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PTEN modulators: a patent review

, PhD & , PhD MBA
Pages 569-580 | Published online: 05 Feb 2013

Bibliography

  • Wiencke JK, Zheng S, Jelluma N, Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neurol Oncol 2007;9(3):271-9
  • Tamguney T, Stokoe D. New insights into PTEN. J Cell Sci 2007;120(Pt 23):4071-9
  • COSMIC: catalog of somatic mutations in cancer. Welcome Trust, Sanger Institute, Cambridge, UK; 2011. Available from: http://www.sanger.ac.uk/perl/genetics/CGP/cosmic?action=gene&ln=PTEN [Cited 11 November 2012]
  • Tumorscape: copy number alterations across multiple cancer types. The Broad Institute of MIT and Harvard, US. Available from: http://www.broadinstitute.org/tumorscape/pages/portalHome.jsf# [Cited 14 November 2012]
  • Govender D, Chetty R. Gene of the month: PTEN. J Clin Pathol 2012;65(7):601-3
  • Gericke A, Munson M, Ross AH. Regulation of the PTEN phosphatase. Gene 2006;374:1-9
  • Miller SJ, Lou DY, Seldin DC, Direct identification of PTEN phosphorylation sites. FEBS Lett 2002;528(1-3):145-53
  • Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem 2001;276(2):993-8
  • Mehenni H, Lin-Marq N, Buchet-Poyau K, LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet 2005;14(15):2209-1
  • Al-Khouri AM, Ma Y, Togo SH, Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J Biol Chem 2005;280(42):35195-202
  • Wu Y, Dowbenko D, Spencer S, Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J Biol Chem 2000;275(28):21477-85
  • Wu X, Hepner K, Castelino-Prabhu S, Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci USA 2000;97(8):4233-8
  • Valiente M, Andres-Pons A, Gomar B, Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J Biol Chem 2005;280(32):28936-43
  • Okahara F, Itoh K, Nakagawara A, Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol Biol Cell 2006;17(11):4888-95
  • Yim EK, Peng G, Dai H, Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 2009;15(4):304-1
  • Li Z, Dong X, Wang Z, Regulation of PTEN by rho small GTPases. Nat Cell Biol 2005;7(4):399-404
  • Hubner A, Mulholland DJ, Standen CL, JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci USA 2012;109(30):12046-51
  • Liang K, Esteva FJ, Albarracin C, Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell 2010;18(5):423-35
  • Schmid AC, Byrne RD, Vilar R, Woscholski R. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett 2004;566(1-3):35-8
  • Horie Y, Suzuki A, Kataoka E, Hepatocyte-specific pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113(12):1774-83
  • Ning K, Miller LC, Laidlaw HA, Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. J Biol Chem 2009;284(14):9331-40
  • Oudit GY, Kassiri Z, Zhou J, Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res 2008;78(3):505-14
  • Butler MG, Dasouki MJ, Zhou XP, Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet 2005;42(4):318-21
  • Kwon CH, Luikart BW, Powell CM, Pten regulates neuronal arborization and social interaction in mice. Neuron 2006;50(3):377-88
  • Gupta A, Dey CS. PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance. Mol Biol Cell 2012;23(19):3882-98
  • Valente EM, Abou-Sleiman PM, Caputo V, Hereditary early-onset parkinson's disease caused by mutations in PINK1. Science 2004;304(5674):1158-60
  • Valente EM, Salvi S, Ialongo T, PINK1 mutations are associated with sporadic early-onset parkinsonism. Ann Neurol 2004;56(3):336-41
  • Kwak YG, Song CH, Yi HK, Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. J Clin Invest 2003;111(7):1083-92
  • Jia G, Mitra AK, Gangahar DM, Agrawal DK. Regulation of cell cycle entry by PTEN in smooth muscle cell proliferation of human coronary artery bypass conduits. J Cell Mol Med 2009;13(3):547-54
  • Mitra AK, Jia G, Gangahar DM, Agrawal DK. Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits. J Cell Mol Med 2009;13(1):177-8
  • Chen Z, Trotman LC, Shaffer D, Crucial role of p53-dependent cellular senescence in suppression of pten-deficient tumorigenesis. Nature 2005;436(7051):725-30
  • Palomero T, Sulis ML, Cortina M, Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007;13(10):1203-10
  • Hettinger K, Vikhanskaya F, Poh MK, C-jun promotes cellular survival by suppression of PTEN. Cell Death Differ 2007;14(2):218-29
  • Chow JY, Quach KT, Cabrera BL, RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis 2007;28(11):2321-7
