References to Primary Literature
- Prusoff WH Synthesis and biological activity of iododeoxyuridine, an analog of thymidine. Biochem. Biophys. Acta 1959 32 295–296.
- Prusoff WH Idoxuridine or how it all began. Clinical use of antiviral drugs De Clercq E Martinus Nijhoff Boston 1988, 15–24.
- Heidelberger C, Parsons D, Remy DC Synthesis of 5-trifluoromethyluracil and 5-(trifluoromethyl)-2′-deoxyuridine. J. Am. Chem. Soc. 1962 84 3597–3598.
- Carmine AA, Brogden RN, Heel RC, Speight TM, Avery GS Trifluridine: A review of its antiviral activity and therapeutic use in topical treatment of viral eye infections. Drugs 1982 23 329–353.
- Lee WS, Benitez A, Goodman L, Baker BR Potential anticancer agents. XL. Synthesis of the β-anomer of 9-(D-arabinofuranosyl)-adenine. J. Am. Chem. Soc. 1960 82 2648–2649.
- Buchanan RA, Hess F Vidarabine (Vira-A®): Pharmacology and clinical experience. Pharmacol. Ther. 1980 8 143–171.
- Schaeffer HJ, Beauchamp C, De Miranda P, Elion GB, Bauer DJ, Collins P 9-(2-hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 1978 272 583–585.
- Remy RJ, Secrist JA III Acyclic nucleosides other than acyclovir as potential antiviral agents. Nucleosides & Nucleotides 1985 4 411–427.
- Chu CK, Cutler SJ Chemistry and antiviral activities of acyclonucleosides. J. Heterocyclic Chem. 1986 23 289–319.
- Ogilvie KK, Cheriyan UO, Radatus BK, Smith KO, Galloway KS, Kennell WL Biologically active acyclonucleoside analogues. II. The synthesis of 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine(BIOLF-62). Can. J. Chem. 1982 60 3005–3010.
- Helgstrand E, Erikkson B, Johansson NG, Lannerö B, Larsson A, Misiorny A, Norén JO, Sjöberg B, Steinberg K, Stening G, Stridh S, Öberg B Trisodium phosphonoformate, a new antiviral compound. Science 1978 201 819–821.
- Hirsch MS, Kaplan JC Antiviral Agents. Virology Fields BN Knipe DM Chanock RM Hirsch MS Melnick JL Monath TP Roizman B Raven Press New York 1990, 441–468.
- Crumpacker CS II Molecular targets of antiviral therapy. New Engl. J. Med. 1989 321 163–172.
- Estes JE, Huang E-S Stimulation of cellular thymidine kinase by human cytomegalovirus. J. Virol. 1977 24 13–21.
- Verheyden JPH Non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). Curr. Opin. Thera. Patents 1991 1 1294–1304.
- Dalziel W, Hesp B, Stevenson KM, Jarvis JAJ The structure and absolute configuration of the antibiotic aphidicolin: A tetracyclic diterpenoid containing a new ring system. J. Chem. Soc. Perkin Trans. I 1973, 2841–2851.
- Huberman JA New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase α. Cell 1981 23 647–648.
- Spector T, Harrington JA, Morrison RW, Lambe CU, Nelson DJ, Averett DR, Biron K, Furman PA 2-Acetylpyridine-5-[(dimethyl-amino)thiocarbonyl]thiocarbonohydrazone (A111OU), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella zoster viruses and a potentiator of acyclovir. Proc. Natl. Acad. Sci. USA 1989 86 1051–1055.
- Reardon JE, Spector T Acyclovir: Mechanism of antiviral action and potentiation by ribonucleotide reductase inhibitors. Adv. Pharmacol. 1991 22 1–27.
- Spector T, Lobe DC, Ellis MN, Blumenkopf TA, Szczech GM Inactivators of herpes simplex virus ribonucleotide reductase: Hematological profiles and in vivo potentiation of the antiviral activity of acyclovir. Antimicrob. Agents Chemother. 1992 36 934–937.
