References to Primary Literature
- Mahi-Brown CA, Prospects for control of fertility in the female dog by active immunization with porcine zona pellucida proteins, Immunological Approaches to Contraception and Promotion of Fertility Talwar GP Plenum Press New York 1986 301–309 Discusses the prospect of using zona pellucida for immunocontraception in female dogs.
- New castration and contraception techniques - an active area of R & D Anim. Pharm. 1991 230 22 Briefly discusses the development of contraceptive vaccines for animals.
- Jeffcoate SL, Holland DT, Fraser HM, Gunn A Preparation and specificity of antibodies to the decapeptide, luteinizing hormone-releasing hormone Immunochem. 1974 11 75–77 A pioneering immunological and chemical study with LHRH. The antigenic site of the decapeptide is localized in the C-terminus of the molecule. The N-terminal residues are relatively non antigenic.
- Fraser HM, Gunn A, Jeffcoate SL, Holland DT Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotrophins, tests and accessory sex organs in the male rat J. Endocr. 1974 63 399–406 Active immunization against LHRH in male rats resulted in aspermatogenesis, atrophy of testes and secondary sex organs and marked decreases in FSH and LH levels in serum.
- Clarke IJ, Fraszer HM, McNeilly AS Active immunizaztion of ewes against luteinizing hormone releasing hormone, and its effects on ovulation and gonadotrophin, prolactin and ovarian steroid secretion J. Endocr. 1978 78 39–47 Ewes immunized with LHRH conjugated to BSA failed to show oestrus or ovulate and had decreased plasma levels of LH with normal FSH and increased prolactin concentration.
- Esbenshade KL, Britt JH Active immunization of gilts against gonatrophins, reproductive function, and responses to agonists of gonadotropin-releasing hormone Biol. Repro. 1985 33 569–577 Active immunization of sexually mature gilts against GnRH caused gonadotropins to decline to undetectable levels and the animals became acyclic. Functional integrity of the pituitary remained intact in the immunized animals.
- Chappe SC, Ellinwood WE, Huckins C, Herbert DC, Spies HG Active immunization of male Rhesus monkeys against luteinizing hormone releasing hormone Biol. Repro. 1980 22 333–342 Continued immunization of male Rhesus monkeys against LHRH caused a dramatic decrease in serum concentrations of LH and testosterone when antibody titres reached the effective level. Serum LH and testosterone levels returned to preimmunization values as the antibody levels decline.
- Johnson HE, Deavila DM, Chang CF, Reeves JJ Active immunization of heifers against luteinizing horme-releasing hormone, human chorionic gonadotropin and bovine luteinizing hormone J. Anim. Sci. 1988 66 719–726 None of the animals immunized with LHRH-OV or bLH-OV with Freund's complete or incomplete adjuvant became pregnant compared to 71% pregnancy rate in the control group.
- Robertson IS, Fraser HM, Innes GM, Jones A The effect of immunological castration on sexual and production characteristics in male cattle Veterinary Record 1982 11 529–531 Temporary immunocastration lasting for six months was obtained in bull calves by giving two to three injections of LHRH conjugated to human serum albumin and mixed with Freund's complete and incomplete adjuvant.
- Gupta SK, Koothan PT Relevance of immuno-contraceptive vaccines for population control: I. Hormonal immunocontraception Arch. Immun. Ther. Exp. 1990 38 47–60 A comprehensive review of hormonal immunocontraception with considerable discussion of Phase I clinical studies in women using β-hCG based vaccines.
- O'Rand MG, Widgren EE Molecular biology of a sperm antigen: Identification of the sequence of an autoantigenic epitope J. Reprod. Immunol. 1980 suppl. 6 A decapeptide fraction, P10G, purified from a 14 kD band related to the rabbit sperm specific antigens (RSA) group is immunoreactive. Antibodies to P10G localized to the sperm equatorial post-acrosomal border and blocked sperm binding to the zona pellucida.
- Wright RM, Klotz JE, Flinger CJ, Herr JC Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10 Biol. Repro. 1990 42 693–701 A recombinant SP-10 fusion protein was produced in an E. coli expression vector and used to generate a polyclonal antisera which inhibited sperm binding and penetration in the zona-free hamster egg penetration assay.
- Primakoff P, Lathrop W, Woolman L, Cowan A, Myles D Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20 Nature 1988 335 543–546 Completely effective contraception was obtained in male and female guinea pigs immunized with the guinea pig sperm surface protein PH-20. Immunized female regain fertility within 6 to 15 months after immunziation.
- Naz R The fertilization antigen (FA-1): Applications in immunocontraception and infertility in humans Am. J. Repro. Immun. 1988 16 21–27 A comprehensive review of the sperm specific antigens with special emphasis on the fertilization antigen (FA-1) and its possible use for immunocontraception.
- Wood DM, Celilia L, Dunbar BS Effect of alloimmunization and heteroimmunization with zonae pellucidae on fertility in rabbits Biol. Reprod. 1981 25 439–450.
- Gulyas BJ, Gwatkin RBL, Yuan LC Active immunization of cynomolgus monkeys (Macaca fascicularis) with procine zona pellucida Gamete Res. 1983 7 4 299–307.
- Sacco AG, Subramanian MG, Yurewicz EC Active immunization of mice with porcine zona pellucida: Immune response and effect on fertility J. Exp. Zool. 1981 218 405–418.
- Drell DW, Wood DM, Bundman D Immunological comparison of antibodies to zonae pellucidae in rats and rabbits Biol. Reprod. 1984 30 435–444.
- Sehgal S, Gupta SK, Disillusions and hopes about zona pellucida glycoproteins, Contraceptiopn Research for Today and the Nineties Talwar GP Springer-Verlag New York 1988 345–356 A detailed review on zona pellucida glycoproteins with special emphasis on the possible problems of their use for immunocontraception.
- Sacco AG Zona pellucida: Current status as a candidate antigen for contraceptive vaccine development Am. J. Repro. Immun. 1987 15 122–130 A comprehensive review on zona pellucida with emphasis on its possible use as immunocontraception.
- Gregoriadis G Immunological adjuvants: A role for liposomes Immunology Today 1990 11 89–97 The use of liposomes as immunoadjuvants is discussed with many examples.
- Yilma T, Usu D, Jones L, Owens S, Grubman M, Mebus C, Yamanaka M, Dale B Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene Science 1988 242 1058–1061 Development of a highly effective vaccine for rinderpest using recombinant vaccine virus expressing haemagglutinin or fusion protein from rinderpest virus.
References to Patent Literature
- Pitman-Moore Inc, US4608251 1986.
- Pitman-Moore Inc, US5036047 1991.
- All India Institute of Medical Science, US4161529 1979.
- Ohio State University, US4201770 1980.
- Ohio State University, US4384995 1983.
- Ohio State University, US4691006 1987.
- Stolle Research and Development Co, US4732763 1988.
- National Institute of Immunology (India), US4780312 1988.
- Ohio State University, US5006334 1991.
- University of North Carolina, WO9108226 1991.
- Cent Innovat Techin, WO9009082 1990.
- Zonagen, Inc, US4996296 1991.
- US Dept of Commerce, WO9015624 1990.
- Syntex (USA) Inc, 4629782 1986.
- Ribi Immunochemical, BE900377 1985.
- Cambridge Bioscience, WOP8809336 1988.
- State of Victoria, WO8800056 1988.