  • Vasudevan KM, Burikhanov R, Goswami A, Rangnekar VM. Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic ras. Cancer Res 2007;67(21):10343-50
  • Xia D, Srinivas H, Ahn YH, Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway. J Biol Chem 2007;282(6):3507-19
  • Wang X, Trotman LC, Koppie T, NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 2007;128(1):129-3
  • Maddika S, Kavela S, Rani N, WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 2011;13(6):728-33
  • Lu Y, Yu Q, Liu JH, Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 2003;278(41):40057-66
  • Gustin JA, Maehama T, Dixon JE, Donner DB. The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem 2001;276(29):27740-4
  • Vivanco I, Palaskas N, Tran C, Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 2007;11(6):555-69
  • Choi BH, Lee KS, Dai W. Phosphorylation and regulation of PTEN by polo-like kinase 1. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; March 31 – April 4; Chicago, IL, Philadelphia (PA). Am Assoc Cancer Res 2012;72(8 Suppl):abstract # 2048
  • Subauste MC, Nalbant P, Adamson ED, Hahn KM. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem 2005;280(7):5676-81
  • Bayascas JR, Leslie NR, Parsons R, Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol 2005;15(20):1839-46
  • Baritaki S, Militello L, Malaponte G, The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-kappaB/snail/RKIP/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis. Int J Oncol 2011;38(6):1683-94
  • Fisson S, Fridman C, Urbain R; inventors; LFB Biotechnologies, assignee. Use of anti-CD20 antibody for treating primary intraocular lymphoma. US20120100133; 2012
  • Nagata Y, Lan KH, Zhou X, PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004;6(2):117-12
  • Agresta S, Klencke B; inventors; Genentech I, assignee. Methods of treating metastatic breast cancer with trastuzumab-MCC-DM1. US20110165155A1; 2011
  • Alder M, Grauschofp U, Mahler HC, Stauch OB; inventors; Genentech I, assignee. Subcutaneous anti-Her2 antibody formulations and uses thereof. US20110044977A1; 2011
  • Goltsov A, Faratian D, Langdon SP, Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition. Cell Signal 2012;24(2):493-504
  • Suzuki E, Umezawa K, Bonavida B. Rituximab inhibits the constitutively activated PI3K-akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene 2007;26(42):6184-93
  • Lopez AG; inventor; Biogen Idec, Inc., assignee. Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody. EP1974747B1; 2012
  • Frattini M, Saletti P, Romagnani E, PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 2007;97(8):1139-45
  • Francoise B, David G, Richard MK, Joseph S; inventors; RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC., assignee. Therapeutic compositions containing monoclonal antibodies specific to human epidermal growth factor receptor. EP0667165B1; 2002
  • Abouantoun TJ, Castellino RC, MacDonald TJ. Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells. J Neurooncol 2011;101(2):215-26
  • Tang CT, Miller TA, Li X, inventors; Sugen, Inc., & Pharmacia Upjohn Co., assignee. Pyrrole substituted 2-indolinone protein kinase inhibitors. US6573293; 2003
  • She QB, Solit D, Basso A, Moasser MM. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/akt pathway signaling. Clin Cancer Res 2003;9(12):4340-6
  • Agus BD; inventor; Cedars-Sinai Medical Center, assignee. Gefitinib (iressa) for the treatment of cancer. EP1509230B1; 2007
  • Sos ML, Koker M, Weir BA, PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 2009;69(8):3256-61
  • Norris T, Ferry G, Raggon JW, inventors; OSI Pharmaceuticals I, assignee. Stable polymorph on N-(3-ethynylphenyl)-6, 7-bis(2methoxyethoxy)-4-quinazolinamine hydochloride, methods of production, and pharmaceutical uses thereof. US6900221; 2005
  • Shen YH, Zhang L, Gan Y, Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. J Biol Chem 2006;281(12):7727-36
  • Ghosh-Choudhury N, Mandal CC, Ghosh-Choudhury N, Ghosh Choudhury G. Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth. Cell Signal 2010;22(5):749-58
  • Kubela R, Radhakrishnan J; inventors; Apotex I, assignee. Process for producing simvastatin and analogs thereof. US5393893; 1995
  • Teresi RE, Shaiu CW, Chen CS, Increased PTEN expression due to transcriptional activation of PPARgamma by lovastatin and rosiglitazone. Int J Cancer 2006;118(10):2390-8
