623
Views
10
CrossRef citations to date
0
Altmetric
Review

Bcr-Abl tyrosine kinase inhibitors: a patent review

, , , &

Bibliography

  • Colicelli J. ABL tyrosine kinases: evolution of function, regulation, and specificity. Sci Signal 2010;3:re6
  • Panjarian S, Iacob RE, Chen S, et al. Structure and dynamic regulation of Abl kinases. J Biol Chem 2013;288:5443-50
  • Nagar B, Hantschel O, Young MA, et al. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 2003;112:859-71
  • Hantschel O, Nagar B, Guettler S, et al. Myristoyl/phosphotyrosine switch regulates c-Abl. Cell 2003;112:845-57
  • Wisniewski D, Lambek CL, Liu C, et al. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res 2002;62:4244-55
  • Kurzrock R, Kantarjian HM, Druker BJ, Talpaz M. Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics. Ann Intern Med 2003;138:819-30
  • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009;9:28-39
  • Mol C, Fabbro D, Hosfield DJ. Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors. Curr Opin Drug Discov Devel 2004;7:639-48
  • Rabiller M, Getlik M, Klüter S, et al. Proteus in the world of proteins: conformational changes in protein kinases. Arch Pharm (Weinheim) 2010;343:193-206
  • Fang Z, Grütter C, Rauh D. Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features. ACS Chem Biol 2013;8:58-70
  • Soverini S, Iacobucci I, Baccarani M, Martinelli G. Targeted therapy and the T315I mutation in Philadelphia-positive leukemias. Haematologica 2007;92:437-9
  • Goldman JM. How I treat chronic myeloid leukemia in the Imatinib era. Blood 2007;110:2828-37
  • Martinelli G, Soverini S, Rosti G, et al. New tyrosine kinase inhibitors in chronic myeloid leukemia. Haematologica 2005;90:534-41
  • Maekawa T, Ashihara E, Kimura S. The Bcr-Abl tyrosine kinase inhibitor imatinib and promising new agents against Philadelphia chromosome-positive leukemias. Int J Clin Oncol 2007;12:327-40
  • Schenone S, Brullo C, Botta M. New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. Curr Med Chem 2010;17:1220-45
  • Melo JV, Chuah C. Resistance to imatinib mesylate in chronic myeloid leukemia. Cancer Lett 2007;249:121-32
  • Mughal TJ, Goldman JM. Emerging strategies for the treatment of mutant Bcr-Abl T315I myeloid leukemia. Clin Lymphoma Myeloma 2007;7(Suppl 2):S81-4
  • Deininger M, Buchdunger E, Druker BJ. The development of Imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005;105:2640-53
  • O’Hare T, Eide CA, Deininger MW. New Bcr-Abl inhibitors in chronic myeloid leukemia: keeping resistance in check. Expert Opin Investig Drugs 2008;17:865-78
  • Baran Y, Saydam G. Cumulative clinical experience from a decade of use: imatinib as first-line treatment of chronic myeloid leukemia. J Blood Med 2012;3:139-50
  • Ohanian M, Cortes J, Kantarjian H, Jabbour E. Tyrosine kinase inhibitors in acute and chronic leukemias. Expert Opin Pharmacother 2012;13:927-38
  • Schenone S, Bruno O, Radi M, Botta M. New insights into small-molecule inhibitors of Bcr-Abl. Med Res Rev 2011;31:1-41
  • Hantschel O, Rix U, Schmidt U, et al. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci USA 2007;104:13283-8
  • Khan AM, Bixby DL. BCR-ABL inhibitors: updates in the management of patients with chronic-phase chronic myeloid leukemia. Hematology 2014;19:249-58
  • Syed YY, McCormack PL, Plosker GL. Bosutinib: a review of its use in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. BioDrugs 2014;28:107-20
  • O’Hare T, Shakespeare WC, Zhu X, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009;16:401-12
  • Ariad Pharmaceuticals, Inc. Methods and compositions for treating cancer using multi-protein kinase inhibitor ponatinib. WO053938; 2011
