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Cardiovascular Agents (Including Blood Products)

Patent Evaluation: Bridged Cyclic Ketal Derivatives as Squalene Synthetase Inhibitors

Pages 1918-1920 | Published online: 02 Mar 2011

Key References

  • Dawson, MJ Farthing, JE Marshall, PS Middleton, RF O'Neill, MJ Shuttleworth, A Stylli, C Tait, RM Taylor, PM Wildman, HG The squalestatins, novel inhibitors of squalene synthase produced by a speicies of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. J. Antibiot. 1992 45 639–647.
  • Sidebottom, PJ Highcock, RM Lane, SJ Procopiou, PA Watson, NS The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation. J. Antibiot. 1992 45 648–658.
  • Biller, SA Forster, C Gordon, EM Harrity, T Rich, LC Marretta, J Ciosek, CP Jr Isoprenyl phosphinylformates: New inhibitors of squalene synthetase. J. Med. Chem. 1991 34 1912–1914.
  • Biller, SA Forster, C Gordon, EM Harrity, T Scott, WA Ciosek, CP Jr Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase. J. Med. Chem. 1988 31 1869–1871.
  • Kaneko, I Hazama-Shimda, Y Endo, A Inhibitory effects on lipid metabolism in cultured cells of ML-236-B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Eur. J. Biochem. 1978 87 313–321.

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