- Liu F, Roizman B The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate. J. Virol. 1991 65 5149–5156.
- Welch AR, Woods AS, McNally LM, Cotter RJ, Gibson W A herpesvirus maturational proteinase, assemblin: Identification of its gene, putative active site domain, and cleavage site. Proc. Natl. Acad. Sci. USA 1991 88 10792–10796.
- Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, Gallo RC Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986 234 596–601.
- Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc. Natl. Acad. Sci. USA 1991 88 5922–5926.
- Schneweis KE, Gelderblom H, Eis-Hübinger AM Das 6. humane Herpesvirus: Diagnostische Möglichkeiten und pathogenetische Probleme (Human herpesvirus 6: Diagnosis of infection and pathogenetic problems). Lab. Med. 1990 14 261–265.
- Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet 1988 ii 1065–1067.
- Portolani M, Cermelli C, Pietrosemoli P, Pecorari M, Farabegoli F, Cavazzuti GB, Bertolani MF, Micheli A Isolation of HHV-6-related virus from children affected by infectious syndrome. Arch. Virol. 1990 110 143–149.
- Montgomery JA, Clayton SD, Thomas HJ Isonucleosides. I. Preparation of methyl 2-deoxy-2-(purin-9-yl)arabinofuranosides and methyl 3-deoxy-3-(purin-9-yl)xylofuranosides. J. Org. Chem. 1975 40 1923–1927.
- Montgomery JA, Thomas HJ Isonucleosides. 2. Purine and pyrimidine derivatives of 1,4-anhydro-2-deoxy-D-arabinitol. J. Org. Chem. 1978 43 541–544.
- Lin T-S, Shen Z-Y, August EM, Brankovan V, Yang H, Ghazzouli I, Prusoff WH Synthesis and antiviral activity of several 2,5′-anhydro analogues of 3′-azido-3′ deoxythymidine, 3′-azido-2′,3′-dideoxyuridine, 3′-azido-2′,3′-dideoxy-5-halouridines, and 3′-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus. J. Med. Chem. 1989 32 1891–1895.
- De Clercq E, Descamps J, Balzarini J, Gizievicz J, Barr PJ, Robins MJ Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides. J. Med. Chem. 1983 26 661–666.
- Norbeck DW, Sham HL, Herrin T, Rosenbrook W, Plattner JJ Synthesis of (±) Cycloprop-G, the cyclopropyl analogue of the broad spectrum antiviral agent Cyclobut-G. J. Chem. Soc. Chem. Commun. 1992, 128–129.
- Shimada N, Hasegawa S, Harada T, Tomisawa T, Fujii A, Takita T Oxetanocin, a novel nucleoside from bacteria. J. Antibiot. 1986 39 1623–1625.
- Nishiyama Y, Yamamoto N, Takahash K, Shimada N Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G. Antimicrob. Agents Chemother. 1988 32 1053–1056.
- Daikoku T, Yamamoto N, Saito S, Kitagawa M, Shimada N, Nishiyama Y Mechanism of inhibition of human cytomegalovirus replication by oxetanocin G. Biochem. Biophys. Res. Commun. 1991 176 805–812.
- Nishiyama S, Yamamura S, Kato K, Takita T Synthetic studies on oxetanocin, a novel nucleoside with an oxetane ring. Synthesis of some chiral D-oxetanosyl acylates. Tetrahedron Lett. 1988 29 4739–4742.
- Nishiyama S, Yamamura S, Kato K, Takita T A total synthesis of oxetanocin, a novel nucleoside with an oxetane ring. Tetrahedron Lett. 1988 29 4743–4746.
- Field AK, Tuomari AV, McGeever-Rubin B, Terry BJ, Mazina KE, Haffey ML, Hagen ME, Clark JM, Braitman A, Slusarchyk WA, Young MG, Zahler R (±)(1α,-2β,3α)-9-[2,3-bis(hydroxymethyl)-cyclobutyl] guanine [(±)-BHCG or SQ 33054]: A potent and selective inhibitor of herpesviruses. Antiviral Res. 1990 13 41–52.
