Cyclooxygenase-2 inhibitors: a literature and patent review (2009 – 2010)

Bibliography

• Kurumbail RG, Kiefer JR, Marnett LJ. Cyclooxygenase enzymes: catalysis and inhibition. Curr Opin Struct Biol 2001;11(9):752-60
   Google Scholar
• Marnett LJ. Cyclooxygenase mechanisms. Curr Opin Chem Biol 2000;4(5):545-52
   PubMed Web of Science ®Google Scholar
• Fitzpatrick FA. Cyclooxygenase enzymes: regulation and function. Curr Pharm Des 2004;10(6):577-88
   PubMed Web of Science ®Google Scholar
• Warner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proc Natl Acad Sci USA 2002;99(21):13371-3
   PubMed Web of Science ®Google Scholar
• Gupta K, Selinsky BS, Kaub CJ, The 2.0 a resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase. J Mol Biol 2004;335(2):503-18
   Google Scholar
• Garavito RM, Malkowski MG, DeWitt DL. The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins Other Lipid Mediat 2002;68-69:129-52
   PubMed Web of Science ®Google Scholar
• Singh P, Mittal A. Current status of COX-2 inhibitors. Mini Rev Med Chem 2008;8(1):73-90
   Google Scholar
• Ramalho TC, Rocha MV, da Cunha EF, The search for new COX-2 inhibitors: a review of 2002 – 2008 patents. Expert Opin Ther Pat 2009;19(9):1193-228
   Web of Science ®Google Scholar
• Jachak SM. Cyclooxygenase inhibitory natural products: current status. Curr Med Chem 2006;13(6):659-78
   PubMed Web of Science ®Google Scholar
• Rao P, Knaus EE. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. J Pharm Pharm Sci 2008;11(2):81s-110s
   PubMed Web of Science ®Google Scholar
• Abdel-Megeed AM, Abdel-Rahman HM, Alkaramany GE, Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity. Eur J Med Chem 2009;44(1):117-23
   Google Scholar
• Rathish IG, Javed K, Ahmad S, Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide. Bioorg Med Chem Lett 2009;19(1):255-8
   Google Scholar
• Boschi D, Lazzarato L, Rolando B, Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization. Chem Biodivers 2009;6(3):369-79
   Google Scholar
• Boschi D, Cena C, Di Stilo A, Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization. Chem Biodivers 2010;7(5):1173-82
   Google Scholar
• Chowdhury MA, Abdellatif KR, Dong Y, Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. J Med Chem 2009;52(6):1525-9
   PubMed Web of Science ®Google Scholar
• Abdellatif KR, Chowdhury MA, Velazquez CA, Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Bioorg Med Chem Lett 2010;20(15):4544-9
   PubMed Web of Science ®Google Scholar
• Chowdhury MA, Abdellatif KR, Dong Y, Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Bioorg Med Chem Lett 2010;20(4):1324-9
   Google Scholar
• Yin LL, Li MH, Wang X, A novel 1,5-diarylpyrazole derivative exerts its anti-inflammatory effect by inhibition of cyclooxygenase-2 activity as a prodrug. Biol Pharm Bull 2009;32(6):1032-6
   Google Scholar
• Bozzo F, Bassignana A, Lazzarato L, Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth. Chem Biol Interact 2009;182(2-3):183-90
   Google Scholar
• Bekhit AA, Ashour HM, Bekhit Ael D, Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents. J Enzyme Inhib Med Chem 2009;24(1):296-309
   PubMed Web of Science ®Google Scholar
• Wuest F, Tang X, Kniess T, Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives. Bioorg Med Chem 2009;17(3):1146-51
   PubMed Web of Science ®Google Scholar
• Feng Z, Chu F, Guo Z, Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. Bioorg Med Chem Lett 2009;19(8):2270-2
   Google Scholar
• Zanatta SD, Manallack DT, Jarrott B, Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors. Bioorg Med Chem Lett 2009;19(2):459-61
   PubMed Web of Science ®Google Scholar
