5 activity and promotes neurodegeneration. Nature (1999) 402:615–622.
   PubMed Web of Science ®Google Scholar
• LEE M-S, KWON YT, LI M et ed.: Neurotoxicity induces cleavage of p35 to p25 by calpain Nature (2000) 405:360–364.
   Google Scholar
• PATZKE H, TSAI LH: Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. j Biol. Chem. (2002) 277:8054–8060.
   Google Scholar
• KESAVAPANY S, LAU KF, MCLOUGHLIN DM et aL: p35/CDK5 binds and phosphorylates 0-catenin and regulates 0-catenin/presenilin-1 interaction. Eur. J. Neurosci. (2001) 13:241–247.
   Google Scholar
• LEDEE DR, GAO CY, SETH R et ed.: A specific interaction between muskelin and the cyclin dependent kinase 5 activator p39 promotes peripheral localization of muskelin. J. Biol. Chem. (2005) Mar 28:(Epub ahead of print).
   Google Scholar
• NEGASH S, WANG HS, GAO C, LEDEE D, ZELENKA P: CDK5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells. J. Cell Sci. (2002) 115:2109–2117.
   PubMed Web of Science ®Google Scholar
• •Demonstrates a role for CDK5 in lens epithelial cells.
   Google Scholar
• PHILPOTT A. PORRO EB, KIRSCHNER MW, TSAI L-H: The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes Dev. (1997) 11:1409–1421.
   PubMed Web of Science ®Google Scholar
• LAZARD J-B, KITZMANN M, POUL M-A et al.: Cyclin-dependent kinase 5, CDK5, is a positive regulator of myogenesis in mouse C2 cells. J. Cell Sci. (1997) 110:1251–1260.
   Google Scholar
• •Demonstrates CDK5 involvement in myogenesis.
   Google Scholar
• FU AK, FU WY, NG AK et ed.: Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. NatL Acad. Sci. USA (2004) 101:6728–6733.
   Google Scholar
• FU WY, FU AK, LOK KC, IP FC, IP NY: Induction of CDK5 activity in rat skeletal muscle after nerve injury. Neuroreport (2002) 13:243–247.
   PubMedGoogle Scholar
• FU AK, FU WY, CHEUNG J et ell.: CDK5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat. Neurosci. (2001) 4:374–381.
   Google Scholar
• LILJA L, YANG SN, WEBB DL et al.: Cyclin-dependent kinase 5 promotes insulin exocytosis. J. Biol. Chem. (2001) 276:34199–34205.
   Google Scholar
• •Demonstrates that CDK5 promotes exocytosis in pancreatic cells.
   Google Scholar
• CHEN F, RAO J, STUDZINSKI GP: Specific association of increased cyclin-dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells. J. Leukoc. Biol. (2000) 67:559–566.
   PubMed Web of Science ®Google Scholar
• ALEXANDER K, YANG HS, HINDS PW: Cellular senescence requires CDK5 repression of Racl activity. Mol. Cell. Biol. (2004) 24:2808–2819.
   PubMedGoogle Scholar
• GAO C, NEGASH S, GUO HT et aL: CDK5 Regulates cell adhesion and migration in corneal epithelial cells. Mol. Cancer Res. (2002) 1:12–24.
   PubMed Web of Science ®Google Scholar
• •Demonstrates a role for CDK5 in corneal epithelial cell adhesion in vitro.
   Google Scholar
• GAO CY, STEPP Mk FARISS R, ZELENKA PS: CDK5 regulates activation and localization of Src during corneal epithelial wound closure. J. Cell Sci. (2004) 117:4089–4098.
   PubMed Web of Science ®Google Scholar
• ••Presents experimental evidence to supporta role for CDK5 in promoting corneal epithelial wound healing.
   Google Scholar
• SUZUKI K, SAITO J, YANAI R et aL: Cell-matrix and cell-cell interactions during corneal epithelial wound healing. Frog. Retin. Eye Res. (2003) 22:113–133.
