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Review

Advances in the treatment of chronic wounds: a patent review

, PhD (Chief Scientific Officer) & , PhD (Professor)

Bibliography

  • Richmond NA, Lamel SA, Davidson JM, et al. US-National institutes of Health-funded research for cutaneous wounds in 2012. Wound Repair Reg 2013;21:789-92
  • Heublein H, Bader A, Giri S. Preclinical and clinical evidence for stem cell therapies as treatment for diabetic wounds. Drug Discov Today 2015. [Epub ahead of print]
  • Sun BK, Siprashvilli Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science 2014;346:941-5
  • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366:1736-43
  • Schreml S, Szeimies RM, Prantl L, et al. Wound healing in the 21st century. J Am Acad Dermatol 2010;63:866-81
  • Tomic-Canic M, Brem H, Samuels HH. De novo synthesis of glucocorticoids in the epidermis and its uses and applications. US 8,802,660 B2; 2014
  • Slominski A, Zbytek B, Nikolakis G, et al. Steroidogenesis in the skin: implication for local immune functions. J Steroid Biochem Mol Biol 2013;137:107-23
  • Slominski AT, Manna PR, Tuckey RC. Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Dermatol 2014;23:369-74
  • Vukelic S, Stojadinovic O, Pastar I, et al. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem 2011;286:10265-75
  • Wikramanayaka TC, Stojadinovic O, Tomic-Canic M. Epidermal differentiation in barrier maintenance and wound healing. Adv Wound Care 2014;3:272-80
  • Gould L, Abadir P, Brem H, et al. Chronic wound repair and healing in older adults: current status and future research. Wound Rep Regen 2015;63(3):427-38
  • Pastar I, Stojadinovic O, Yin NC, et al. Epithelialization in wound healing: a comprehensive review. Adv Wound Care 2014;3:445-64
  • Santoro MM, Gaudino G. Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res 2005;304:274-86
  • Carty SM, Cochrane CA, Clegg PD, Percival SL. The role of endogenous enzymes in chronic wounds: a focus on the implications of aberrant levels of both host and bacterial proteases in wound healing. Wound Rep Reg 2012;20:125-36
  • Churko JM, Laird DW. Gap junction remodeling in skin repair following wounding and disease. Physiology 2013;28:190-8
  • Becker DL, Thrasivoulou C, Philips ARJ. Connexins in wound healing: perspectives in diabetic patients. Biochim Biophys Acta 2012;1818:2068-75
  • Stojadinovic O, Gordon KA, Lebrun E, Tomic-Canic M. Stress-induced hormones cortisol and epinephrine impair wound epithelization. Adv Wound Care 2012;1:29-35
  • Yao J, Yang W, Liu Y, et al. Dexamethasone inhibits TGF-ß2-induced migration of human lens epithelial cells: implications for posterior capsule opacification prevention. Mol Med Reports 2012;5:1509-13
  • Shikatani EA, Trifonova A, Mandel ER, et al. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS ONE 2012;7:e46625
  • Tiganescu A, Tahrani AA, Morgan SA, et al. 11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest 2013;123:3051-60
  • Wang AS, Armstrong EJ, Armstrong AW. Corticosteroids and wound healing: clinical considerations in the perioperative period. Am J Surg 2013;206:410-17
  • Hille UE, Zimmer C, Haupenthal J, Hartmann RW. Optimization of the first selective steroid-11β-hydroxylase (CYP11B1) inhibitors for the treatment of cortisol dependent diseases. ACS Med Chem. Lett 2011;2:559-64
  • Emmerich J, Hu Q, Hanke N, Hartmann RW. Cushing’s syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)-pyridine type. J Med Chem 2013;56:6022-32
  • Zhu W, Hu Q, Hanke N, et al. Potent 11ß-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing. J Med Chem 2014;57:7811-17
  • Hartmann R, Hille U, Hu Q, et al. Selective Cyp11b1 inhibitors for the treatment of cortisol dependent diseases. WO2012052540 A1; 2012
  • Bionetworks GmbH. Wilckens T. 11β-Hydroxysteroid dehydrogenases. WO 2006097337 A2; 2006
  • Amgen Inc. Biovitrum Ab. Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1. WO2008011453 A2; 2008
  • Amgen Inc. Biovitrum. Ab. Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1. CA2630718 A1; 2007