• Dundar Y, Unlu S, Banoglu E, Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors. Eur J Med Chem 2009;44(5):1830-7
   PubMed Web of Science ®Google Scholar
• Scholz M, Ulbrich HK, Soehnlein O, Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem 2009;17(2):558-68
   Google Scholar
• Youssef AM, Neeland EG, Villanueva EB, Synthesis and biological evaluation of novel pyrazole compounds. Bioorg Med Chem 2010;18(15):5685-96
   Google Scholar
• Mohy El-Din MM, Senbel AM, Bistawroos AA, A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug. Basic Clin Pharmacol Toxicol 2010;108:263-73
   Google Scholar
• Desai D, Kaushal N, Gandhi UH, Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib. Chem Biol Interact 2010;188(3):446-56
   Google Scholar
• Jiang B, Zeng Y, Li MJ, Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors. Arch Pharm (Weinheim) 2010;343(9):500-8
   Google Scholar
• Che H, Tuyen TN, Kim HP, 1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells. Bioorg Med Chem Lett 2010;20(14):4035-7
   Google Scholar
• Biava M, Porretta GC, Poce G, Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. J Med Chem 2010;53(2):723-33
   Google Scholar
• Zarghi A, Arefi H, Dadrass OG, Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Med Chem Res 2010;19:782-93
   Web of Science ®Google Scholar
• Eren G, Unlu S, Nunez MT, Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors. Bioorg Med Chem 2010;18(17):6367-76
   PubMed Web of Science ®Google Scholar
• Alam MM, Husain A, Hasan SM, 3-arylidene-5-(4-isobutylphenyl)-2(3H)-furanones: a new series of anti-inflammatory and analgesic compounds having antimicrobial activity. J Enzyme Inhib Med Chem 2010;25(3):323-30
   PubMed Web of Science ®Google Scholar
• Bekhit AA, Fahmy HT, Rostom SA, Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents. Eur J Med Chem 2010;45(12):6027-38
   Google Scholar
• Beswick PJ, Blackaby AP, Bountra C, Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach. Bioorg Med Chem Lett 2009;19(15):4509-14
   Google Scholar
• Raffa D, Maggio B, Plescia F, Pyrazolo[3,4-d]pyrimidine derivatives as COX-2 selective inhibitors: synthesis and molecular modelling studies. Arch Pharm (Weinheim) 2009;342(6):321-6
   PubMed Web of Science ®Google Scholar
• Unsal-Tan O, Ozden K, Rauk A, Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones. Eur J Med Chem 2010;45(6):2345-52
   Google Scholar
• Swarbrick ME, Beswick PJ, Gleave RJ, Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 2009;19(15):4504-8
   Google Scholar
• Lacerda RB, de Lima CK, da Silva LL, Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes. Bioorg Med Chem 2009;17(1):74-84
   PubMed Web of Science ®Google Scholar
• Renard JF, Arslan D, Garbacki N, Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. J Med Chem 2009;52(19):5864-71
   PubMed Web of Science ®Google Scholar
• Chowdhury MA, Abdellatif KR, Dong Y, Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorg Med Chem Lett 2009;19(24):6855-61
   Google Scholar
• Zebardast T, Zarghi A, Daraie B, Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett 2009;19(12):3162-5
   Google Scholar
• Zarghi A, Zebardast T, Daraie B, Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem 2009;17(15):5369-73
   Google Scholar
• Singh P, Bhardwaj A. Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation. J Med Chem 2010;53(9):3707-17
   Google Scholar
• Wang JL, Carter J, Kiefer JR, The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Bioorg Med Chem Lett 2010;20(23):7155-8
   PubMed Web of Science ®Google Scholar
• Wang JL, Limburg D, Graneto MJ, The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. Bioorg Med Chem Lett 2010;20(23):7159-63
