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Patent Evaluation

Antibodies to dickkopf-1 protein

Amgen: WO2006015373

Pages 1453-1458 | Published online: 04 Oct 2006

Bibliography

  • GLINKA A, WU W, DELIUS H, MONAGHAN AP, BLUMENSTOCK C, NIEHRS C: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 391(6665):357-362.
  • KRUPNIK VE, SHARP JD, JIANG C et al.: Functional and structural diversity of the human dickkopf gene family. Gene (1999) 238(2):301-313.
  • BAFICO A, LIU G, YANIV A, GAZIT A, AARONSON SA: Novel mechanism of Wnt signalling inhibition mediated by dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. (2001) 3(7):683-686.
  • DAVIDSON G, MAO B, DEL BARCO BARRANTES I, NIEHRS C: Kremen proteins interact with dickkopf1 to regulate anteroposterior CNS patterning. Development (2002) 129(24):5587-5596.
  • WANG J, SHOU J, CHEN X: Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene (2000) 19(14):1843-1848.
  • KATO M, PATEL MS, LEVASSEUR R et al.: Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. (2002) 157(2):303-314.
  • LITTLE RD, CARULLI JP, DEL MASTRO RG et al.: A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. (2002) 70(1):11-19.
  • BOYDEN LM, MAO J, BELSKY J et al.: High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. (2002) 346(20):1513-1521.
  • OHNAKA K, TANIGUCHI H, KAWATE H, NAWATA H, TAKAYANAGI R: Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochem. Biophys. Res. Commun. (2004) 318(1):259-264.
  • OHNAKA K, TANABE M, KAWATE H, NAWATA H, TAKAYANAGI R: Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem. Biophys. Res. Commun. (2005) 329(1):177-181.
  • GUNN WG, CONLEY A, DEININGER L, OLSON SD, PROCKOP DJ, GREGORY CA: A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK-1 and IL-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells (2006) 24(4):986-991.
  • TIAN E, ZHAN F, WALKER R et al.: The role of the Wnt-signaling antagonist DKK-1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. (2003) 349(26):2483-2494.
  • POLITOU MC, HEATH DJ, RAHEMTULLA A et al.: Serum concentrations of dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int. J. Cancer (2006) 119(7):1728-1731.
  • WIRTHS O, WAHA A, WEGGEN S et al.: Overexpression of human dickkopf-1, an antagonist of wingless/Wnt signaling, in human hepatoblastomas and Wilms' tumors. Lab. Invest. (2003) 83(3):429-434.
  • HALL CL, BAFICO A, DAI J, AARONSON SA, KELLER ET: Prostate cancer cells promote osteoblastic bone metastases through Wnts. Cancer Res. (2005) 65(17):7554-7560.
  • GREGORY CA, SINGH H, PERRY AS, PROCKOP DJ: The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J. Biol. Chem. (2003) 278(30):28067-28078.
  • GREGORY CA, PERRY AS, REYES E, CONLEY A, GUNN WG, PROCKOP DJ: DKK-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow. J. Biol. Chem. (2005) 280(3):2309-2323.
  • VAN DER HORST G, VAN DER WERF SM, FARIH-SIPS H, VAN BEZOOIJEN RL, LOWIK CW, KARPERIEN M: Downregulation of Wnt signaling by increased expression of dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J. Bone Miner. Res. (2005) 20(10):1867-1877.
  • YAMAGUCHI Y, HEARING VJ, ITAMI S, YOSHIKAWA K, KATAYAMA I: Mesenchymal-epithelial interactions in the skin: aiming for site-specific tissue regeneration. J. Dermatol. Sci. (2005) 40(1):1-9.
  • CARICASOLE A, COPANI A, CARACI F et al.: Induction of dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J. Neurosci. (2004) 24(26):6021-6027.
  • ANDL T, REDDY ST, GADDAPARA T, MILLAR SE: Wnt signals are required for the initiation of hair follicle development. Dev. Cell (2002) 2(5):643-653.

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