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Cardiovascular Agents (Including Blood Products)

Patent Update: Thrombin Inhibitors

Pages 1457-1466 | Published online: 02 Mar 2011

References to Primary Literature

  • Wallis, RB Inhibition of thrombin, a key step in thrombosis. Drugs of Today 1989 25 9 597–605.
  • Fitzgerald, DJ Fitzgerald, GA Antiplatelet and Anticoagulant Therapy during Coronary Thrombosis. Trends in Cardiovascular Medicine 1991 1 1 29–35.
  • Bjork, I Olson, ST Shore, JD Molecular Mechanisms of the accelerating effect of heparin on the reactions between antithrombotic and clotting proteases Heparin Lane, DA, Lindahl, U Edward Arnold London 1989 229–255.
  • Tollefsen, DM Heparin Cofactor II Heparin Lane, DA, Lindahl, U Edward Arnold London 1989 257–273.
  • Demuth, H-U Recent Developments in Inhibiting Cysteine and Serine Proteases J. Enzyme Inhibition 1990 3 249–278.
  • Blombäck, B Blombäck, M Olsson, P Svendsen, L Aberg, G Synthetic peptides with anticoagulant and vasodilating activity. Scand. J. Clin. Lab. Invest. 1969 24 suppl 107 59–64.
  • Ni, F Meinwald, YC Vásquez, M Scheraga, HA High-resolution NMR studies of Fibrinogen-like Peptides in Solution: Structure of a Thrombin-bound Peptide Corresponding to Residues 7–16 of the Aα chain of Human Fibrinogen. Biochemistry 1989 28 7 3094–3105.
  • Martin, PD Robertson, W Turk, D Huber, R Bode, W Edwards, BFP The Structure of Residues 7–16 of the Aα-chain of Human Fibrinogen Bound to Bovine Thrombin at 2.3A Resolution. J. Biol. Chem. 1992 267 11 7911–7920.
  • Bajusz, S Szell, E Bagdy, D Barabas, E Horvath, G Dioszegi, M Fittler, Z Szabo, G Juhasz, A Tomori, E Szilagyi, G Highly Active and Selective Anticoagulants: D-Phe-Pro-Arg-H, a free Tripeptide Aldehyde Prone to Spontaneous Inactivation, and its Stable N-Methyl Derivative, D-MePhe-Pro-Arg-H. J. Med. Chem. 1990 33 6 1729–1735.
  • Hussain, MA Knabb, R Aungst, BJ Kettner, C Anticoagulant Activity of a Peptide Boronic Acid Thrombin Inhibitor by Various Routes of Administration in Rats. Peptides 1991 12 1153–1154.
  • Bone, R Frank, D Kettner, CA Agard, DA Structural Analysis of Specificity: α-Lytic Protease Complexes with Analogues of Reaction Intermediates. Biochemistry 1989 28 19 7600–7609.
  • Tapparelli, C Powling, M Gfeller, P Metternicht, R Novel Boron Containing Thrombin Inhibitor SDZ 217–766. In vitro and in vivo Evaluation. Thromb. Haemostas. 1991 65 6 774.
  • Elgendy, S Scully, MF Goodwin, CA Kakkar, VV Claeson, G Peptide aminoboronic acids as thrombin inhibitors. Effects on Ki and hypotensive side-effects by the modification of the boronic acid side chain. Throm. Haemostas. 1991 65 6 775.
  • Neises, B Tarnus, C Thrombin Inhibition by the Tripeptide Trifluorometyl Ketone D-Phe-Pro-Arg-CF3 (MDL 73756). Thromb. Haemostas. 1991 65 6 1290.
  • Altenburger, JM Schirlin, D General Synthesis of Polyfunctionalised Fluoromethylene Ketone Retroamides as Potential Inhibitors of Thrombin. Tetrahedron Lett. 1991 32 49 7255–7258.
  • Cheng, L Goodwin, CA Scully, MF Kakkar, VV Claeson, G Substrate related phosphonopeptides, a new class of thrombin inhibitors. Tetrahedron Lett. 1991 32 49 7333–7336.
  • Doherty, JB Ashe, BM Argenbright, LW Barker, PL Bonney, RJ Chandler, GO Dahlgren, ME Dorn, CP Finke, PE Firestone, RA Fletcher, D Hagmann, WK Mumford, R O'Grady, L Maycock, AL Pisano, JM Shah, SK Thompson, KR Zimmerman, M Cephalosporin antibotics can be modified to inhibit human leucocyte elastase. Nature 1986 332 10 192–194.