   PubMed Web of Science ®Google Scholar
• Wang JL, Aston K, Limburg D, The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: the three microdose candidates. Bioorg Med Chem Lett 2010;20(23):7164-8
   PubMed Web of Science ®Google Scholar
• Gurung SK, Kim HP, Park H. Inhibition of prostaglandin E2 production by synthetic wogonin analogs. Arch Pharm Res 2009;32(11):1503-8
   PubMed Web of Science ®Google Scholar
• Lim H, Kim SB, Park H, New anti-inflammatory synthetic biflavonoid with C-C (6-6") linkage: differential effects on cyclooxygenase-2 and inducible nitric oxide synthase. Arch Pharm Res 2009;32(11):1525-31
   Google Scholar
• Eissa AA, Farag NA, Soliman GA. Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents. Bioorg Med Chem 2009;17(14):5059-70
   Google Scholar
• Che H, Park BK, Lim H, Synthesis of biflavones having a 6-O-7′′linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg Med Chem Lett 2009;19(1):74-6
   Google Scholar
• Uddin MJ, Crews BC, Blobaum AL, Synthesis and evaluation of [123I]-indomethacin derivatives as COX-2 targeted imaging agents. J Label Compd Radiopharm 2009;52:387-93
   Web of Science ®Google Scholar
• Chowdhury MA, Huang Z, Abdellatif KR, Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors. Bioorg Med Chem Lett 2010;20(19):5776-80
   Google Scholar
• Zarghi A, Ghodsi R, Azizi E, Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors. Bioorg Med Chem 2009;17(14):5312-17
   Google Scholar
• Zarghi A, Ghodsi R. Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors. Bioorg Med Chem 2010;18(16):5855-60
   Google Scholar
• Ghodsi R, Zarghi A, Daraei B, Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors. Bioorg Med Chem 2010;18(3):1029-33
   Google Scholar
• Laube T, Bernet A, Dahse HM, Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones. Bioorg Med Chem 2009;17(4):1422-7
   Google Scholar
• Bandgar BP, Patil SA, Gacche RN, Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Bioorg Med Chem Lett 2010;20(2):730-3
   PubMed Web of Science ®Google Scholar
• Arfaie S, Zarghi A. Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors. Eur J Med Chem 2010;45(9):4013-17
   Google Scholar
• Tan QG, Cai XH, Feng T, A new cyclooxygenase inhibitor from Incarvillea arguta. Z Naturforsch 2009;64b:439-42
   Google Scholar
• Landa P, Kokoska L, Pribylova M, In vitro anti-inflammatory activity of carvacrol: inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis. Arch Pharm Res 2009;32(1):75-8
   PubMed Web of Science ®Google Scholar
• Stanikunaite R, Khan SI, Trappe JM, Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother Res 2009;23(4):575-8
   Google Scholar
• Wang H, Wu T, Yan M, Sesquiterpenes from Ainsliaea fragrans and their inhibitory activities against cyclooxygenases-1 and 2. Chem Pharm Bull (Tokyo) 2009;57(6):597-9
   Google Scholar
• Suh Y, Afaq F, Johnson JJ, A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis 2009;30(2):300-7
   PubMed Web of Science ®Google Scholar
• Gautam R, Srivastava A, Jachak SM, Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory and antioxidant effects of Dysophylla stellata Benth. Fitoterapia 2010;81(1):45-9
   Google Scholar
• Coy ED, Cuca LE, Sefkow MCOX. LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett 2009;19(24):6922-5
   PubMed Web of Science ®Google Scholar
• Yang MH, Yoon KD, Chin YW, Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita. Bioorg Med Chem 2009;17(7):2689-94
   PubMed Web of Science ®Google Scholar
• Li W, Zhou P, Zhang Y, Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity. J Ethnopharmacol 2011;133(2):922-7
   PubMed Web of Science ®Google Scholar