  • Deininger M. The current status of ponatinib in the treatment of chronic myeloid leukemia. Clin Adv Hematol Oncol 2014;12:329-31
  • Zhou T, Commodore L, Huang WS, et al. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance. Chem Biol Drug Des 2011;77:1-11
  • FDA Drug Safety Communication: FDA asks manufacturer of the leukemia drug Iclusig (ponatinib) to suspend marketing and sales. FDA Safety Communication. 2013-10-31 Available from: http://www.fda.gov/Drugs/DrugSafety/ucm373040.htm
  • FDA OK’s Iclusig’s return to market. Cancer Discov 2014;4:138
  • Naito H, Kimura S, Nakaya Y, et al. In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations. Leuk Res 2006;30:1443-6
  • Deciphera Pharmaceuticals LLC. Preparation of urea derivatives as kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases. WO046003; 2008
  • Chan WW, Wise SC, Kaufman MD, et al. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell 2011;19:556-68
  • Eide CA, Adrian LT, Tyner JW, et al. The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT 315I and exhibits a narrow resistance profile. Cancer Res 2011;71:3189-95
  • Meulenbeld HJ, Mathijssen RH, Verweij J, et al. Danusertib, an aurora kinase inhibitor. Expert Opin Investig Drugs 2012;21:383-93
  • Kimura S, Ando T, Kojima K. Ever-advancing chronic myeloid leukemia treatment. Int J Clin Oncol 2014;19:3-9
  • Jain P, Kantarjian H, Cortes J. Chronic myeloid leukemia: overview of new agents and comparative analysis. Curr Treat Options Oncol 2013;14:127-43
  • Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA 2005;102:11011-16
  • Young MA, Shah NP, Chao LH, et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006;66:1007-14
  • Giles FJ, Swords RT, Nagler A, et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia 2013;27:113-17
  • IRM LCC. Novel compounds and compositions as protein kinase inhibitors. WO089286; 2004
  • Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety. WO033746; 2008
  • Bali P, Pranpat M, Bradner J, et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005;280:26729-34
  • Vertex Pharmaceuticals, Inc. Aminopyrimidines useful as kinase inhibitors. WO115973; 2008
  • Vertex Pharmaceuticals, Inc. Aminopyrimidines useful as kinase inhibitors. WO128009; 2008
  • IRM LLC, Novartis AG. Preparation of pyrimidinylpyrazolamines as protein kinase inhibitors. WO042639; 2008
  • Novartis AG. Preparation of naphthalenecarboxylic acid and isoquinolinecarboxylic acid amides as tyrosine kinase inhibitors. WO125691; 2008
  • Natco Pharma Ltd. Preparation of phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase for treating cancer. US0306100; 2008
  • Natco Pharma Ltd. Crystal form of phenylamino pyrimidine derivatives. WO109867; 2009
  • IRM LLC. Preparation of pyrrolo[2,3-b]pyridinecarboxamides as protein kinase inhibitors. WO144253; 2008
  • IRM LCC. Preparation of as protein kinase inhibitors. WO157131; 2008
  • 4SC AG. Preparation of bifunctional compounds as inhibitors of protein kinases and histone deacetylases. WO063054; 2009
  • Dana Farber Cancer Institute. Small molecule myristate inhibitors of Bcr-abl and methods of use. WO073153; 2009
  • Sun Pharma Advanced Research Company Ltd. Preparation of novel hydrazide containing tyrosine kinase inhibitors. WO109991; 2009
  • Università degli Studi di Milano- Bicocca, Université de Geneve, Université Claude Bernard Lyon I. Alfa-carboline inhibitors of NPM-ALK, Ret, and Bcr-Abl. WO025872; 2010
  • The Regents of the University of California. Preparation of pyrazolo[3,4-d]pyrimidine derivatives as kinase inhibitors. WO045542; 2010
