13
Views
0
CrossRef citations to date
0
Altmetric
Patent Evaluation

The use of peptides that pick up prions: protection or poison?

Chiron Corp.: WO2005016127

Pages 1287-1290 | Published online: 02 Dec 2005

Bibliography

  • BASLER K, OESCH B, SCOTT M et al.: Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 46:417–428.
  • STAHL N, BORCHELT DR, PRUSINER SB: Differential release of cellular and scrapie prion protein from cellular membranes of phosphatidylinositol specific phospholipase C. Biochemistry (1990) 29:5405–5412.
  • SALES N, RODOLFO K, HASSIG R et al.: Cellular prion protein localization in rodent and primate brain. Eur. J. Neurosci. (1998). 10:2464–2471.
  • HORNSHAW MP, MCDERMOTT JR, CANDY JM: Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein. Biochem. Biophys. Res. Commun. (1995) 207:621–629.
  • BROWN D R, QIN K, HERMS jw et al.:The cellular prion protein binds copper in vivo. Nature (1997) 390:684–687.
  • BROWN DR, NICHOLAS RST, CANEVARI L: Lack of prion protein expression results in a neuronal phenotype sensitive to stress. J. Neurosci. Res. (2002) 67:211–224
  • COLLINGE J, WHITTINGTON MA,SIDLE KC et al.: Prion protein is necessary for normal synaptic function. Nature (1994) 370:295–297.
  • HUBER R, DEBOE T, TOBLER I: Sleepdeprivation in prion protein deficient mice sleep deprivation in prion protein deficient mice and control mice: genotype dependent regional rebound. Neuroreport (2002) 13:1–4.
  • GRANER E, MERCADANTE AF, ZANATA SM, MARTINS VR, JAY DG, BRENTANI RR: Laminin-induced PC-12 cell differentiation is inhibited following laser inactivation of cellular prion protein. FEBS Lett. (2000) 482:257–260.
  • CHIARINI LB, FREITAS AR, ZANATA SM, BRENTANI RR, MARTINS VR, LINDEN R: Cellular prion protein transduces neuroprotective signals. EMBO J. (2002) 21:3317–3326.
  • BROWN DR, WONG BS, HAFIZ F, CLIVE C, HASWELL SJ, JONES IM: Normal prion protein has an activity like that of superoxide dismutase. Biochem. (1999) 344:1–5.
  • BROWN DR: Prion protein expression aids cellular uptake and veratridine-induced release of copper. J. Neurosci. Res. (1999) 58:717–725.
  • PAULY PC, HARRIS DA: Copper stimulates endocytosis of the prion protein. J. Biol. Chem. (1998) 273:33107–33110.
  • KUWATA K, LI H, YAMADA H et al.: Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc? Biochemistry (2002) 41:12277–12283.
  • GASSET M, BALDWIN MA, FLETTERICK RJ, PRUSINER SB: Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. Proc. Natl. Acad. Sci. USA. (1993) 90:1–5.
  • PRUSINER SB. Prions. Proc. Natl. Acad. Sci. USA. (1998) 95:13363–13383.
  • BROWN DR: Mayhem of the multiple mechanisms: modelling neurodegeneration in prion disease. J. Neurochem. (2002) 82:209–215.
  • ETTAICHE M, PICHOT R, VINCENT JP, CHABRY J: In vivo cytotoxicity of the prion protein fragment 106-126.1 Biol. Chem. (2000) 275:36487–36490.
  • KANEKO K, BALL HL, WILLE H et al.:A synthetic peptide initiates Gerstmann-Straussler-Scheinker (GSS) disease in transgenic mice. 1 MoL BM/ (2000) 295:997–1007.
  • SHMERLING D, HEGYI I, FISCHER M et al.: Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 93:203–214.
  • LEGNAME G, BASKAKOV IV, NGUYEN HO et al.: Synthetic mammalian prions. Science (2004) 305:673–676.
  • BROWN DR: Prion protein peptides: optimal toxicity and peptide blockade of toxicity. MoL Cell Neurosci. (2000) 15:66–78.
  • KORTH C, STIERLI B, STREIT P et al.:Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature (1997) 390:74–77.
  • CURIN SERBEC V BRESJANAC M, POPOVIC M et al.: Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue. 1 Biol. Chem. (2004) 279:3694–3698.
  • KHALILI-SHIRAZI A. QUARATINO S, LONDEI M et al.: Protein conformation significantly influences immune responses to prion protein./ immune)/ (2005) 174:3256–3263.
  • PARAMITHIOTIS E, PINARD M, LAWTON T et al.: A prion protein epitope selective for the pathologically misfolded conformation. Nature Med. (2003) 9:893–899.
  • RHIE A, KIRBY L, SAYER N et aL: Characterization of 2.-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. J. Biol. Chem. (2003) 278:39697–39705.
  • KANEKO K, PERETZ D, PAN KM et al.: Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform. Proc. NatL Acad. Sci. USA. (1995) 92:11160–11164.
  • KANEKO K, WILLE H, MEHLHORN I et al.: Molecular properties of complexes formed between the prion protein and synthetic peptides. J. MoL Biol. (1997) 270:574–586.
  • BROWN DR: PrPsc-like prion protein peptide inhibits the function of cellular prion protein. Biochem. J. (2000) 252:511–518.
  • KESHET GI, BAR-PELED 0, YAFFE D, NUDEL U, GABIZON R: The cellular prion protein colocalizes with the dystroglycan complex in the brain. 1 Neurochem. (2000) 75:1889–1897.
  • RIEGER R, EDENHOFER F, LASMEZAS CI, WEISS S: The human 37 kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat. Med. (1997) 3:1383–138.
  • YEHIELY F, BAMBOROUGH P, DA COSTA M et al.: Identification of candidate proteins binding to prion protein. NeurobioL Dis. (1997) 3:339–355.
  • SIGURDSSON EM, BROWN DR, DANIELS M et al.: Immunization delays the onset of prion disease in mice. Am. J. PathoL (2002) 161:13–17.
  • MAGRI G, CLERICI M, DALL'ARA P et al.: Decrease in pathology and progression of scrapie after immunisation with synthetic prion protein peptides in hamsters. Vaccine (2005) 23:2862–288.
  • GONI F, KNUDSEN E, SCHREIBER F et al.: Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience (2005) 133:413–421.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.