  • Vitae Pharmaceuticals Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. WO2010091067 A2; 2010
  • Davidson JM. First-class delivery: getting growth factors to their destination. J Invest Dermatol 2008;128:1360-2
  • Judith R, Nithya M, Rose C, et al. Application of a PDGF-containing novel gel for ctaneous wound healing. Life Sci 2010;87:1-8
  • Cheng B, Liu HW, Fu XB, et al. Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats. J Dermatol Sci 2007;45:193-201
  • Sun W, Lin H, Xie H, et al. Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model. Growth Fact 2007;25:309-18
  • Vegenics Pty Ltd. Methods of stimulating wound healing by administration of vascular endothelial growth factor D (VEGF-D). US8227410 B2; 2012
  • Gene Signal International SA. Novel peptides for wound healing. US20110306545 A1; 2011
  • Ranbaxy Laboratories Ltd. Matrix metalloproteinase inhibitors. US8846910 B2; 2014
  • Janssen Pharmaceutica NV. Thiazol derivatives as pro-matrix metalloproteinase inhibitors. WO2012162468 A1; 2012
  • Dyax Corp. Metalloproteinase 9 and metalloproteinase 2 binding proteins. US8013125 B2. 2011
  • Amgen. Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods. US20140228540 A1; 2014
  • Kimberly - Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing. US7186693 B2; 2007
  • Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care 2014;3:390-9
  • Bayer Intellectual Property GmbH. Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors. US8524699 B2; 2013
  • Amgen. Diazaquinolones that inhibit prolyl hydroxylase activity. US8097620 B2; 2012
  • GlaxoSmithKline Llc. Prolyl hydroxylase inhibitors. WO2010059552 A1; 2010
  • Janssen Pharmaceutica N.V. Benzoimidazole glycinamides as prolyl hydroxylase inhibitors. WO2009134754 A1; 2009
  • Ruthenborg RJ, Ban J-J, Wazir A, et al. Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. Mol Cells 2014;37:637-43
  • Maxson S, Lopez EA, Yoo D, et al. Concise review: role of mesenchymal stem cells in wound repair. Stem Cells Trans Med 2012;1:142-9
  • Chen JS, Wong VW, Gurtner GC. Therapeutic potential of bone marrow-derived mesenchymal stem cells for cutaneous wound healing. Front Immun 2012;3:192
  • Nuschke A. Activity of mesenchymal stem cells in therapies for chronic skin wound healing. Organesis 2014;10:29-37
  • Cryo-Cell International, Inc. Cell therapy to improve wound healing and related compositions and methods. EP2553089 A1; 2013
  • Mesoblast International Sarl. Mesenchymal stem cells and uses therefor. US 2011/0318314 A1; 2011
  • US Department of Veterans Affairs, University of Utah Research Foundation. Stem cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction. US20140086886 A1; 2014
  • Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells and isolated cell populations generated thereby. US20140023623 A1; 2014
  • Barros SC, Martins JA, Marcos JC, Cavaco-Paulo A. Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzym Micro Tec 2012;50:107-14
  • Carty SM, Percival SL. Proteases and delayed wound healing. Adv Wound Care 2013;2:438-47
  • Delano FA, Schönbein GW. Methods to accelerate tissue and wound healing rates and reduce swelling and scar formation. WO2011038417 A2; 2011
  • Essler A, Nisbet L. Promotion of wound healing. WO20060145182 A2; 2006
  • Lezdey J, Lezdey DB. Topical wound therapeutic compositions. US6262020 B1; 2001
  • Ormondo S, Chou C-Y, Goold L, et al. Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds. J Membr Biol 2012;245:381-8
  • Ongstad EL, O’Quinn MP, Ghatnekar G. A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart. Adv Wound Care 2013;2:55-62
  • Ghatnekar GS, Grek CL, Armstrong DG, et al. The effect of a connexin43.based peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial. J Invest Dermatol 2015;135:289-98
  • Gourdie R, Ghatnekar G, Jourdan J. Compositions and methods for promoting wound healing and tissue regeneration. EP2377546 A2; 2011
  • Coda Therapeutics Inc. Anti-connexin compounds targeted to connexins and methods of use thereof. US8815819; 2014

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