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Patent Evaluation

RAF modulators and methods of use

Exelixis, Inc.: WO2005112932

Pages 1031-1036 | Published online: 21 Jun 2006

Bibliography

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  • LOWINGER TB, RIEDL B, DUMAS J, SMITH RA: Design and discovery of small molecules targeting RAF-1 kinase. Curr. Pharm. Des. (2002) 8(25):2269-2278.
  • AMIRI A, AIKAWA M, DOVE N et al.: CHIR-265 is a potent selective inhibitor of c-RAF/B-RAF/mutB-RAF that effectively inhibits proliferation and survival of cancer cell lines with Ras/RAF pathway mutations. Proc. Am. Assoc. Cancer Res. Washington DC, USA (2006) Abstract 4855.
  • HEIMBROOK DC, HUBER HE, STIRDIVANT SM et al.: Identification of potent, selective inhibitors of RAF protein kinase. Proc. Am. Assoc. Cancer Res. New Orleans, USA (1998) Abst. 3793.
  • LACKEY K, CORY M, DAVIS R et al.: The discovery of potent cRAF1 kinase inhibitors. Bioorg. Med. Chem. Lett. (2000) 10(3):223-226.
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Patents

Websites

  • http://www.bionetresearch.co.uk/ screenin.htm Key organics website.
  • http://www.exelixis.com/pipeline.shtml Exelixis website.

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