• Cerella C, Sobolewski C, Dicato M, Targeting COX-2 expression by natural compounds: a promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy. Biochem Pharmacol 2010;80(12):1801-15
   Google Scholar
• Lee YJ, Park SY, Kim SG, Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis. Biochem Biophys Res Commun 2010;391(4):1687-92
   Google Scholar
• Chen CS, Tan CM, Huang CH, Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production. Bioorg Med Chem 2010;18(2):597-604
   Google Scholar
• Mbalaviele G, Pauley AM, Shaffer AF, Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem Pharmacol 2010;79(10):1445-54
   Google Scholar
• Kang SS, Cuendet M, Endringer DC, Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. Bioorg Med Chem 2009;17(3):1044-54
   PubMed Web of Science ®Google Scholar
• Abdellatif KR, Chowdhury MA, Dong Y, Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Bioorg Med Chem Lett 2009;19(11):3014-18
   Google Scholar
• Kuge Y, Obokata N, Kimura H, Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. Nucl Med Biol 2009;36(8):869-76
   Google Scholar
• Huang Z, Velazquez C, Abdellatif K, Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies. Org Biomol Chem 2010;8(18):4124-30
   PubMed Web of Science ®Google Scholar
• El-Gamal MI, Bayomi SM, El-Ashry SM, Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: molecular modeling study. Eur J Med Chem 2010;45(4):1403-14
   Google Scholar
• Leem DH, Choi KH, Han HS, KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. Eur J Cancer Prev 2010;19(1):23-30
   Google Scholar
• Harrak Y, Casula G, Basset J, Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem 2010;53(18):6560-71
   Google Scholar
• Cappelli A, Anzini M, Biava M, 3-substituted-1,5-diaryl-2-alkyl-pyrroles highly selective and orally effective COX-2 inhibitors. US0264500A1; 2009
   Google Scholar
• Eak A. New use. US0170854A1; 2009
   Google Scholar
• Okunieff P, Zhang L, Xiao Z. Methods and compositions related to esculentoside A. US0118204A1; 2009
   Google Scholar
• Park SC, Han JA. Composition for regulating cellular senescence comprising N-[2-(cyclohexy-loxyl)-4-nitrophenyl]-methanesulfonamide. US0152297A1; 2010
   Google Scholar
• Bandarage RR, Bandarage UK, Fang X, Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use. US0099139A1; 2009
   Google Scholar
• Lin EH. Nitrosated fluorocytidine derivatives and COX-2 inhibitors for the treatment of cancer. US0156548A1; 2009
   Google Scholar
• Van Dykes TE, Petasis NA, Serhan CN. Lipoxin analogs and methods for the treatment of periodontal. US0311201A1; 2009
   Google Scholar
• Apkarian AV. Method for treatment of neuropathic pain. US0118341A1; 2009
   Google Scholar
• Reiss AB, Carsons S. Method for improving cardiovascular risk profile of COX inhibitors. US0275529A1; 2009
   Google Scholar
• Schaller G. Method for establishing the sensitivity of tumours to capecitabin and test kit. US0263399A1; 2009
   Google Scholar
• Konstantopoulos K, Talalay P, Healy ZR. Phase 2 inducers and related signalling pathways project cartilage against inflammation/infection, apoptosis and stress. US0015085A1; 2010
   Google Scholar
• Fox A, Nash M, Sohal B, Synergistic combinations of VR-1 antagonits and COX-2 inhibitors. US0144740A1; 2010
   Google Scholar
• Christgau S, Hansen C, Nilsson H. Method of improving treatments in rheumatic and arthritic diseases. US00353115A1; 2009
   Google Scholar
• Kasahara Y, Hikino H, Tsurufuji S, Antiinflammatory actions of ephedrines in acute inflammations1. Planta Med 1985;51(4):325-31
   Google Scholar
• Winter CA, Risley, Edwin AN, George W. Carrageenin-induced edema in hind paw of rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol 1962;111:544-7
