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Current Opinion on Therapeutic Patents Volume 2, 1992 - Issue 9
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Antimicrobials

Overview: Dual-Action β-Lactam Antibacterials

Scott L. Dax Roche Research Center, Hoffmann-La Roche Inc, Nutley, New Jersey, USA
Pages 1375-1384 | Published online: 02 Mar 2011

References to Primary Literature

  • O'Callaghan, CH Sykes, RB Staniforth, SE A New Cephalosporin with a Dual Mode of Action. Antimicrob. Agents Chemother. 1976 10 2 245–248 First report of a dual-action β-lactam and introduction into the dual-action mechanism.
  • Mobashery, S Lerner, SA Johnston, M Conscripting β-Lactamase for Use in Drug Delivery. Synthesis and Biological Activity of a Cephalosporin C10-Ester of an Antibiotic Dipeptide. J. Am. Chem. Soc. 1986 108 7 1685–1686 β-Lactam Assisted delivery of an antibiotic.
  • Jungheim, LN Shepherd, TA Meyer, DL Synthesis of Acylhydrazido-Substituted Cephems. Design of Cephalosporin-Vinca Alkaloid Prodrugs: Substrates for an Antibody-Targeted Enzyme. J. Org. Chem. 1992 57 8 2334–2340.
  • Fiere, JM Jovis, B Penicillin-Sensitive Enzymes in Peptidoglycan Biosynthesis CRC Crit. Rev. Microbiol. 1985 11 299–396 For discussion on β-lactam antibiotic inhibition of peptidoglycan biosynthesis see:.
  • Roberts, J Antibiotics (β-Lactams) in Kirk-Othmer Encyclopedia of Chemical Technology - 4th, Ed. John Wiley & Sons Inc New York, NY 1992 Volume No. 3 28–82 and references cited therein.
  • Synder, M Drlica, K DNA Gyrase on the Bacterial Chromosome: DNA Cleavage Induced by Oxolinic Acid. J. Mol. Biol. 1979 131 287–302.
  • Drlica, K Coughlin, S Gennaro, ML Mode of Action of Quinolones: Biochemical Aspects in the New Generation of Quinolones. Siporin, C, Heifetz, CL, Domagala, JM Marcel Dekker Inc New York, NY. 1990.
  • Chemistry and Biology of β-Lactam Antibiotics Morin, RB, Gorman, M Academic Press New York, NY. 1982 Vols 1–3 For an overview see:.
  • Albrecht, R Development of Antibacterial Agents of the Nalidixic Acid Type. Prog. Drug Res. 1977 21 9 9–104.
  • Wentland, MP Structure-Activity Relationships of Fluoroquinolones in The New Generation of Quinolones Siporin, C, Heifetz, CL, Domagala, JM Marcel Dekker Inc New York, NY. 1990.
  • Albrecht, HA Beskid, G Chan, K-K Christenson, JG Cleeland, R Deitcher, KH Georgopapadakou, NH Keith, DD Pruess, DL Sepinwall, J Specian, AC Jr Then, RL Weigele, M West, K Yang, R Cephalosporin 3′-Quinolone Esters with a Dual Mode of Action. J. Med. Chem. 1990 33 1 77–85 First journal publication on ester-linked DACs.
  • Demuth, TP Jr White, RE Tietjen, RA Storrin, RJ Skuster, JR Andersen, JA McOsker, CC Freedman, R Rourke, FJ Synthesis and Antibacterial Activity of New C-10 Quinolonyl-Cephem Esters. J. Antibiotics 1991 44 2 200–209 Report on new ester-linked DACs.
  • Corraz, AJ Dax, SL Dunlap, NK Georgopapadakou, NH Keith, DD Pruess, DL Rossman, PL Then, R Unowsky, J Wei, C-C Dual-Action Penems and Carbapenems. J. Med. Chem. 1992 35 10 1828–1839 First journal publication on dual-action carbapenems.
  • Perrone, E Jabes, D Alpegiani, M Patrizia Andreini, B Della Bruna, C Del Nero, S Rossi, R Visentin, G Zarini, F Franceschi, G Dual-Action Penems. J. Antibiotics 1992 45 4 589–594 First journal publication on dual-action penems (concurrent with reference above).
  • Albrecht, HA Beskid, G Christenson, JG Georgopapadakou, NH Keith, DD Konzelmann, FM Pruess, DL Rossman, PL Wei, C-C Dual-Action Cephalosporins: Cephalosporin 3′-Carbamates. J. Med. Chem. 1991 34 9 2857–2864 First journal publication on carbamate-linked DACs.
  • Albrecht, HA Beskid, G Christenson, JG Deitcher, KH Georgopapadakou, NH Keith, DD Konzelmann, FM Pruess, DL Wei, C-C Dual-Action Cephalosporins Incorporating 3′-Tertiary Amine-linked Quinolones. 31st Interscience Conference on Antimicrobial Agents and Chemotherapy 1991 Session 121. First report on amine-linked DACs.
  • Albrecht, HA Beskid, G Christenson, JG Durkin, JW Fallat, V Georgopapadakou, NH Keith, DD Konzelmann, FM Lipschitz, ER McGarry, DH Siebelist, J Wei, C-C Weigele, M Yang, R Dual-Action Cephalosporins: 3′-Quaternary Ammonium Quinolones. J. Med. Chem. 1991 34 2 669–675 First journal publication on ammonium-linked DACs.
  • Chu, DTW Fernandes, PB Claiborne, AK Shen, L Pernet, AG New Structure Activity Relationship of Quinolone Antibacterials: The Nature of the 3-Carboxylic Acid Group. 27th Interscience Conference on Antimicrobial Agents and Chemotherapy 1987 Abstract 250.
  • Chu, DTW Fernandes, PB Pernet, AG Synthesis and Biological Activity of Benzothiazolo[3,2-a]quinolone Antibacterial Agents. J. Med. Chem. 1986 29 8 1531–1534.
  • Taguchi, M Kondo, H Sakamoto, F Kawahata, Y Inoue, Y Tsukamoto, G Mitsuhasi, S New Quinolone Antibacterials Having a Tetracyclic Structure: KB-5246. 28th Interscience Conference on Antimicrobial Agents and Chemotherapy 1988 Abstract 1491.
  • Roberts, JL Beskid, G Borgese, J Christenson, JG Georgopapadakou, NH Keith, DD Pruess, DL Wei, CC Yang, R Quinolone-Amidino-β-Lactams: Synthesis and Biological Properties. 30th Interscience Conference on Antimicrobial Agents and Chemotherapy 1990 Abstract 406. Novel modification of the dual-action process.
  • Alpegiani, M Bedeschi, E Perrone, E Zarini, F Franceschi, G 2-(Heteroatom-substituted)-methyl Penems III. Nitrogen Derivatives. Heterocycles 1988 27 1329–1340.

References to Patent literature

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