   PubMed Web of Science ®Google Scholar
• •Excellent review of corneal epithelial wound healing with a complete bibliography.
   Google Scholar
• ZHAO M, SONG B, PU J, FORRESTER JV, MCCAIG CD: Direct visualization of a stratified epithelium reveals that wounds heal by unified sliding of cell sheets. FASEB J. (2003) 17:397–406.
   PubMed Web of Science ®Google Scholar
• HARDARSON T, HANSON C, CLAESSON M, STENEVI U: Time-lapse recordings of human corneal epithelial healing. Acta OphthalmoL Scand. (2004) 82:184–188.
   Google Scholar
• DANJO Y, GIPSON IK: Actin 'purse string' filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement. J. Cell Sci. (1998) 111:3323–3332.
   PubMed Web of Science ®Google Scholar
• ETIENNE-MANNEVILLE S, HALL k Rho GTPases in cell biology. Nature (2002) 420:629–635.
   PubMed Web of Science ®Google Scholar
• HOLLY SP, LARSON MK, PARISE LV: Multiple roles of integrins in cell motility. Exp. Cell Res. (2000) 261:69–74.
   PubMed Web of Science ®Google Scholar
• HAZLETT L: Corneal and ocular surfacehistochemistry. Frog. Histochem. Cytochem. (1993) 25:1–60.
   PubMedGoogle Scholar
• IMANISHI J, KAMIYAMA K, IGUCHI I et al.: Growth factors: importance in wound healing and maintenance of transparency of the cornea. Frog. Retin. Eye Res. (2000) 19:113–129.
   PubMed Web of Science ®Google Scholar
• YAMADA N, YANAI R, INUI M, NISHIDA T: Sensitizing effect of substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-6. Invest. OphthalmoL Vis. Sci. (2005) 46:833–839.
   PubMed Web of Science ®Google Scholar
• FISCHER P, GIANELLA- BORRADORI A: CDK inhibitors in clinical development for the treatment of cancer. Expert Opin. Investig. Drugs. (2003) 12:955–970.
   PubMed Web of Science ®Google Scholar
• EDO M, ROLDAN M, ANDRES V: Cyclin-dependent protein kinases as therapeutic targets in cardiovascular disease. Expert Opin. Ther. Patents (2003) 13:579–588.
   Web of Science ®Google Scholar
• WAGMAN AS, JOHNSON KW, BUSSIERE DE: Discovery and development of GSK3 inhibitors for the treatment of Type 2 diabetes. Curr. Pharm. Des. (2004) 10:1105–1137.
   PubMed Web of Science ®Google Scholar
• MAPELLI M, MASSIMILIANO L, CROVACE C et al.: Mechanism of CDK5/ p25 Binding by CDK Inhibitors. J. Med. Chem. (2005) 48:671–679.
   PubMed Web of Science ®Google Scholar
• ••High resolution X-ray crystal structures ofCDK5/p25 in complex with roscovitine and aloisine.
   Google Scholar
• ZHENG YL, KESAVAPANY S, GRAVELL M et al.: A CDK5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. EMBO J. (2005) 24:209–20.
   PubMed Web of Science ®Google Scholar
• MATSUDA T, CEPKO CL: Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc. NatL Acad. Sci. USA (2004) 101:16–22.
   PubMed Web of Science ®Google Scholar
• WADIA JS, DOWDY SF: Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv. Drug Deliv. Rev. (2005) 57:579–596.
   PubMed Web of Science ®Google Scholar
• PASTOR JC, CALONGE M: Epidermal growth factor and corneal wound healing. A multicenter study. Cornea (1992) 11:311–314.
   PubMed Web of Science ®Google Scholar
• GORDON JF, JOHNSON P, MUSCH DC: Topical fibronectin ophthalmic solution in the treatment of persistent defects of the corneal epithelium. Chiron Vision Fibronectin Study Group. Am. J. OphthalmoL (1995) 119:281–287.
   Google Scholar
• TSUBOTA K: Ocular surface managementin corneal transplantation, a review. Jpn. OphthalmoL (1999) 43:502–508.