  • Bajusz, S Barabas, E Tolney, P Szell, E Bagdy, D Inhibition of Thrombin and Trypsin by Tripeptide Aldehydes. Int. J. Peptide Protein Res. 1978 12 217–221.
  • Bagdy, D Barabas, E Szabo, G Bajusz, S Szell, E In vivo Anticoagulant and Antiplatelet Effect of D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H. Thromb. Haemostas. 1992 67 3 357–365.
  • Geratz, JD Synthetic Low Molecular Weight Inhibitors of Thrombin. Folia Haematol. Leipzig 1972 98 4S 477–470.
  • Haycraft, JB On the action of secretion obtained from the medicinal leech on the coagulation of blood. Proc. Roy Soc. London 1884 36 478–487.
  • Walenga, JM Pifarre, R Fareed, J Recombinant Hirudin as an Antithrombotic Agent. Drugs of the Future 1990 15 3 267–280.
  • Bode, W Mayr, I Baumann, U Huber, R Stone, SR Hofsteenge, J The refined. 1.9A crystal structure of human α-thrombin; interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J. 1989 8 11 3467–3475.
  • Banner, DW Hadvary, P Crystallographic Analysis at 3.0A Resolution of the Binding to Human Thrombin of Four Active Site-directed Inhibitors. J. Biol. Chem. 1991 266 30 20085–20093.
  • Grütter, MG Priestle, JP Rahuel, J Grossenbacher, H Bode, W Hofsteenge, J Stone, SR Crystal Structure of the thrombin-hirudin complex: A novel mode of serine protease inhibition. EMBO J. 1990 9 8 2361–2365.
  • Rydel, TJ Ravichandran, KG Tulinsky, A Bode, W Huber, R Roitsch, C Fenton, JW The structure of a complex of recombinant hirudin and human α-thrombin. Science 1990 249 277–280.
  • Rydel, TJ Tulinsky, A Bode, W Huber, R Refined structure of the Hirudin-Thrombin complex. J. Mol. Biol. 1991 221 583–601.
  • Krstenansky, JL Broersma, RJ Owen, TJ Payne, MH Yates, MT Mao, SJT Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin. Thromb. Haemostas. 1990 63 2 208–214.
  • Witting, JI Bourdon, P Brezniak, DV Maraganore, JM Fenton, JW Thrombin-specific inhibition by a slow cleavage of hirulog-1. Biochem. J. 1992 283 737–743.
  • Dimaio, J Gibbs, B Munn, D Lefebvre, J Ni, F Konishi, Y Bifunctional Thrombin Inhibitors Based on the Sequence of Hirudin 45–65. J. Biol. Chem. 1990 265 35 21698–21703.
  • Knabb, RM Kettner, CA Reilly, TM Thrombin Inhibition with DUP 714 accelerates reperfusion and delays reocclusion in dogs. Circulation 1991 84 4 1860 ( Suppl II).
  • Kamiyama, T Umino, T Nakayama, N Itezono, Y Satoh, T Yamashita, Y Yamaguchi, A Yokose, K Ro-09–1679, a Novel Thrombin Inhibitor. J. Antibiot. 1992 45 3 424–427.
  • Fusetani, N Nakao, Y Matsunaga, S Nazumamide A, a Thrombin-inhibitory Tetrapeptide from a Marine Sponge, Theonella sp. Tetrahedron Lett. 1991 32 48 7073–7074.
  • Bock, LC Griffin, LC Latham, JA Vermaas, EH Toole, JJ Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature 1992 355 6360 564–566.
  • Gasic, GJ Thrombin inhibitors promote metastasis. Period Biol. 1991 93 4 633–640.
  • Higuchi, H Kunitoni, O Nishida, Y Etoh, T Nakajima, T Kanamaru, A Kakishita, E Nagai, K Ikezawa, K Effect of MD-805, a synthetic thrombin inhibitor, on disseminated intravascular coagulation developed on haemotological disorders. Jpn. J. Clin. Haematol. 1985 26 1754–1762.
  • Talbot, M Biology of Recombinant Hirudin (CGP 39393): A New Prospect in the Treatment of Thrombosis. Semin. Thromb. Haemostas. 1989 15 3 293–301.

References to Patent literature

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