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Antimicrobials

Patent Evaluation: Aryl Macrocyclic Compositions for Treating Viral Infections

Pages 1852-1854 | Published online: 02 Mar 2011

Key References

  • Baba, M Snoeck, R Pauwels, R de Clercq, E Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antimicrob. Agents Chemother. 1988 32 1742–1745.
  • Schols, D Pauwels, R Desmyter, J de Clercq, E Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. Virology 1990 175 556–561.
  • Ottenbrite, RM Structure and biological activities of some polyanionic polymers. Anionic Polymeric Drugs. Donaruma, LG, Ottenbrite, RM, Vogl, O Wiley New York1990 21–48.
  • Nakashima, H Yoshida, O Baba, M de Clercq, E Yamamoto, N Anti-HIV activity of dextran sulfate as determined under different experimental conditions. Antiviral Res. 1989 11 233–246.

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