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Perspective

Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective

, , MBBS FRACS, &
Pages 121-130 | Published online: 05 Jan 2011

Bibliography

  • Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. J Biol Chem 1995;270:25992-9
  • Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Opthalmol Vis Sci 1989;30:1700-7
  • Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epitherlium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991;53(3):411-14
  • Cao W, Tombran-Tink J, Elias R, In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Opthalmol Vis Sci 2001;42:1646-52
  • Bilak MM, Corse AM, Bilak SR, Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol 1999;58(7):719-28
  • Araki T, Taniwaki T, Becerra SP, Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res 1998;53(1):7-15
  • Cayouette M, Smith SB, Becerra SP, Gravel C. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 1999;6(6):523-32
  • Dawson DW, Volpert OV, Gillis P, Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285:245-8
  • Maik-Rachline G, Seger R. Variable phosphorylation states of pigment-epithelim-derived factor differentially regulate its function. Blood 2006;107:2745-52
  • Dass CR, Ek ET, Choong PF. PEDF as an emerging therapeutic candidate for osteosarcoma. Curr Cancer Drug Targets 2008;8(8):683-90
  • Broadhead ML, Dass CR, Choong PF. In vitro and in vivo biological activity of PEDF against a range of tumors. Expert Opin Ther Targets 2009;13(12):1429-38
  • Yamagishi S, Imaizumi T, Shimizu H, Abe R. Method for preventing or treating malignant melanoma. US20050222031; 2005
  • Yamagishi S, Imaizumi T. Method for preventing or treating osteosarcoma. US20060122112; 2006
  • Kovesdi I, Brough DE, McVey DL, Wei L. Viral vector encoding pigment epithelium-derived factor. US20050101018; 2005
  • Manning WC, Dwarki VJ, Rendahl K, Use of recombinant gene delivery vectors for treating or preventing diseases of the eye. US6943153; 2005
  • Bouck NP, Dawson DW, Gillis PR, Methods and compositions for inhibiting angiogenesis. US7105496; 2006
  • Becerra SP, Notari L, Laborda J, Escribano-Martinez J. PEDF-R receptor and uses. US20090162363; 2009
  • Gordon MS, Mendelson DS, Kato G. Tumor angiogenesis and novel antiangiogenic strategies. Int J Cancer 2010;126(8):1777-87
  • Folkman J. Fighting cancer by attacking its blood supply. Sci Am 1996;275(3):150-4
  • Bouck N. PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med 2002;8:330-4
  • Volz K, Filleur S, Volpert O, Zaichuk T. Anti-angiogenic fragments of pigment epithelium-derived factor (PEDF). US20090118191; 2009
  • Seger R, Maik-Rachline G. Variants of pigment epithelium derived factor and uses thereof. US20090269320; 2009
  • Ho TC, Chen SL, Yang YC, PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilican vein endothelial cells. Cardiovasc Res 2007;76:213-23
  • Gao D, Nolan D, McDonnell K, Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Biochim Biophys Acta 2009;1796:33-40
  • Ek ET, Dass CR, Contreras KG, Choong PF. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Clin Exp Metastasis 2007;24:93-106
  • Ek ET, Dass CR, Contreras KG, Choong PF. PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma. J Orthop Res 2007;25:1671-80
  • Ta HT, Dass CR, Larson I, A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma. Biomaterials 2009;30(21):3605-13
  • Broadhead ML, Dass CR, Choong PF. Cancer cell apoptotic pathways mediated by PEDF: Prospects for therapy. Trends Mol Med 2009;15(10):461-7
  • Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ. Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts. J Cell Physiol 2003;195:12-20
  • Zhou XY, Liao Q, Pu YM, Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization. Chin Med J (Engl) 2009;122(22):2711-17
  • Dass CR, Contreras K, Dunstan DE, Choong PF. Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. Biomaterials 2007;28:3026-33
  • Alberdi E, Aymerich MS, Becerra SP. Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem 1999;274(44):31605-12
  • Valnickova Z, Petersen SV, Nielsen SB, Heparin binding induces a conformational change in pigment epithelium-derived factor. J Biol Chem 2007;282:6661-7
  • Alberdi EM, Weldon JE, Becerra SP. Glycosaminoglycans in human retinoblastoma cells: Hepara sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions. BMC Biochem 2003;19(4):1
  • Filleur S, Nelius T, de Riese W, Kennedy RC. Characterization of PEDF: A multi-functional serpin family protein. J Cellular Biochem 2009;106:769-75
  • Bernard A, Gao-Li J, Franco CA, Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor. J Biol Chem 2009;284(16):10480-90
  • Notari L, Baladron V, Aroca-Aguilar JD, Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 2006;49:38022-37
  • Subramanian P, Notario PM, Becerra SP. Pigment epithelium-derived factor receptor (PEDF-R): A plasma membrane-linked phospholipase with PEDF binding affinity. Adv Exp Med Biol 2010;664:29-37
  • Konson A, Pradeep S, D'Acunto CW, Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem. 2010; In press
  • Yang J, Duh EJ, Caldwell RB, Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signalling pathway and uPAR expression. Invest Opthalmol Vis Sci 2010:51(6):3273-80
  • Zhang SX, Wang JJ, Gao G, Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF- VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol 2006:37(1):1-12
  • Crowe S, Wu LE, Economou C, Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab 2009:10(1):40-7
  • Tombran-Tink J. The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signalling. Front Biosci 2005;10:2131-49
  • Rychli K, Kaun C, Hohensinner PJ, The anti-angiogenic factor PEDF if present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts. J Cell Mol Med 2010;14(1-2):198-205
  • Chung C, Doll JA, Gattu AK, Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J Hepatol 2008;48(3):471-8
  • Cheugh L, Au S, Cheung A, Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology 2006;147(9):4179-91
  • Grayhack JT, Smith ND, Ilio K, Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. J Urol 2004;171(1):434-38
  • Quan G, Ojaimi J, Li Y, Localization of pigment epithelim-derived factor in growing mouse bone. Calcif Tissue Int 2005;76:146-53
  • Notari L, Arakaki N, Mueller D, Pigment epithelium-derived factor binds to cell-surface F(1)-ATP synthase. FEBS J 2010;277(9):2192-205

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