- Blackburn GM Phosphonates as analogues of biological phosphates. Chem. & Ind. 1981, 134–138.
- Blackburn GM, Kent DE, Kolkmann F The synthesis and metal binding characteristics of novel, isopolar phosphonate analogues of nucleosides. J. Chem. Soc. Perkin Trans. I 1984, 1119–1125.
- Chambers RD, O'Hagan D, Lamont RB, Jain SC The difluoromethylenephosphonate moiety as a phosphate mimic: X-Ray structure of 2-amino-1,1-difluoroethylphosphonic acid. J. Chem. Soc. Chem. Commun. 1990, 1053–1054.
- Drugs of the Future 1985 10 586–588.
- Nishiyama Y, Yamamoto N, Takahash K, Shimada N Selective inhibition of human cytomegalovirus replication by a novel nucleoside, Oxetanocin G. Antimicrob. Agents Chemother. 1988 32 1053–1056.
- Sakuma T, Saijo M, Suzutani T, Yoshida I, Saito S, Kitagawa M, Hasegawa S, Azuma M Antiviral activity of oxetanocins against varicella-zoster virus. Antimicrob. Agents Chemother. 1991 35 1512–1514.
- Slusarchyk WA, Bisacchi GS, Hockstein DR, Young MG, Field AK, McGeever-Rubin B, Tuomari AV, Zahler R SQ-33,054: A potent member of a new class of nucleosideanalog antivirals. XXIX Inter-science Conference on Antimicrobial Agents and Chemotherapy Houston 1989 Abstract #1330.
- Harnden MR, Parkin A, Wyatt PG Synthesis of 9-(3-hydroxy propoxy)guanine, a novel antiviral acyclonucleoside. Tetrahedron Lett. 1988 29 701–704.
- Harnden MR, Jennings LJ, Parkin A Synthesis of 1-(hydroxyalkoxy)pyrimidines, a novel series of acyclic nucleoside analogues. Tetrahedron Lett. 1988 29 4013–4016.
- De Clercq E, Holý A, Rosenberg I, Sakuma T, Balzarini J, Maudgal PC A novel selective broad-spectrum anti-DNA virus agent. Nature 1986 323 464–467.
- Megati S, Phadtare S, Zemlicka J Unsaturated phosphonates as acyclic nucleotide analogues. Anomalous Michaelis Arbuzov and Michaelis-Becker reactions with multiple bond systems. J. Org. Chem. 1992 57 2320–2327.
- Holý A, Rosenberg I Phosphonylalkoxyalkyl and phosphonylalkyl derivatives of heterocyclic bases. Nucleosides & Nucleotides 1989 8 673–688.
- Holý A, Votruba I, Merta A, Cerný J, Veselý J, Vlach J, Sediva K, Rosenberg I, Otmar M, Hrebabecký H, Trávnícek M, Vonka V, Snoeck R, De Clercq E Acyclic nucleotide analogues: Synthesis, antiviral activity and inhibitory effects on some cellular and virus encoded enzymes in vitro.. Antiviral Res. 1990 13 295–312.
- Winkler I, Winkelmann E, Scholl T, Rösner M, Jähne G, Helsberg M Antiviral activity and phamacokinetics of HOE 602, an acyclic nucleoside, in animal models. Antiviral Res. 1990 14 61–73.
- Winkler I, Helsberg M, Scholl T, Meichsner C, Jähne G, Rösner M Antiviral activity and metabolism of 7-isomer derivatives of the purine nucleoside analogue HOE 602. Antiviral Res. (Suppl. I) 1990 Abstract #31.
- Helsberg M, Jähne G, Rösner M, Scholl T, Winkler I Antiviral activity of acyclic 7-isomers of purine nucleoside derivatives. VIIIth International Congress of Virology Berlin 1990, 34–022.
- Goldstein DJ, Weller SK Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensible for virus growth and DNA synthesis: Isolation and characterization of an ICP6 lacZ insertion mutant. J. Virol. 1988 62 196–205.