  • Hanke JH, Gardner JP, Dow RL, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 1996;271:695-701
  • Nova Decision, Azasynth. Derivatives of azaindoles as inhibitors of protein kinases Abl and Src. WO092489; 2010
  • Synthec Solution LLC. Amides as kinase inhibitors and as antitumor agents. WO096395; 2010
  • ArQule, Inc. Substituted dipyrido-pyrimido-diazepine and benzo-pyrido-pyrimido compounds. US249108; 2010
  • Deciphera Pharmaceuticals LLC. Kinase inhibitors useful for the treatment of myeloproliferative diseases and other proliferative diseases. US7790756; 2010
  • Zhang D. Preparation of fluoro-substituted compounds as kinase inhibitors. WO008788; 2011
  • Hanmi Holdings CO LTD, Korea Institute of Science and Technology and Catholic University Industry Academic Cooperation Foundation. Preparation of thienopyrimidine derivatives for use as protein kinase inhibitors. WO093684; 2011
  • Pyramal Life Sciences Ltd. Oxadiazole compounds, their preparation and use for treating cancer. WO104680; 2011
  • Novartis AG. Preparation of cyclic ether compounds useful as kinase inhibitors for treatment of cancer or autoimmune diseases. WO004217; 2012
  • Schenone S, Tintori C, Botta M. Using insights into Pim1 structure to design new anticancer drugs. Curr Pharm Des 2010;16:3964-78
  • F. Hoffmann-La Roche AG. Substituted 6,6-fused nitrogenous heterocyclic compounds as c-Abl kinase inhibitors and their preparation. WO080284; 2012
  • Pierre Fabre Medicament. Derivatives of azaindazole or diazaindazole type as medicament. WO101239; 2012
  • Università degli Studi di Padova. Biphenyl tricyclic quinazoline compounds. WO127012; 2012
  • Ho TH, Jonasch E. Axitinib in the treatment of metastatic renal cell carcinoma. Future Oncol 2011;7:1247-53
  • Musumeci F, Radi M, Brullo C, Schenone S. Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors. J Med Chem 2012;55:10797-822
  • Pfizer, Inc. N-methyl-2-[3-((e)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukaemia. WO068909; 2013
  • Novartis AG. Preparation of benzamide compounds as ABL1, ABL2, and BCR-ABL1 inhibitors for treating cancer, viral infections, and CNS disorders. WO171641; 2013
  • Novartis AG. Preparation of benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 for treating cancer. WO171639; 2013
  • Astar Biotech LLC. Preparation of ethynylbenzamide and piperdinecarboxamide compounds as protein kinase inhibitors. WO019338; 2014
  • Nanjing Sanhome Pharmaceutical Co., Ltd. Alkynyl heteroaromatic ring compounds ABL kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. WO040549; 2014
  • Nanjing Sanhome Pharmaceutical Co., Ltd. Preparation of heteroaryl alkynes as antitumor agents. WO082578; 2014
  • Nant Holdings Ip, Lic. Preparation of substituted indol-5-ol derivatives and their therapeutical applications. WO071378; 2014
  • Agency Science Tech & Res. Preparation of N-[4-(piperazinomethyl)phenyl] amides as MAP kinase interacting kinases 1 and 2 (MNK1 and MNK2) modulators and ABL and ABL (T3151) inhibitors. WO088519; 2014
  • Oribase Pharma. Azaindoles as protein kinase inhibitors and their preparation. WO102376; 2014
  • Oribase Pharma. Azaindole derivatives as inhibitors of protein kinases and their preparation. WO102378; 2014
  • Shanghai Pharmaceuticals Holding Co., Ltd. Deuterated 3-cyanoquinoline compounds as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. WO086284; 2014
  • Terrabay Pharmaceuticals, Inc. Fluorocyclobutanylimidazole compounds as ABL tyrosine kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancers. WO108021; 2014

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.