   Google Scholar
• VAJPAYEE RB, MUKERJI N, TANDON R et al.: Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects. Br. J. OphthalmoL (2003) 87:1312–1316.
   PubMed Web of Science ®Google Scholar
• CHEN HJ, PIRES RT, TSENG SC: Amniotic membrane transplantation for severe neurotrophic corneal ulcers. Br. J. OphthalmoL (2000) 84:826–833.
   PubMed Web of Science ®Google Scholar
• PUSHKER N, DADA T, VAJPAYEE RB et al.: Neurotrophic keratopathy. CLAO J. (2001) 27:100–107.
   Google Scholar
• MAH-SADORRA JH, YAVUZ SG, NAJJAR DM et aL: Trends in contact lens-related corneal ulcers. Cornea (2005) 24:51–58.
   PubMed Web of Science ®Google Scholar
• MCCULLEY J, ALIZADEH H: The diagnosis and management of acanthamodeba keratitits. CLAO J. (2000) 26:47–51.
   PubMedGoogle Scholar
• SUDESH S, LAIBSON PR: The impact of the herpetic eye disease studies on the management of herpes simplex vius ocular infections. Curr. Opin. OphthalmoL (1999) 10:230–233.
   PubMedGoogle Scholar
• ••A comprehensive summary of impact of allthe seminal herpetic eye disease studies on the management of herpes ocular infections.
   Google Scholar
• REIDY JJ, PAULUS MP, GONA S: Recurrent erosions of the cornea: epidemiology and treatment. Cornea (2000) 19:767–771.
   PubMed Web of Science ®Google Scholar
• BURNS R: Meesman's corneal dystrophy. Trans. Am. OphthalmoL Soc. (1968) 66:530–635.
   Google Scholar
• HEYWORTH P, MORLET N, RAYNER S, HYKIN E DART J: Natural history of recurrent erosion syndrome - a 4 year review of 117 patients. Br. J. OphthalmoL (1998) 82:26–28.
   PubMed Web of Science ®Google Scholar
• ALPER MG: The anesthetic eye: an investigation of changes in the anterior ocular segment of the monkey caused by interrupting the trigeminal nerve at various levels along its course. Trans. Am. Ophthalmol Soc. (1975) 73:313–365.
   Google Scholar
• REID TW, MURPHY CJ, IWAHASHI CK, FOSTER BA, MANNIS MJ: Stimulation of epithelial cell growth by the neuropeptide substance P. J. Cell Biochem. (1993) 52:476–485.
   PubMed Web of Science ®Google Scholar
• DAVIS EA, DOHLMAN CH: Neurotrophic keratitis. Int. Ophthalmol Clin. (2001) 41:1–11.
   PubMedGoogle Scholar
• ••An unusually thorough review ofneurotrophic keratitis with a complete bibliography.
   Google Scholar
• AZAR DT, SPURR-MICHAUD SJ, TISDALE AS, GIPSON IK: Decreased penetration of anchoring fibrils into the diabetic stroma. A morphometric analysis. Arch. Ophthalmol (1989) 107:1520–1523.
   PubMed Web of Science ®Google Scholar
• SAITO J, ENOKI M, HARA M et al.: Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy. Cornea (2003) 22:15–18.
   PubMed Web of Science ®Google Scholar
• ANG L, TAN D: Ocular surface stem cells and disease: current concepts and clinical applications. Ann. Acad. Med. Singapore (2004) 33:576–580.
   PubMed Web of Science ®Google Scholar
• FURRER P, MAYER JM, PLAZONNET B, GURNY R: Ocular tolerance of absorption enhancers in ophthalmic preparations. AAPS Pharm. Sci. (2002) 4
   Google Scholar
• SCHANG L: Cyclin-dependent kinases as cellular targets for antiviral drugs. Antimicrob. Chemother. (2002) 50:779–792.
   Web of Science ®Google Scholar
• http://www.pharmsci.org See [67]. Affiliation
   Google Scholar