   PubMed Web of Science ®Google Scholar
• Patrignani P, Panara MR, Greco A, Biochemical and pharmacological characterization of the cyclooxygenase activity in human blood prostaglandin endoperoxide synthases. J Pharmacol Exp Ther 1994;271(3):1705-12
   Google Scholar
• Zhang W, Yang X, Jin D, Zhu X. Expression and enzyme activity determination of human cyclooxygenase-1 and -2 in a baculovirus-insect cell system. Acta Pharmacol Sin 2004;25:1000-6
   Google Scholar
• Uddin MJ, Rao PN, Knaus EE. Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem 2004;12(22):5929-40
   Google Scholar
• Shen F, Bai A, Guo Z, Cheng G. Inhibitory effect of 3,4-diaryl-3-pyrrolin-2-one derivatives on cyclooxygenase 1 and 2 in murine peritoneal macrophages. Acta Pharmacol Sin 2002;23(8):762-8
   Google Scholar
• Dannhardt G, Lehr M. In vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC. J Pharm Pharmacol 1992;44(5):419-24
   Google Scholar
• Wakitani K, Nanayama T, Masaki M, Matsushita M. Profile of JTE-522 as a human cyclooxygenase-2 inhibitor. Jpn J Pharmacol 1998;78(3):365-71
   Google Scholar
• Chi YS, Cheon BS, Kim HP. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem Pharmacol 2001;61(10):1195-203
   Google Scholar
• Zarghi A, Najafnia L, Daraee B, Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett 2007;17(20):5634-7
   Google Scholar
• Futaki N, Takahashi S, Yokoyama M, NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro Prostaglandins 1994;47(1):55-9
   Google Scholar
• Janusz JM, Young PA, Ridgeway JM, New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 1. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Discovery and Variation of the 5-Keto Substituent. J Med Chem 1998;41(7):1112-23
   Google Scholar
• Bingham S, Beswick PJ, Bountra C, The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. J Pharmacol Exp Ther 2005;312(3):1161-9
   Google Scholar
• Glaxo Group (UK) Ltd. Preparation of pyrimidine derivatives as selective COX-2 inhibitors. WO02096885; 2002
   Google Scholar
• Rao PNP, Amini M, Li H, Design, Synthesis, and Biological Evaluation of 6-Substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: A Novel Class of Diarylheterocyclic Selective Cyclooxygenase-2 Inhibitors. J Med Chem 2003;46(23):4872-82
   Google Scholar
• Chowdhury MA, Abdellatif KRA, Dong Y, Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorg Med Chem Lett 2008;18(23):6138-41
   Google Scholar
• Pharmacia Corporation (USA). Preparation of 2H-chromene-3-carboxylates and analogs as selective COX-2 inhibitors for treating inflammatory conditions. WO04087686; 2004
   Google Scholar
• Duan W, Zhang L. Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation. Prostag Leukotr Ess 2006;74(5):317-21
   Google Scholar
• Cuendet Mu, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 2000;17(1-4): 109-157 T59/P74
   Google Scholar
• Homhual S, Zhang H, Bunyapraphatsara N, A new sulfur compound from Bruguiera gymnorrhiza. Planta Med 2006;72(3):255
   Google Scholar
• Velazquez C, Vo D, Knaus EE. Syntheses, calcium channel modulation effects, and nitric oxide release studies of O2-alkyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate 4-aryl(heteroaryl)-1,4-dihydro-2,6-dimethyl-3-nitropyridine-5-carboxylates. Drug Dev Res 2003;60(3):204-16
   Google Scholar
• Kuge Y, Katada Y, Shimonaka S, Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression. Nucl Med Biol 2006;33(1):21-7
   Google Scholar
• Uddin MJ, Rao PNP, McDonald R, Knaus EE. A New Class of Acyclic 2-Alkyl-1,1,2-Triaryl (Z)-Olefins as Selective Cyclooxygenase-2 Inhibitors. J Med Chem 2004;47(24):6108-11
   Google Scholar