  • Monaghan RL, Alberts AW, Hoffman CH, Schonberg GA; inventors; Merck & Co, assignee. Hypocholesteremic fermentation products and process of preparation. US4231938; 1980
  • Patel L, Pass I, Coxon P, Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 2001;11(10):764-8
  • Isebaert SF, Swinnen JV, McBride WH, Haustermans KM. Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells. Int J Radiat Oncol Biol Phys 2011;81(1):239-47
  • Bonavida B, Palladino MA; inventors; The Regents of the University of California & Nereus Pharmaceuticals, Inc., assignee. Methods of sensitizing cancer to therapy-induced cytotoxicity. US20090148445A1; 2009
  • Berggren M, Sittadjody S, Song Z, Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells. Nutr Cancer 2009;61(3):322-31
  • Stambolic V, MacPherson D, Sas D, Regulation of PTEN transcription by p53. Mol Cell 2001;8(2):317-25
  • Virolle T, Adamson ED, Baron V, The egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol 2001;3(12):1124-8
  • Yoshimi A, Goyama S, Watanabe-Okochi N, Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood 2011;117(13):3617-28
  • Olson MV, Alonso MM, Gomez-Manzano C, E2F1 transcriptionally activates PTEN [abstract #2808]. Proc Am Assoc Cancer Res. Cellular and Molecular Biology 38: oncogenic pathways in cancer; Philadelphia (PA). Am Assoc Cancer Res 2005;46(1):661
  • Wang Y, He X, Ngeow J, Eng C. GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer. Hum Mol Genet 2012;21(3):569-76
  • Escriva M, Peiro S, Herranz N, Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol 2008;28(5):1528-40
  • Vasudevan KM, Gurumurthy S, Rangnekar VM. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol 2004;24(3):1007-21
  • Giagulli C, Marsico S, Magiera AK, Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells. PLoS One 2011;6(3):e17831
  • Perdigoto AL, Chaudhry N, Barnes GN, A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol Cell Neurosci 2011;46(1):235-44
  • Sumitomo M, Iwase A, Zheng R, Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell 2004;5(1):67-78
  • Yang S, Kim HM. The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior. Biomaterials 2012;33(10):2902-15
  • Vemula S, Shi J, Hanneman P, ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood 2010;115(9):1785-96
  • Zhu Z, Jia J, Lu R, Expression of PTEN, p27, p21 and AKT mRNA and protein in human BEL-7402 hepatocarcinoma cells in transplanted tumors of nude mice treated with the tripeptide tyroservatide (YSV). Int J Cancer 2006;118(6):1539-44
  • Bhoopathi P, Gorantla B, Sailaja GS, SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. PLoS One 2012;7(5):e36093
  • Oinuma I, Ito Y, Katoh H, Negishi M. Semaphorin 4D/plexin-B1 stimulates PTEN activity through R-ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. J Biol Chem 2010;285(36):28200-9
  • Ma L, Chang N, Guo S, CSIG inhibits PTEN translation in replicative senescence. Mol Cell Biol 2008;28(20):6290-301
  • Lima-Fernandes E, Enslen H, Camand E, Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins. EMBO J 2011;30(13):2557-68
  • Verma A, Guha S, Wang H, Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res 2008;14(7):1997-2005
  • Lu D, Han C, Wu T. Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression. Gastroenterology 2011;140(7):2084-9
  • Papakonstanti EA, Ridley AJ, Vanhaesebroeck B. The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J 2007;26(13):3050-61
  • Fine B, Hodakoski C, Koujak S, Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 2009;325(5945):1261-5
  • Okumura K, Mendoza M, Bachoo RM, PCAF modulates PTEN activity. J Biol Chem 2006;281(36):26562-8
  • He L, Ingram A, Rybak AP, Tang D. Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest 2010;120(6):2094-108
  • He L, Fan C, Kapoor A, Alpha-mannosidase 2C1 attenuates PTEN function in prostate cancer cells. Nat Commun 2011;2:307
  • Seo JH, Ahn Y, Lee SR, The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/akt pathway. Mol Biol Cell 2005;16(1):348-57
  • Takahashi Y, Morales FC, Kreimann EL, Georgescu MM. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 2006;25(4):910-12
  • Edwin F, Singh R, Endersby R, The tumor suppressor PTEN is necessary for human sprouty 2-mediated inhibition of cell proliferation. J Biol Chem 2006;281(8):4816-22

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