- Cameron JM, McDougall I, Marsden HS, Preston VG, Ryan DM, Subak-Sharpe JH Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target. J. Gen. Virol. 1988 69 2607–2612.
- Dutia BM, Frame MC, Subak-Sharpe JH, Clark WN, Marsden DH Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides. Nature 1986 321 439–441.
- Cohen EA, Gaudreau P, Brazeau P, Langelier Y Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2. Nature 1986 321 441–443.
- Zamecnik PC, Stephenson M Inhibition of Rous sarkoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 1978 75 280–284.
- Uhlmann E, Peyman A Antisense oligonucleotides: A new therapeutic principle. Chem. Rev. 1990 90 543–584.
- Cohen JS Oligonucleotides as therapeutic agents. Pharmac. Ther. 1991 52 211–225.
- Look SA, Fenical W, Matsumoto GK, Clardy J The pseudopterosins: A new class of antiinflammatory and analgesic diterpene pentosides from the marine sea whip Pseudopterogorgia elisabethae (Octocorallia). J. Org. Chem. 1986 51 5140–5145.
- Drugs of the Future 1988 13 673–674.
References to Patent Literature
- The Wellcome Foundation Ltd, DE2539963.
- Syntex (USA) Inc, US4355032.
- ER Squibb & Sons Inc, EP-464769-A2.
- ER Squibb & Sons Inc, EP-394893-A.
- Hoechst Aktiengesellsckaft, EP-464642-A1.
- The Wellcome Foundation Ltd, EP-453247-A2.
- Burroughs Wellcome, EP-272065-A.
- Burroughs Wellcome, EP-375164-A.
- The Wellcome Foundation Ltd, EP-417560-A1.
- Glaxo Group Ltd, EP-430518-A2.
- Glaxo Group Ltd, EP-345076-A1.
- Nippon Kayaku, KK, EP-468352-A2.
- Abbott Laboratories, EP-433898-A2.
- ER Squibb & Sons, Inc, EP-33535-A2.
- Nippon Kayaku KK, EP-358154-A2.
- Abbott Laboratories, EP-366059-A2.
- ER Squibb & Sons Inc, EP-458363-A1.
- Nippon Kayaku KK, EP-458312-A1.
- ER Squibb & Sons Inc, EP-433897-A2.
- Beecham Group PLC, EP-404296-A1.
- Beecham Group PLC, EP-405748-A1.
- Beecham Group PLC, WO9201698.
- Beecham Group PLC, WO9200742.
- Beecham Group PLC, WO9111187.
- Bristol-Myers Squibb Co, EP-452935-A1.
- Ceskoslovenska Academie Ved/Rega Foundation, EP-253412-B1.
- Ceskoslovenska Academie Ved/Katholieke Universiteit Rega, EP-454427-A1.
- Hoechst Aktiengesellschaft, EP-452680-A; Hoechst AG, DE4008858-A1.
- Merck & Co, EP-438873-A1.
- Bio-Mega Inc, EP-461546-A2.
- ISIS Pharmaceuticals Inc, WO9112811.
- Schering Corporation, WO9204326.
- Schering Corporation, WO9204327.
- Schering Corporation, WO9204328.
- Universidad Autonoma de Nuevo-Leon, EP-467407-A2.
- Lomapharm Rudolf Lohmann GmbH KG, EP-454058-A2.
- Pharma Mar, EP-432983-A2.
- Manikas J, WO9112012.
- Nihon Chemical Research KK/Noda Shokukin Kogyo KK, EP-437346-A1.
- Tsumura & Co, EP-442744-A2.
- Taito Co Ltd, EP-463540-A1.
- The President and Fellows of Harvard College, WO9113175.
- The Council of the Oueensland Institute of Medical Research, WO9108224.
- The Salk Institute for Biological Studies, WO9107982.
- Fileco, WO9113626.
- Surtech International Ltd, WO9107969.
- Chai-Tech Corporation, WO9115212.
- US Departrnent of Commerce, WO9201816.
- The University of Maryland, WO9205284.
- Genta Inc, WO9203051.
- ISIS Pharmaceuticals Inc, WO9203568.